A case is presented of repeated arsenic poisoning over two years misdiagnosed as Landry-Guillain-Barré syndrome. [ncbi.nlm.nih.gov]

We present a case of arsenic poisoning demonstrating both increased hepatic and splenic attenuation. [uncch.pure.elsevier.com]

• Anemia

  Skin pigmentation changes, palmar and plantar hyperkeratoses, gastrointestinal symptoms, anemia, and liver disease are common. Noncirrhotic portal hypertension with bleeding esophageal varices, splenomegaly, and hypersplenism may occur. [ncbi.nlm.nih.gov]

  frequent infections (leukopenia) and easy bruising / petechia (thrombocytopenia) Anemia and leukopenia are common in chronic arsenic toxicity, are often accompanied by thrombocytopenia and mild eosinophilia Chronic arsenic exposure may be associated [pathologyoutlines.com]

  Other symptoms include breakdown of the hemoglobin of red blood cells (hemolysis), a low level of iron in the red blood cells (anemia), and low blood pressure (hypotension). [rarediseases.org]

  Acute lung injury (ALI), acute respiratory distress syndrome (ARDS), frank respiratory failure, hepatitis, hemolytic anemia, and renal failure have all been reported. [calpoison.org]

  […] exposure, the more common effects include gradual loss of strength; diarrhea or constipation; pigmentation and scaling of the skin, which may undergo malignant changes; nervous manifestations marked by paralysis and confusion; degeneration of fatty tissue; anemia [britannica.com]

• Weight Loss

  Weight loss always accompanies stomach cancer in its advanced stage. [napoleon.org]

  Symptoms include nausea, vomiting, weight loss, diarrhea, abdominal pain, headaches, irritability, insomnia, poor balance, numbness and tingling of the extremities, and a few other symptoms. [writersforensicsblog.wordpress.com]

  Patient had history of weight loss and was bed bound for 3 months. None of his brothers or sisters had such a disease. His parents were not alive and they were reported not to have had any such disorder. [jpma.org.pk]

  […] of weight. ◦ Loss of appetite and salivation. ◦ Colicky pain and constipation. ◦ Vomiting and diarrhoea. ◦ Gums are red and soft. ◦ Tongue is coated, is thin white salivary furred. ◦ Oedema of eyelids and ankles ◦ Temperature and pulse is raised 27. [slideshare.net]

  Subscribe to MedicineNet's Weight Loss/Healthy Living Newsletter By clicking "Submit," I agree to the MedicineNet Terms and Conditions and Privacy Policy. [medicinenet.com]

• Fatigue

  Overexposure may cause fatigue, headaches, nausea, vomiting, abdominal cramps, diarrhea, and fever. [rarediseases.org]

  Chronic arsenic intoxication ( arsenicosis) is characterized initially by such nonspecific symptoms as malaise and fatigue. Eventually gastrointestinal disturbances develop, along with changes in the skin and a peripheral neuropathy. [pathopedia-india.com]

  Appl Pharmacol 2001;172:225 ) Clinical features Bone marrow depression: due to acute or more commonly chronic arsenic intoxication, may initially manifest as pancytopenia and be reversible; may have nonspecific clinical presentation of pancytopenia, fatigue [pathologyoutlines.com]

  Symptoms of exposure to small amounts of Arsenic vary and may include fatigue and sleeplessness increased production of saliva and sweat and hallucinations. As the exposure increases, one may start having problems with his stomach and urinary track. [chemsee.com]

• Vomiting

  Trait Arsenic poisoning Cholera 1.Pain in throat Before vomiting After vomiting 2.Purging Follows vomiting Precedes vomiting 3.StoolsLike Bloody later rice-water in early stage, Rice-watery and pass in continuous involuntary jet 4.Tenesmus Present Absent [slideshare.net]

  His vomiting and diarrhea would be bloody and his abdominal pain severe. With an acute poisoning, death can take many hours and is not pleasant. [writersforensicsblog.wordpress.com]

  THALLIUM POISONING Symptoms associated with thallium poisoning include extreme drowsiness (somnolence), nausea, vomiting, abdominal pain, and bloody vomiting (hematemesis). [rarediseases.org]

  Course of the disease Severe abdominal pain, cramps, blood circulation, severe diarrhea and vomiting begin after the adoption of a human poison. Water-salt balance is disrupted; the body loses a lot of protein. [medical-enc.com]

  Acute arsenic poisoning, which may result in shock and death, is marked by skin eruptions, swelling of eyelids and limbs, vomiting, diarrhea, and cramps. [medical-dictionary.thefreedictionary.com]

• Diarrhea

  His vomiting and diarrhea would be bloody and his abdominal pain severe. With an acute poisoning, death can take many hours and is not pleasant. [writersforensicsblog.wordpress.com]

