Unlike Parkinson Disease, people often fall backward instead of forward. They may also develop severe stiffness in the neck. [brain.northwestern.edu]

Devices that make walking safer, such as a walker that is weighted in the front, can be helpful to prevent falls. Shoes with built-up heels can also help decrease falling backwards. [bcm.edu]

I am falling frequently. What should I do? Falls are one of the leading causes of injury, disability, and even death in the elderly. [movementdisorders.ufhealth.org]

The beginning stages of PSP include the inability to walk, falling spells, and stiffness. Falls experienced by a PSP patient are often described as having a state of dizziness, prior to actually falling. [webmd.com]

PSP-Parkinsonism (PSP-P) is characterized by prominent early parkinsonism (tremor, limb bradykinesia, axial and limb rigidity) rather than falls and cognitive change. [orpha.net]

") (1931-2007) Rae Ferren, American impressionist painter (1929-2016) Richard Frank, past leader of nonprofit Population Services International and first husband of Jane Harman, died 20 April 2014, age 77 [43] Phyllis Frelich, actress (1944-2014) Bob [ipfs.io]

If swallowing issues are identified, such as coughing or choking on food or liquids, it is advisable to undergo evaluation with a speech-language pathologist, who can help advise on dietary modifications to aid in safe swallowing. [bcm.edu]

Patients present with disturbance of balance, a disorder of downward gaze and L-DOPA-unresponsive parkinsonism and usually develop progressive dysphagia and dysarthria leading to death from the complications of immobility and aspiration. [pmj.bmj.com]

Its principal potential side effects are dry mouth, constipation, confusion, swelling of the ankles and a pink skin discoloration in a lacy pattern called livedo reticularis. [psp.org]

Common symptoms at disease onset include postural instability and falls, dysarthria, bradykinesia and visual disturbances such as diplopia, blurred vision, burning eyes, and light sensitivity. [patient.info]

Additional, and important symptoms to note, include: Diplopia Bradykinesia Burning eyes Blurred vision Sensitivity to light Rigidity of the spine Eye movement paralysis The eyelids of people with PSP might be held wide open with eye movement paralysis [disabled-world.com]

Despite her limited eye movements, the patient had not noted diplopia and denied vision changes. [webeye.ophth.uiowa.edu]

Because the eyes have trouble coming together to focus at short distances, the patient may complain of diplopia (double vision) when reading. [ipfs.io]

[…] supranuclear vertical gaze limitation after extravolitional pathway activation with the vestibular ocular reflex (VOR) or the Bell phenomenon Nearly continuous square wave jerks commonly observed with fixation Impairment of convergence eye movements (may cause diplopia [emedicine.medscape.com]

Ups and downs, “roller coaster” emotions In PSP emotional lability, or pseudobulbar affect, may occur and is characterized by sudden or inappropriate laughter or inconsolable crying. [movementdisorders.ufhealth.org]

Obvious facial signs may be present with examples including decreased blink rate and a “startled” facial expression, which results from rigid facial muscles, but these signs may not be present in the early stages of the disease. [bcm.edu]

Then came new symptoms: falls, tremors, difficulty speaking, troubled sleep, irritability. It was only when Swankie's GP was at a conference where a geriatrician was talking about PSP that the pieces started to fall into place. [theguardian.com]

As regards behavioral symptoms, an interview with relatives revealed depression, anxiety, apathy, irritability, and sleep disorders. [dovepress.com]

Cognitive symptoms include forgetfulness and personality changes, such as loss of interest in formerly pleasurable activities (apathy), impaired attention and concentration, depression, and increased irritability. [rarediseases.org]

They may lose interest in ordinary pleasurable activities or show increased irritability and forgetfulness. [ninds.nih.gov]

Behavior or personality changes - Irritation, grouchiness Memory loss, forgetfulness Apathy (indifference) Slowed thinking, reasoning, planning Inappropriate laughing or crying Angry or aggressive outbursts Slurred speech Swallowing problems - Solids [emedicinehealth.com]

dystonia Behavior changes: apathy, disinhibition, anxiety Frontal release signs, including grasp reflex and the applause sign May exhibit cross-over with other Tauopathies (e.g., Progressive Non-Fluent Aphasia) Diagnosis Clinical (see above) MRI shows [webeye.ophth.uiowa.edu]

Over a period of 2 years, he progressed to complete vertical gaze palsy, axial dystonia, retrocollis, and generalized severe akinesia. [emedicine.medscape.com]

Neurological examination at age 67 disclosed pseudobulbar palsy, spastic gait, hyperreflexia, and presence of bilateral Hoffmann and Babinski signs. [okayama.pure.elsevier.com]

The gait has a characteristic reeling or staggering quality, due to the stiff posture of the trunk and neck with irregular large steps forwards, which allow a distinction to be made from the veering broad based gait of cerebellar ataxia. [pmj.bmj.com]

Glabellar and palmomental reflexes in parkinsonian disorders. Neurology. 2004;63:1096-8. Burrell JR, Hodges J.R, Rowe J.B. Cognition in corticobasal syndrome and progressive supranuclear palsy: A review. Mov Disord. 2014;29:684–93. [bcm.edu]

Symptomatic characteristics of parkinsonism and the width of substantia nigra pars compacta on MRI according to ischemic changes in the putamen and cerebral white matter: implications for the diagnosis of vascular parkinsonism. [ajnr.org]