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Chronic Ebstein-Barr Virus Infection

Chronic EBV Infection


Presentation

  • Past Infection If antibodies to both the viral capsid antigen and EBNA are present, then past infection (from to 6 months to years earlier) is indicated.[phoenixrising.me]
  • (Two studies suggest reduced cytotoxic T-cell responses are present in ME/CFS as well.)[simmaronresearch.com]
  • EBV LPD ). [2] Presentation [ edit ] The most common symptoms of CAEBV include: [1] [3] [4] [5] Complications include: [1] [3] [5] Pathophysiology [ edit ] It arises from the cells that constitute the immune system, most often the T-cells and NK cells[en.wikipedia.org]
  • There was no greater fatigue at onset or after 6 months in either cohort, but those who complained of fatigue at 6 months were more likely to have had fatigue at onset and psychological distress before presentation.[healio.com]
  • […] in his childhood due to idiopathic thrombocytopenic purpura (ITP) presented with jaundice and dark urine.[austinpublishinggroup.com]
Fatigue
  • There was no greater fatigue at onset or after 6 months in either cohort, but those who complained of fatigue at 6 months were more likely to have had fatigue at onset and psychological distress before presentation.[healio.com]
  • Abstract Twenty-three patients with polymyalgia rheumatica (PMR) followed in an academic rheumatology practice frequently reported symptoms commonly found in the recently described "chronic fatigue syndrome" or "chronic Epstein-Barr infection syndrome[unboundmedicine.com]
  • Detailed immunologic, neurologic, endocrinologic, and psychologic studies are being conducted on selected patients with chronic fatigue.[grantome.com]
  • These symptoms persisted for months after treatment had reduced the severity of the myalgias and lowered the sedimentation rate: periodically disabling fatigue (33%), recurrent pharyngitis (30%), sleep disorder (65%) and arthralgias (70%).[globinmed.com]
Chronic Fatigue Syndrome
  • Since CRH induces CNS arousal, these neuroendocrine findings suggest a new mechanism whereby the lethargy of Chronic Fatigue Syndrome patients may be explained.[grantome.com]
  • Chronic Fatigue Syndrome. N.Y. Wiley 1993; pp. 83-101. 3. Jason LA, Richman JA, Rademaker AW, et al. A community-based study of chronic fatigue syndrome. Arch Intern Med. 1999;159:2129-2137. 4. Dowsett EG, Colby J.[healio.com]
  • Abstract Twenty-three patients with polymyalgia rheumatica (PMR) followed in an academic rheumatology practice frequently reported symptoms commonly found in the recently described "chronic fatigue syndrome" or "chronic Epstein-Barr infection syndrome[unboundmedicine.com]
  • The CDC believes EBV reactivation plays no role in chronic fatigue syndrome.[phoenixrising.me]
Chronic Fatigue Syndrome
  • Since CRH induces CNS arousal, these neuroendocrine findings suggest a new mechanism whereby the lethargy of Chronic Fatigue Syndrome patients may be explained.[grantome.com]
  • Chronic Fatigue Syndrome. N.Y. Wiley 1993; pp. 83-101. 3. Jason LA, Richman JA, Rademaker AW, et al. A community-based study of chronic fatigue syndrome. Arch Intern Med. 1999;159:2129-2137. 4. Dowsett EG, Colby J.[healio.com]
  • Abstract Twenty-three patients with polymyalgia rheumatica (PMR) followed in an academic rheumatology practice frequently reported symptoms commonly found in the recently described "chronic fatigue syndrome" or "chronic Epstein-Barr infection syndrome[unboundmedicine.com]
  • The CDC believes EBV reactivation plays no role in chronic fatigue syndrome.[phoenixrising.me]
Disability
  • These symptoms persisted for months after treatment had reduced the severity of the myalgias and lowered the sedimentation rate: periodically disabling fatigue (33%), recurrent pharyngitis (30%), sleep disorder (65%) and arthralgias (70%).[unboundmedicine.com]
  • Chronic infectious mononucleosis is an illness characterized primarily by chronic and occasionally disabling fatigue and other constitutional complaints, only sometimes beginning with an episode of acute infectious mononucleosis, and associated with an[jimmunol.org]
High Fever
  • After the EBV had been eradicated, the mediastinal mass, high fever and splenomegaly also resolved.[nature.com]
Chronic Cough
Arthralgia
  • These symptoms persisted for months after treatment had reduced the severity of the myalgias and lowered the sedimentation rate: periodically disabling fatigue (33%), recurrent pharyngitis (30%), sleep disorder (65%) and arthralgias (70%).[unboundmedicine.com]
  • In addition, four or more of the following need to be present: substantial impairment in short-term memory or concentration; sore throat; tender lymph nodes; myalgia; arthralgia; headache; unrefreshed sleep; and postexertional malaise lasting more than[healio.com]
  • He developed lymphadenopathy, pleural effusions, arthralgias, and hepatitis. DNA analysis demonstrated a deletion of exon 1 of SH2D1A, the gene mutated in XLP.[ajnr.org]
  • For the past few months the patient had suffered weight loss (approximately 30–35 lb), generalized malaise, low grade fevers (99.9 F), non-productive cough, myalgias and arthralgias.[bmchematol.biomedcentral.com]
Lethargy
  • Since CRH induces CNS arousal, these neuroendocrine findings suggest a new mechanism whereby the lethargy of Chronic Fatigue Syndrome patients may be explained.[grantome.com]
  • In September 2001, his short-term memory was severely impaired, and he experienced episodic disorientation and lethargy. His therapeutic regimen included intravenous immunoglobulins, acyclovir, and steroids.[ajnr.org]
Seizure
  • Importantly, there was a clinical improvement after alprazolam; suggesting a nonconvulsive seizures responding to benzodiazepine.[bmchematol.biomedcentral.com]
  • Uncommon: hemolytic anemia, cytopenias, pneumonitis, carditis, seizures, palsies, Guillain-Barré, encephalitis (late).[hopkinsguides.com]

