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Ciprofloxacin


Presentation

  • Here we present the first reported case of bilateral iliopsoas tendon rupture associated with prolonged ciprofloxacin use. This older woman presented with non-traumatic, sudden onset hip pain which was diagnosed as a right iliopsoas rupture on MRI.[ncbi.nlm.nih.gov]
Intravenous Administration
  • Intravenous administration of ciprofloxacin in patients with additional risks may elevate the risk of QTc interval prolongation.[ncbi.nlm.nih.gov]
  • Most quinolones have excellent oral bioavailability, with serum drug concentrations equivalent to intravenous administration. Quinolones have few adverse effects, most notably nausea, headache, dizziness, and confusion.[aafp.org]
  • Observation period was 10 days, respectively, after a single oral, subcutaneous and intravenous administration. The LD 50 value was determined by the Litchfield-Wilcoxon method. The results were shown in Table 12.[google.com]
  • Ciprofloxacin concentrations in human aqueous humor following intravenous administration. Chemotherapy. 1987; 33:328-30. 279. Wolff M, Boutron L, Singlas E et al.[drugs.com]
Foreign Body Aspiration
  • Foreign body aspirations occur among children more than adults and can cause life threatening complications. Acute respiratory failure due to foreign body aspiration in adults is a rare condition.[ncbi.nlm.nih.gov]
Movement Disorder
  • CONCLUSION: Careful dosing and a high index of suspicion of the neurological adverse effects of ciprofloxacin including movement disorders are warranted especially in cirrhotic patients. Copyright 2009 S. Karger AG, Basel.[ncbi.nlm.nih.gov]
Gangrene
  • In one patient the vasculitis resolved after termination of the ciprofloxacin therapy; in the other patient the ciprofloxacin-induced hemorrhagic vasculitis was superimposed on a severe forefoot infection, leading to progressive gangrene and a below-knee[ncbi.nlm.nih.gov]
Pleural Effusion
  • An unusual case of bacteraemia with bilateral pleural effusion caused by Salmonella enterica serotype Typhi in a 10-year-old previously healthy girl is reported.[ncbi.nlm.nih.gov]
Nausea
  • She presented to clinic with nausea and anorexia within a few days of addition of ciprofloxacin to her current regimen of medications, which included digoxin.[ncbi.nlm.nih.gov]
  • Vol. 54, Pg. 115, 1993. man TDLo oral 200mg/kg (200mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING BEHAVIORAL: TREMOR GASTROINTESTINAL: OTHER CHANGES Annals of Pharmacotherpy.[chem.nlm.nih.gov]
  • Can be exacerbated by the drugs’ effects on cell membrane channels Adverse Effects Use of fluoroquinolones may result to these adverse effects: GI: nausea, vomiting, diarrhea, dry mouth CNS: headache, dizziness, insomnia, depression Immunological: bone[nurseslabs.com]
Abdominal Pain
  • Upon physical examination a slight general abdominal pain on palpation and some fresh blood at rectal digital examination were found.[ncbi.nlm.nih.gov]
  • The most frequently reported adverse effects are nausea, diarrhoea, vomiting, dyspepsia, abdominal pain, headache, restlessness, rash, dizziness and pruritus. Drug interactions Plasma levels of theophylline may be increased.[apps.who.int]
  • Common side effects of Cipro include abdominal pain, diarrhea, headache, and rash.[medicinenet.com]
Hip Pain
  • This older woman presented with non-traumatic, sudden onset hip pain which was diagnosed as a right iliopsoas rupture on MRI. Despite stopping ciprofloxacin, she went on to develop rupture of the contralateral iliopsoas tendon.[ncbi.nlm.nih.gov]
Musculoskeletal Pain
  • CASE SUMMARY: A 58-year-old male developed fulminating musculoskeletal pain associated with third-time exposure to ciprofloxacin administered for treatment of chronic otitis media.[ncbi.nlm.nih.gov]
Exanthema
  • Maculopapular exanthema has been associated with noncovalent interactions with T cell receptors and major histocompatibility complex.[doi.org]
Intertrigo
  • Clinical history revealed that she had been treating a bacterial inguinal intertrigo for 4 days with ciprofloxacin 500 mg tablets twice daily and desloratadine 5 mg tablet once daily.[ncbi.nlm.nih.gov]
Kidney Failure
  • We present a case of myoglobin-associated kidney failure in the setting of repeated ciprofloxacin administration in a lung transplant patient. Kidney biopsy was critical to establishing the diagnosis and avoiding future exposure.[ncbi.nlm.nih.gov]
  • Other possible serious side effects and adverse events include liver dysfunction or failure. high blood sugar (hyperglycemia), renal failure (kidney failure), cardiac arrest, hepatitis, stroke, convulsions, seizures, jaundice, leukopenia, C. difficile[medicinenet.com]
  • Ciprofloxacin can cause damage to the liver and kidneys, which can result in sudden liver or kidney failure. Patients can also develop problems with making new blood cells, resulting in anemia.[livestrong.com]
  • You must tell your doctor if your child has ever had any reaction to any antibiotic or if your child has kidney failure. If you have forgotten to tell your doctor, check with the doctor or pharmacist before giving ciprofloxacin to your child.[medicinesforchildren.org.uk]
Headache
  • Headache, confusion, seizures, cortical visual disturbances or blindness are the key symptoms. As this syndrome is reversible and readily treated by interrupting or discontinuing the aetiology, it should sharply be acknowledged.[ncbi.nlm.nih.gov]
  • Common ciprofloxacin side effects may include: nausea, vomiting, diarrhea, stomach pain; vaginal itching or discharge; headache; or abnormal liver function tests. This is not a complete list of side effects and others may occur.[drugs.com]
  • Headache hit as well and anxiety. After reading reviews and dangers, I refused to continue taking this and was put on Cephalexin instead.[everydayhealth.com]
  • Potential side effects include flatulence, flushing, headache, rash, dizziness, vivid dreams and muscle and joint pains. May impair skilled task such as driving, effects enhanced by alcohol.[doctorfox.co.uk]
Encephalopathy
  • Hemiballism accompanied by mental changes imposed a diagnostic challenge in the differentiation between hepatic encephalopathy and stroke.[ncbi.nlm.nih.gov]
Involuntary Movements
  • A 72-year-old haemodialysis patient presented with a 4-day history of progressive weakness, restlessness and involuntary movements of all limbs.[ncbi.nlm.nih.gov]

