Previously it was shown that amoxicillin-clavulanate can provide clavulanate inhibition of ESBLs and protect an oral cephalosporin present in combination when tested by broth microdilution. [ncbi.nlm.nih.gov]

Fifty (89%) patients presented with persistent symptoms, and 6 (11%) presented with nonpersistent symptoms. In 24 (43%) children, the illness was classified as mild, whereas in the remaining 32 (57%) children it was severe. [pediatrics.aappublications.org]

The enzymatic mechanisms present in the isolates, which were also amoxicillin-clavulanic acid (AMC)-resistant (18/54) were herein analyzed. [elsevier.es]

• Swelling

  […] loss of heat from the body lower back or side pain muscle stiffness nausea or vomiting pain pain, swelling, or redness in the joints painful or difficult urination pale skin pinpoint red spots on the skin puffiness or swelling of the eyelids or around [drugs.com]

  SIDE EFFECTS: Swelling, redness, pain, or soreness at the injection site may occur. Dizziness, trouble sleeping, nausea, vomiting, diarrhea, or headache may also occur. [medicinenet.com]

  Symptoms of shock include confusion, rash, hives, itching, difficulty breathing, tightness in the chest and swelling of the mouth, face, lips or tongue. [livestrong.com]

  However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching /swelling (especially of the face/ tongue /throat), severe dizziness, trouble breathing. [webmd.com]

  Get emergency medical help if you have signs of an allergic reaction : hives; difficult breathing; swelling of your face, lips, tongue, or throat. [uwhealth.org]

• Chills

  Patient teaching ☞ Instruct patient to immediately report signs or symptoms of hypersensitivity reaction, such as rash, fever, or chills. • Tell patient he may take drug with or without food. • Inform patient that drug lowers resistance to some types [medical-dictionary.thefreedictionary.com]

  Get medical help right away if you have signs like red, swollen, blistered, or peeling skin; red or irritated eyes; sores in your mouth, throat, nose, eyes, genitals, or any areas of skin; fever; chills; body aches; shortness of breath; or swollen glands [mskcc.org]

  […] lower legs Incidence Not Known Abdominal or stomach cramps or tenderness back, leg, or stomach pains black, hairy tongue black, tarry stools bleeding gums blistering, peeling, or loosening of the skin bloating blood in the stools bloody nose chest pain chills [drugs.com]

  Interactions Sort By: Adverse Effects 1-10% Rash Nausea Diarrhea Phlebitis at injection site Increased eosinophils Increased AST Increased ALT Postmarketing Reports Hypersensitivity reactions: Skin rash, pruritus, urticaria, arthralgia, myalgia, drug fever, chills [reference.medscape.com]

  The other woman presented to an outside hospital 5 days after her 2-week visit with subjective fever and shaking chills, urgency, and low back pain and reported that she had a temperature of 39.8°C. [jamanetwork.com]

• Collapse

  If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911. [medlineplus.gov]

  Collapse all Expand all Antecedentes La otitis media aguda (OMA) es una afección habitual en los niños y con frecuencia la amoxicilina con o sin ácido clavulánico se prescribe como tratamiento de elección. [cochranelibrary.com]

• Severe Pain

  Oxycodone Oxycodone is indicated for the treatment of moderate to severe pain.[Label] There is also an extended release formulation indicated for chronic moderate to severe pain requiring continuous opioid analgesics for... [drugbank.ca]

• Rhinorrhea

  Brushing or dental cleaning reduced or eliminated the discoloration in most cases. [ Ref ] Respiratory Respiratory side effects associated with amoxicillin have included cough and rhinorrhea. [ Ref ] References 1. [drugs.com]

• Abdominal Pain

  Tell the doctor right away if you develop: persistent diarrhea, abdominal or stomach pain /cramping, blood / mucus in your stool. Use of this medication for prolonged or repeated periods may result in oral thrush or a new yeast infection. [webmd.com]

  Infections 1 3 Recruiting Treatment Enterobacteriaceae Infections 1 3 Terminated Treatment Abdominal Abscess / Abdominal Pain (AP) / Abscess, Intra-Abdominal / Acute Abdomen / Appendicitis / Ileus / Infection NOS / Intestinal Perforations / Peritonitis [drugbank.ca]

  Adverse reactions CNS: lethargy, hallucinations, anxiety, confusion, agitation, depression, dizziness, fatigue, hyperactivity, insomnia, behavioral changes, seizures (with high doses) GI: nausea, vomiting, diarrhea, abdominal pain, stomatitis, glossitis [medical-dictionary.thefreedictionary.com]

• Jaundice

  Abstract This report describes two patients who developed jaundice within two weeks of receiving an amoxycillin-clavulanate potassium combination. Causes of jaundice, other than drug administration, were excluded. [ncbi.nlm.nih.gov]

