They form the basis of this report because of either the unusualness of the clinical presentation, hitherto undescribed associated diseases or the unusual age of presentation and sites of lesions. [ncbi.nlm.nih.gov]

• Parotid Mass

  CONCLUSIONS: Parotid mass or swelling is a common presentation of CRMO involving the mandible. The possibility of this diagnosis should be raised when typical clinical and imaging features are present. [ncbi.nlm.nih.gov]

  Parotid swelling and chronic recurrent multifocal osteomyelitis of mandible in children – “Parotid mass or swelling is a common presentation of CRMO involving the mandible.” [saidsupport.org]

• Parotid Swelling

  Parotid swelling and chronic recurrent multifocal osteomyelitis of mandible in children – “Parotid mass or swelling is a common presentation of CRMO involving the mandible.” [saidsupport.org]

• Musculoskeletal Pain

  Because of a high frequency of musculoskeletal disorders in children/ adolescents, it can be quite challenging to distinguish CRMO/ CNO from nonspecific musculoskeletal pain or from malignancies. [ncbi.nlm.nih.gov]

  Risk factors for development of non-specific musculoskeletal pain in preteens and early adolescents: a prospective 1-year follow-up study. [doi.org]

• Arthralgia

  A case of acute lymphotic leukemia which was difficult to make a diagnosis of CRMO for moving arthralgia and periarticular swelling. [saidsupport.org]

  Showing of 34 | 80%-99% of people have these symptoms Abnormality of bone marrow cell morphology 0005561 Arthralgia Joint pain 0002829 Bone pain 0002653 Cachexia Wasting syndrome 0004326 Congenital hypoplastic anemia 0004810 Fever 0001945 Hypochromic [rarediseases.info.nih.gov]

• Shoulder Swelling

  There were periodic exacerbations of pain, swelling and discharge over affected areas. He had a short limb gait and shoulder asymmetry. His left shoulder was warm, erythematous and there was decreased range of movement in all directions. [ncbi.nlm.nih.gov]

• Long-Bone Deformity

  It has been proven to be a non-benign disease in the long term, with persistent pain and bone deformity as the most common complaints. [jocr.co.in]

• Suggestibility

  Two genetic syndromes have CRMO as a prominent phenotype-Majeed syndrome and deficiency of the interleukin-1 receptor antagonist-and suggest that interleukin-1 may be a key cytokine in disease pathogenesis. [ncbi.nlm.nih.gov]

  It is characterized by insidious onset of pain, local bone expansion and radiological findings suggestive of osteomyelitis at multiple sites. CRMO predominantly affects metaphyses of long bones but clavicle and mandible are suggestive of diagnosis. [moh-it.pure.elsevier.com]

• Incontinence

  She had no significant history of weight loss, infective symptoms or neurological symptoms, including bladder or bowel incontinence. There was no recent travel history. [casereports.bmj.com]

[…] description While histological analysis of bone lesions may help to exclude malignant processes, the histologic appearance of CRMO may mimic acute and secondary chronic osteomyelitis caused by microbiological infection Therefore, an extensive microbiological workup [pathologyoutlines.com]

In relation to this case report and our difficulty diagnosing CRMO, we would recommend that whole-body MRI should considered when possible, as part of the diagnostic workup. [em-consulte.com]

• Microcytosis

  Peripheral blood films showed hypochromia and microcytosis. The sites involved by CRMO were periarticular, mainly around the elbow, knee, wrist and small joints of the hand. [ncbi.nlm.nih.gov]

Goals of treatment of CRMO/CNO include: - Reduce inflammation - Prevent bone damage and bone deformities - Decrease pain CRMO/CNO is different for each patient. Not every child responds to every treatment. [en.wikipedia.org]

To describe an unusual manifestation and treatment of a rare disease. CRMO is a rare inflammatory bone disease that should be differentiated from bacterial osteomyelitis. [ncbi.nlm.nih.gov]

Pain resolution was achieved within 3 months of PAM treatment in every case. One patient subsequently developed a pain amplification syndrome. [doi.org]

Favorable, self-limited long-term prognosis of CRMO has been assumed. Antibiotics provide no improvement. Course, severity and recurrency can be influenced positively by antiphlogistic substances, although this has not yet been proved. [ncbi.nlm.nih.gov]

The prognosis can vary among individuals: some children may go into complete remission when they become adults and some may continue with this disease. [checkorphan.org]

Prognosis will depend on your child's individual disease and response to treatment. It is best to discuss the prognosis with your child's pediatric rheumatologist. [en.wikipedia.org]

Treatment and prognosis CRMO should be treated by a rheumatologist. While non-steroidal anti-inflammatory drugs may cause some symptomatic relief, there is often the need for a greater degree of immunosupression and possibly biological agents. [radiopaedia.org]

Several observations suggest the contribution of genetic factors to the etiology of chronic recurrent multifocal osteomyelitis. [ncbi.nlm.nih.gov]

No epidemiological data on incidence and prevalence have been published so far. However, the incidence might be estimated at 1:1,000,000.The cause of this condition is unknown, despite the intensive investigation over a period of more than 30 years. [medigoo.com]

Eriksen J, Sjøgren P, Bruera E, Ekholm O, Rasmussen NK (2006) Critical issues on opioids in chronic non-cancer pain: An epidemiological study. Pain 125: 172-179. [omicsonline.org]

Epidemiology of Infectious Disease 12. Epidemiologic Principles 13. Emerging and Reemerging Infectious Disease Threat 14. Bioterrorism: An Overview Section D. Clinical Microbiology 15. The Clinician and the Microbiology Laboratory Section E. [euro-libris.ro]

[…] based on presumed etiology and pathogenesis of disease These criteria are therefore considered a tertiary classification criteria These tertiary criteria help determine the necessary therapeutic strategies which may differ somewhat among the subgroups Epidemiology [pathologyoutlines.com]

We summarize the clinical presentation, diagnostic approaches, most recent advances in understanding the pathophysiology, and available treatment options and outcomes in CNO/CRMO. [ncbi.nlm.nih.gov]

Hedrich, Chronic Nonbacterial Osteomyelitis: Pathophysiological Concepts and Current Treatment Strategies, The Journal of Rheumatology, 10.3899/jrheum.160256, 43, 11, (1956-1964), (2016). [doi.org]

Remember, trauma is part of the pathophysiology of this disease. First they bang into something, then they have a transient bacteremia and the bacteria sets up shop in that bone. So, the legs are particularly prone. [lecturio.com]

It is important to publish cases like this, because the recognition of CRMO can prevent aggressive surgical and medical treatment. [ncbi.nlm.nih.gov]

The aim of the treatment is to try to prevent flare-ups and treat them if they occur. [medigoo.com]