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Chronic Nephritis


Presentation

  • Abstract Forty-six patients from 23 Indian families with hereditary chronic nephritis (HCN) with or without Alport's syndrome are presented. The occurrence of this disease in diverse Indian races, communities and castes is now documented.[ncbi.nlm.nih.gov]
  • The patients with uremia presented dramatically higher level of urinary FPA than those in the renal insufficiency group (P 0.01). A positive correlation was found between the level of urinary FPA and the blood creatine (r 0.9120, P 0.01).[ncbi.nlm.nih.gov]
  • Few glomeruli may still present changes which permit to discern the etiology of chronic glomerulonephritis.[pathologyatlas.ro]
  • Physical examination  Hypertension  Jugular venous distention (if severe volume overload is present)  Pulmonary rales (if pulmonary edema is present)  Pericardial friction rub in pericarditis  Tenderness in the epigastric region or blood in the stool[slideshare.net]
  • Its presentation depends on the specific disease entity: it may present with isolated hematuria and/or proteinuria (blood or protein in the urine); or as a nephrotic syndrome, a nephritic syndrome, acute kidney injury, or chronic kidney disease.[renaldiseases.org]
Orthopnea
  • […] for chronic renal disease and may report vague symptoms (nausea, fatigue, joint aches) which may mask glomerular disease Decreased urine output Smoky or coffee-colored urine (hematuria) Proteinuria Fluid volume excess symptoms Shortness of breath • Orthopnea[quizlet.com]
Loss of Appetite
  • […] of appetite; overall itching; headache; easy bruising; frequent hiccups or bleeding; and impaired vision Increased pigmentation of the skin Abdominal pain Chronic Glomerulonephritis Prevention There is no known way to prevent chronic glomerulonephritis[healthcommunities.com]
  • (dark, rust-colored, or brown urine) foamy urine swelling (edema) of the face, eyes, ankles, feet, legs, or abdomen symptoms that may also appear include the following: abdominal pain cough diarrhea general ill feeling fever joint aches muscle aches loss[allnurses.com]
  • […] urine Passing blood in urine Change in the frequency and quantity of urine Needing to pass urine frequently at night Frothing or foaming urine Pain in the loin area Ankle swelling Lethargy Lack of concentration Shortness of breath High blood pressure Loss[kidneys.co.nz]
  • It mostly begins with the loss of appetite, increased heat and vertigo; to which succeed nausea, vomiting, great languor, and pain in the head, which is variously described, by some like cold water pouring over the top, by others a sense of weight.[antiquusmorbus.com]
  • Loss of appetite, nausea, vomiting, abdominal pain, and joint pain are also common. About 50% of people have a flu-like illness in the month before kidney failure develops. These people have edema and usually produce very little urine.[msdmanuals.com]
Bruxism
  • […] world-wide spread mortal disorders such as acute gastritis, adenomyosis, alzheimer, amyloidosis, amyotrophic, anaphylactic, angelman syndrome, anorexia, arthitis, arthropathy, asperger disorder, asthma, ataxia, attention deficit, autism, bell palsy, bruxism[books.google.com]
Hypertension
  • These data show that antihypertensive therapy for CGN with hypertension has an important effect on prognosis. Propranolol was given to 10 hypertensive patients with CGN and hypotensive effect on renal function was observed.[jstage.jst.go.jp]
  • […] syndrome (hypertension is hyperkinetyc and not severe) • Hypertensive stage: complains on headache, disturbances of vision, insomnia; objective examination reveals high blood pressure, hypertrophy of left ventricular, signs of heart failure, cerebral[intranet.tdmu.edu.ua]
  • The question may arise as to whether hypertension of the essential type could occur independently in a case in which evidence of past or latent chronic glomerulonephritis is found.[annals.org]
  • ESKD), with the prognosis varying depending on the specific cause, but it is not good Immunological reactions • Primary infection with group A beta-hemolytic streptococcal infection (most common cause) • Systemic lupus erythematosus • Vascular injury (hypertension[quizlet.com]
  • This reduction leads to hypertrophy and hyperfiltration of the remaining nephrons and to the initiation of intraglomerular hypertension.[emedicine.medscape.com]
Unstable Gait
  • Unstable gait B. Delayed speech C. Fluid and electrolyte changes D. BP and any other cardiac changes E. C and D[proprofs.com]
Ataxia
  • […] complete healing cures, treatments for nowdays world-wide spread mortal disorders such as acute gastritis, adenomyosis, alzheimer, amyloidosis, amyotrophic, anaphylactic, angelman syndrome, anorexia, arthitis, arthropathy, asperger disorder, asthma, ataxia[books.google.com]
Dystonia
  • , bulemia, cachexia, cancer, carpal tunnel syndrome, cerebral aneurysm, cfs, chronic pain, cluster headaches, cmt disease, colitis, colon diverticulitis, crohn, cure, depression, diabetes, diarrhea, disease, dravet, dupuytren contracture, dyspepsia, dystonia[books.google.com]
Nocturia
  • […] confusion* [*]skin changes flushed or reddened skin moist skin (diaphoresis) warm skin [*]urination problems blood in the urine cloudy or abnormal urine color foul or strong urine odor increased urinary frequency or urgency need to urinate at night (nocturia[allnurses.com]
  • […] needle biopsy針生検 neobladder 新膀胱 nephrectomy腎摘出[術]、腎摘、腎切除[術] nephritis腎炎 nephrolithiasis腎結石 nephrology腎臓病学 nephropathy腎症 nephrostomy 腎瘻造設術 nephrotic syndromeネフローゼ症候群 nephrotoxicity腎毒性 neurogenic神経[原]性の neurogenic bladder 神経因性膀胱 neuropathic bladder 神経因性膀胱 nocturia[tokyo-med.ac.jp]
  • Urinary concentration defects (secondary to dysfunction of the kidney concentrating mechanism located in the medulla Occurs early in the course Associated: nocturia, polyuria and nephrogenic diabetes insipidus (NDI) with complications of dehydration Sodium[renalandurologynews.com]
Polyuria
  • Urinary concentration defects (secondary to dysfunction of the kidney concentrating mechanism located in the medulla Occurs early in the course Associated: nocturia, polyuria and nephrogenic diabetes insipidus (NDI) with complications of dehydration Sodium[renalandurologynews.com]
  • オストミー(①人工的な瘻孔 ②瘻造設術、吻合術) ostomy bag (urine collecting bag) 集尿袋 overhydration溢水、体液過剰 p pain on urination排尿時痛 pelvic 骨盤の pelvic floor muscle骨盤底筋 percutaneous nephrolithotomy経皮的腎結石破砕術 peritoneal dialysis (PD)腹膜透析 polycystic kidney disease (PKD)多発性のう胞腎 polyuria[tokyo-med.ac.jp]
Nocturnal Enuresis
  • Clinical Presentation: Present in up to 30-50% of children with UTI Female predominance 4:1 Caucasian:African American 10:1 Often associated: nocturnal enuresis, GI disturbances and flank pain Physical examination must include: Measurement of blood pressure[renalandurologynews.com]

