We present an overview of the subject and a pictorial review of the spectrum of computed tomographic features of beryllium disease. [ncbi.nlm.nih.gov]

Plexin A protein expression in antigen-presenting cells, BAL fluid, and lung tissue To address whether plexins are present at the site of inflammation in CBD, we used Western blot analysis to assess expression of plexin A2 and A4 proteins in the antigen-presenting [jem.rupress.org]

• Fatigue

  Its symptoms include coughing, shortness of breath, fatigue, weight loss or loss of appetite, fever and sweating. [web.archive.org]

  Beryllium ore Watch out for such CBD symptoms as: Difficulty in breathing while doing physical activities Recurrent dry cough Fatigue Night sweats Pain in the chest and joints Fever Lack of appetite Treating the symptoms Your doctor may recommend three [chronicberylliumdisease.com]

  Over time, the inflammation response continues, and eventually symptoms may appear, including: Difficulty breathing/ shortness of breath Weakness Fatigue Loss of appetite Weight loss Joint pain Cough Fever Cleveland Clinic News & More Cleveland Clinic [my.clevelandclinic.org]

  In the early stages, CBD may not cause any noticeable symptoms, however over time, the exposed individual may experience shortness of breath, fatigue, chronic dry cough, chest/joint pain, loss of appetite, and night sweats. [madeksholaw.com]

• Pathologist

  J.L.A. reported serving as a consultant pathologist and expert witness for various law firms and physicians in cases of known or suspected occupational/environmental lung and other diseases ( 50,000–99,000). [doi.org]

• Productive Cough

  Affected workers present with non-productive cough, dyspnoea on exertion and sometimes fever. [occmed.oxfordjournals.org]

• Exertional Cough

  The chronic form of berylliosis develops along with symptoms of dyspnea or exertion, cough, fatigue, chest pain, weight loss, night sweats, fever and anorexia. [occupational-injury.com]

Workup of Berylliosis The workup consists of a thorough patient history with details and duration of Be exposure, blood BePLT, bronchoscopy with bronchoalveolar lavage fluid, beryllium lymphocyte proliferation test (BePLT), pulmonary CT scan and biopsy [lecturio.com]

To make the diagnosis of CBD, the following criteria need to be satisfied: (1) evidence of sensitization to beryllium by positive findings on blood or bronchoalveolar lavage (BAL) beryllium lymphocyte proliferation test (BeLPT) (see Workup) and (2) the [emedicine.com]

• Ground Glass Appearance

  A high-resolution CT scan of the chest showing the typical ground glass appearance in a patient with chronic beryllium disease, or berylliosis. [emedicine.com]

Please consult your physician for accurate medical advices and treatment. Copyright 2005, health-cares.net, all rights reserved. Last update: July 18, 2005 [respiratory-lung.health-cares.net]

What's the treatment for berylliosis (beryllium disease)? - Ventilators can help patients with acute berylliosis breathe. Prompt corticosteroid therapy is required to lessen lung inflammation. [web.archive.org]

Not everyone who has CBD will need treatment, but many patients will eventually need treatment as the disease progresses. The type of treatment a patient requires depends on the severity of the disease. [nationaljewish.org]

Many businesses sell unreliable tests and expensive or even dangerous treatments. Hair analysis or chelation challenge tests (“provoked urine ” tests). They’re inaccurate. They can’t tell you if you’re sick or need treatment. [webmd.com]

The effect of treatment should be monitored using pulmonary function tests and high-resolution computed tomography of the chest. However, once pulmonary fibrosis has developed, corticosteroid therapy cannot reverse the damage. [ncbi.nlm.nih.gov]

To analyse the natural course of beryllium sensitization and clarify the prognosis following cessation of exposure among sensitized workers. [ncbi.nlm.nih.gov]

Treatment and prognosis While there is no cure, commonly adopted management options involve cessation of beryllium exposure and use of systemic corticosteroids 4. [radiopaedia.org]

[…] lung fields lupus pernio lymph nodes lymphocytes macrophages mesothelioma mottling nerve nodular nodules occasionally occur onset opacities pathogenesis Pathology patients peripheral plaques pleural effusion pneumoconiosis polyarteritis nodosa present prognosis [books.google.com]

Aims To analyse the natural course of beryllium sensitization and clarify the prognosis following cessation of exposure among sensitized workers. [occmed.oxfordjournals.org]

Sarcoidosis is a granulomatosis that predominantly affects the lungs and is of unknown etiology. Chronic beryllium disease is a granulomatosis that predominantly affects the lungs and is due to a hypersensitivity response to beryllium. [ncbi.nlm.nih.gov]

As with chronic lung disease of other etiologies, one should evaluate for bacterial respiratory infections and should treat infections promptly with antibiotics when indicated, especially for those on immunosuppressive therapy. [atsdr.cdc.gov]

Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Pascal 002 Biological and medical sciences / 002B Medical sciences / 002B11 Pneumology Discipline Pulmonology Sarcoidosis. [pascal-francis.inist.fr]

In human studies, the gene has been shown to confer increased susceptibility to beryllium in exposed workers, thus suggesting that HLA gene markers may be used as epidemiological probes to identify population groups at higher risk of environmental lung [doi.org]

Epidemiology of beryllium sensitization and disease in nuclear workers. [ncbi.nlm.nih.gov]

Epidemiology Frequency United States A small percentage of exposed persons (1-10%) develop beryllium hypersensitivity and a portion of those go on to develop chronic disease. [emedicine.com]

Pathophysiology and Presentation of Berylliosis Beryllium is a rare earth metal, which can form alloys with several other metals. [lecturio.com]

Pathophysiology The key to the pathogenesis of chronic beryllium disease (CBD) is a delayed-type hypersensitivity reaction in which beryllium most likely functions as a hapten and acts as a class II restricted antigen, stimulating local proliferation [emedicine.com]

[…] factors are the determinants of the immunopathogenesis of asthma, pulmonary granulomatous disorders, hypersensitivity pneumonitis and fibrotic lung disorders, an understanding of the interaction between environmental factors is crucial to epidemiology, prevention [doi.org]

Health safety in the workplace Prevention is better than cure. Exposure to beryllium is inevitable if your job is among those mentioned earlier. However, workplaces have safety regulations to prevent releasing high amount of beryllium in the air. [chronicberylliumdisease.com]

This systematic review focuses on the use of BeLPT for secondary prevention of CBD in sensitized workers but not on its use for the evaluation of primary prevention programmes. [occmed.oxfordjournals.org]