Edit concept Question Editor Create issue ticket

Clindamycin

7 Chloro 7 Deoxylincomycin


Presentation

  • To present a case of toxoplasmosis with an atypical presentation and treated successfully with intravitreal clindamycin. A young Brazilian woman presented with panuveitis and disc swelling with associated hemispheric vascular occlusion in one eye.[ncbi.nlm.nih.gov]
  • We present a case of a patient that received an inadvertent injection clindamycin 600 mg in 4 mL through a radial arterial line.[ncbi.nlm.nih.gov]
  • A 36-year-old woman with late-stage AIDS who presented with disseminated, nodular cutaneous lesions and underlying osteomyelitis.[ncbi.nlm.nih.gov]
  • Peripheral eosinophilia was present, and urine studies were consistent with intrinsic renal failure.[ncbi.nlm.nih.gov]
  • A Caucasian woman presenting with recurrence of intra-ocular toxoplasmosis was given intravitreal clindamycin. She subsequently developed a hypersensitivity reaction in the form of a generalized erythematous rash.[ncbi.nlm.nih.gov]
Intravenous Administration
  • This case report suggests that a pancuronium-induced blockade was prolonged as a result of intravenous administration of Clindamycin phosphate. Neostigmine was an ineffective antagonist of this blockade, and indeed may have prolonged it.[doi.org]
  • OBJECTIVE: To report a case of acute toxicity in a patient with chronic verapamil toxicity, possibly precipitated by intravenous administration of the highly protein-bound drugs ceftriaxone and clindamycin.[ncbi.nlm.nih.gov]
  • DIRECTIONS FOR USE CLEOCIN PHOSPHATE IV Solution in Galaxy Plastic Container Premixed CLEOCIN PHOSPHATE IV Solution is for intravenous administration using sterile equipment. Check for minute leaks prior to use by squeezing bag firmly.[web.archive.org]
  • Local thrombophlebitis may follow intravenous administration of the drug. Continue on to the next page, Daptomycin Back to Top[antibiotics-info.org]
  • administration, 011360, 薬物療法, ヤクブツリョウホウ, drug therapy, 023545, 腫瘍, シュヨウ, tumor, 011325, ハロゲノ糖, ハロゲノトウ, halogeno sugar, 008340, アミノ糖, アミノトウ, amino sugar, 009681, 窒素複素環化合物, チッソフクソカンカゴウブツ, nitrogen heterocyclic compound, 009934, 有機塩素化合物, ユウキエンソカゴウブツ[togodb.biosciencedbc.jp]
Splenectomy
  • Risk factors that may be associated with a more severe clinical course include immunosuppression, splenectomy, and advanced age.[ncbi.nlm.nih.gov]
  • […] diagnosis of babesiosis should begin with a descriptive history, which might include appropriate clinical manifestations, history of travel to an area where it is endemic, tick bite or exposure to a tick-infested area, recent blood transfusion, and splenectomy[doi.org]
Sneezing
  • Within 5 minutes after initiating the drug (600-mg dose) the patient began to sneeze and his eyes began to tear and itch. Within 10 minutes, his lips and nasal passages began to swell.[ncbi.nlm.nih.gov]
Severe Clinical Course
  • Risk factors that may be associated with a more severe clinical course include immunosuppression, splenectomy, and advanced age.[ncbi.nlm.nih.gov]
Refractory Shock
  • We report the case of a 14-year-old patient with Panton-Valentine leucocidin producing methicillin-resistant Staphylococcus aureus infection and Influenza B pneumonia requiring veno-arterial extra-corporeal membrane oxygenator for refractory shock.[ncbi.nlm.nih.gov]
Skin Lesion
  • The patient was successfully managed with combined surgical and medical management; removal of the large hyperkeratotic skin lesions combined with administration of clindamycin, which led to regression of the smaller skin lesions.[ncbi.nlm.nih.gov]
  • Disseminated microsporidial infection with an Encephalitozoon-like species was diagnosed by electron microscopic examination of material obtained from the skin lesions.[ncbi.nlm.nih.gov]
Alopecia
  • Folliculitis decalvans of the scalp is a recurrent, purulent follicular inflammation leading to scarring alopecia.[ncbi.nlm.nih.gov]
Lip Edema
  • We believe this to be the first published case of nasal passage swelling and only the second case reporting lip edema associated with the intravenous form of this agent. Clinicians should be aware of this uncommon but potentially severe reaction.[ncbi.nlm.nih.gov]

Workup

  • Extensive workup for AKI that included evaluation for pre-renal, intrinsic renal, and post-renal etiologies failed to point to other etiologies apart from clindamycin-induced AKI.[ncbi.nlm.nih.gov]
Neutrophil Count Decreased
  • After four days of clindamycin use, their patient’s leukocytes abruptly decreased to 1.1   10 9 cells/L, and their absolute neutrophil count decreased to 165 cells/μl.[dx.doi.org]
Liver Biopsy
  • Her liver biopsy specimen showed mixed-type (both hepatocellular and cholestatic) hepatic injury, compatible with a diagnosis of drug-induced hepatitis.[ncbi.nlm.nih.gov]

