A literature review was also performed, with particular emphasis on incidence, clinical presentation and management of clonidine poisoning. [ncbi.nlm.nih.gov]

In this edition, the Pain and Pain Management section is now at the front of the book, since a large percentage of emergency department patients present with pain-related complaints. [books.google.de]

• Hypothermia

  Hypothermia is common but is of minor clinical significance. Paradoxical hypertension should be treated with tolazoline. [ncbi.nlm.nih.gov]

  His symptoms included bradycardia, hypotension, hypothermia, pallor, cyanosis, and impaired consciousness. Treatment included isoprenaline for 28 hours. The victim was released from hospital the next day. [tandfonline.com]

  Toxic presentations also may include hypotension, hypertension, mydriasis, hypothermia, ileus, hypotonia, hyporeflexia, intermittent apnea, atrioventricular (AV) nodal heart block, and seizures. [emedicine.medscape.com]

  It is largely eliminated unchanged by the kidneys.1 Risk Assessment Clonidine toxicity is manifest by CNS despression, miosis, bradycardia, hypotension and hypothermia.1 Its onset can be rapid within 30-60 minutes. [emergpa.net]

• Nightmare

  Other common side effects of the medication include: Nervousness Hallucinations Constipation Dry mouth Agitation Depression Insomnia Palpitations, tachycardia, and bradycardia Anxiety Nightmares Nausea and vomiting Decreased sexual activity and libido [americanaddictioncenters.org]

  Side Effects of Clonidine Common side effects of clonidine tablets and extended-release include: fatigue upper airway tract infection irritability sore throat insomnia nightmares emotional disorder constipation nasal congestion increased body temperature [rxwiki.com]

• Intravenous Administration

  Intravenous administration of the antidote clonidine – tolazoline. Special attention is paid to the correction of cardiac disorders. For this purpose, anticholinergics (atropine), beta-adrenergic agonists (isoproterenol, dopamine). [medicalj-center.info]

• Blister

  Storage and disposal Storage Keep your tablets in the blister strip until it is time to take them. The blister strip protects the tablets. If you take the tablets out of the blister strip they may not keep well. [news-medical.net]

• Fear

  Forced diuresis is not advised for fear of potentiation of hypotension(4). [indianpediatrics.net]

• Kidney Failure

  But it can cause serious problems such as stroke, heart failure, heart attack and kidney failure. [coding-pro.com]

  Damage to these organs may cause heart disease, a heart attack, heart failure, stroke, kidney failure, loss of vision, and other problems. In addition to taking medication, making lifestyle changes will also help to control your blood pressure. [medlineplus.gov]

• Somnolence

  Naloxone reversal of clonidine toxicity: dose, dose, dose Medicine Clinical toxicology 2018 Administration of naloxone to somnolent pediatric patients with clonidine toxicity awoke the majority and resolved bradycardia and hypotension in some and avoided [semanticscholar.org]

  Total of 51 somnolent patients: 5- 10 mg of naloxone reversed 40 patients 22 patients awoke with 6 mg or less Bradycardia reversed in 17 of 44 patients Hypotension reversed in 7 of 11 patients There was no adverse effect from naloxone administration. [umem.org]

  She is somnolent, but arousable. Her mother comes to the ED and reports the patient had been at her grandmother’s that day. [toxikonconsortium.org]

  Nous rapportons le cas d’un enfant âgé de 9 ans, 25 kg, qui a présenté rapidement une somnolence importante avec bradycardie, hypotension et myosis après avoir reçu accidentellement, en vue d’un test de stimulation de l’hormone de croissance, 0,23 mg [em-consulte.com]

  History and Physical Poisoning with clonidine classically presents with somnolence, respiratory depression, hypotension, bradycardia, and miosis. [ncbi.nlm.nih.gov]

• Hyporeflexia

  Hyporeflexia may develop, and seizures may occur. Dysrhythmias may occur and include AV nodal block, Wenckebach, and tachycardia. Pallor and cool extremities have been reported. [emedicine.medscape.com]

  Other uncommon features of clonidine overdose described are cardiac arrhythmia, hypotonia, hyporeflexia, extensor plantar reflex, unreactive pupils, xerostomia and apnea(1,2,4). [indianpediatrics.net]

• Tingling

  […] sleep disturbances mental depression irrational or abnormal thoughts irritability decreased sexual drive / impotence generally feeling unwell thinning of hair rash / hives / itching constipation dryness of the nose and eyes pain in the salivary glands tingling [news-medical.net]