Workup

  • Further infectious workup from a nasopharyngeal swab was positive for rhinovirus detected by PCR.[austinpublishinggroup.com]
  • Infectious Mononucleosis Workup. Medscape. Available online at . Accessed June 13, 2016. (Aug 2004) Hess, R. Routine Epstein-Barr Virus Diagnostics from the Laboratory Perspective: Still Challenging after 35 Years. Journal of Clinical Microbiology.[labtestsonline.it]
  • Splenomegaly of 10.76 cm was found incidentally during workup.[scielo.org.mx]
Mediastinal Mass
  • After the EBV had been eradicated, the mediastinal mass, high fever and splenomegaly also resolved.[nature.com]
  • Unfortunately patients with the LDCHL tumor often have more unfavorable characteristics such as more advanced stage, B symptoms, mediastinal mass, extranodal disease, high ESR, and more lymph node involvement.[bmchematol.biomedcentral.com]
Pericardial Effusion
  • effusion successfully treated with allogeneic peripheral blood stem cell transplantation. ( 27263789 ) Matsui S....Nakaseko C. 2016 20 Successful Cord Blood Stem Cell Transplantation for an Adult Case of Chronic Active Epstein-Barr Virus Infection. ([malacards.org]

Treatment

  • Expanded Access : Baylor College of Medicine has indicated that access to an investigational treatment associated with this study is available outside the clinical trial.[clinicaltrials.gov]
  • You can help by adding to it. ( February 2019 ) Treatment [ edit ] The only known cure for CAEBV is allogenic haematopoietic stem cell transplant (HSCT), with all other treatment options ( rituximab, cytotoxic chemotherapy and immunosuppressive therapy[en.wikipedia.org]
  • The ultimate prognosis of CAEBV is very poor and to date there are no established treatment strategies for this disorder.[nature.com]
  • We continue to examine immunologic features of patients with severe chronic EBV- associated lymphoproliferation and explore treatments.[grantome.com]
  • These symptoms persisted for months after treatment had reduced the severity of the myalgias and lowered the sedimentation rate: periodically disabling fatigue (33%), recurrent pharyngitis (30%), sleep disorder (65%) and arthralgias (70%).[unboundmedicine.com]

