Table 1: Causes of PRCA Acquired Acute self-limited Red Cell Aplasia Viral Infections: Respiratory infections, primary atypical pneumonia, gastroenteritis, infectious mononucleosis, mumps and viral hepatitis Parvovirus B19 Antiepileptic medications (eg [ijmstrust.in]

mononucleosis Mumps Viral hepatitis Most cases of acute transient PRCA are caused by parvovirus B19 infection. [21, 22] Parvovirus B19 can cross the placenta in infected women and can destroy erythroid cells in the fetus and induce spontaneous abortions [emedicine.medscape.com]

Compared to the overall CHC cohort, possible PRCA cases were more likely to have a history of hepatitis B virus infection (8.0% versus 2.5%), infectious mononucleosis (4.0% versus 0.1%), chronic renal insufficiency (8.0% versus 3.3%), anemia (48.0% versus [hoajonline.com]

Other viral infections have been implicated in pure red cell aplasia, including infectious mononucleosis and, in some patients, hepatitis (an unknown agent in seronegative hepatitis). [patient-help.com]

Purtilo DT, Zelkowitz L, Harada S, et al: Delayed onset of infectious mononucleosis associated with acquired agammaglobulinemia and red cell aplasia. Ann Intern Med 101:180, 1984. 24. [medtextfree.wordpress.com]

No h/o cold intolerance /constipation /voice change ; No h/o polyuria/polydipsia /polyphagia; No h/o loose stools /vomiting/altered bowel habits; No h/o yellowish discoloration of urine ; No h/o abdominal distension/swelling of legs; No h/o weakness of [slideshare.net]

Long-term use of high-dose prednisone results in significant toxicity, including some combination of growth retardation, cushingoid facies, buffalo hump, osteoporosis, aseptic necrosis of the hip and fractures, diabetes, hypertension, and cataracts. [patient-help.com]

Long-term use of high-dose prednisone results in significant toxicity, including some combination of growth retardation, cushingoid facies, buffalo hump, osteoporosis, aseptic necrosis of the hip and fractures, diabetes, hypertension, and cataracts. [patient-help.com]

Long-term use of high-dose prednisone results in significant toxicity, including some combination of growth retardation, cushingoid facies, buffalo hump, osteoporosis, aseptic necrosis of the hip and fractures, diabetes, hypertension, and cataracts. [patient-help.com]

[…] aplasia. [15] [16] [17] [18] [19] Acutely presenting in children Acute acquired form is predominantly present in children. [1] Chronically presenting in adults Chronic form is predominantly present in adults. [1] Features of acute heart failure i.e. orthopnea [explainmedicine.com]

Velu; 42/m; Korukkupet- Manual labourer 3. c/o :- breathlessness on exertion 6months cough HOPI :- patient was apparently normal 6 months before ; h/o breathlessness present; grade 1; no h/o PND/orthopnea/chest pain /palpitation; h/o dry cough ; intermittent [slideshare.net]

Velu; 42/m; Korukkupet- Manual labourer 3. c/o :- breathlessness on exertion 6months cough HOPI :- patient was apparently normal 6 months before ; h/o breathlessness present; grade 1; no h/o PND/orthopnea/chest pain /palpitation; h/o dry cough ; intermittent [slideshare.net]

Symptoms of Acquired Pure Red Cell Aplasia Symptomatic anemia in the older patient may manifest as pallor, fatigue, lassitude, pulsatile tinnitus, and anginal chest pain. [patient-help.com]

General examination : conscious oriented afebrile pallor no icterus/ cyanosis clubbing pedal edema lymphadenopathy sternal tenderness 7. [slideshare.net]

Vitals: PR- 88/mt; felt in all peripheral pulses equally; BP- 110/80 mmHg; System examination : CVS: ApicaI impulse – normal in position; S 1 S 2 heard ; haemic murmur heard in all areas ; no thrill ; 8. [slideshare.net]

RS:- trachea in midline; normal vesicular breath sounds heard in all areas;no added sounds ; ABDOMEN: soft, no organomegaly; no free fluid; CNS: higher functions/motor,sensory,cranial nerves- normal; no involuntary movements; spine cranium normal 9. [slideshare.net]

Final diagnosis MEDIASTINAL MASS s/o THYMOMA ANEMIA PURE RED CELL APLASIA 24. [slideshare.net]

Figure 1: Chest X-ray with deviation of the mediastinum to the right suggesting left superior mediastinal mass Click here to view Figure 2: Whole body positron imaging tomography-computed tomography reveals splenomegaly with multiple enlarged faintly [ijhonline.org]