A 31-year-old Malay female presented with nephrotic syndrome without renal impairment. Renal biopsy features were in keeping with immunotactoid glomerulopathy (ITG). [ncbi.nlm.nih.gov]

• Cervical Lymphadenopathy

  The patient showed cervical lymphadenopathy, asymptomatic proteinuria of nephrotic range, and hematuria without any defined immunologic disease. [ncbi.nlm.nih.gov]

• Hypertension

  This group had severe hypertension (4/6) and nephrotic-range proteinuria (5/6) at some point in their course. [ncbi.nlm.nih.gov]

  Recurs in transplants Cryoglobulins: randomly arranged curved microtubules 25-35nm in diameter Fibronectin glomerulopathy: 10-15nm fibrils Hereditary, autosomal dominant Presents with proteinuria, hematuria, hypertension Collagenofibrotic glomerulopathy [renalfellow.blogspot.com]

• Suggestibility

  For example, a lymphoproliferative disorder, monoclonal gammopathy, cryoglobulinemia, or SLE may suggest immunotactoid glomerulonephritis. [msdmanuals.com]

  It is suggested that skin and renal involvement are part of the same systemic disease. [ncbi.nlm.nih.gov]

• Kidney Failure

  Monitor for sign of kidney failure, heart failure, and hypertensive encephalopathy. [en.wikipedia.org]

  Keywords: End-stage renal failure; fibrillary glomerulonephritis; immunotactoid glomerulopathy; kidney failure; chronic; outcomes; renal function recovery; renal transplantation; residual renal function Rights: © 2015 S. [digital.library.adelaide.edu.au]

• Polyneuropathy

  At the same time, a POEMS syndrome diagnosis (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin abnormalities) was confirmed in light of the following: 1) IgG κ monoclonal gammopathy, 2) axonal neuropathy, 3) osteosclerosis [ncbi.nlm.nih.gov]

• Headache

  One day prior to his referral, he experienced speech disturbance, headache, and vomiting, and on the next day he was referred to our hospital. The laboratory examination revealed massive proteinuria (11.3 g/day) and hematuria. [ncbi.nlm.nih.gov]

The kidney biopsy was consistent with ITG Given the diagnosis of ITG, a hematologic workup was conducted to investigate a possible underlying LPD. [bmcnephrol.biomedcentral.com]

• Creatinine Decreased

  Her serum creatinine decreased to 1.53 mg/dl and her urine protein to creatinine ratio was 0.57 g/g as of June 2012. 4. [file.scirp.org]

Treatment of immunotactoid glomerulonephritis is not well-defined, with poor outcomes seen in native kidneys. [file.scirp.org]

He was presently on 2 drug anti-tubercular treatment (ATT) (isoniazid and rifampicin) after first 8 weeks of 4 drugs, which additionally included pyrazinamide and ethambutol. [revistanefrologia.com]

More recently, rituximab has been suggested as a treatment and has demonstrated improved outcomes in other glomerular diseases. [ncbi.nlm.nih.gov]

1 A case of immunotactoid glomerulopathy with false-negative IgG staining. ( 29907095 ) 2018 2 A case report of POEMS syndrome with renal involvement as immunotactoid glomerulopathy. ( 29489695 ) Wang Y....Zuo L. 2018 3 Successful treatment with rituximab [malacards.org]

ITG appears to have a better prognosis than other paraprotein-related renal lesions, with a half of patients expected to recover kidney function with immunosuppressive therapy or chemotherapy. [mayoclinic.pure.elsevier.com]

These forms present with the nephritic syndrome, hypocomplementemia, and have a poor prognosis. [en.wikipedia.org]

[…] monoclonal gammopathy or hematologic malignancy Laboratory Tests Serum or urine protein electrophoresis Immunofixation or immunoelectrophoresis Treatment Drugs Chemotherapy for underlying lymphoproliferative disorder or plasma cell dyscrasia, if present Prognosis [basicmedicalkey.com]