  Augmentin-induced jaundice. Med J Aust 1991; 154: 698-701. [livertox.nih.gov]

  You should not use this medicine if you have severe kidney disease, if you have had liver problems or jaundice while taking amoxicillin and clavulanate potassium, or if you are allergic to any penicillin or cephalosporin antibiotic, such as Amoxil, Ceftin [uwhealth.org]

  Cautions Before taking a combination of potassium clavulanate with any other penicillin-based antibiotic, one should discuss with medical providers and let them know whether they have severe kidney disease, jaundice or liver problems. [chemicalbook.com]

• Hypertension

  On a chronic basis, he took montelukast (Singular) and used inhalers (with albuterol, fluticasone and salmeterol) for asthma; was prescribed losartan (Cozaar) for hypertension; and, used several topical lotions for psoriasis. [livertox.nih.gov]

• Arthralgia

  Significant - Monitor Closely All Interactions Sort By: Adverse Effects 1-10% Rash Nausea Diarrhea Phlebitis at injection site Increased eosinophils Increased AST Increased ALT Postmarketing Reports Hypersensitivity reactions: Skin rash, pruritus, urticaria, arthralgia [reference.medscape.com]

  This may include skin rashes, pruritus, urticaria, serum sickness-like reactions (skin rash accompanied by arthritis, arthralgia, myalgia, and frequently fever), hypersensitivity vasculitis, and an occasional case of exfoliative dermatitis. [healthquestions.medhelp.org]

  […] asthma, hay fever, or urticaria. [ Ref ] Hypersensitivity reactions have occurred in up to 10% of patients, and may present as a skin rash, urticaria, pruritus, angioedema, serum sickness-like reactions (urticaria or skin rash accompanied by arthritis, arthralgia [drugs.com]

  Allergic manifestations can occur and include rash, fever, arthralgias and eosinophilia. Several studies have reported an HLA Class II association with DRB1*15:01 and the extended haplotype DRB1*15:01-DRB1*01:01-DQB1*06:02. [livertox.nih.gov]

  GlaxoSmithKline, Research Triangle Park, NC 27709 SIDE EFFECTS As with other penicillins, the following adverse reactions may occur: Hypersensitivity Reactions Skin rash, pruritus, urticaria, arthralgia, myalgia, drug fever, chills, chest discomfort, [rxlist.com]

• Irritability

  61177-45-5 Hazard statements H315 Causes skin irritation H317 May cause an allergic skin reaction H319 Causes serious eye irritation H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled Precautionary statements P261 Avoid [duchefa-biochemie.com]

  Side effects Side effects of Clavpod (Cefpodoxime/Potassium Clavulanate) may include an upset stomach, nausea, diarrhea, gassiness, discomfort, irritation, or headaches. [unitedpharmacies.md]

  Drugs.com recommends taking amoxicillin and clavulanate with food to reduce stomach irritation. However, consult with the doctor or pharmacist about an alternative antibiotic if nausea or vomiting continues. [livestrong.com]

  Vaginal irritation or discharge. Feeling very tired or weak. Any unexplained bruising or bleeding. Diarrhea is common with antibiotics. Rarely, a severe form called C diff–associated diarrhea (CDAD) may happen. [mskcc.org]

  I started noticing irritation when I urinated and thought it was a uti. Yesterday when the irritation increased after urinating into more of a bv situation, I took some Metronidazole pills I had already. [medschat.com]

• Phenylketonuria

  Children ages 3 months to 12 years: 90 mg/kg/day of Augmentin ES-600 P.O. q 12 hours for 10 days Dosage adjustment • Severe renal impairment • Hemodialysis • Infants ages 3 months and younger Contraindications • Hypersensitivity to drug or any penicillin • Phenylketonuria [medical-dictionary.thefreedictionary.com]

  Tell your doctor if you have phenylketonuria (PKU). Tell your doctor if you are pregnant or breastfeeding. Amoxicillin and clavulanate potassium can make birth control pills less effective. [drugs.com]

  Talk to your doctor before using these forms of this medicine if you have phenylketonuria (PKU). How should I take amoxicillin and clavulanate potassium? Follow all directions on your prescription label. [uwhealth.org]

  If you have phenylketonuria (PKU) or any other condition that requires you to limit/avoid aspartame (or phenylalanine) in your diet, ask your doctor or pharmacist about using this medication safely. [webmd.com]

• Hematuria

  The renal failure and hematuria resolved over 6 days after discontinuation of the antibiotic. [ Ref ] Hematologic Amoxicillin has been shown to induce hemolytic anemia in rare cases. [drugs.com]

