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Chronic Berylliosis


Presentation

  • We present an overview of the subject and a pictorial review of the spectrum of computed tomographic features of beryllium disease.[ncbi.nlm.nih.gov]
  • Plexin A protein expression in antigen-presenting cells, BAL fluid, and lung tissue To address whether plexins are present at the site of inflammation in CBD, we used Western blot analysis to assess expression of plexin A2 and A4 proteins in the antigen-presenting[jem.rupress.org]
  • We present an overview of the subject and a pictorial review of the spectrum of computed tomographic features of beryllium disease. Related Topics Loading Related Articles[dx.doi.org]
Inflammation
  • Prompt corticosteroid therapy is required to lessen lung inflammation.[web.archive.org]
  • Medical tests may reveal abnormal lung sounds, lung scars, decreased pulmonary function, granulomas (a nodular form of chronic inflammation) and an allergy to beryllium.[respiratory-lung.health-cares.net]
  • Abstract CD4( ) T cells play a key role in granulomatous inflammation in the lung of patients with chronic beryllium disease.[ncbi.nlm.nih.gov]
  • When a person begins to develop CBD, inflammation (swelling) occurs in the lungs because they are reacting to a foreign object.[my.clevelandclinic.org]
Fatigue
  • Its symptoms include coughing, shortness of breath, fatigue, weight loss or loss of appetite, fever and sweating.[web.archive.org]
  • Beryllium ore Watch out for such CBD symptoms as: Difficulty in breathing while doing physical activities Recurrent dry cough Fatigue Night sweats Pain in the chest and joints Fever Lack of appetite Treating the symptoms Your doctor may recommend three[chronicberylliumdisease.com]
  • Over time, the inflammation response continues, and eventually symptoms may appear, including: Difficulty breathing/ shortness of breath Weakness Fatigue Loss of appetite Weight loss Joint pain Cough Fever Cleveland Clinic News & More Cleveland Clinic[my.clevelandclinic.org]
  • In the early stages, CBD may not cause any noticeable symptoms, however over time, the exposed individual may experience shortness of breath, fatigue, chronic dry cough, chest/joint pain, loss of appetite, and night sweats.[madeksholaw.com]
Physician
  • , American College of Physicians, American College of Physicians-American Society of Internal Medicine, American Heart Association, American Thoracic Society, Royal College of Physicians and Surgeons of Canada, Society of Critical Care Medicine Disclosure[emedicine.medscape.com]
  • Patients with more advanced disease should see a physician more frequently. You should talk with your physician about how frequently you should be seen.[nationaljewish.org]
Asymptomatic
  • There are several challenges of conducting systematic longitudinal follow-up of individuals who are asymptomatic: the need for high participation rates limits the possibility to conduct regular bronchoscopic examinations of asymptomatic individuals in[doi.org]
  • The natural history of the disease is not clear in patients who have granulomas on TBBX but who are asymptomatic and have no physiologic or radiographic abnormalities.[emedicine.medscape.com]
Anorexia
  • Fever, anorexia, and weight loss are common. Skin lesions are the most common extrathoracic manifestation. Granulomatous hepatitis, hypercalcemia, and kidney stones can also occur.[ncbi.nlm.nih.gov]
  • The chronic form of berylliosis develops along with symptoms of dyspnea or exertion, cough, fatigue, chest pain, weight loss, night sweats, fever and anorexia.[occupational-injury.com]
Dry Cough
  • In individuals with chronic beryllium disease, associated symptoms and findings often include dry coughing, fatigue, weight loss, chest pain, and increasing shortness of breath.[web.archive.org]
  • Beryllium ore Watch out for such CBD symptoms as: Difficulty in breathing while doing physical activities Recurrent dry cough Fatigue Night sweats Pain in the chest and joints Fever Lack of appetite Treating the symptoms Your doctor may recommend three[chronicberylliumdisease.com]
  • It generally causes shortness of breath, especially after exercise, exhaustion, and a dry cough and can produce a permanent, though moderate, disability.[britannica.com]
  • In the early stages, CBD may not cause any noticeable symptoms, however over time, the exposed individual may experience shortness of breath, fatigue, chronic dry cough, chest/joint pain, loss of appetite, and night sweats.[madeksholaw.com]
Productive Cough
  • Affected workers present with non-productive cough, dyspnoea on exertion and sometimes fever.[doi.org]
Exertional Cough
  • The chronic form of berylliosis develops along with symptoms of dyspnea or exertion, cough, fatigue, chest pain, weight loss, night sweats, fever and anorexia.[occupational-injury.com]
Chronic Cough
  • Typical CBD symptoms: Difficulty breathing Chest pain Excessive or chronic coughing Loss of weight General weakness Pulmonary fibronodular disease CBD Treatment While there is currently no cure for CBD there are treatment options to slow the development[nuclearworkers.org]
Loss of Appetite
  • Its symptoms include coughing, shortness of breath, fatigue, weight loss or loss of appetite, fever and sweating.[web.archive.org]
  • Over time, the inflammation response continues, and eventually symptoms may appear, including: Difficulty breathing/ shortness of breath Weakness Fatigue Loss of appetite Weight loss Joint pain Cough Fever Cleveland Clinic News & More Cleveland Clinic[my.clevelandclinic.org]
  • In the early stages, CBD may not cause any noticeable symptoms, however over time, the exposed individual may experience shortness of breath, fatigue, chronic dry cough, chest/joint pain, loss of appetite, and night sweats.[madeksholaw.com]
Skin Lesion
  • Skin lesions are the most common extrathoracic manifestation. Granulomatous hepatitis, hypercalcemia, and kidney stones can also occur. Radiographic and physiologic abnormalities are similar to those in sarcoidosis.[ncbi.nlm.nih.gov]