Prognosis

  • [ edit ] Without HSCT the condition is inevitably fatal and even HSCT is no guarantee, with a significant portion of patients dying from the disease progression. [8] Factors indicative of a poor prognosis include: thrombocytopenia, late onset of the[en.wikipedia.org]
  • Epileptic Spasms After Stem Cell Transplantation for Chronic Epstein-Barr Virus Infection Stem cell transplantation has been performed for various diseases, contributing to a markedly improved prognosis in some cases.[drcalapai.net]
  • The majority of people with EBV have a good prognosis; a few have a more guarded prognosis. There is no vaccine for EBV, and prevention is difficult.[medicinenet.com]
  • The ultimate prognosis of CAEBV is very poor and to date there are no established treatment strategies for this disorder.[nature.com]
  • Incidence, risk and prognosis of acute and chronic fatigue syndromes and psychiatric disorders after glandular fever. Br J Psychiatr. 1998;173:475-481. 14. White PD, Thomas JM, Kangro HO, et al.[healio.com]

Etiology

  • In adolescents older than 12 years, the prevalence of CFS was almost 0.15%.5 The etiology of CFS is unknown. Many patients recall a viral infection that seems to have triggered their chronic fatigue.[healio.com]
  • An etiologic relation between Epstein-Barr virus replication and the clinical manifestations of this syndrome is further shown by the response of each patient to acyclovir therapy.[annals.org]
  • Intracranial aneurysm etiologies include atherosclerosis, hypertension, vasculopathy, trauma, drug abuse, neoplasm, and infection.[ajnr.org]
  • Hooks JJ: Possibility of a viral etiology in recurrent aphthous ulcers and Behçet's syndrome. J Oral Pathol 1978;7:353-364.[karger.com]
  • Occult malignancies are also etiologies of such a clinical presentation, especially in elderly population [ 6 – 8 ].[bmchematol.biomedcentral.com]

Epidemiology

  • Epidemiology EBV is a ubiquitous, worldwide pathogen that is harbored persistently by virtually all adults, regardless of geographic location.[pedsinreview.aappublications.org]
  • .; the Departments of Pediatrics and Epidemiology and Public Health, Yale University School of Medicine, New Haven, Conn.; and the Pathology Department, Stanford University School of Medicine, Palo Alto, Calif. Address reprint requests to Dr.[nejm.org]
  • However, changes in economic status may have changed both the age of initial infection and the incidence of infectious mononucleosis since the large epidemiologic studies were completed.[emedicine.medscape.com]
  • Epidemiology of chronic fatigue syndrome: The Centers for Disease Control study. In: Bock G, Whelan J, eds. Chronic Fatigue Syndrome. N.Y. Wiley 1993; pp. 83-101. 3. Jason LA, Richman JA, Rademaker AW, et al.[healio.com]
  • The changing epidemiology of infectious mononucleosis? J Infect. 2002;45(2):107-9.[hopkinsguides.com]
Sex distribution
Age distribution

Pathophysiology

  • EBV LPD ). [2] Presentation [ edit ] The most common symptoms of CAEBV include: [1] [3] [4] [5] Complications include: [1] [3] [5] Pathophysiology [ edit ] It arises from the cells that constitute the immune system, most often the T-cells and NK cells[en.wikipedia.org]
  • Studying adolescents following EBV infection undoubtedly will prove important for delineating the pathophysiology of both infectious mononucleosis and CFS.[healio.com]
  • The pathophysiological mechanism of these features that mimic liver failure is related to macrophages activated by high levels of cytokines, which are secreted by proliferating T lymphocytes.[journals.lww.com]

Prevention

  • This list is a group of supplements that inhibit Th1 but also prevent its reactivation. I plan on creating a list of EBV inhibitors that also increase Th1 cells. To prevent EBV reactivation you want to take Th1 supplements instead.[selfhacked.com]
  • - China Yi Zeng, Cangwu Institute for Nasopharyngeal Carcinoma Control and Prevention - China Stephen J.[nsuworks.nova.edu]
  • Is it possible to prevent an Epstein-Barr virus infection? Is there an EBV vaccine? There is no vaccine available to prevent EBV infections.[medicinenet.com]
  • Causes According to the Centers for Disease Control and Prevention (CDC), the most common cause of mono is the Epstein-Barr virus (EBV), which is found all over the world and infects the majority of the human population at some point in their lives.[livescience.com]
  • (Updated Feb 2, 2009) Centers for Disease Control and Prevention. Epstein-Barr Virus and Infectious Mononucleosis. Available online at . Accessed February 2009. Bennett, N. and Domachowske, J. (Updated 2012 May 30).[labtestsonline.it]

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