Rather, transfected cells presented with a marked decrease of apoptosis as compared with controls, suggesting that GSTO1-1 overexpression may prevent cisplatin toxicity by interfering with the apoptotic process. [ncbi.nlm.nih.gov]

This score could then be presented to patients as a low-, medium- or high-risk measure to further inform their decision-making regarding the treatment and to jointly (with their physicians) make an informed choice in the context of other options available [dash.harvard.edu]

• Asymptomatic

  Concomitant use of cardiotoxic drugs should be avoided, and early detection of asymptomatic cardiac dysfunction is important. [uspharmacist.com]

  The toxicity of anthracyclines can be manifested as acute cardiac dysfunction, especially supraventricular, or tachyarrhythmias (administration in bolus), including in asymptomatic patients. [medichub.ro]

  Among exclusion criteria were pregnancy, current organ dysfunction and symptomatic central nervous system metastases (asymptomatic was allowed in some trials). Details of those RCTs are available in the Characteristics of included studies table. [cochranelibrary.com]

• Swelling

  Myocarditis is inflammation (swelling) of the heart. This can lead to changes in heart rhythm or heart failure. Pericarditis is inflammation (swelling) of the sac surrounding the heart. This can cause chest pain or heart failure. [nccn.org]

  If you experience pain or notice redness or swelling at the IV site while you are receiving cisplatin, alert your health care professional immediately. [chemocare.com]

• Congestive Heart Failure

  Congestive heart failure is when the heart is unable to pump enough blood throughout the body. Chemotherapy can cause mild or severe damage to the heart. If severe, congestive heart failure or other life-threatening problems can occur. [nccn.org]

  Cardiac toxicity Cardiac toxicity is commonly chronic (chronic alterations of myocardial fiber, associated with congestive heart failure), and more rarely acute (direct lesions, with dysrhythmias). [medichub.ro]

• Nausea

  Nearly all patients experienced nausea and vomiting. Myelosuppression was mild. [moh-it.pure.elsevier.com]

  Self-Care Tips: To reduce nausea, take anti-nausea medications as prescribed by your doctor, eat small amounts of food frequently. Try dry cereal, toast, or crackers, especially in the morning, to help curb nausea. [chemocare.com]

  Nausea and vomiting usually begin within 1 to 4 hours after treatment and last up to 24 hours. Various degrees of vomiting, nausea and/or anorexia may persist for up to 1 week after treatment. [rxlist.com]

  Although renal damage is the most serious effect of cisplatin, it actually displays few symptoms, those of which are relatively mild compared to the nausea and vomiting. [ch.ic.ac.uk]

  Acetyl-L-Carnitine One study found evidence that the supplement acetyl-L-carnitine might reduce symptoms of peripheral neuropathy caused by cisplatin. 13 Ginger The herb ginger is widely used for treatment of nausea. [azkrmc.com]

• Vomiting

  Nearly all patients experienced nausea and vomiting. Myelosuppression was mild. [moh-it.pure.elsevier.com]

  We observed 53 vomiting toxicity, essentially grade 1 (37.5%) and grade 2 (17.7%). [omicsonline.org]

  Nausea and vomiting usually begin within 1 to 4 hours after treatment and last up to 24 hours. Various degrees of vomiting, nausea and/or anorexia may persist for up to 1 week after treatment. [rxlist.com]

  Although renal damage is the most serious effect of cisplatin, it actually displays few symptoms, those of which are relatively mild compared to the nausea and vomiting. [ch.ic.ac.uk]

  Contact your health care provider within 24 hours of noticing any of the following: Nausea (interferes with ability to eat and unrelieved with prescribed medication) Vomiting (vomiting more than 4-5 times in a 24 hour period) Diarrhea (4-6 episodes in [chemocare.com]

• Hypotension

  The reactions consist of facial edema, wheezing, tachycardia, and hypotension within a few minutes of drug administration. Reactions may be controlled by intravenous epinephrine with corticosteriods and/or antihistamines as indicated. [rxlist.com]

  Furthermore, Mizuno et al. reported 36 ) that lower blood pressure was significantly correlated with hypoalbuminemia, and reported hypoalbuminemia and hypotension as nephropathic risk factors. [jstage.jst.go.jp]

• Peripheral Neuropathy

  Cumulative renal damage, loss of hearing, and peripheral neuropathy were not observed. Nearly all patients experienced nausea and vomiting. Myelosuppression was mild. [moh-it.pure.elsevier.com]

  A pilot study on the effect of acetyl-L-carnitine in paclitaxel- and cisplatin-induced peripheral neuropathy. Tumori. 2005;91:135–8. [azkrmc.com]

  The neuropathy, however, may progress further even after stopping treatment. Preliminary evidence suggests peripheral neuropathy may be irreversible in some patients. [rxlist.com]

  A pilot study on the effect of acetyl-L-carnitine in paclitaxel- and cisplatin-induced peripheral neuropathy. Tumori. 2005;91:135-8. La información aquí suministrada complementa la atención recibida por su médico. [wnyurology.com]