Workup

Pleural Effusion
  • An unusual case of bacteraemia with bilateral pleural effusion caused by Salmonella enterica serotype Typhi in a 10-year-old previously healthy girl is reported.[ncbi.nlm.nih.gov]

Treatment

Prognosis

  • Effect of penicillin resistance of Streptococcus pneumoniae on the presentation, prognosis, and treatment of pneumococcal endocarditis in adults. Clin Infect Dis. 2002 ; 35 : 130–139.[doi.org]
  • Malignant external otitis: report on therapy with ceftazidime and review of therapy and prognosis. Clin Infect Dis. 1990; 12:173-80. 782. Hern JD, Ghufoor K, Jayaraj SM et al. ENT manifestations of Pseudomonas aeruginosa infection in HIV and AIDS.[drugs.com]

Etiology

  • Furthermore, one of the more consensual etiologic factors is the presence of biofilms in the nasal mucosa.[elsevier.es]
  • The microbial etiology and antimicrobial therapy of adults with acute community-acquired sinusitis: a fifteen-year experience at the University of Virginia and review of other selected studies.[doi.org]

Epidemiology

  • Nevertheless, local differences indicate that other epidemiologic parameters should be further evaluated. Dr.[doi.org]
  • California, USA. 5 Department of Medicine, Harvard Medical School and Massachusetts General Hospital, Boston, USA. 6 Division of Infectious Diseases, Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, California, USA. 7 Department of Epidemiology[ncbi.nlm.nih.gov]
Sex distribution
Age distribution

Pathophysiology

  • Pathophysiology of varicoceles in male infertility. Hum Reprod Update. 2001; 7 (5):437–481. [ PubMed ] [ Google Scholar ] 15. Reagan-Shaw S, Nihal M, Ahmad N. Dose translation from animal to human studies revisited.[ncbi.nlm.nih.gov]
  • Pathophysiology and pharmacotherapy of peptic disease, Thesis, University of Amsterdam, 1981 Google Scholar Brouwers JRBJ. Pharmacokinetics of the newer fluoroquinolones.[doi.org]
  • […] surveillance data indicating that these medications were associated with subsequent tendonitis and tendon rupture. 4 Several large epidemiological studies have confirmed this association. 5, 6 Secondary cell biology and animal research has elucidated the pathophysiology[bmjopen.bmj.com]

Prevention

  • These data suggest that ciprofloxacin monotherapy as a prophylaxis regimen prior to leech therapy may not be effective in preventing infection.[ncbi.nlm.nih.gov]
  • […] topoisomerase inhibitor that inhibits DNA topoisomerase IV, which catalyses ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands. antibacterial drug A drug used to treat or prevent[ebi.ac.uk]

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