  Acute arsenic poisoning leads to nausea and vomiting, developing into massive intestinal tract inflammation with diarrhea two hours later. [dmsachelation.com]

  Acute poisoning is manifested by abdominal pain, diarrhea and dehydration. [medical-dictionary.thefreedictionary.com]

  Overexposure may cause fatigue, headaches, nausea, vomiting, abdominal cramps, diarrhea, and fever. [rarediseases.org]

  Course of the disease Severe abdominal pain, cramps, blood circulation, severe diarrhea and vomiting begin after the adoption of a human poison. Water-salt balance is disrupted; the body loses a lot of protein. [medical-enc.com]

• Nausea

  A wide range of signs and symptoms may be seen in acute arsenic poisoning including headache, nausea, vomiting, diarrhea, abdominal pain, hypotension, fever, hemolysis, seizures, and mental status changes. [mayomedicallaboratories.com]

  Overexposure may cause fatigue, headaches, nausea, vomiting, abdominal cramps, diarrhea, and fever. [rarediseases.org]

  Acute arsenic poisoning is associated initially with nausea, vomiting, abdominal pain, and severe diarrhoea. Encephalopathy and peripheral neuropathy are reported. Chronic arsenic toxicity results in multisystem disease. [ncbi.nlm.nih.gov]

  Small amounts absorbed over a period of time may result in chronic poisoning, producing nausea, headache, coloration and scaling of the skin, hyperkeratoses, anorexia, and white lines across the fingernails. [medical-dictionary.thefreedictionary.com]

  Symptoms of acute poisoning from swallowing arsenic include nausea, vomiting, burning of the mouth and throat, and severe abdominal pains. Circulatory collapse may occur and be followed by death within a few hours. [britannica.com]

• Abdominal Pain

  His vomiting and diarrhea would be bloody and his abdominal pain severe. With an acute poisoning, death can take many hours and is not pleasant. [writersforensicsblog.wordpress.com]

  Nausea, epigastric pain, colic (abdominal pain), diarrhea, and paresthesias of the hands and feet can occur. Reference Values Describes reference intervals and additional information for interpretation of test results. [mayomedicallaboratories.com]

  Additional symptoms may include fever, headaches, fatigue, sluggishness (letheragy), vomiting, loss of appetite (anorexia), abdominal pain, constipation, joint pain, loss of recently acquired skills, incoordination, listlessness, difficulty sleeping [rarediseases.org]

  Acute arsenic poisoning is associated initially with nausea, vomiting, abdominal pain, and severe diarrhoea. Encephalopathy and peripheral neuropathy are reported. Chronic arsenic toxicity results in multisystem disease. [ncbi.nlm.nih.gov]

  Acute poisoning is manifested by abdominal pain, diarrhea and dehydration. [medical-dictionary.thefreedictionary.com]

• Abdominal Cramps

  Overexposure may cause fatigue, headaches, nausea, vomiting, abdominal cramps, diarrhea, and fever. [rarediseases.org]

  There could be no doubt about arsenic's efficacy as a single large dose, which provoked violent abdominal cramping, diarrhea and vomiting, often followed by death from shock. [dartmouth.edu]

  Napoleon suffered stomach troubles, pain in the upper part of the stomach, anorexia, nausea, vomiting, hiccup (irritation of the diaphragm), dysuria, lethargy, spikes of fever, diarrhea, constipation, abdominal cramps, excessive weakness, heavy perspiration [napoleon.org]

• Muscle Weakness

  Obviously, part of this weakening of muscles can be attributed to lack of energy or general weakness, but the health biography gives the impression of a gradual setting-in of partial paralysis that can better be accredited to declining muscle strength [gurupoison.tripod.com]

  Swallowing high levels of arsenic can cause nausea, vomiting, diarrhea, muscle weakness and cramping, skin rashes, and other problems. Exposure to high enough amounts of arsenic can be fatal. [cancer.org]

• Hyperpigmentation

  RESULTS: Among the 116 residents screened, 81 (70%) had clinically confirmed arsenic keratoses and hyperpigmentation. Among them, 52 were males and 29 were females with age range of 4-82 years. [ncbi.nlm.nih.gov]

  Skin lesions : Hyperpigmentation, hyperkeratosis and cancer / Chien-Jen Chen -- ch. 4. Arsenics and urothelial carcinoma / Chung-Hsin Chen and Yeong-Shiau Pu -- ch. 5. Arsenic exposure and lung cancer / Chi-Ling Chen -- ch. 6. [books.google.com]

