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Circadian Rhythm


Presentation

  • We report two patients who presented with this circadian rhythm disorder, and were then diagnosed with a Parkinsonian syndrome. The cases.[ncbi.nlm.nih.gov]
Plethora
  • A large number of the proteins involved in the regulation of this clock are transcription factors controlling rhythmic transcription of so-called clock-controlled genes, which participate in a plethora of physiological functions in the organism.[ncbi.nlm.nih.gov]
Heat Intolerance
  • She referred episodes of heat intolerance when ambient temperature was around 35 degrees C. Skin biopsies of both forearms and left axilla revealed atrophy and morphologic changes of eccrine glands.[ncbi.nlm.nih.gov]
Enuresis
  • WHAT IS KNOWN: • Disturbance in the circadian rhythm of arginine vasopressin secretion is related to nocturnal polyuria in children with enuresis. • Desmopressin is recommended as a treatment for monosymptomatic nocturnal enuresis, working as a vasopressin[ncbi.nlm.nih.gov]
Family History of Suicide
  • Younger onset age of BD and family history of suicide were associated with presence of CRSWD in BD patients.[ncbi.nlm.nih.gov]
Orthostatic Hypotension
  • hypotension (OH) and orthostatic hypertension (OHT) patients were excluded). (2) The syncopal attacks of morning hours occurred more in males than females, but the episodes in the evening occurred more in females than males (P 0.034). (3) The younger[ncbi.nlm.nih.gov]
Anhidrosis
  • We evaluated the CRT in a 45-year-old female with a lack of sweating since birth because of congenital generalized anhidrosis. She referred episodes of heat intolerance when ambient temperature was around 35 degrees C.[ncbi.nlm.nih.gov]
Flushing
  • Circadian rhythm was detected in the daily pattern of hot flushes, with a peak in the afternoons.[ncbi.nlm.nih.gov]
Social Isolation
  • Circadian and circaseptan (about-7-day) free-running physiologic rhythms of a woman in social isolation. Proc 2nd Ann IEEE Symp on Computer-Based Medical Systems, Minneapolis, June 26–27 1989. Washington DC: Computer Society Press, pp. 273–278.[doi.org]
Compulsive Disorder
  • The main augmentation strategy in the treatment of obsessive-compulsive disorder (OCD) is the addition of low-dose dopamine antagonists, such as risperidone.[ncbi.nlm.nih.gov]
  • Péter Simor, András Harsányi, Kata Csigó, Gergely Miklós, Alpár Sándor Lázár and Gyula Demeter, Eveningness is associated with poor sleep quality and negative affect in obsessive–compulsive disorder, Journal of Behavioral Addictions, 10.1556/2006.7.2018.07[doi.org]
Psychiatric Symptoms
  • This review summarizes the current literature regarding the association between circadian rhythm and mood regulation from a chronobiological perspective, and may provide insight into therapeutic approaches to target psychiatric symptoms in neurodegenerative[ncbi.nlm.nih.gov]
Nocturnal Polyuria
  • There is increasing evidence that other disturbed circadian rhythms might play a role in nocturnal polyuria. This review focuses on renal aspects in the pathophysiology of nocturnal polyuria in MNE, with special emphasis on circadian rhythms.[ncbi.nlm.nih.gov]
Hot Flushes
  • Circadian rhythm was detected in the daily pattern of hot flushes, with a peak in the afternoons.[ncbi.nlm.nih.gov]
Nocturia
  • In this article, we describe how age-related changes in sleep depth and continuity and age-related changes in circadian rhythm amplitude may contribute to nocturia, and how nocturia in turn leads to sleep disruption.[ncbi.nlm.nih.gov]
Nocturnal Enuresis
  • Nocturnal polyuria in monosymptomatic nocturnal enuresis (MNE) has so far mainly been attributed to a disturbed circadian rhythm of renal water handling.[ncbi.nlm.nih.gov]
Somnolence
  • EXCESSIVE DAYTIME SOMNOLENCE Excessive daytime somnolence (EDS) is defined as the inability to stay awake or alert throughout the course of the day, resulting in sleepiness or inadvertent dozing during passive (reading, watching television) or active[doi.org]
  • Although the molecular underpinnings of sleep remain largely mysterious, analyses of narcolepsy, a syndrome characterized by abrupt episodes of somnolence and cataplexy, have uncovered a role of the hypocretin/orexin as a neuropeptide connecting circadian[science.sciencemag.org]
Dysarthria
  • A 47-year-old man, who was being evaluated for presurgical investigation for refractory temporal lobe epilepsy, presented with complaints suggestive of dysarthria, bradykinesia of limbs and frequent falls for 5 months.[ncbi.nlm.nih.gov]
Motor Symptoms
  • Patients with PD also exhibit non-motor symptoms, including sleep disorder and neuropsychiatric disorders.[ncbi.nlm.nih.gov]
Bradykinesia
  • Examination revealed severe axial rigidity, restricted vertical gaze and bradykinesia of limbs. A diagnosis of progressive supranuclear palsy was made.[ncbi.nlm.nih.gov]
Involuntary Movements
  • One explanation for this is the occurrence of 'break through' involuntary movements during sleep in the HD patients, which are incorrectly assessed as wakeful periods by the activity monitor algorithms.[ncbi.nlm.nih.gov]