Workup

Uric Acid Increased
  • Obermayr, RP, Temml, C, Gutjahr, G, Knechtelsdorfer, M, Oberbauer, R, Klauser-Braun, R. ” Elevated uric acid increases the risk for kidney disease”. J Am Soc Nephrol. vol. 19. 2008. pp. 2407-2413.[renalandurologynews.com]

Treatment

  • The conventional treatments and latest treatments for chronic nephritis will be introduced in the following content. Conservative treatment *A balanced diet plays a vital role in managing chronic nephritis.[sjzkidneyhospital.com]
  • Treatment Treatment for chronic nephritis depends on the type and cause of the condition. It aims at reducing inflammation, relieving the symptoms and repairing the damaged kidney tissues, as well as improving kidney function.[kidneyservicechina.com]
  • Patient : what treatments help improve kidney function with no relapse? Doctor : the systematic treatment includes: Micro-Chinese Medicine Osmotherapy, Medicated bath, Foot baht, Immunotherapy, Toxins-Removing Treatments, Acupuncture, etc.[tongshantanghospital.com]
  • It is known across India for its expertise in the treatment of the most complex kidney related diseases. The institute is a pioneer in renal transplantation in both live and cadaveric donor programs.[carehospitals.com]
  • In our treatment center point , we do use Micro-Chinese Medicine Osmotheray, a new developed treatment from Traditional Chinese Medicine ( TCM ), to fight against infection, inflammation and treat various kidney diseases.[renaldiseases.org]

