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Chronic Cadmium Poisoning


Presentation

  • The present study suggests thus that cadmium can increase the urinary excretion of anionic macromolecules such as albumin by reducing the glomerular polyanion charge.[ncbi.nlm.nih.gov]
  • The present results will be disseminated to the general public through the Ministry of Environment in Japan.[bmjopen.bmj.com]
  • In the present study, to evaluate chronic Cd hepatotoxicity, we examined specimens from cases of itai-itai disease, the most severe form of chronic Cd poisoning.[ncbi.nlm.nih.gov]
  • Cadmium is also present at alarmingly high levels in cigarette smoke.[livescience.com]
  • Presentation The presentation will depend on the age of the individual, the metal absorbed and whether this was the result of acute exposure - eg, vapour inhalation - or exposure over a more prolonged period of time.[patient.info]
Fatigue
  • Acute inhalation of Cadmium dusts, fumes or soluble salts may produce cough, pneumonitis and fatigue. Manifestations of Cadmium toxicity may be lessened or delayed by an individualâ s protective and detoxification capacities.[chelationmedicalcenter.com]
  • Overexposure may cause fatigue, headaches, nausea, vomiting, abdominal cramps, diarrhea, and fever.[rarediseases.org]
  • Could cadmium be responsible for some of the neurological signs and symptoms of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. Med Hypotheses. 2012 Sep;79(3):403-7. doi: 10.1016/j.mehy.2012.06.007. Epub 2012 Jul 12.[globalhealingcenter.com]
  • […] with lead-containing paint Action : heme synthesis disruption via inhibition of aminolevulinate dehydratase (catalyzes the conversion of aminolevulinic acid to porphobilinogen ) Clinical features Nervous system Polyneuropathy, encephalopathy, headache, fatigue[amboss.com]
  • MFF, or "brass founder’s ague," "zinc shakes," or "Monday morning fever" as it is variously known, is characterized by fever, headache, fatigue, dyspnea, cough, and a metallic taste occurring within 3-10 hours after exposure.[emedicine.medscape.com]
Burning Feet
  • […] of the margins of the gums Teratogenicity Diagnosis Inorganic mercury in urine Organic mercury in blood Treatment References: [26] [27] [28] [29] [30] Thallium Sources of exposure Glass industry Rat poison Clinical features Hair loss Polyneuropathy (“burning[amboss.com]
Nausea
  • Nausea and Vomiting Ingestion of a large dose of cadmium can cause severe gastrointestinal effects.[livestrong.com]
  • Nausea, vomiting, diarrhea, and prostration usually occur within 15 minutes after ingestion and subside within 24 hours. Inhalation of cadmium fumes in industry produces an acute, extremely severe inflammation of the lungs that may be fatal.[britannica.com]
  • Nausea, vomiting and diarrhoea. Impaired sensation. Difficulty breathing, cough, chest pain. Complications include pneumonitis and pulmonary oedema.[patient.info]
  • Overexposure may cause fatigue, headaches, nausea, vomiting, abdominal cramps, diarrhea, and fever.[rarediseases.org]
  • Oral poisoning appear the following clinical signs of intoxication: profuse nausea and vomiting; strong, cutting and sharp pain in the abdomen; multiple diarrhea; weakness; rapid pulse; lowering blood pressure; may develop severe dehydration, shock.[medicalj-center.info]
Abdominal Pain
  • Gastrointestinal symptoms include a flu-like illness (gastroenteritis) that is characterized by vomiting; abdominal pain; fever; and diarrhea, which, in some cases, may be bloody.[rarediseases.org]
  • General considerations Overview of principal metal toxicities Signs and Symptoms Diagnosis Further information Treatment Arsenic Acute Nausea and vomiting Abdominal pain QT prolongation Chronic Hyperkeratosis Mees' lines : white bands across the nails[amboss.com]
  • Ingested cadmium poisoning causes symptoms of: shock vertigo choking salivation dyspepsia convulsions abdominal pain muscle cramps nausea, vomiting loss of consciousness Breathing high levels of cadmium can severely irritate and damage your lungs.[healthblurbs.com]
  • Gastrointestinal upset (abdominal pain, gingivitis and stomatitis, nausea, vomiting). Renal problems include acute renal failure, nephrotic syndrome and acute tubular necrosis.[patient.info]
  • Clinical signs of chronic cadmium poisoning: increased secretion of saliva (sialorrhea); nausea and vomiting; frequent abdominal pain, heartburn; headache, dizziness; cramps; General weakness, drowsiness, tendency to depression; the appearance of sections[medicalj-center.info]
Hypertension
  • Age distribution, smoking rates and history of hypertension among patients with Itai-itai disease, screened cases and controls are shown in table 1 .[bmjopen.bmj.com]
  • However, chronic low-level exposure may cause renal insufficiency and hypertension independent of tubulointerstitial disease.[msdmanuals.com]
  • In severe toxic damage of the kidneys developing hypertension. The examination of these patients revealed renal failure. It can be acute or chronic. Treatment of this condition includes hemodialysis, drug therapy and diet.[medicalj-center.info]