Treatment

  • BACKGROUND: Epidermal growth factor receptor inhibitors are recent antineoplastic treatments used for the treatment of some non-cutaneous tumours, which aberrantly express EGFR.[ncbi.nlm.nih.gov]
  • The clinical application as alternative treatment for acne is advised.[ncbi.nlm.nih.gov]
  • Trough and peak serum concentrations of clindamycin were measured at day-1 (D1), D15 and D30 of oral treatment. Cure was evaluated at a minimum of one year after the initiation of treatment.[ncbi.nlm.nih.gov]
  • PURPOSE: To report the clinical outcomes of local treatment of toxoplasmic retinochoroiditis (TRC) with intravitreal injections of clindamycin and dexamethasone.[ncbi.nlm.nih.gov]
  • Following treatment with intravenous corticosteroids, macular star appeared 1 week after treatment. On the 2nd week, a focus of retinitis appeared, and the patient was started on antitoxoplasma treatment.[ncbi.nlm.nih.gov]

Prognosis

  • The parameters included in our study were age, sex, clinical manifestations, efficacy and prognosis. Results All patients were diagnosed with clindamycin-induced kidney diseases within 48 hours of the application of clindamycin at 1.0-2.0 g/day.[ncbi.nlm.nih.gov]
  • Endometriosis (Symptoms, Causes, Treatments, and Prognosis) Endometriosis implants are most commonly found on the ovaries, the Fallopian tubes, outer surfaces of the uterus or intestines,...[medicinenet.com]
  • Related Disease Conditions Endometriosis (Symptoms, Causes, Treatments, and Prognosis) Endometriosis implants are most commonly found on the ovaries, the Fallopian tubes, outer surfaces of the uterus or intestines,...[medicinenet.com]
  • The decision to terminate resuscitation is a clinical one, and clinicians take into account duration of arrest, age of the patient, and prognosis of underlying medical conditions.[merck.com]
  • Landmann, Prognose extrem unreifer Frühgeborener Prognosis of extremely premature babies, Monatsschrift Kinderheilkunde, 10.1007/s00112-005-1260-9, 153, 12, (1148-1156), (2005).[doi.org]

Etiology

  • Extensive workup for AKI that included evaluation for pre-renal, intrinsic renal, and post-renal etiologies failed to point to other etiologies apart from clindamycin-induced AKI.[ncbi.nlm.nih.gov]
  • Acute generalized exanthematous pustulosis is a rare but distinctive entity that may be associated with various etiologies. Drug exposure is the most common cause.[ncbi.nlm.nih.gov]
  • View Article Google Scholar Andrés E, Affenberger S, Alt M, Kaltenbach G, Maloisel F: The etiology, epidemiology and management of idiosyncratic drug-induced agranulocytosis. Med Hypotheses Res. 2005, 2 (3): 515-524.[dx.doi.org]
  • Hct should be maintained at 30 (if cardiac etiology is suspected), and glucose at 140 to 180 mg/dL; electrolytes, especially potassium, should be within the normal range.[merck.com]

Epidemiology

  • METHODS: Clinical and epidemiological data on eleven CDI cases were collected.[ncbi.nlm.nih.gov]
  • This article strengthens the need for monitoring the epidemiology of invasive GAS strains as they could lead to changes in treatment guidelines. Copyright 2015 Elsevier Masson SAS. All rights reserved.[ncbi.nlm.nih.gov]
  • (See "Clostridium difficile in adults: Epidemiology, microbiology, and pathophysiology" .)[uptodate.com]
  • “The epidemiology of S. aureus infection in children continues to evolve, which makes it important to align therapy with the most recent local antibiotic-susceptibility results,” Khamash and colleagues wrote.[healio.com]
  • This paper aims to provide an overview of the epidemiology, pathomechanisms, and clinical presentation of TSS, and criteria for selecting drugs among available antibiotics.[doi.org]
Sex distribution
Age distribution

Pathophysiology

  • Abstract Acne vulgaris (AV) is a common skin disease that is challenging to successfully treat due to its complex underlying pathophysiology and chronicity.[ncbi.nlm.nih.gov]
  • (See "Clostridium difficile in adults: Epidemiology, microbiology, and pathophysiology" .)[uptodate.com]
  • Hypoxic brain injury is a result of ischemic damage and cerebral edema (see pathophysiology of cardiac arrest ). Both damage and recovery may evolve over 48 to 72 h after resuscitation.[merck.com]

Prevention

  • Centers for Disease Control and Prevention.[web.archive.org]
  • AIM: To perform a retrospective analysis of the high occurrence of Clostridium difficile infection in the surgical department of a Czech tertiary care hospital and to identify weaknesses in C. difficile infection (CDI) prevention and control policies.[ncbi.nlm.nih.gov]
  • CONCLUSION: MRSA nasal carriage among healthcare workers needs infection control practice in hospitals to prevent transmission of MRSA.[ncbi.nlm.nih.gov]
  • Clindamycin is used to prevent or treat bacterial infection. Clindamycin is also applied topically to the skin as an ointment to treat or prevent acne. Like any medication, clindamycin can have side effects, and some can be severe.[livestrong.com]
  • Based on the results, combination therapy which is performed for treatment or prevention of other infections may cause toxin production and probably the severity of C. difficile AAD to increase. Copyright 2017 Elsevier Ltd. All rights reserved.[ncbi.nlm.nih.gov]

Ask Question

5000 Characters left Format the text using: # Heading, **bold**, _italic_. HTML code is not allowed.
By publishing this question you agree to the TOS and Privacy policy.
• Use a precise title for your question.
• Ask a specific question and provide age, sex, symptoms, type and duration of treatment.
• Respect your own and other people's privacy, never post full names or contact information.
• Inappropriate questions will be deleted.
• In urgent cases contact a physician, visit a hospital or call an emergency service!