Presentation
In this case report, we describe dysphonia as an uncommon presentation of a rare posterior fossa tumor. To our knowledge, a case of choroid plexus papilloma presenting with dysphonia has not been described before. [ncbi.nlm.nih.gov]
Respiratoric
- Rhinorrhea
Postoperative course was uneventful, just after the operation rhinorrhea ceased completely, and hearing of the right ear dramatically improved. Choroid plexus papillomas rarely cause cerebrospinal fluid (CSF) rhinorrhea. [ncbi.nlm.nih.gov]
Ears
- Progressive Hearing Loss
Case 2 : A 32 year old female was admitted in December 1995 with history of progressive hearing loss in the right ear for 7 months. [neurologyindia.com]
Eyes
- Progressive Loss of Vision
Six months later, he came to us with progressive loss of vision due to raised intracranial pressure. The lesion may not be detected on CT scans and MRI scan is the imaging modality of choice. [ncbi.nlm.nih.gov]
Musculoskeletal
- Joint Stiffness
Characteristics include red or dark patches on the skin; burning, itching, swelling, hardening, and tightening of the skin; yellow spots on the whites of the eyes; joint stiffness with trouble moving or straightening the arms, hands, legs, or feet; pain [emedicine.com]
Face, Head & Neck
- Facial Numbness
Three years later, her right cerebellar signs reappeared and facial numbness intensified, headache and difficulty in swallowing also became worse. [neurologyindia.com]
- Episodic Headache
History of severe episodic headache, diplopia and progressive diminution of vision for one and a half months was also reported. [neurologyindia.com]
- Facial Pain
The patient's facial pain gradually resolved. Involvement of the trigeminal nucleus in the brainstem by the cerebellopontine angle tumour is suggested as the possible cause for trigeminal neuralgia in this case. [ncbi.nlm.nih.gov]
Neurologic
- Headache
A 51-year-old female presented with a rare case of choroid plexus papilloma originating in the sella turcica manifesting as headaches that was not readily distinguishable preoperatively from pituitary adenoma. [ncbi.nlm.nih.gov]
Most common signs/symptoms are of raised ICT, Macrocrania, bulging fontanelle, vomiting, headache, ataxia. [neuroradiologycases.com]
We present an illustrative case with 73 years old male patient who consult with headache to neurosurgery department. [panafrican-med-journal.com]
- Trigeminal Neuralgia
Involvement of the trigeminal nucleus in the brainstem by the cerebellopontine angle tumour is suggested as the possible cause for trigeminal neuralgia in this case. [ncbi.nlm.nih.gov]
Urasaki E : Choroidal epithelial cyst in cerebellopontine angle associated with trigeminal neuralgia case report. Neurol Med Chir (Tokyo) 1989; 29: 424-428. [neurologyindia.com]
- Cerebellar Ataxia
We present a case of a 54-year-old male manifesting slurred speech,nystagmus and cerebellar ataxia. [webview.isho.jp]
- Morning Headache
Case Description: A 21-year-old man with past medical history of asthma presented to us with the chief complaint of morning headache for one month. [file.scirp.org]
- Myoclonus
[…] disorders Basal ganglia disease Parkinsonism PD Postencephalitic NMS PKAN Tauopathy PSP Striatonigral degeneration Hemiballismus HD OA Dyskinesia Dystonia Status dystonicus Spasmodic torticollis Meige's Blepharospasm Athetosis Chorea Choreoathetosis Myoclonus [theinfolist.com]
Workup
After doing the workup for primary, he underwent sub-occipital craniotomy, and gross total excision. The tumor was greyish, soft, suckable, and very vascular; gross total excision was done. [ruralneuropractice.com]
Clinical presentationThe patient is a 37 year old woman referred from anoutside hospital for workup of an intracranial mass. 3. [de.slideshare.net]
This workup often necessitates a battery of immunohistochemical studies. Transthyretin and/or S100 expression is supportive evidence for a choroid plexus neoplasm, although, unfortunately these stains are not 100% reliable. [r-radiology.com]
Microbiology
- Blood Culture Positive
Her laboratory results were significant for an absolute neutrophil count of 0/µL and blood cultures positive for Capnocytophagia species. She was supported with broad spectrum antibiotics and myeloid growth factors. [ncbi.nlm.nih.gov]
Other Pathologies
- Lymphocytic Infiltrate
The sub epithelial cord substance of the papillae appears focally odematous with congested blood vessels and sparse lymphocytic infiltrates. There is no evidence of cytological anaplasia. Histopathological diagnosis : Choroid Plexus Papilloma. [neuroradiologycases.com]
Treatment
Total surgical resection is the treatment of choice for choroid plexus tumors. However, the hypervascular nature of such lesions imposes challenges to the surgical treatment. [ncbi.nlm.nih.gov]
Treatment planning included placement of a ventriculoperitoneal shunt to treat hydrocephalus and to allow the child to grow prior to resection. [inovaideas.org]
