RESULTS: The IRS was present in 99.5 /- 0.01% (mean /- standard error) of normal follicles at the level of the arrector pili muscle/sebaceous gland/sweat gland coil (L2) and variably present at higher levels. [ncbi.nlm.nih.gov]

• Heat Intolerance

  Hypohidrosis in the affected areas, heat intolerance, and febrile convulsions were noted in infancy and childhood. No new skin lesions developed, and the existing ones, the sweating disturbance, and the heat intolerance gradually improved with time. [ncbi.nlm.nih.gov]

• Dyspnea

  He also reported a chronic cough and dyspnea. According to the patient's medical history, he was treated for tinea capitis with radiotherapy of the scalp at the age of 7, with temporary hair-loss and subsequent total re-growth. [ncbi.nlm.nih.gov]

• Chronic Cough

  He also reported a chronic cough and dyspnea. According to the patient's medical history, he was treated for tinea capitis with radiotherapy of the scalp at the age of 7, with temporary hair-loss and subsequent total re-growth. [ncbi.nlm.nih.gov]

• Lesion of the Tongue

  Scarring alopecia, congenital absence of three toenails, and a scarlike lesion of the tongue were also present. [ncbi.nlm.nih.gov]

• Alopecia

  DESIGN: We evaluated 22 non-scarring alopecia cases, including alopecia areata (AA) and androgenetic alopecia (AGA), and 22 scarring alopecia cases, including follicular degeneration syndrome (FDS)/central centrifugal cicatricial alopecia and other scarring [ncbi.nlm.nih.gov]

• Sweating

  RESULTS: The IRS was present in 99.5 /- 0.01% (mean /- standard error) of normal follicles at the level of the arrector pili muscle/sebaceous gland/sweat gland coil (L2) and variably present at higher levels. [ncbi.nlm.nih.gov]

  The disease may be asymptomatic or associated with pruritus, dysesthesia, and increased scalp sweating 3. Frontal fibrosing alopecia: frontal hairline recession (a, b); partly also occipital involvement (c), loss of eyebrows (d, e). [onlinelibrary.wiley.com]

• Blisters on Sun-Exposed Areas

  The initial clinical presentation commonly includes mechanical fragility of the skin and blisters in sun-exposed areas. Sclerodermatous skin changes and scarring alopecia are described in up to 20% of patients. [ncbi.nlm.nih.gov]

Figures 1 and 2 depict flowcharts for the clinical diagnosis of the various forms of primary cicatricial alopecia as well as for the histopathological workup 8. [onlinelibrary.wiley.com]

Although DLE usually responds to topical or intralesional corticosteroids and/or oral antimalarials, some DLE is resistant to these treatments or adverse effects limit their effectiveness. [ncbi.nlm.nih.gov]

Many patients do not respond to the first treatment they receive and often the condition relapses when treatment is stopped. [americanhairresearchsociety.org]

CONCLUSIONS: The psychological burden is heavier and quality of life is more severely impaired among women with scarring alopecia compared with non-scarring alopecia, probably depicting the poorer prognosis of the former. 2015 Deutsche Dermatologische [ncbi.nlm.nih.gov]

Prognosis The prognosis depends upon how advanced the condition is at the time a diagnosis is made and the extent of the hair that has been lost. The earlier treatment is started, the better the outcome. [houstonhairlossclinic.com]

What is the prognosis/ likely outcome of CCCA? Without early treatment, CCCA is likely to progress over years eventually causing severe, non-reversible scarring and permanent hair loss (bald patches). [dermcoll.edu.au]

[…] terminology based on clinical features Once the patient is determined to have scarring alopecia, establishing and clarifying the diagnostic options and terminology is important to assist in confirming the diagnosis, initiating treatment, and suggesting a prognosis [emedicine.medscape.com]

Prognosis Cicatricial alopecias do not negatively affect ones general health. Although hair will not regrow once the follicle is destroyed, doctors can often treat the inflammation before too many follicles have been destroyed. [bernsteinmedical.com]

Even in cases that show a complete loss of follicles, it is possible to suggest the etiology based on epidermal and connective tissue changes. [ncbi.nlm.nih.gov]

The etiology is not completely understood, but CCCA likely results from a combination of hair-grooming practices, a pro-inflammatory state within the hair follicles, and genetic factors. [clinicaltrials.gov]

The scars resulting from severe injuries, infections, burns, radiodermatitis, chemical injuries or after certain surgical procedures (facelift, brow lift, neurosurgery, surgery of skin tumors) are of a different origin (etiology) than scarring alopecia [haircenter.rs]

Author information 1 Department of Dermatology, Affiliated Wuxi People's Hospital of Nanjing Medical University, 299 Qingyang Road, Wuxi. 2 Department of Gynecology, Hua-Dong Sanatorium, 67 Dajishan Road, Wuxi. 3 Department of Epidemiology & Biostatistics [ncbi.nlm.nih.gov]

In this first part, the authors summarize the classification, epidemiology, diagnostic approach, and patient management of lymphocytic cicatricial alopecias. [read.qxmd.com]

The study aims at evaluating epidemiological and clinicopathological characteristics of patients suffering from cicatricle alopecia in Tabriz. [scialert.net]

Epidemiologic studies have not been performed to determine the incidence of cicatricial alopecias. In general, they are not common. There have been a few reports of cicatricial alopecia occurring in a family. [rarediseases.org]

Epidemiologic studies have not been performed to determine the incidence of cicatricial alopecias. In general, they are not common. The majority of patients with cicatricial alopecia have no family history of a similar condition. [en.wikipedia.org]

The primary pathophysiology resulting in the formation of pigment casts more correctly reflects the sudden termination of the anagen phase of the hair cycle. [ncbi.nlm.nih.gov]

Although the cause is unknown, it is believed to be associated with immune response and hormone component (menopause) of the pathophysiology of this condition. Diagnosis is based on clinical picture and typical hair loss. [haircenter.rs]

Pathophysiology The initial response is thought to be premature desquamation of the inner root sheath below the level of the eccrine coil/arrector pili, though this has now been described in at least equal frequency in a variety of other scarring alopecias [dermatologyadvisor.com]

Due to its analogies with lichen planus, graft versus host disease (GvHD) constitutes a valid model for a better understanding of the pathophysiological features underlying both lichen planus and LPP. [ijtrichology.com]

Treatment should begin as soon as possible to relieve the discomfort and prevent further hair loss. [haircenter.rs]

Topical, oral, or injected corticosteroids, oral antibiotics, and other anti-inflammatory agents may help reduce inflammation and prevent hair loss in African American women. 1-2 Minoxidil may also be used to help stimulate hair growth from follicles [skinofcolorsociety.org]

Treatment of central centrifugal cicatricial alopecia The goal of therapy is to halt progression of disease and prevent further hair loss. In areas where the hair follicle has been replaced with fibrosis, regrowth is not possible. [dermnetnz.org]

How can it be prevented? There are no known preventative options. Treatment The first treatment goal is to stop the follicle destroying inflammatory cells so that hair loss does not progress. [houstonhairlossclinic.com]