  • […] and, possibly, years later, cancer. cadmium poisoning A condition associated with industrial exposure; cadmium poisoning occurred in Japan due to contamination of drinking water by mining runoffs, resulting in itai-itai (“ouch-ouch”) disease, possibly hypertension[medical-dictionary.thefreedictionary.com]
  • There were differences in the occurrence of diabetes and hypertension between cases and referents, and a tendency towards a difference in smoking habits.[ehjournal.biomedcentral.com]
Ulcer
  • The most common direct causes of death in these patients were bronchopneumonia/pneumonia (10 deaths, 37% of the patients) and GI tract diseases (nine deaths, 33% of the patients) including haemorrhage and ulcers (see online supplementary tabl e 2 ).[bmjopen.bmj.com]
  • […] in children Cadmium Irritation of the airways Kidney damage Lung disease Acute toxicity: cadmium in blood Chronic toxicity: cadmium and β2‑microglobulin in urine Chronic exposure causes Itai‑itai disease No known antidote Chromium Contact dermatitis Ulcerations[amboss.com]
Erythema
  • Some individuals may experience skin changes such as painful swelling and pink coloration of the fingers and toes (acrodynia); persistent redness or inflammation of the skin (erythema); extreme sensitivity (hyperesthesia) of the affected areas; and tingling[rarediseases.org]
Bone Pain
  • Itai-Itai disease, resulting from cadmium poisoning, includes a number of health effects including the weakening and deformation of bones, gait abnormalities, bone pain, anemia, coughing, kidney failure and death.[worstpolluted.org]
  • pain and is associated with renal tubular dysfunction. 1–3 Itai-itai disease mainly affects women residing in rice farming areas irrigated by the contaminated Jinzu River in Toyama, Japan. 1–3 As of 28 December 1999, 410 patients were officially diagnosed[bmjopen.bmj.com]
Back Pain
  • ) pain, cancer, and peripheral neuropathy.[chelationmedicalcenter.com]
  • Toxic metal accumulation in the kidneys including aluminum, mercury and cadmium, also contributes to kidney infections, kidney stones, electrolyte imbalances, back pain, and edema.[tvernonlac.com]
Arthritis
  • It impairs calcium metabolism, replaces calcium in the bones, and can contribute to conditions such as osteoporosis and osteomalacia, ureter and kidney stones, excessive calcium in the urine (hypercalcuria), pain in the low back and legs, rheumatoid arthritis[tvernonlac.com]
  • Overexposure to gold (as in treatment of rheumatoid arthritis) may cause skin rashes; bone marrow depression; stomach and intestinal bleeding; headaches; vomiting; focal or generalized continuous fine vibrating muscle movements (myokymia); and yellowing[rarediseases.org]
Arthralgia
  • Later on you may experience some of these toxic cadmium inhalation symptoms: dyspnea sweating shivering coughing arthralgia wheezing dry throat headache chest pain pneumonitis muscle weakness Inhalation of cadmium fumes can cause severe lung inflammation[healthblurbs.com]
Suggestibility
  • The present study suggests thus that cadmium can increase the urinary excretion of anionic macromolecules such as albumin by reducing the glomerular polyanion charge.[ncbi.nlm.nih.gov]
  • These data suggested that the causes of death in the many patients with Itai-itai disease before our study may be Cd poisoning or neuralgia.[bmjopen.bmj.com]
  • Useful For Suggests clinical disorders or settings where the test may be helpful Detecting exposure to cadmium, a toxic heavy metal Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory[mayomedicallaboratories.com]
  • Other studies have suggested that, over the timeframe of 1980 - 1985, levels of cadmium intake have been relatively constant ( OECD 1994 ).[cadmium.org]
  • The research findings do not show that cadmium directly causes liver disease, the scientists caution, but do suggest an association that needs more investigation.[sciencedaily.com]
Stroke
  • Cadmium has also been associated with carotid atherosclerosis, electro-cardiogram diagnosed myocardial infarction, self-reported ischemic heart disease, stroke, heart failure and peripheral arterial disease.[pathopedia-india.com]
  • Cadmium is also a known cardiovascular risk factor and has been shown to contribute to the onset of atherosclerosis, which may contribute to hypertension, stroke, cardiac arrest and heart failure. 7 A correlation exists between osteoporosis and cadmium[worstpolluted.org]
  • In previous studies of residents in Cd-polluted areas, identified the causes of deaths contributing to increased mortality were renal diseases, 9–11 stroke 10–13 and cancer. 14 Increased cancer mortality is a significant research interest, because Cd[bmjopen.bmj.com]
Neuralgia
  • These data suggested that the causes of death in the many patients with Itai-itai disease before our study may be Cd poisoning or neuralgia.[bmjopen.bmj.com]
Neuralgia
  • These data suggested that the causes of death in the many patients with Itai-itai disease before our study may be Cd poisoning or neuralgia.[bmjopen.bmj.com]
Renal Insufficiency
  • However, chronic low-level exposure may cause renal insufficiency and hypertension independent of tubulointerstitial disease.[msdmanuals.com]
  • View Article Google Scholar Lin JL, Tan DT, Hsu KH, Yu CC: Environmental lead exposure and progressive renal insufficiency. Arch Intern Med. 2001, 161: 264-271. 10.1001/archinte.161.2.264.[ehjournal.biomedcentral.com]

