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Chromophobe Adenoma


Presentation

  • Two cases of pituitary necrosis was presented, one occurring post partum in an otherwise normal gland, the other in a large chromophobe adenoma.[ncbi.nlm.nih.gov]
High Fever
  • At the onset of disease polydypsia and polyuria were marked followed by interstitial pneumonia with high fever, and later generalized tonic convulsion terminated in death. This case is peculiar in at least two respects.[ncbi.nlm.nih.gov]
Vietnamese
  • […] chromium plating chromolithograph chromolithography chromophobe adenoma chromosomal chromosome chromosome aberration chromosphere chronic chronic bronchitis chronic myelogenous leukemia chronic polyarthritis chronically chronically ill Have a look at the Vietnamese-English[en.bab.la]
Epilepsy
  • 523 522 Frontoopercular gliosis with calcification and retraction 526 Lowgrade astrocytoma no progression in two years 528 Periinsular gliosis 529 Refractory partial epilepsy gliosis of the temporal lobe 530 Partial complex epilepsy temporal lobe atrophy[books.google.com]
Pneumonia
  • This report deals with a 1.5-year-old male infant terminating in viral pneumonia and "diabetes insipidus".[ncbi.nlm.nih.gov]
Dysphagia
  • Unlike most other body Hypothalamus Headaches Pituitary Headaches, visual defect 'systems' the very nature of the endocrine system Thyroid Pressure symptoms, dysphagia, ensures that the effects of disordered function in a goitre gland affect the body[books.google.com]
Palpitations
  • Most patients with a cardiac problem present with one or more specific symptoms such as chest pain, palpitations and oedema.[books.google.com]
Chest Pain
  • Most patients with a cardiac problem present with one or more specific symptoms such as chest pain, palpitations and oedema.[books.google.com]
Fear
  • Chromophobia noun a fear of colors; also called chromatophobia, psychrophobia See chromatophobia Word Origin chromo- ‘color’ chromophobia chro·mo·pho·bi·a (krō’mə-fō’bē-ə) or chro·mat·o·pho·bi·a (krō-māt’ə-, krō’mə-tō-) n.[definithing.com]
Convulsions
  • At the onset of disease polydypsia and polyuria were marked followed by interstitial pneumonia with high fever, and later generalized tonic convulsion terminated in death. This case is peculiar in at least two respects.[ncbi.nlm.nih.gov]
Tremor
  • HISTORY Similarly, most patients with a gastro-enterological and neurological problem will present with a specific Present history symptom - diarrhoea, or tremor - which will direct attention to that organ system.[books.google.com]

Workup

  • Size A MICROadenoma is less than 1 cm and is often an incidental finding on an MRI of the brain done for other reasons, like workup of a headache.[neurosurgerybasics.com]
  • While a majority of patients with endogenous Cushing syndrome have thyrotrophic adenomas (called Cushing Disease - see below), other tumors should also be considered as part of the endocrinologic workup, including adrenal tumors and especially ACTH-secreting[eyewiki.aao.org]
  • Endocrine Testing Apparently nonfunctioning adenomas may be associated with abnormal results on serum endocrine studies; these studies should be done as part of the comprehensive workup of an apparently nonsecretory lesion.[pituitaryadenomas.com]
Enlarged Sella
  • Abstract A 50-year-old man with bitemporal hemianopsia and an enlarged sella turcica was found to have hyperthyroidism with elevated serum thyrotropin levels (17 mμg per milliliter) measured by radioimmunoassay.[nejm.org]
  • sella with an intact floor Grade III: Localized erosion or destruction of the sellar floor Grade IV: Diffusely eroded or destroyed floor Treatment Overview [ edit ] Observation for select nonsecreting microadenomas and small prolactinomas Microadenoma[en.wikibooks.org]
  • On MRI non secretory pituitary adenomas are usually associated with an enlarged sella turcica.[pituitaryadenomas.com]
Aldosterone Increased
  • Plasma renin activity and aldosterone increased from 1.1 to 16 ng/ml per hour and from 6.7 to 39 ng/dl, respectively, and remained elevated for three and a half hours after tilt testing.[ncbi.nlm.nih.gov]
Ovarian Mass
Gliosis
  • […] with calcification and retraction 526 Lowgrade astrocytoma no progression in two years 528 Periinsular gliosis 529 Refractory partial epilepsy gliosis of the temporal lobe 530 Partial complex epilepsy temporal lobe atrophy 532 POSTOPERATIVE CONDITIONS[books.google.com]
Adrenocortical Hyperplasia
  • NELSON et al. 1 , 2 recently described the occurrence of ACTH-secreting chromophobe adenomas in patients with adrenocortical hyperplasia after bilateral total adrenalectomy.[nejm.org]

Treatment

  • Adrenalectomy performed in the treatment of Cushing's disease may be followed by skin pigmentation and an enlarging pituitary tumour (Nelson's syndrome), changes which are commonly attributed to the removal of the negative feed-back mechanism.[ncbi.nlm.nih.gov]
  • Master the latest advances in ophthalmology: radical changes in the management of macular disease, including the widespread introduction of VEGF inhibitor therapy; recent developments in the investigation and treatment of retinal vascular disease; new[books.google.de]
  • After treatment of the remaining pituitary tumor with external irradiation there was remission of the hyperthyroidism without other antithyroid therapy. The serum thyrotropin levels have subsequently been normal (1.6 to 2.8 mμg per milliliter).[nejm.org]