  The spirulina plus zinc patients had a statistically significant reduction of hyperpigmentation (melanosis) of the upper chest and arms and cracks and fissures (keratosis) of the palms and soles starting at 8-12 weeks of treatment. [rainbow.coop]

  Skin features of chronic arsenic poisoning Typical findings include: Affected organ Features Skin Excessive darkening of the skin ( hyperpigmentation ) in areas that are not exposed to sunlight Excessive formation of scaly skin on the palms and soles [dermnetnz.org]

• Alopecia

  Also, exfoliative dermatitis, alopecia, conjunctivitis, corneal ulceration. GI: Anorexia, weight loss, abdominal pain, diarrhoea. Jaundice, hepatomegaly; development of portal fibrosis and cirrhosis. [patient.info]

  Overexposure to selenium may cause irritation of the respiratory system, gastrointestinal tract, and eyes; inflammation of the liver; loss of hair (alopecia); loss of skin color (depigmentation); and peripheral nerve damage. [rarediseases.org]

  ◦ Hair are dry patchy and diffuse alopecia. ◦ Painless perforation in the nasal septum. 30.  that look much like traumatic injuries are found on the fingernails. 31. ◦ Peripheral neuritis with glove and stocking type of anaesthesia resembling alcoholism [slideshare.net]

  Patchy alopecia, desquamation, herpetiform lesions and diaphoresis and edema of the face may similarly occur. Chronic arsenic poisoning is somewhat more insidious and occurs most frequently from environmental or occupational exposures. [calpoison.org]

• Desquamating Rash

  Over the next 2 weeks he developed profound distal weakness, desquamating rash over trunk and limbs, rain drop pigmentation ( Figure 1A ) and Mees’ lines ( Figure 1B ). 24-h urine arsenic levels were 405.2 μ g/l. [academic.oup.com]

• Hematuria

  Manifestations are suggestive of a general toxic state with alterations of consciousness, from confusion until delirium, crash, hematuria, jaundice and renal insufficiency. [pathopedia-india.com]

• Peripheral Neuropathy

  Rehabilitation specialists have traditionally dealt with the debilitating consequences of the classic arsenic-induced sensorimotor peripheral neuropathy; however, a knowledge of the presentation of acute toxicity combined with the effects of chronic exposure [ncbi.nlm.nih.gov]

  Peripheral neuropathy is the most frequent manifestation after the initial phase. [jpma.org.pk]

• Headache

  Overexposure may cause headaches, drowsiness, confusion, seizures, and life-threatening complications. [rarediseases.org]

  Symptoms include nausea, vomiting, weight loss, diarrhea, abdominal pain, headaches, irritability, insomnia, poor balance, numbness and tingling of the extremities, and a few other symptoms. [writersforensicsblog.wordpress.com]

  Nails Transverse white bands of arsenic deposits across the bed of the fingernails (Mee's lines) Hair Arsenic deposits in hair Nervous system Sensory changes, numbness and tingling in a “stocking-glove” distribution (sensory peripheral neuropathy ) A headache [dermnetnz.org]

  Haug Browse recently published Learning/CME Learning/CME View all learning/CME CME Case 3-2019: A 70-Year-Old Woman with Fever, Headache, and Progressive Encephalopathy Caplacizumab Treatment for Acquired Thrombotic Thrombocytopenic Purpura Randomized [nejm.org]

  A wide range of signs and symptoms may be seen in acute arsenic poisoning including headache, nausea, vomiting, diarrhea, abdominal pain, hypotension, fever, hemolysis, seizures, and mental status changes. [mayomedicallaboratories.com]

• Paresthesia

  Nausea, epigastric pain, colic (abdominal pain), diarrhea, and paresthesias of the hands and feet can occur. Reference Values Describes reference intervals and additional information for interpretation of test results. [mayomedicallaboratories.com]

  The latter is characterized by paresthesias, motor palsies, and painful neuritis. [pathopedia-india.com]

• Dysesthesia

  These methods can result in scarring and potential dysesthesias. [clinicaladvisor.com]

• Giddiness

   It produces mainly CNS symptoms:  Giddiness  Precordial distress.  Tenderness of muscles.  Delirium.  Dilated pupils and complete paralysis of the muscles at times  Usual symptoms can also be produced such as  Convulsion,  Lockjaw,  Raised [slideshare.net]

A thorough history and physical examination should be performed and further imaging and workup should be based on these findings. [clinicaladvisor.com]

• Leukopenia

  and easy bruising / petechia (thrombocytopenia) Anemia and leukopenia are common in chronic arsenic toxicity, are often accompanied by thrombocytopenia and mild eosinophilia Chronic arsenic exposure may be associated with immunosuppression ( National [pathologyoutlines.com]

