Images
Presentation
The survival factors present in serum, insulin-like growth factor-1 and hepatocyte growth factor, were also protective. The present data suggest that apoptosis induction is a mechanism contributing to cidofovir nephrotoxicity. [ncbi.nlm.nih.gov]
Entire Body System
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Intravenous Administration
Local cidofovir therapy for viral hemorrhagic cystitis could be an alternative to intravenous administration of cidofovir. [ncbi.nlm.nih.gov]
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Intravenous Drugs
Because of this infrequent dosing schedule, patients do not need to have a catheter surgically implanted, as is required for other intravenous drugs for cytomegalovirus. [aidsmap.com]
The risk factor for HIV infection was intravenous drug use in five, and sexual risk relationships in three. [journals.lww.com]
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Crying
A previously healthy, full-term, 4-month-old boy presented with progressively weakening cry, hoarseness, and increased work of breathing. [ncbi.nlm.nih.gov]
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Splenectomy
Remission of progressive multifocal leukoencephalopathy following splenectomy and antiretroviral therapy in a patient with HIV infection (letter). N Engl J Med 1997 ;336: 661 – 2. Google Scholar Crossref Medline ISI 10. [doi.org]
Skin
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Keratosis
Trichodysplasia spinulosa (TS) is a rare entity, characterized by a follicular digitate keratosis predominantly affecting the face and variable degrees of hair loss, most severely facial hair, that occurs in immunosuppressed individuals, and is considered [ncbi.nlm.nih.gov]
Urogenital
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Bladder Pain
Interstitial cystitis causes disabling bladder pain and is usually diagnosed in the absence of infection. [ncbi.nlm.nih.gov]
Neurologic
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Focal Neurologic Deficit
We report on a stem cell-transplanted patient with B cell chronic lymphatic leukemia who presented with a subacute onset of focal neurological deficits, gait abnormalities, emotional lability and dementia. [ncbi.nlm.nih.gov]
Workup
X-Ray
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Pulmonary Infiltrate
In this study, we report 2 renal transplant patients who presented with fever and pulmonary infiltrates. Both patients continued to worsen despite antibiotic therapy. [ncbi.nlm.nih.gov]
Microbiology
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Human Parvovirus B19
KEYWORDS: Cidofovir; Human erythroid progenitor cells; Human parvovirus B19; qPCR [ncbi.nlm.nih.gov]
Treatment
OBJECTIVE: The treatment of recurrent respiratory papillomatosis (RRP) continues to be difficult. Adjuvant pharmacological treatment is increasingly being used, and intralesional cidofovir injection remains the leading option. [ncbi.nlm.nih.gov]
Prognosis
Our results suggest that cidofovir-treated children have a better prognosis compared to those treated surgically only; the duration of treatment until eradication of JRRP was shorter in the former. [scielo.br]
Potent thymidine phosphorylase (TP) inhibitors with anti-angiogenic activity are required to improve the prognosis of patients with TP-positive tumors. [ncbi.nlm.nih.gov]
HAART improves prognosis in HIV-associated progressive multifocal leukoencephalopathy. Neurology 52 : 623–625. PubMed Google Scholar De Luca A, Fantoni M, Tartaglione T, Antinori A (1999). [link.springer.com]
Pou AM, Rimell FL, Jordan JA, Shoemaker DL, Johnson JT, Barua P, Post JC, Ehrlich GD (1995) Adult respiratory papillomatosis: human papillomavirus type and viral coinfections as predictors of prognosis. [doi.org]
HAART improves prognosis in HIV -associated progressive multifocal leukoencephalopathy [see Comments]. Neurology 1999, 52: 623–625. 7. Andrei G, Snoeck R, Vandeputte M, De Clercq E. [journals.lww.com]
Etiology
Human herpesvirus 6 (HHV-6) is the etiologic agent of exanthema subitum, a febrile rash illness that can occur during early childhood and that is occasionally accompanied by convulsions. [academic.oup.com]
In a study of the etiology and epidemiology of acute viral lower respiratory tract infections of South Korean soldiers in our institution, six cases of severe AdV pneumonia were identified. [journals.plos.org]
Epidemiology
Clinical epidemiology group. French hospital database on HIV. AIDS 1999 ;13: 1881 – 7. Google Scholar Crossref Medline ISI 11. Tantisiriwat, W, Tebas, P, Clifford, DB, Powderly, WG, Fichtenbaum, CJ. [doi.org]
Mandal, “Adenovirus Infections in Human Immunodeficiency Virus-Positive Patients: Clinical Features and Molecular Epidemiology,” Journal of Infectious Diseases, Vol. 172, No. 3, 1995, pp. 629-637. doi:10.1093/infdis/172.3.629 [ 3 ] M. [dx.doi.org]
CrossRef PubMed Google Scholar Tassie JM, Gasnault J, Bentata M, Deloumeaux J, Boue F, Billaud E, Costagliola D, and the Clinical Epidemiology Group from the French Hospital Database on HIV (1999). [link.springer.com]
Epidemiology of progressive multifocal leukoencephalopathy in the United States: analysis of national mortality and AIDS surveillance data [see Comments]. Neurology 1991, 41: 1733–1736. 2. Dworkin MS, Wan PC, Hanson DL, Jones JL. [journals.lww.com]
Pathophysiology
The pathophysiology of AdV pneumonia remains unclear; few studies have been performed. [journals.plos.org]
Prevention
Cell death was specific as it was also present in a human proximal tubular epithelial cell line (HK-2), but not in a human kidney fibroblast cell line, and was prevented by probenecid. An inhibitor of caspase-3 (DEVD) prevented cidofovir apoptosis. [ncbi.nlm.nih.gov]
Mechanism of action Acting as an antiviral agent by preventing the replication of CMV, cidofovir targets viral DNA polymerase and prevents transcription. [web.stanford.edu]
Cidofovir is an antiviral medication that prevents certain viral cells from multiplying in your body. Cidofovir is used to treat an eye infection called cytomegalovirus retinitis (CMV) in people who have AIDS (acquired immunodeficiency syndrome). [everydayhealth.com]