An atypical CPP is more likely to come back after treatment. If CPP does come back, you may need chemotherapy or radiation therapy to treat it. You will need to work with your medical team to decide on the best treatment plan for you. [cedars-sinai.edu]
Prognosis
Immunophenotype cytokeratins: positive (especially CK7) vimentin : positive transthyretin usually positive also found in normal choroid plexus better prognosis if positive 10 S100 variable better prognosis if positive 10 KIR7.1 usually positive and specific [radiopaedia.org]
This case highlights the available treatment and good prognosis that is possible with Choroid plexus papilloma. [ncbi.nlm.nih.gov]
Complete resection of this malignant tumor is the primary goal of treatment since it allows best chance of survival and improves the overall prognosis [1] [4] [5]. [file.scirp.org]
Etiology
One theory of the etiology involves the presence of simian vacuolating virus No. 40 (SV40)–related viral DNA. Pathology: They may arise wherever a choroid plexus exists. Tumoral distribution varies between pediatric and adult patients. [thamburaj.com]
Etiology CPPs arise from the single layer of cuboidal epithelial cells lining the papillae of the choroid plexus. [emedicine.medscape.com]
[…] factori fumatul ţigarete ţigări de foi pipă mestecatul prizatul Consumul de alcool Factori chimici azbest crom nichel arsenic formaldehidă Alţi factori radiaţii ionizante sindromul Plummer-Vinson virusul Epstein-Barr virusul HPV As with lung cancer, many etiologic [slideplayer.com]
There is no significant sex predilection. [1] Etiology Although the vast majority of choroid plexus tumors are sporadic, hereditary factors appear to play a role in the development of some choroid plexus papillomas and carcinomas. [r-radiology.com]
Epidemiology
Epidemiology Frequency CPPs are rare, comprising less than 1% of brain tumors in patients of all ages. [emedicine.medscape.com]
Epidemiology Choroid plexus papilloma accounts for less than 1% of all brain tumors, and about 2-4% of those that occur in children. 10-20% of all choroid plexus papillomas aise in the first year of life. The average incidence is 0.3 per 1,000,000. [prod.wiki.cns.org]
Jump to navigation Jump to search Epidemiology [ edit ] 0.5% intracranial neoplasms 10-20% intracranial neoplasms in 70% of choroid plexus tumors occur in pts Histology [ edit ] Choroid plexus papillomas are WHO grade I. [en.wikibooks.org]
Hankinson, Pediatric choroid plexus tumors: epidemiology, treatments, and outcome analysis on 202 children from the SEER database, Journal of Neuro-Oncology, 2015, 121, 1, 201 CrossRef 3 Annalisa Passariello, Maria Tufano, Pietro Spennato, Lucia Quaglietta [onlinelibrary.wiley.com]
The relatively small number of CPC cases in the literature, coupled with the lack of relevant epidemiological data and controversies about their clinical and pathological diagnosis makes it difficult to establish a standardized therapeutic approach in [journals.plos.org]
Pathophysiology
The challenges in this situation are to recognize CSF leak, to rapidly understand the pathophysiology of the leak, and to choose the best treatment strategy in emergency. [ncbi.nlm.nih.gov]
Contents 1 Pathophysiology 2 Frequency and age affected 3 Signs and symptoms 4 Surgical treatment 5 See also 6 Additional images 7 References 8 External links Pathophysiology[edit] The tumor is neuroectodermal in origin and similar in structure to a normal [theinfolist.com]
Pathophysiology Neuroectodermal origin: The structure is similar to normal choroid plexus, and it is formed of epithelial cells. [ispn.guide]
Pathophysiology The tumor is neuroectodermal in origin and similar in structure to a normal choroid plexus. They may be created by epithelial cells of the choroid plexus. [howlingpixel.com]
TWIST-1 is involved in the p53 tumor suppressor pathway as an inhibitor. [19] Pathophysiology Symptoms from choroid plexus tumors generally result from secretion of CSF by tumor cells, leading to an increased amount of fluid and, eventually, to hydrocephalus [emedicine.medscape.com]
Prevention
We recommend precise evaluation of intracranial cystic lesions to prevent wrong diagnosis and operation. Total resection of all enhancing nodules in cystic choroid plexus papilloma is proposed to warrant total cure of tumor. [ncbi.nlm.nih.gov]
They bring together our team of multidisciplinary experts to deliver a coordinated approach to neuroscience, from research and prevention to treatment and post-treatment care. [northwell.edu]
Radiation therapy : This process destroys cancer cells and prevents others from growing. [aurorahealthcare.org]
In this particular case, two lines of chemotherapy had failed, and poor marrow reserve secondary to craniospinal radiotherapy in an adult patient (36 Gy of craniospinal irradiation and 54 Gy to the cranium) prevented further delivery of cytotoxics. [pagepress.org]
Chemotherapy contributes to long-term survival, but it can not prevent recurrence [ 8 ]. Bleggi-Torres et al. reported 15 cases of CPC and the oldest patient of his series is 22 years old [ 9 ]. [panafrican-med-journal.com]