Prognosis

  • Abstract Renal oncocytoma, conventional RCC (granular cell type) and chromophobe RCC have different prognosis. Sometimes differentiation between them is difficult in HandE slides.[ncbi.nlm.nih.gov]
  • Prognosis Recurrent symptoms requiring further intervention is relatively common, with 18% of patients with non-functioning tumors and 25% of patients with prolactinomas eventually needing further treatment 6 .[radiopaedia.org]
  • Prognosis The anatomic extent of the disease represented by stage of disease is the single most important indicator of prognosis in RCC.[atlasgeneticsoncology.org]
  • Department of Pathology, Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran Click here for correspondence address and email Abstract Renal oncocytoma, conventional RCC (granular cell type) and chromophobe RCC have different prognosis[ijpmonline.org]
  • Identification of these subtypes could lead to separation of hepatocellular carcinomas into discrete groups with unique underlying genetic changes, prognosis, or therapeutic responses.[nature.com]

Etiology

  • In none of these cases, however, was the diagnosis of an ACTH-secreting chromophobe adenoma established at the outset, and the present evidence favoring a pituitary etiology is based on retrospective reasoning and demonstration of abnormally high levels[nejm.org]
  • Etiology A specific factor in the etiology of RCC is not known at the moment, although a number of dietary, environmental factors, hormonal, celllular and genetic factors associated with increased risk.[atlasgeneticsoncology.org]
  • The etiology and pathophysiology of CH are unknown.[jmedicalcasereports.biomedcentral.com]
  • If the presenting symptom is sudden monocular visual loss, a pituitary adenoma may be acutely missed, as other more common etiologies are evaluated.[eyewiki.aao.org]
  • […] subtype can be identified by routine surgical pathology and when its recognition as a subtype conveys clinically meaningful information, with the realization that the clinically meaningful information may take many forms, including prognostic information, etiological[nature.com]

Epidemiology

  • Epidemiology [ 1 ] Pituitary tumours account for 10% to 25% of all intracranial neoplasms. Adenomas account for the largest portion of pituitary neoplasms (estimated at approximately 17%). Only a minority of adenomas are symptomatic.[patient.info]
  • […] cell borders, finely reticular pale cytoplasm, perinuclear halos and wrinkled raisinoid nuclei First described in 1985 ( Virchows Arch B Cell Pathol Incl Mol Pathol 1985;48:207 ) Cell of origin: distal convoluted tubules and cortical collecting ducts Epidemiology[pathologyoutlines.com]
  • Epidemiology ChRCC comprise 5% of all renal cell carcinomas. Most tumors are sporadic, with a slight male predilection. Pathology ChRCC tumors can vary in size and have a tan to brown cut surface.[atlasgeneticsoncology.org]
  • Jump to navigation Jump to search Pituitary Adenoma Epidemiology [ edit ] Comprise 10% of intracranial tumors On autopsy found in 5-25% Male:female 1:1 Majority present between 30-50 years old Genetic predisposition in MEN-1 Benign histologically Nonsecretory[en.wikibooks.org]
Sex distribution
Age distribution

Pathophysiology

  • The etiology and pathophysiology of CH are unknown.[jmedicalcasereports.biomedcentral.com]
  • Our growing understanding of pituitary pathophysiology has led to a steady diminution in the number of pituitary adenomas considered to be nonsecretory.[pituitaryadenomas.com]
  • The histogenesis still remains controversial, and ongoing research is required to understand its pathophysiology and draw any firm conclusions to assist and guide clinical practice.[edmcasereports.com]
  • The exact pathophysiology of this phenomenon is unknown; however, as most of these lesions involve the chiasm and/or diencephalon, many have proposed that disruption of visual and vestibular input contribute to this pathology.[eyewiki.aao.org]
  • It also suggests, however, that pituitary adenomas may arrive by different pathophysiologic pathways. Non-hormone-secreting pituitary tumors tend to grow slowly and insidiously.[glowm.com]

Prevention

  • Prevention There are no known ways to prevent pituitary cancer, but there are ways to lower your chances of getting any kind of cancer, and to kill it early if you do get cancer. Such methods include: 1.[slideshare.net]
  • There is no way to prevent kidney cancer from forming. It is more a matter of avoiding risk factors, such as unhealthy diet and smoking.[my.clevelandclinic.org]
  • At present, most patients are treated as having a clinically nonfunctioning adenoma, and the therapeutic goals are restoration of visual deficits, preservation of pituitary function, and prevention of recurrence. [15] Null cell adenomas and oncocytomas[emedicine.medscape.com]
  • Immunoreactions were developed using a non-biotin, highly sensitive system (Envision peroxidase detection system, DAKO, Carpinteria, CA, USA) preventing possible false-positive staining due to endogenous biotin present in the tissues.[nature.com]
  • Bromocriptine administration is noninvasive and may reduce tumor size or may retard or prevent potential tumor growth; therapeutic benefits depend on its continued use.[glowm.com]

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