Tizanidine is a chemically related agent used for the treatment of muscle spasticity. [mhmedical.com]

Recovery occurred within 48 h with only symptomatic treatment. Significant morbidity from clonidine ingestion occurred in terms of hospitalization, invasive monitoring, and mechanical ventilation. [ncbi.nlm.nih.gov]

Cessation of opioids Stopping opioid use can lead to withdrawal symptoms which need systematic treatment. Often a long-term treatment plan or program is necessary for weaning an addict off the opioid. [news-medical.net]

The purpose of this book is to provide an up-to-date account of the diag nosis and treatment of all the clinically important poisons. [books.google.de]

For the majority of patients with clonidine toxicity, the prognosis is good with treatment. However, those who delay seeking treatment may suffer adverse cardiac or neurological problems. [ncbi.nlm.nih.gov]

It will be enough quite a bit of alcohol for unfavourable prognosis. Clonidine in reasonable dosages, can ease the life of high blood pressure, and in high concentrations it can deprive a person of life and health. [medicalj-center.info]

This activity reviews the etiology, presentation, evaluation, and management/prevention of clonidine toxicity and reviews the role of the interprofessional team in evaluating, diagnosing, and managing the condition. [ncbi.nlm.nih.gov]

Patients with specific etiologies for polydipsia were excluded as were those considered too frail to tolerate the drug regimen proposed. [nature.com]

"Elevated Norepinephrine may be a Unifying Etiological Factor in the Abuse of a Broad Range of Substances: Alcohol, Nicotine, Marijuana, Heroin, Cocaine, and Caffeine". Substance Abuse. 7 : 171–83. doi : 10.4137/SART.S13019. PMC 3798293. [en.wikipedia.org]

Pulse oximetry should be initiated in patients with respiratory distress or cyanosis; cardiac monitoring is indicated for patients with hemodynamic instability. 5 In patients with altered mental status of unknown etiology, consider giving naloxone (formerly [aafp.org]

STUDY OBJECTIVE: To describe the epidemiology of clonidine-related hospitalization in children, to evaluate the efficacy of naloxone, and to review the clinical effects of clonidine toxicity. [ncbi.nlm.nih.gov]

James Published 1997 in Annals of emergency medicine STUDY OBJECTIVE To describe the epidemiology of clonidine-related hospitalization in children, to evaluate the efficacy of naloxone, and to review the clinical effects of clonidine toxicity. [semanticscholar.org]

There is a contrasting difference in the epidemiology of clonidine poisoning in the developed and developing countries. [jdrntruhs.org]

[…] applications such as treatment of migraines, treatment of vasomotor symptoms associated with menopause or withdrawal, and in a number of pediatric applications such as pre-anesthesia, postoperative pain management, and panic/anxiety disorders.[1, 5] Epidemiology [aaemrsa.blogspot.com]

He has since completed further training in emergency medicine, clinical toxicology, clinical epidemiology and health professional education. [lifeinthefastlane.com]

Certain topics are discussed in depth either because of their clinical importance or because recent data have become available concerning pathophysiology or treatment. [books.google.de]

Pharmacology, pathophysiology, and management of calcium channel blocker and beta-blocker toxicity. Toxicol Rev. 2004;23(4):223-38. Engebretsen KM, Kaczmarek KM, Morgan J, et al. [toxikonconsortium.org]

Objectives: Describe the basic pathophysiology/toxicokinetics of clonidine toxicity. Summarize some of the various presenting signs and symptoms that would accompany clonidine toxicity. [ncbi.nlm.nih.gov]

Pathophysiology Clonidine is an imidazole derivative and was first used as a nasal decongestant. [emedicine.medscape.com]

Pathophysiology Hypotension is conventionally defined as a systolic blood pressure less than 90 mm Hg in adults (with normal parameters adjusted in children depending on age and weight). [calpoison.org]

More effective measures are needed to prevent these potentially serious intoxications. [ncbi.nlm.nih.gov]

Now in its second edition, this popular and essential comprehensive resource provides a detailed analysis of how to identify, prevent, and manage drug-induced diseases. Edited by James E. Tisdale and Douglas A. [books.google.de]

If significant CNS depression exists, intubate before administering activated charcoal to prevent aspiration. The clinician should be aware that even intubated patients are at risk of activated charcoal aspiration. [emedicine.medscape.com]