Treatment

  • The treatment is performed in hospital at the Department of toxicology or intensive care. There is no specific antidote. Even with timely treatment the patient can later develop severe kidney disease, requiring long-term or permanent cure.[medicalj-center.info]
  • Information about a therapy, service, product or treatment does not in any way endorse or support such therapy, service, product or treatment and is not intended to replace advice from your doctor or other registered health professional.[betterhealth.vic.gov.au]
  • Treatment with chelation therapy can stabilize renal function, but recovery may be incomplete. Cadmium exposure due to contaminated water, food, or tobacco and, mainly, due to workplace exposures can cause nephropathy.[msdmanuals.com]
  • No effective treatment for cadmium toxicity exists. For the general public, the primary source of exposure to cadmium is dietary. Smoking tobacco adds an additional burden of cadmium.[atsdr.cdc.gov]
  • Treatment usually includes the oral administration of calcium edetate.[britannica.com]

Prognosis

  • These immunological alterations of CKD may be observed in patients with Itai-itai disease, causing infections such as pneumonia and GI inflammation and contributing to a poor prognosis.[bmjopen.bmj.com]

Epidemiology

  • Epidemiology Heavy metal poisoning is rare in the UK, even in industries where there is an increased risk. [ 1 ] The most common cause of heavy metal poisoning is lead.[patient.info]
  • Most of the available epidemiological information on cadmium has been obtained from occupationally exposed workers or on Japanese populations in highly contaminated areas.[cadmium.org]
  • […] out, H yperuricemia/ H ypertension References: [7] [8] [9] [10] [11] [12] [13] [14] [15] [16] [17] [18] [19] [20] [21] Cadmium Iron Definition : chemical element often used as supplement in pediatrics and prenatal care and in the management of anemia Epidemiology[amboss.com]
  • An epidemiological survey conducted between 1967 and 1968 revealed the largest-scale epidemic of Cd pollution-induced Itai-itai disease in the world, affecting individuals 30 years of age residing in the Jinzu River basin in Toyama. 1 2 Women with Itai-itai[bmjopen.bmj.com]
Sex distribution
Age distribution

Pathophysiology

  • Useful For Suggests clinical disorders or settings where the test may be helpful Detecting exposure to cadmium, a toxic heavy metal Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory[mayomedicallaboratories.com]
  • […] and urine Welder's lung None References: [1] [2] [3] [4] [5] Arsenic Sources of exposure Metal smelting ;, pesticides, herbicides, contaminated water (esp. in developing countries), ore mining, semiconductor production, paint and glass manufacturing Pathophysiology[amboss.com]

Prevention

  • The Centers for Disease Control and Prevention is authorized by IACET to offer .15 IACET CEU's for this program.[atsdr.cdc.gov]
  • "In mice, chronic cadmium exposure has been shown to cause liver failure, but we need to understand more about the factors that may cause liver disease in humans, and whether we can do anything to prevent it."[sciencedaily.com]
  • Basophilic stippling of erythrocytes on peripheral blood smear Microcytic, hypochromic anemia Imaging (not routinely indicated): lead flecks on abdominal x-ray, lead lines on long-bone x-rays Inspection of the patient's environment for lead sources to prevent[amboss.com]
  • Extensive preventative hygiene programs and medical follow-up programs have been developed to control the risk related to cadmium exposure at the workplace (ACGIH 1996, OSHA 1992, Lauwerys 1986 , Cadmium Council 1986).[cadmium.org]
  • View Article Google Scholar Hwang SJ, Tsai JC, Chen HC: Epidemiology, impact and preventive care of chronic kidney disease in Taiwan. Nephrology (Carlton). 2010, 15 (Suppl 2): 3-9.[ehjournal.biomedcentral.com]

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