  Analytical, diagnostic and therapeutic context of CLAVULANATE POTASSIUM OBJECTIVE: To report a case of warfarin-amoxicillin/ clavulanate potassium (AM/CL) interaction resulting in an elevated international normalized ratio ( INR ) and hematuria [15]. [wikigenes.org]

  Effects Central nervous system seizures (high doses) (life-threatening) confusion lethargy Cardiovascular chf (life-threatening) arrhythmias Gastrointestinal pseudomembranous colitis (life-threatening) diarrhea ( most frequent ) nausea Genitourinary hematuria [medical-dictionary.thefreedictionary.com]

• Liver Biopsy

  A liver biopsy was obtained which showed a mixed hepatocellular-cholestatic pattern of injury compatible with drug induced liver disease. [livertox.nih.gov]

Virus (HIV) Infections / Sinusitis 1 Not Available Completed Treatment Perforated Appendicitis 1 Not Available Completed Treatment Sinusitis 1 Not Available Completed Treatment Treatment of Helicobacter Pylori 1 Not Available Recruiting Treatment Tic [drugbank.ca]

These findings indicate that amoxycillin-clavulanate therapy remains an effective treatment for gonococcal infections in PNG, and support the maintenance of the present standard treatment for gonorrhoea in PNG. [ncbi.nlm.nih.gov]

Another important factor that influenced prognosis was “season”. Illnesses in autumn and winter were constant strongly associated with a poor prognosis in this retrospective cohort study. [hindawi.com]

XDR (extensively drug-resistant) and pre-XDR tuberculosis (TB) seriously compromise prognosis and treatment possibilities, and inevitably require the use of group V drugs (World Health Organization). [ncbi.nlm.nih.gov]

Single-center experience with drug-induced liver injury from India: causes, outcome, prognosis, and predictors of mortality. Am J Gastroenterol 2010; 105: 2396-404. [livertox.nih.gov]

In total, 170 eligible children will be stratified by site and bronchiectasis etiology, and randomized (allocation concealed) to receive: 1) azithromycin (5 mg/kg daily) with placebo amoxycillin-clavulanate or 2) amoxycillin-clavulanate (22.5 mg/kg twice [ncbi.nlm.nih.gov]

[…] review of hepatotoxicity published in 1999; amoxicillin-clavulanate is capable of causing acute liver injury with jaundice that is typically cholestatic in pattern but can be hepatocellular, onset is delayed as long as 35 days after the drug is stopped, etiology [livertox.nih.gov]

Author information 1 Division of Infection, Barts Healthcare NHS Trust, London, UK These authors contributed equally to this work. 2 Clinical Epidemiology and Medical Statistics Unit, Dept of Biomedical Sciences, University of Sassari - Research, Medical [ncbi.nlm.nih.gov]

Epidemiological and clinical complexity of amoxicillin-clavulanate-resistant Escherichia coli. J Clin Microbiol., 51 (2013), pp. 2414-2417 [25.] A. Rossi, H. Lopardo, M. Woloj, A.M. Picandet, M. Mariño, M. Galas, M. Radice, G. Gutkind. [elsevier.es]

Molecular epidemiology はPFGE, mutilocuc sequence typing Total 257株採取：110（43%）はnosocominal-acquired infections, 170株（65.9%）は尿路由来であった。30株（12%）は創部、38(14.7)は他の臨床サンプルであった。Prevalenceは9.3%であった。 [blog.goo.ne.jp]

Demographic, epidemiological, clinical and microbiological variables were retrospectively collected from medical records using standardised ad hoc E-forms. [erj.ersjournals.com]

CONCLUSION: Parenteral amoxycillin/clavulanate is a safe and effective antibiotic as the monotherapy for prevention of SSI following intra-abdominal surgery. [ncbi.nlm.nih.gov]

2-1-4-7(8(12)13)9-5(11)3-6(9)14-4/h1,6-7,10H,2-3H2,(H,12,13)/b4-1-/t6-,7-/m1/s1 HZZVJAQRINQKSD-PBFISZAISA-N [H][[email protected]@]12CC(=O)N1[[email protected]@H](C(O)=O)\C(O2)=C\CO Streptomyces clavuligerus (NCBI:txid1901) See: PubMed antibacterial drug A drug used to treat or prevent [ebi.ac.uk]

Clavulanate potassium is a beta-lactamase inhibitor that helps prevent certain bacteria from becoming resistant to amoxicillin. [drugs.com]

When Clavulanate Acid or its potassium salt form, Clavulanate Potassium, (beta-lactamase inhibitors) are used in combined form with the penicillins, such as amoxicillin, they prevent hydrolyzed penicillins like amoxicillin from being inactivated by bacterial [ratguide.com]