Workup

  • Placement of a urinary catheter early in the workup of a patient with ARF not only allows diagnosis and treatment of urethral and bladder outlet urinary obstruction but also allows for accurate measurement of urine output.[emedicine.com]
Gliosis
  • Although, the number of AVP-positive neurons was decreased in neither the supraoptic nucleus nor the paraventricular nucleus, the number of AVP-positive neurons in the SCN was decreased and gliosis was present in the SCN.[ncbi.nlm.nih.gov]

Treatment

  • CONCLUSIONS: The main problem in the treatment of CRSWD is an invalid diagnosis. Hypnotics and/or psychostimulants are often used instead of chronotherapeutic interventions, what can alleviate symptoms but is not an effective treatment.[ncbi.nlm.nih.gov]

Prognosis

  • However, less is known about how circadian rhythm disruptions may relate to psychosis symptoms and prognosis for adolescents with clinical high-risk (CHR) syndromes.[ncbi.nlm.nih.gov]
  • The following provide an outlook into some sleep disorders: Jet lag: This is a transient condition that has a good prognosis.[emedicinehealth.com]
  • Prognosis Because most cases of community-acquired acute renal failure (ARF) are secondary to volume depletion, as many as 90% of cases are estimated to have a potentially reversible cause.[emedicine.com]

Etiology

  • Pruritus and scratching could lead to sleep disruption but is unlikely the sole etiology. The circadian rhythm of cytokines, the immune system, and skin physiology such as transcutaneous water loss and skin blood flow might also play a role.[ncbi.nlm.nih.gov]
  • This information can be used clinically to help differentiate prerenal failure from other etiologies of ARF.[emedicine.com]
  • Conclusion: Without such quantitative knowledge, limited insights can be gained about the causal relationship between melatonin and the etiology of breast cancer from epidemiological studies and from parametric studies using animal models.[doi.org]
  • ., etiology) of the disease remains unknown (Brunello et al. 2000).[pubs.niaaa.nih.gov]
  • Discussion Despite tremendous efforts to improve our understanding of prostate cancer, its etiology remains largely unknown and it continues to be a major health problem.[cancerres.aacrjournals.org]

Epidemiology

  • Author information 1 Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD. 2 Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY. 3 Epidemiology Research Program, American Cancer Society[ncbi.nlm.nih.gov]
  • .: Cancer spectrum Gültige URL nicht zu ermitteln Online-Ressource JNCI Cancer Spectrum includes NCI's Physician Data Query (PDQ ) database; cancer statistics from NCI's Surveillance, Epidemiology, and End Results program; a database of oncology drugs[zdb-katalog.de]
  • Epidemiology of the human circadian clock. Sleep Med Rev, 11(6), 429-438. - summary of the basic MCTQ findings up to 2007, explanation of MSF vs. MSFsc Roenneberg, T., Allebrandt, K. V., Merrow, M., & Vetter, C. (2012). Social jetlag and obesity.[thewep.org]
Sex distribution
Age distribution

Pathophysiology

  • However, the pathophysiology of sleep disturbance in children with AD is poorly understood, and there is no consensus on how to manage sleep problems in these patients.[ncbi.nlm.nih.gov]

Prevention

  • The ability to identify agents that can disrupt central and/or peripheral biological clocks, and agents that can prevent or mitigate the effects of circadian disruption, has significant implications for prevention of chronic diseases.[ncbi.nlm.nih.gov]

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