The purpose of the work was to permit leading investigators in the field to present a critical review with sufficient documentation to support their interpretations and conclusions. [books.google.com]

The present study suggests thus that cadmium can increase the urinary excretion of anionic macromolecules such as albumin by reducing the glomerular polyanion charge. [ncbi.nlm.nih.gov]

Cadmium is also present at alarmingly high levels in cigarette smoke. [livescience.com]

Presentation The presentation will depend on the age of the individual, the metal absorbed and whether this was the result of acute exposure - eg, vapour inhalation - or exposure over a more prolonged period of time. [patient.info]

The present results will be disseminated to the general public through the Ministry of Environment in Japan. [bmjopen.bmj.com]

• Fatigue

  Acute inhalation of Cadmium dusts, fumes or soluble salts may produce cough, pneumonitis and fatigue. Manifestations of Cadmium toxicity may be lessened or delayed by an individual’s protective and detoxification capacities. [chelationmedicalcenter.com]

  Overexposure may cause fatigue, headaches, nausea, vomiting, abdominal cramps, diarrhea, and fever. [rarediseases.org]

  Could cadmium be responsible for some of the neurological signs and symptoms of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. Med Hypotheses. 2012 Sep;79(3):403-7. doi: 10.1016/j.mehy.2012.06.007. Epub 2012 Jul 12. [globalhealingcenter.com]

  […] with lead-containing paint Action : heme synthesis disruption via inhibition of aminolevulinate dehydratase (catalyzes the conversion of aminolevulinic acid to porphobilinogen ) Clinical features Nervous system Polyneuropathy, encephalopathy, headache, fatigue [amboss.com]

  MFF, or "brass founder’s ague," "zinc shakes," or "Monday morning fever" as it is variously known, is characterized by fever, headache, fatigue, dyspnea, cough, and a metallic taste occurring within 3-10 hours after exposure. [emedicine.medscape.com]

• Asymptomatic

  It can also cause a glomerulopathy that is usually asymptomatic. [msdmanuals.com]

  […] nails, red skin, paresthesia, hemiplegia Mild toxicity: [Se] >1 mg/L (serum); Serious: >2 mg/L * Silver Very high doses: hemorrhage, bone marrow suppression, pulmonary edema, hepatorenal necrosis Argyria: blue-grey discoloration of skin, nails, mucosae Asymptomatic [emedicine.medscape.com]

• Burning Feet

  feet”) Memory disorders White bands across the nails (Mees's lines) Diagnosis : present in blood and/or urine Manganese Sources of exposure : metallurgy, welding Clinical features Manganese pneumonia = fibrinous pneumonia Manganism = parkinsonism (see [amboss.com]

• Nausea

  Nausea and Vomiting Ingestion of a large dose of cadmium can cause severe gastrointestinal effects. [livestrong.com]

  Overexposure may cause fatigue, headaches, nausea, vomiting, abdominal cramps, diarrhea, and fever. [rarediseases.org]

  Nausea, vomiting and diarrhoea. Impaired sensation. Difficulty breathing, cough, chest pain. Complications include pneumonitis and pulmonary oedema. [patient.info]

  Nausea, vomiting, diarrhea, and prostration usually occur within 15 minutes after ingestion and subside within 24 hours. Inhalation of cadmium fumes in industry produces an acute, extremely severe inflammation of the lungs that may be fatal. [britannica.com]

  Oral poisoning appear the following clinical signs of intoxication: profuse nausea and vomiting; strong, cutting and sharp pain in the abdomen; multiple diarrhea; weakness; rapid pulse; lowering blood pressure; may develop severe dehydration, shock. [medicalj-center.info]

• Vomiting

  THALLIUM POISONING Symptoms associated with thallium poisoning include extreme drowsiness (somnolence), nausea, vomiting, abdominal pain, and bloody vomiting (hematemesis). [rarediseases.org]

  Nausea, vomiting and diarrhoea. Impaired sensation. Difficulty breathing, cough, chest pain. Complications include pneumonitis and pulmonary oedema. [patient.info]

  Typical Presentation of the Most Commonly Encountered Metals and Their Treatment (Open Table in a new window) Metal Acute Chronic Toxic Concentration Treatment Arsenic Nausea, vomiting, "rice-water" diarrhea, encephalopathy, MODS, LoQTS, painful neuropathy [emedicine.medscape.com]

  Nausea and Vomiting Ingestion of a large dose of cadmium can cause severe gastrointestinal effects. [livestrong.com]

  General considerations Overview of principal metal toxicities Signs and Symptoms Diagnosis Further information Treatment Arsenic Acute Nausea and vomiting Abdominal pain QT prolongation Chronic Hyperkeratosis Mees' lines : white bands across the nails [amboss.com]

• Abdominal Pain

  Additional symptoms may include fever, headaches, fatigue, sluggishness (letheragy), vomiting, loss of appetite (anorexia), abdominal pain, constipation, joint pain, loss of recently acquired skills, incoordination, listlessness, difficulty sleeping [rarediseases.org]