Workup

  • Workup of Berylliosis The workup consists of a thorough patient history with details and duration of Be exposure, blood BePLT, bronchoscopy with bronchoalveolar lavage fluid, beryllium lymphocyte proliferation test (BePLT), pulmonary CT scan and biopsy[lecturio.com]
  • To make the diagnosis of CBD, the following criteria need to be satisfied: (1) evidence of sensitization to beryllium by positive findings on blood or bronchoalveolar lavage (BAL) beryllium lymphocyte proliferation test (BeLPT) (see Workup) and (2) the[emedicine.com]
Normal Chest X-Ray
  • A 65-year-old factory worker with dyspnea on exertion and a normal chest x-ray. Cleve Clin J Med. 2000 Nov. 67(11):791-2, 794, 797-8, 800. [Medline]. Stokes RF, Rossman MD.[emedicine.medscape.com]
Ground Glass Appearance
  • A high-resolution CT scan of the chest showing the typical ground glass appearance in a patient with chronic beryllium disease, or berylliosis.[emedicine.com]

Treatment

  • Please consult your physician for accurate medical advices and treatment. Copyright 2005, health-cares.net, all rights reserved. Last update: July 18, 2005[respiratory-lung.health-cares.net]
  • What's the treatment for berylliosis (beryllium disease)? - Ventilators can help patients with acute berylliosis breathe. Prompt corticosteroid therapy is required to lessen lung inflammation.[web.archive.org]
  • The effect of treatment should be monitored using pulmonary function tests and high-resolution computed tomography of the chest. However, once pulmonary fibrosis has developed, corticosteroid therapy cannot reverse the damage.[ncbi.nlm.nih.gov]
  • Not everyone who has CBD will need treatment, but many patients will eventually need treatment as the disease progresses. The type of treatment a patient requires depends on the severity of the disease.[nationaljewish.org]

Prognosis

  • To analyse the natural course of beryllium sensitization and clarify the prognosis following cessation of exposure among sensitized workers.[ncbi.nlm.nih.gov]
  • Treatment and prognosis While there is no cure, commonly adopted management options involve cessation of beryllium exposure and use of systemic corticosteroids 4.[radiopaedia.org]
  • […] lung fields lupus pernio lymph nodes lymphocytes macrophages mesothelioma mottling nerve nodular nodules occasionally occur onset opacities pathogenesis Pathology patients peripheral plaques pleural effusion pneumoconiosis polyarteritis nodosa present prognosis[books.google.com]
  • Aims To analyse the natural course of beryllium sensitization and clarify the prognosis following cessation of exposure among sensitized workers.[doi.org]

Etiology

  • Sarcoidosis is a granulomatosis that predominantly affects the lungs and is of unknown etiology. Chronic beryllium disease is a granulomatosis that predominantly affects the lungs and is due to a hypersensitivity response to beryllium.[ncbi.nlm.nih.gov]
  • As with chronic lung disease of other etiologies, one should evaluate for bacterial respiratory infections and should treat infections promptly with antibiotics when indicated, especially for those on immunosuppressive therapy.[atsdr.cdc.gov]

Epidemiology

  • In human studies, the gene has been shown to confer increased susceptibility to beryllium in exposed workers, thus suggesting that HLA gene markers may be used as epidemiological probes to identify population groups at higher risk of environmental lung[erj.ersjournals.com]
  • Epidemiology of beryllium sensitization and disease in nuclear workers.[ncbi.nlm.nih.gov]
  • Epidemiology Frequency United States A small percentage of exposed persons (1-10%) develop beryllium hypersensitivity and a portion of those go on to develop chronic disease.[emedicine.com]
Sex distribution
Age distribution

Pathophysiology

  • Pathophysiology and Presentation of Berylliosis Beryllium is a rare earth metal, which can form alloys with several other metals.[lecturio.com]
  • Pathophysiology The key to the pathogenesis of chronic beryllium disease (CBD) is a delayed-type hypersensitivity reaction in which beryllium most likely functions as a hapten and acts as a class II restricted antigen, stimulating local proliferation[emedicine.com]

Prevention

  • […] factors are the determinants of the immunopathogenesis of asthma, pulmonary granulomatous disorders, hypersensitivity pneumonitis and fibrotic lung disorders, an understanding of the interaction between environmental factors is crucial to epidemiology, prevention[erj.ersjournals.com]
  • Health safety in the workplace Prevention is better than cure. Exposure to beryllium is inevitable if your job is among those mentioned earlier. However, workplaces have safety regulations to prevent releasing high amount of beryllium in the air.[chronicberylliumdisease.com]
  • This systematic review focuses on the use of BeLPT for secondary prevention of CBD in sensitized workers but not on its use for the evaluation of primary prevention programmes.[occmed.oxfordjournals.org]

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