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Cladribine

Adenosine 2 Chloro 2' Deoxy


Presentation

  • The second presentation reported data from the open-label maintenance phase of the ORACLE-MS study ( NCT00725985 ).[multiplesclerosisnewstoday.com]
  • EMD Serono to Present Data Highlighting Investigational Cladribine Tablets at CMSC 2017 - Company to present eight abstracts evaluating the efficacy and safety of Cladribine Tablets for the treatment of relapsing multiple sclerosis - Oral presentation[media.emdserono.com]
  • […] at EAN Congress are consistent with other clinical safety presentations of MAVENCLAD (Cladribine Tablets) at the congress Merck announced the presentation of safety and efficacy data on MAVENCLAD (Cladribine Tablets) for the treatment of relapsing MS[acnr.co.uk]
  • Two and a half years after presentation, she developed haematuria and proteinuria and renal biopsy revealed WHO Class III lupus nephritis.[ard.bmj.com]
  • For oral administration the composition may be presented as a tablet, a capsule or a liquid formulation. It may also be presented in a liquid formulation suitable for injection.[google.com]
Intravenous Drugs
  • Solutions containing LEUSTATIN Injection should not be mixed with other intravenous drugs or additives or infused simultaneously via a common intravenous line, since compatibility testing has not been performed.[globalrph.com]
  • Do not mix solutions containing cladribine with other intravenous drugs or additives or infuse simultaneously via a common intravenous line, as compatibility testing has not been performed.[pdr.net]
Intravenous Administration
  • Cladribine plasma concentration after intravenous administration declines multi-exponentially with an average half-life of 6.7 /- 2.5 hours.[globalrph.com]
  • Intravenous Administration CAUTION: Observe and exercise usual cautions for handling and preparing solutions of cytotoxic drugs.[pdr.net]
Weight Gain
  • Signs of kidney problems like unable to pass urine, change in how much urine is passed, blood in the urine, or a big weight gain. Shortness of breath. Very loose stools (diarrhea). Very upset stomach or throwing up. Feeling very tired or weak.[mskcc.org]
Weak Pulse
  • ; numbness or tingly feeling around your mouth; feeling like you might pass out; lower back pain, blood in your urine, urinating less than usual or not at all; muscle weakness, tightness, or contraction, overactive reflexes; fast or slow heart rate, weak[uofmhealth.org]
  • pulse, feeling short of breath; pale or yellowed skin, dark colored urine, fever , confusion; easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin; or signs of infection such as fever, chills,[emedicinehealth.com]
  • pulse, feeling short of breath; pale or yellowed skin, dark colored urine, fever, confusion; easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin; or signs of infection such as fever, chills,[rxlist.com]
Subcutaneous Nodule
  • CASE 1 A 32 year old woman was diagnosed with SLE at age 28, with polyarthritis, photosensitive rash, subcutaneous nodules, fatigue and lymphopenia. ANA, anti-dsDNA, anti-Sm and anti-RNP antibodies were present.[ard.bmj.com]
Blurred Vision
  • While symptoms can vary, the most common symptoms of MS include blurred vision, numbness or tingling in the limbs and problems with strength and coordination. The relapsing forms of MS are the most common.[newswire.ca]
  • While symptoms can vary, the most common symptoms of MS include blurred vision, numbness or tingling in the limbs and problems with strength and coordination. The relapsing forms of MS are the most common. About EMD Serono, Inc.[media.emdserono.com]
Peripheral Neuropathy
  • Although, severe neurologic toxicity appears to be dose related, rarely severe neurotoxicity, axonal peripheral neuropathy, has been reported following standard dose cladribine therapy.[pdr.net]
  • Cladribine has also been reported to have been used to treat a single patient suffering from IgM associated inflammatory peripheral neuropathy that, unlike MS and NMO, is a non-relapsing, non-remitting disease.[google.com]
  • In contrast, Vahdat and colleagues at the Memorial Sloan-Kettering Cancer Center reported that sensorimotor peripheral neuropathy was dose-limiting non-hematologic toxicity in a dose escalation study in patients with acute myeloid leukemia, excluding[academic.oup.com]
  • neuropathy after completing 2 courses of low-dose cladribine (0.1 mg/kg per day 2-hour infusion for 7 days). 119 In addition, at very elevated doses (more than triple the approved dose), a delayed severe motor weakness developed. 120 Future research[bloodjournal.org]