Prognosis

  • Prognosis The prognosis of chronic nephritis varies from individual to individual as it is affected by many factors. Factors which may affect the prognosis include: Pathological types 1.[sjzkidneyhospital.com]
  • There will be a decrease in GFR • Prognosis varies depending upon the specific cause, but spontaneous recovery generally occurs after the acute illness Chronic glomerulonephritis (CGN) Can occur in a patient without a previous history or known onset •[quizlet.com]
  • These data show that antihypertensive therapy for CGN with hypertension has an important effect on prognosis. Propranolol was given to 10 hypertensive patients with CGN and hypotensive effect on renal function was observed.[jstage.jst.go.jp]
  • The prognosis also depends on the cause, the person's age, and any other diseases the person might have. When the cause is unknown or the person is older, the prognosis is worse.[msdmanuals.com]

Etiology

  • The etiology for chronic nephritis, chronic nephritis experts said: clear etiology has not been confirmed, but many speculate and infection especially viral infection.[kidneyhealthy.com]
  • Pathogenesis Etiology Often unknown etiology. Leptospirosis Leptospira icterohemorrhagiae or canine adenovirus-1 Canine adenovirus type 1 may play a possible role but are probably rare.[vetstream.com]
  • Few glomeruli may still present changes which permit to discern the etiology of chronic glomerulonephritis.[pathologyatlas.ro]
  • Alcoholism and syphilis, undoubtedly, are forces that must be considered as etiological factors.[henriettes-herb.com]
  • Etiology The progression from acute glomerulonephritis to chronic glomerulonephritis is variable, depending to a considerable extent on the cause of the condition.[emedicine.medscape.com]

Epidemiology

  • CRF and ESRD in 10 years; however, patients with certain histologic variants (eg, class IV) may have a more rapid decline. [5] The presence of antineutrophil cytoplasmic antibody (ANCA) is also an independent risk factor for poor renal outcomes. [6] Epidemiology[emedicine.medscape.com]
  • “Lead-related nephrotoxicity: A review of the epidemiologic evidence”. Kidney International. vol. 70. 2006. pp. 2074-2084. Evans, M, Elinder, C-G. “Chronic renal failure from lead: myth or evidence-based fact”.[renalandurologynews.com]
Sex distribution
Age distribution

Pathophysiology

  • What is the Pathophysiology of glomerulonephritis? A.[proprofs.com]
  • Pathophysiology Reduction in nephron mass from the initial injury reduces the GFR. This reduction leads to hypertrophy and hyperfiltration of the remaining nephrons and to the initiation of intraglomerular hypertension.[emedicine.medscape.com]
  • Allergic interstitial nephritis Crystal-induced acute kidney injury Etiology Antibiotics, NSAIDs, diuretics, allopurinol, PPIs, phenytoin E.g, acyclovir, indinavir, ciprofloxacin, methotrexate Pathophysiology Drugs, particularly antibiotics and NSAIDs[amboss.com]
  • […] im in my adults rotation and during our lecture today, were were differentiating between "glomerulonephritis, and pyelonephritis." we need to know what each is (pathophysiology), risks factors/causes, acute/chronic symptons, diagnosis, and interventions[allnurses.com]

Prevention

  • Prevention To avoid developing chronic nephritis, the best preventive measure is to control the triggering factors.[sjzkidneyhospital.com]
  • There is no known way to prevent chronic glomerulonephritis.[healthcommunities.com]
  • Prevention Although it is not always possible to prevent nephritis, certain lifestyle practices can reduce the risk for many people.[medicalnewstoday.com]
  • —But little can be expected from medicines in the way of curing interstitial nephritis,, and our attention will be directed to preventing or retarding further retrograde tendencies, and meet the complications, as far as possible, as they arise.[henriettes-herb.com]
  • Can glomerulonephritis be prevented? Not until more is known about its causes. However, good hygiene, practicing “safe sex” and avoiding IV drugs are helpful in preventing viral infections such as HIV and hepatitis, which could lead to this illness.[kidney.org]

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