  Peripheral neuropathy is a common side effect of cisplatin. The drug alters the amplitude of action potential on sensory nerves, as well as conduction velocity through the nerve fibers. [cisplatin.org]

• Paresthesia

  Blood test abnormalities (low magnesium, low calcium, low potassium) These are less common side effects (occurring in 10-29%) for patients receiving Cisplatin: Peripheral neuropathy: Although less common, a serious side effect of decreased sensation and paresthesia [chemocare.com]

  The 16 symptomatic patients reported persisting peripheral neuropathy (predominantly typical paresthesias) since chemotherapy. [academic.oup.com]

  PPE is a medicine-induced toxic reaction that begins as a desquamative rash of the palms and the plantar surface of the soles, associated with paresthesias, and it progresses towards severe conditions up to deep erosions and ulcerations with total functional [medichub.ro]

• Agitation

  All patients experienced toxicity during the DDTC infusion, including hypertension, flushing, diaphoresis, agitation, and local burning. We conclude that DDTC can protect against CP nephrotoxicity at doses up to 160 mg/m2. [ncbi.nlm.nih.gov]

Biological toxicity time All patients Cervical cancer Head and neck cancer n=16 n=1 n=15 After 4 th treatment 3 (18.8) 1 (100) 2 (13.3) After 5 th treatment 7 (43.8) 0 (0) 7 (46.7) After 6 th treatment 6 (37.5) 0 (0) 6 (40) Qualitative variables presented [omicsonline.org]

Reactive oxygen species (ROS)-mediated autophagy was induced after pro-longed treatment of ANE (six days, 3 μg). Cisplatin toxicity (IC 50, 48 h) was decreased in OSCC cells after ANE treatment (six days, 3 μg). [ncbi.nlm.nih.gov]

The improved prognosis of testicular germ-cell cancer has brought the long-term toxicity of the treatment and life-quality after treatment into focus. [academic.oup.com]

Escalante, MD, FACP Professor and Chair, Dept of General Internal Medicine,Ambulatory Treatment and Emergency CareThe University of Texas, M. D. Anderson Cancer CenterHouston, Texas Robert F. [books.google.com]

Your heart will likely be checked before you start treatment. This will tell your doctor about your baseline (pre-treatment) heart health. [nccn.org]

We revealed that advanced OSCC patients with areca nut chewing habits presented higher LC3 expression and poorer prognosis. Reactive oxygen species (ROS)-mediated autophagy was induced after pro-longed treatment of ANE (six days, 3 μg). [ncbi.nlm.nih.gov]

As the prognosis of patients with partial response in terms of overall survival was not better than ones with stable or progressive disease ( P =0.99), partial responders were combined with non-responders for analysis. [nature.com]

The improved prognosis of testicular germ-cell cancer has brought the long-term toxicity of the treatment and life-quality after treatment into focus. [academic.oup.com]

Our results are supported by the report by Willox et al., in which the supplementation with magnesium did not modify the chemotherapeutic response or prognosis for patients with testicular cancer ( 9 ). [jtd.amegroups.com]

In breast cancer, human epidermal growth factor receptor 2 (HER2)–positive receptors have been associated with aggressive disease and a worse prognosis. 3 Trastuzumab, a humanized Mab, has shown a 50% reduction in recurrence rates and a 33% improvement [uspharmacist.com]

Our first aim is to compare the estimated glomerular filtration rate (eGFR) equation by the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) for determining eligibility to receive cisplatin, since it is the most accurate equation available [dash.harvard.edu]

Creatinine serum levels before each R-DHAP cycle and two to three weeks after the last R-DHAP were assessed and GFR was calculated according to the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation. [bloodjournal.org]

Non-small cell lung cancer in never smokers as a representative 'non-smoking-associated lung cancer': epidemiology and clinical features. Int J Clin Oncol 2011;16:287-93. Scagliotti GV, Parikh P, von Pawel J, et al. [jtd.amegroups.com]

Nevertheless, the pathophysiology of cisplatin-induced ototoxicity remains unclear. This review summarizes all of the known transporters that could play a role in cisplatin influx, leading to cisplatin-induced ototoxicity. [ncbi.nlm.nih.gov]

Chemotherapy-induced cardiotoxicity: pathophysiology and prevention. Clujul Med. 2014;87:135-142. 2. Romond EH, Perez EA, Bryant J, et al. Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer. [uspharmacist.com]

Streptozotocin is also nephrotoxic and may cause proteinuria and renal tubular acidosis; progressive renal failure can be predicted by a close monitoring of proteinuria and prevented by drug discontinuance. [ncbi.nlm.nih.gov]

Mannitol and furosemide have been studied as preventative agents, but results have not been uniformly promising. [renalfellow.blogspot.com]

How can cardiac toxicity be prevented? Cardiac toxicity can often be prevented by giving less of the cancer drug. Also, you could get lower doses more often instead of larger doses less often. There may be drugs that are less toxic. [nccn.org]