Treatment

  • (MS) and switch to treatment with a different disease-modifying drug (ie, subcutaneous interferon beta-1a), according to data presented at the 32nd Congress of the European Committee for Treatment and Research in MS (ECTRIMS).[mdedge.com]
  • Treatment for other conditions Always tell other doctors, nurses, pharmacists or dentists that you’re having this treatment if you need treatment for anything else, including teeth problems.[cancerresearchuk.org]
  • For the treatment of hairy cell leukaemia a single course of treatment is given. Your drip will be set up to admister the medicine continuously for seven days.[netdoctor.co.uk]
  • Will Cladribine become a licensed treatment for pwMS? We are unable to predict whether Cladribine will be licensed in Western Europe and/or the US for treatment of pwMS.[de.slideshare.net]

Prognosis

  • The aim was to improve prognosis especially in FAB M4/M5/MLL patients, who represent the largest subgroup of HR patients.[cancerindex.org]
  • Therefore, 2-CdA could be effective in the treatment of adult T-cell leukemia-lymphoma (ATL), which is a T-cell malignancy with an extremely poor prognosis.[academic.oup.com]
  • This distinction is of great importance as management of NMO and prognosis of the disease are fundamentally different from MS.[google.com]
  • However, a random nonbalanced distribution of the 17p-deleted patients placed more advanced-stage patients in the fludarabine-based cohort, undermining this promising trend. 88 Opportunity for improved therapies in this poor-prognosis setting remains[bloodjournal.org]

Etiology

  • […] the rate of neoplasms, both malignant and benign, was similar but numerically slightly higher for the 3.5-mg drug group than the placebo group (1.14 and 1.01), the researchers said, adding that there was "no clustering of malignancies with a common etiology[medpagetoday.com]
  • Respiratory, thoracic and mediastinal disorders: Pulmonary interstitial infiltrates (including lung infiltration, interstitial lung disease, pneumonitis and pulmonary fibrosis ); in most cases, an infectious etiology was identified.[rxlist.com]
  • In view of the known toxicities of agents of this class, it would be prudent to proceed carefully in patients with known or suspected renal insufficiency or severe bone marrow impairment of any etiology.[globalrph.com]

Epidemiology

  • . · Category Pharmacology Cladribine is a small molecule that may interfere with the behaviour and the proliferation of certain white blood cells, particularly lymphocytes, thought to be involved in the pathological process of MS Epidemiology NICE estimate[sps.nhs.uk]
  • […] combination did report a statistical increase in lung cancer incidence among cladribine-based therapy, but the authors made no definitive conclusions. 110 A comparison of purine analog-treated patients to an age-adjusted population from the Surveillance, Epidemiology[bloodjournal.org]
  • We presented three very different cases of HCL in very old patients diagnosed in a single center and discussed some epidemiological and therapeutical issues in such patients.[cancerindex.org]
Sex distribution
Age distribution

Pathophysiology

  • Immunotherapeutic approaches in MS: update on pathophysiology and emerging agents or strategies 2006. Endocr Metab Immune Disord Drug Targets 2007 ;7: 35 - 63 4. Cohen BA, Rieckmann P. Emerging oral therapies for multiple sclerosis.[nejm.org]

Prevention

  • Wash your hands well to prevent the spread of infections. To lower your risk of getting cut, bruised, or injured, use caution with sharp objects like razors and nail cutters, and avoid activities such as contact sports.[webmd.com]
  • Tips to preventing infection: Washing hands , both yours and your visitors, is the best way to prevent the spread of infection.[oncolink.org]
  • Women who could get pregnant should use effective contraception to prevent pregnancy, and men should use effective contraception to prevent fathering a child, both during treatment, and for at least six months after treatment is finished.[netdoctor.co.uk]
  • Your doctor will give you anti-sickness drugs to help prevent or control sickness. Take the drugs exactly as your nurse or pharmacist tells you. It is easier to prevent sickness than to treat it after it has started.[macmillan.org.uk]
  • If nausea and vomiting are a problem, patients can be given medicines known as antiemetics before receiving cladribine to help prevent or decrease these side effects.[encyclopedia.com]

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