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Chronic Inflammation


Presentation

  • A 53-year-old premenopausal woman presented with a recent onset of abdominal distention and menorrhagia.[ncbi.nlm.nih.gov]
  • The first sibling presented at the age of 9 months with hypertrichosis and hyperpigmentation, particularly on her back and legs and then developed diabetes mellitus at the age of 4 yr.[ncbi.nlm.nih.gov]
  • On histological examination, granulomatous formation was present in three samples, and multinucleated Langhans' giant cells were seen in one.[ncbi.nlm.nih.gov]
  • Primary renal lymphomas are very rare, and primary kidney-limited lymphomas with cystic presentation have never been described before.[ncbi.nlm.nih.gov]
  • Herein we present a family with 3 affected cases in an autosomal dominant inheritance pattern. The first case was a man diagnosed to have immunoglobulin (Ig)A-type myeloma at the age of 50.[ncbi.nlm.nih.gov]
Cesarean Section
  • We describe a rare case of localized LEGH, which developed adjacent to a cesarean section scar. A 53-year-old premenopausal woman presented with a recent onset of abdominal distention and menorrhagia.[ncbi.nlm.nih.gov]

Treatment

  • Now it is generally accepted that inflammation-related molecules and pathways are useful targets for the prevention and treatment of cancer.[ncbi.nlm.nih.gov]
  • OBJECTIVE: To use biomarkers to gain insight into and gauge the residual (post-treatment) level of inflammation in two groups of intensively treated patients with severe chronic pain.[ncbi.nlm.nih.gov]
  • The study included 20 participants with varying levels and severities of SCI randomized (3:2) to either a treatment group, consisting of a 12-week anti-inflammatory diet program, or control group.[ncbi.nlm.nih.gov]
  • Electronic address: wplee@vghtpe.gov.tw. 2 Endoscopy Center for Diagnosis and Treatment, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Medicine Division of Gastroenterology, Taipei Veterans General Hospital, Taipei, Taiwan. 3 Department[ncbi.nlm.nih.gov]
  • Although inhibitors targeting tumor angiogenic pathway have provided improvement for clinical treatment in patients with various solid tumors, the still very limited anti-cancer efficacy and acquired drug resistance demand new agents that may offer better[ncbi.nlm.nih.gov]

Prognosis

  • Clinically, it is characterized by a mass arising in a long-standing inflammation and by a poor prognosis. Recently, DLBCL-CI has been described growing along the wall of a preexisting cyst, without forming a mass.[ncbi.nlm.nih.gov]
  • Herein we bring examples for the use of cellular and molecular biomarkers in diagnosis, prognosis and follow-up of patients suffering from various cancers, for prediction of response to immune-based anti-cancer therapy and for prediction of cardiovascular[ncbi.nlm.nih.gov]
  • Clinical investigation revealed that cytokeratin 19/Oval cell 6-positive liver cancer patients displayed a worse prognosis and exhibited superior response to sorafenib treatment.[ncbi.nlm.nih.gov]
  • The length of time this inflammatory state has been aggravated is often directly linked to the severity of the resulting condition, as well as its prognosis In fact, the effect of the body’s inflammatory response is the cause behind many chronic diseases[drlam.com]

Etiology

  • The etiology of MM is unknown, with no established lifestyle, occupational, or environmental risk factors. Because MM is an uncommon disease, etiologic assessments can be difficult.[ncbi.nlm.nih.gov]
  • The mechanisms' influences of intruding etiologic pathologic agents (microbe, virus, etc.) lead to these changes of energy interactions between nucleus and mitochondria functions causing general acute inflammation, then passing into local chronic inflammation[ncbi.nlm.nih.gov]
  • The etiology and pathogenesis of VX have yet to be determined; however, recent literature has reported that multifocal cutaneous VX are frequently associated with pre-existing inflammatory processes.[ncbi.nlm.nih.gov]
  • Classification of granulomatous inflammation, according to the etiology : Infectious granuloma : Bacterial : Mycobacterium tuberculosis (Koch bacillus) - Tuberculosis Mycobacterium leprae - Leprosy Treponema pallidum - Syphilis Gram-positive bacillus[pathologyatlas.ro]
  • Great advances have been made to eradicate some of the etiologies of liver cancer formation (e.g. efficient treatment of HCV infections), whereas other etiologies of liver cancer – such as non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis[dkfz.de]

Epidemiology

  • BACKGROUND: Large epidemiologic studies have reported the premature onset of age-related conditions, such as ischemic heart disease and diabetes mellitus, in childhood cancer survivors, decades earlier than in their peers.[ncbi.nlm.nih.gov]
  • Author information 1 Clinical Epidemiology Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden. 2 Ateneo Vita-Salute, Pathology and Lymphoid Malignancies Unit, San Raffaele H. Scientific Institute, Milan, Italy.[ncbi.nlm.nih.gov]
  • Specific discussion topics include: (1) Molecular mechanisms of inflammation : overview of current knowledge on the role of chronic inflammation in disease development (2) Biomarkers of inflammation : tools and techniques for biomarker discoveries and epidemiological[eventbrite.com]
Sex distribution
Age distribution

Pathophysiology

  • The role of hepcidin-ferroportin axis in the pathophysiology of ACI is stimulating the development of new diagnostics and targeted therapies.[ncbi.nlm.nih.gov]
  • This case suggests that a relationship exists between chronic inflammation and CTEPH, and furthermore, may contribute towards elucidating the pathophysiology of CTEPH.[ncbi.nlm.nih.gov]
  • However, their role in pathophysiology and therapy is still debated.[ncbi.nlm.nih.gov]
  • BACKGROUND: Inflammation may play a crucial role in the pathophysiology of depression. However, the association between chronic inflammation and health outcomes in depression remains unclear, particularly for patient-reported outcomes.[ncbi.nlm.nih.gov]
  • Thus, we focus on comparative studies of human and animal model tissues, recapitulating human disease on a histo-pathological and pathophysiological level.[dkfz.de]

Prevention

  • Now it is generally accepted that inflammation-related molecules and pathways are useful targets for the prevention and treatment of cancer.[ncbi.nlm.nih.gov]
  • The presence of a granulomatous inflammatory reaction around the polycarbonate motility peg in this case may have prevented complete osseous transformation of the hydroxyapatite implant.[ncbi.nlm.nih.gov]
  • Author information 1 Institute for Cardiovascular Prevention, Ludwig-Maximilians-Universität Munich, Pettenkoferstr. 9, 80336 Munich, Germany. 2 German Center for Cardiovascular Research (DZHK), partner site Munich Heart Alliance, Pettenkoferstr. 9, 80336[ncbi.nlm.nih.gov]
  • It highlights the complexity associated with chronic inflammation, as well as provides insights into potential new targets for therapies that could be used to treat chronic inflammation and consequently prevent disease progression.[ncbi.nlm.nih.gov]
  • Perhaps the closed space of the pseudocyst, by preventing a cytolytic response to EBV-infected cells, results in local immunodeficiency that may be most important for pathogenesis.[ncbi.nlm.nih.gov]

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