  […] system Sensory changes, numbness and tingling in a “stocking-glove” distribution (sensory peripheral neuropathy ) A headache, drowsiness, confusion The distal weakness of small muscles of the. hands and feet Blood and urine Haemolytic anaemia (moderate) leukopenia [dermnetnz.org]

  Leukocytosis acutely followed by leukopenia and thrombocytopenia may occur. Basophilic stippling and karyorrhexis (rupture of a cell nucleus) may be seen following arsenic exposure. [calpoison.org]

There is no specific treatment. Some authors suggest the use of vitamins and minerals for more than 6 months. [ncbi.nlm.nih.gov]

Side effects associated with these treatments are inflammation, oozing, ulceration, crusting, pain, hypo/hyperpigmentation, and treatment failure. Surgical excision can be performed for arsenical keratoses. [clinicaladvisor.com]

Tamra Carlson - 2019-01-07 15:18 Disease Topic Myeloproliferative Neoplasms- MPN implications for classification, diagnosis, and prognosis. [arupconsult.com]

Pregnancy and breast-feeding: arsenic is probably transferred to the baby via the placenta and breast milk. [ 2 ] Prognosis [ 2 ] The prognosis varies with the amount and rate of arsenic ingestion. [patient.info]

Early diagnosis is the key for this condition and offers the best prognosis visually, as well as systemically, for the affected patient. Dr. Pate is a Clinical Associate Professor at the University of Houston College of Optometry. [reviewofoptometry.com]

Bowen's disease was followed by four internal malignant tumors, even though the etiological relation between these cancers and arsenic is not clear. [ncbi.nlm.nih.gov]

Franklin M, Bean WB, Hardin RC: Fowler's solution as an etiologic agent in cirrhosis. Am J Med Sci 219:589–596, 1950 Google Scholar 19. Wade HJ, Frajer ES: Toxipathic hepatitis due to Fowler's solution. A case treated with dimercaprol. [springerlink.com]

Besides skin and lung cancer, industrial and agricultural exposure to arsenic has been implicated in the etiology of cancers of the urinary bladder, kidney, and liver in exposed populations. [pathopedia-india.com]

[…] c-Jun / AP1 transcription complex High doses of inorganic arsenicals induce release of TNF alpha Arsenic can induce cross tolerance to cytotoxicity, genotoxicity and apoptosis induced by nickel and other metals ( Toxicol Appl Pharmacol 2001;176:127 ) Etiology [pathologyoutlines.com]

Discussion of case questions The patient does demonstrate some findings suggestive of arsenic poisoning, however these symptoms are also nonspecific and may reflect other etiologies. [calpoison.org]

Effects of prolonged exposure to high levels of As in drinking water have been observed and documented in various epidemiological studies from all over the world. [ncbi.nlm.nih.gov]

The National Epidemiology Board of Thailand and Prince Songkhla University. Google Scholar Auan-orn, T. (1988) Natural Characteristics of Arsenic in Thailand and Its Environmental Impact. [link.springer.com]

His Scientific Publications are mainly on Toxicology and Epidemiology of environmental agents, particularly metals. [books.google.com]

This case report demonstrates the wide spectrum of medical complications associated with arsenic poisoning and briefly reviews its pathophysiology and treatment from both the medical and psychosocial perspective. [ncbi.nlm.nih.gov]

Useful For Suggests clinical disorders or settings where the test may be helpful Detection of acute or very recent arsenic exposure Monitoring the effectiveness of therapy Clinical Information Discusses physiology, pathophysiology, and general clinical [mayomedicallaboratories.com]

[…] is present in air, usually due to volcanic eruption and purposeful human activities Arsenic also found as sulphuric compound in lead, copper, nickel and ferrous ores; also in soil in small quantities Also a medicinal used by physicians for 2000 years Pathophysiology [pathologyoutlines.com]

Pathophysiology The exact mechanism for chromosomal damage has yet to be fully elucidated. [clinicaladvisor.com]

The article reports treatment and preventative measures based on a review of the literature.) [clinicaladvisor.com]

The Centers for Disease Control and Prevention (CDC) can assist with concerns about arsenic and other toxins. [medicalnewstoday.com]

It is a matter of international importance to be able to correctly diagnose chronic arsenic poisoning and to prevent the development of cancers and circulatory disturbances and to supply arsenic-free drinking water"--Preface. [searchworks.stanford.edu]

There are no proven therapies for treating chronic arsenic toxicity or for preventing arsenical cancers. Selenium has been known to counter arsenic toxicity in a variety of animal models. [clinicaltrials.gov]

One of the most effective preventive measures against arsenic poisoning is to make sure you drink clean, filtered water. You can also make sure that all foods are prepared in clean water. [healthline.com]