  General considerations Overview of principal metal toxicities Signs and Symptoms Diagnosis Further information Treatment Arsenic Acute Nausea and vomiting Abdominal pain QT prolongation Chronic Hyperkeratosis Mees' lines : white bands across the nails [amboss.com]

  Gastrointestinal upset (abdominal pain, gingivitis and stomatitis, nausea, vomiting). Renal problems include acute renal failure, nephrotic syndrome and acute tubular necrosis. [patient.info]

  Ingested cadmium poisoning causes symptoms of: shock vertigo choking salivation dyspepsia convulsions abdominal pain muscle cramps nausea, vomiting loss of consciousness Breathing high levels of cadmium can severely irritate and damage your lungs. [healthblurbs.com]

  Clinical signs of chronic cadmium poisoning: increased secretion of saliva (sialorrhea); nausea and vomiting; frequent abdominal pain, heartburn; headache, dizziness; cramps; General weakness, drowsiness, tendency to depression; the appearance of sections [medicalj-center.info]

• Hypertension

  However, chronic low-level exposure may cause renal insufficiency and hypertension independent of tubulointerstitial disease. [msdmanuals.com]

  In severe toxic damage of the kidneys developing hypertension. The examination of these patients revealed renal failure. It can be acute or chronic. Treatment of this condition includes hemodialysis, drug therapy and diet. [medicalj-center.info]

  […] and, possibly, years later, cancer. cadmium poisoning A condition associated with industrial exposure; cadmium poisoning occurred in Japan due to contamination of drinking water by mining runoffs, resulting in itai-itai (“ouch-ouch”) disease, possibly hypertension [medical-dictionary.thefreedictionary.com]

  There were differences in the occurrence of diabetes and hypertension between cases and referents, and a tendency towards a difference in smoking habits. [ehjournal.biomedcentral.com]

  This toxic metal is known to cause cancer, hypertension and enzyme activity decrease as well. [healthblurbs.com]

• Heart Disease

  […] ischaemic heart diseases was found in the Kakehashi River basin. [bmjopen.bmj.com]

  Cadmium has also been associated with carotid atherosclerosis, electro-cardiogram diagnosed myocardial infarction, self-reported ischemic heart disease, stroke, heart failure and peripheral arterial disease. [pathopedia-india.com]

  It will be retained in the kidneys, blood vessels, brain and lungs and it weakens the immune system giving rise to the typical smokers diseases: lung infections, lung cancer, emphysema, heart disease, and malignant tumors. [tvernonlac.com]

• Alopecia

  Mees lines, residual neurologic symptoms Alopecia, neuropathy Toxic: >3 µg/L (blood) MDAC Prussian blue Zinc MFF (oxide fumes); vomiting, diarrhea, abdominal pain (ingestion) Copper deficiency: anemia, neurologic degeneration, osteoporosis Normal range [emedicine.medscape.com]

  Overexposure to selenium may cause irritation of the respiratory system, gastrointestinal tract, and eyes; inflammation of the liver; loss of hair (alopecia); loss of skin color (depigmentation); and peripheral nerve damage. [rarediseases.org]

• Osteoporosis

  Cadmium chronic poisoning causes mainly renal tubulopathy and could be the cause of osteomalacia and diffuse osteoporosis. Cadmium is classified as certain carcinogen agent for humans by International Agency for Research on Cancer (IARC). [ncbi.nlm.nih.gov]

  […] inhalation exposure to low doses of cadmium can cause poisoning symptoms of: coughing proteinuria weight loss difficulty breathing sense of smell loss Chronic cadmium exposure can also cause an increased risk for these health conditions: anemia liver damage osteoporosis [healthblurbs.com]

  Cases of bone disease, including osteoporosis and osteomalcia, have also been reported. [livestrong.com]

  […] microcytic-hypochromic anemia, lymphocytosis (excess white blood cells), proteinuria (protein in the urine) with wasting of beta2 microglobulin, emphysema and pulmonary fibrosis (if inhalation was a route of contamination), atherosclerosis, osteomalacia, osteoporosis [chelationmedicalcenter.com]

  It impairs calcium metabolism, replaces calcium in the bones, and can contribute to conditions such as osteoporosis and osteomalacia, ureter and kidney stones, excessive calcium in the urine (hypercalcuria), pain in the low back and legs, rheumatoid arthritis [tvernonlac.com]

• Back Pain

  pain, cancer, and peripheral neuropathy. [chelationmedicalcenter.com]

  Toxic metal accumulation in the kidneys including aluminum, mercury and cadmium, also contributes to kidney infections, kidney stones, electrolyte imbalances, back pain, and edema. [tvernonlac.com]

• Arthralgia

  Later on you may experience some of these toxic cadmium inhalation symptoms: dyspnea sweating shivering coughing arthralgia wheezing dry throat headache chest pain pneumonitis muscle weakness Inhalation of cadmium fumes can cause severe lung inflammation [healthblurbs.com]

• Seizure

  Overexposure may cause headaches, drowsiness, confusion, seizures, and life-threatening complications. [rarediseases.org]