From the histological examination in conjunction with an electron microscopic examination and immunohistochemical staining of the biopsy specimen conclusions can be drawn for the therapy and the prognosis can be drawn. [memim.com]

Imaging studies done for lymphoproliferative disease as an etiology were negative too. He was treated with ATT for a total of 6 months. His blood pressures were kept under control with ramipril 10 mg daily. [revistanefrologia.com]

Herrera, Ahmet Dogan Humana Press, ١٧‏/٠٨‏/٢٠١٥ - 542 من الصفحات The second edition of this text presents an overview of the most recent developments in this area including clinical presentation, etiology, pathogenesis, and differential diagnosis. [books.google.com]

TERMINOLOGY Abbreviations Immunotactoid glomerulopathy (ITG) Synonyms Congo red negative organized glomerular immunoglobulin deposits Definitions Congo red negative microtubular deposits typically > 30 nm in diameter and arranged in parallel arrays ETIOLOGY [basicmedicalkey.com]

The glomerulosclerosis, as noted above, though increased (26%) relative to the patient's age is not randomly distributed, but rather, is concentrated in a subcapsular distribution on one core suggesting the possibility of a focal ischemic etiology. [path.upmc.edu]

The past medical history was remarkable for normochromic normocytic anemia of unknown etiology, hyperuricemia and glucosuria for the last two years. Drug history was unremarkable. [sjkdt.org]

New chapters on glomerulonephritis associated with complement disorders, interventional treatments for hypertension, renal disease and cancer, and epidemiology and prognostic impact of acute kidney injury. [books.google.com]

[…] deposits Definitions Congo red negative microtubular deposits typically > 30 nm in diameter and arranged in parallel arrays ETIOLOGY/PATHOGENESIS Unknown Mechanism Microtubular glomerular deposits usually represent monotypic immunoglobulins CLINICAL ISSUES Epidemiology [basicmedicalkey.com]

Neurology and Neurosurgery Czech and Slovak Ophthalmology Czech and Slovak Psychiatry Czech Geriatric Review Czech Gynaecology Czech Rheumatology Czech Dental Journal Czech Urology Czech-Slovak Dermatology Czecho-Slovak Pathology Czech-Slovak Pediatrics Epidemiology [prolekare.cz]

HIV-associated nephropathies: epidemiology, pathology, mechanisms and treatment. Nat. Rev. Nephrol. 10, 150–160 (2015). 6. Benveniste, O. et al. [nature.com]

[…] of contraception Able and willing to give written informed consent and comply with the requirements of the study protocol Adequate renal function as indicated by estimated glomerular filtration rate (GFR) > 25 mL/min using the Chronic Kidney Disease Epidemiology [clinicaltrials.gov]

The pathophysiologic basis for organization of the glomerular deposits as fibrils or microtubules in these entities remains obscure. [ncbi.nlm.nih.gov]

Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test Fibrillary glomerulonephritis (FGN) is a rare kidney disease with fibrillary deposits in the glomeruli that contain polyclonal [mayomedicallaboratories.com]

From basic science and pathophysiology to clinical best practices, Brenner & Rector’s The Kidney is your go-to resource for any stage of your career. [books.google.com]

This case report addresses the need for further understanding of pathophysiology of ITGN so as to better define the treatment. [file.scirp.org]

He received oral prednisolone (30 mg/day), resulting in reduction of proteinuria, improvement of hypocomplementemia, and prevention of renal functional deterioration. [ncbi.nlm.nih.gov]

Hyperlipidemia is thought to be a result of the increased activity of the liver. [4] : 549 Nephritic syndrome [ edit ] Podocytes, cells which line the glomerulus, are negatively charged and have small gaps, preventing the filtration of large molecules [en.wikipedia.org]

Normally, the filtration barrier prevents proteins from getting into the urine. The barrier keeps the proteins in the blood. When the filter is damaged, proteins are able to cross the filter and enter the urine. [unckidneycenter.org]

In the era of HAART, the incidence of HIV-associated glomerular disease has decreased owing to drug efficacy in preventing and treating HIVAN. [kidneynews.org]