  […] disruption via inhibition of aminolevulinate dehydratase (catalyzes the conversion of aminolevulinic acid to porphobilinogen ) Clinical features Nervous system Polyneuropathy, encephalopathy, headache, fatigue, muscle weakness, paresthesias, delirium, seizures [amboss.com]

  […] excretion: 25 µg/24 h (urine) BAL D-Penicillamine Succimer Iron Vomiting, GI hemorrhage, cardiac depression, metabolic acidosis Hepatic cirrhosis Nontoxic: < 300 µg/dL Severe: >500 µg/dL Deferoxamine Lead Nausea, vomiting, encephalopathy (headache, seizures [emedicine.medscape.com]

• Convulsions

  Ingested cadmium poisoning causes symptoms of: shock vertigo choking salivation dyspepsia convulsions abdominal pain muscle cramps nausea, vomiting loss of consciousness Breathing high levels of cadmium can severely irritate and damage your lungs. [healthblurbs.com]

  Overexposure to tin may damage the nervous system and cause psychomotor disturbances including tremor, convulsions, hallucinations, and psychotic behavior. [rarediseases.org]

• Neuralgia

  These data suggested that the causes of death in the many patients with Itai-itai disease before our study may be Cd poisoning or neuralgia. [bmjopen.bmj.com]

• Renal Insufficiency

  However, chronic low-level exposure may cause renal insufficiency and hypertension independent of tubulointerstitial disease. [msdmanuals.com]

  View Article Google Scholar Lin JL, Tan DT, Hsu KH, Yu CC: Environmental lead exposure and progressive renal insufficiency. Arch Intern Med. 2001, 161: 264-271. 10.1001/archinte.161.2.264. [ehjournal.biomedcentral.com]

The treatment is performed in hospital at the Department of toxicology or intensive care. There is no specific antidote. Even with timely treatment the patient can later develop severe kidney disease, requiring long-term or permanent cure. [medicalj-center.info]

Information about a therapy, service, product or treatment does not in any way endorse or support such therapy, service, product or treatment and is not intended to replace advice from your doctor or other registered health professional. [betterhealth.vic.gov.au]

Treatment with chelation therapy can stabilize renal function, but recovery may be incomplete. Cadmium exposure due to contaminated water, food, or tobacco and, mainly, due to workplace exposures can cause nephropathy. [msdmanuals.com]

No effective treatment for cadmium toxicity exists. For the general public, the primary source of exposure to cadmium is dietary. Smoking tobacco adds an additional burden of cadmium. [atsdr.cdc.gov]

General considerations Overview of principal metal toxicities Signs and Symptoms Diagnosis Further information Treatment Arsenic Acute Nausea and vomiting Abdominal pain QT prolongation Chronic Hyperkeratosis Mees' lines : white bands across the nails [amboss.com]

These immunological alterations of CKD may be observed in patients with Itai-itai disease, causing infections such as pneumonia and GI inflammation and contributing to a poor prognosis. [bmjopen.bmj.com]

Epidemiology Heavy metal poisoning is rare in the UK, even in industries where there is an increased risk. [ 1 ] The most common cause of heavy metal poisoning is lead. [patient.info]

Most of the available epidemiological information on cadmium has been obtained from occupationally exposed workers or on Japanese populations in highly contaminated areas. [cadmium.org]

[…] out, H yperuricemia/ H ypertension References: [7] [8] [9] [10] [11] [12] [13] [14] [15] [16] [17] [18] [19] [20] [21] Cadmium Iron Definition : chemical element often used as supplement in pediatrics and prenatal care and in the management of anemia Epidemiology [amboss.com]

Studies and regulatory actions involving cadmium exploded after this incident, and research performed in the United States in the 1960s confirmed the carcinogenic effects of the metal through rodent and epidemiological studies. [dartmouth.edu]

Useful For Suggests clinical disorders or settings where the test may be helpful Detecting exposure to cadmium, a toxic heavy metal Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory [mayomedicallaboratories.com]

[…] and urine Welder's lung None References: [1] [2] [3] [4] [5] Arsenic Sources of exposure Metal smelting ;, pesticides, herbicides, contaminated water (esp. in developing countries), ore mining, semiconductor production, paint and glass manufacturing Pathophysiology [amboss.com]

The Centers for Disease Control and Prevention is authorized by IACET to offer .15 IACET CEU's for this program. [atsdr.cdc.gov]

"In mice, chronic cadmium exposure has been shown to cause liver failure, but we need to understand more about the factors that may cause liver disease in humans, and whether we can do anything to prevent it." [sciencedaily.com]

Numerous regulations and use of pollution controls are enforced to prevent such releases. [en.wikipedia.org]

Basophilic stippling of erythrocytes on peripheral blood smear Microcytic, hypochromic anemia Imaging (not routinely indicated): lead flecks on abdominal x-ray, lead lines on long-bone x-rays Inspection of the patient's environment for lead sources to prevent [amboss.com]

Extensive preventative hygiene programs and medical follow-up programs have been developed to control the risk related to cadmium exposure at the workplace (ACGIH 1996, OSHA 1992, Lauwerys 1986, Cadmium Council 1986). [cadmium.org]