Presentation
Clonorchiasis usually presents with chronic gastrointestinal disturbances or cholangiocarcinoma. We describe a rare acute presentation of clonorchiasis in a child with diarrhea and liver abscess. [ncbi.nlm.nih.gov]
We experienced a 62-year-old man who had a history of ingestion of raw freshwater fish and presented with acute pancreatitis and cholangitis. [e-ce.org]
Entire Body System
- Chills
Symptoms of Clonorchiasis include heavier infections can cause fever, chills, epigastric pain, tender hepatomegaly, mild jaundice, and eosinophilia. [omicsonline.org]
In the acute phase, heavier infections can cause fever, chills, epigastric pain, tender hepatomegaly, mild jaundice, and eosinophilia. Later, diarrhea may occur. [msdmanuals.com]
- Painless Jaundice
A 26-yr-old male presented with complaints of fatigue, weight loss and painless jaundice. The history was significant for frequent ingestion of raw freshwater fish. [ncbi.nlm.nih.gov]
Gastrointestinal
- Abdominal Pain
The patient presented with complaints of abdominal pain and was found on imaging to have clonorchiasis infestation of the bile ducts. [ncbi.nlm.nih.gov]
In the acute phase of the disease, heavier infections can lead to fever, episodes of chills, abdominal pain, nausea, hepatomegaly (tender in nature), jaundice (mild to moderate), diarrhea, and eosinophilia. [xpertdox.com]
The signs and symptoms of Clonorchiasis may include: Abdominal pain, nausea, and diarrhea Any pathology (infection) of the bile duct and adjacent organs can cause abdominal pain (particularly under the rib cage to the right), jaundice, fever, or chills [dovemed.com]
- Nausea
He had no abdominal symptoms, such as nausea, vomiting, abdominal pain, diarrhea, or constipation. He used to consume raw beef and fish frequently. [ncbi.nlm.nih.gov]
The common symptoms of clonorchiasis include jaundice, liver tenderness and enlargement, nausea, diarrhea, vomiting, abdominal pain, loss of appetite, and anisakiasis. [biology-online.org]
The early stage of Clonorchiasis, known as the acute stage, manifests as nausea, eosinophilia, diarrhea, and abdominal pain. Untreated, the infection progresses and can develop into pancreatitis, cholangitis, cholangiocarcinoma, or cholelithiasis. [medic8.com]
Liver, Gall & Pancreas
- Hepatomegaly
Symptoms of Clonorchiasis include heavier infections can cause fever, chills, epigastric pain, tender hepatomegaly, mild jaundice, and eosinophilia. [omicsonline.org]
In the acute phase, heavier infections can cause fever, chills, epigastric pain, tender hepatomegaly, mild jaundice, and eosinophilia. Later, diarrhea may occur. [msdmanuals.com]
In the acute phase of the disease, heavier infections can lead to fever, episodes of chills, abdominal pain, nausea, hepatomegaly (tender in nature), jaundice (mild to moderate), diarrhea, and eosinophilia. [xpertdox.com]
Workup
26099940 ) Kang J.M....Na B.K. 2015 18 Identification and characterization of Clonorchis sinensis cathepsin B proteases in the pathogenesis of clonorchiasis. ( 26691339 ) Chen W....Yu X. 2015 19 In vivo diagnosis of clonorchiasis during cholangioscopy for workup [malacards.org]
Treatment
This case demonstrates the importance of early recognition and treatment of this disease to prevent subsequent morbidity and mortality. Diagnosis and treatment of clonorchiasis as well as the possible modes of cancer induction are discussed. [ncbi.nlm.nih.gov]
Clonorchiasis Treatment For treatment of Clonorchiasis there is only one medicine Praziquantel. It should be administered at the dose of 25 mg/kg 3 times daily for 2–3 consecutive days or of 40 mg/kg, single administration. [omicsonline.org]
Prognosis
BACKGROUND: Intrahepatic cholangiocarcinoma caused by clonorchiasis (CICC) has a poor prognosis, and there have been insufficient studies regarding risk and prognostic factors. We aimed to identify CICC-associated factors. [ncbi.nlm.nih.gov]
Prognosis Light infections may resolve spontaneously within one year, even without treatment. However the prognosis may be grave in patients with heavy infection. Immunocompromised hosts may be at an increased risk of complications. [patient.info]
This practice must be strictly eliminated to prevent Clonorchiasis What is the Prognosis of Clonorchiasis? (Outcomes/Resolutions) A proper and timely diagnosis and treatment can lead to a good prognosis. [dovemed.com]
Association of C. sinensis infection with CCA CCA, usually with poor prognosis, is a primary hepatic malignancy arising from bile duct epithelium and ranks the second most common primary hepatic malignancy[ 73 – 75 ]. [idpjournal.biomedcentral.com]
Etiology
Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology. [icd10coded.com]
Cholangiocarcinoma was related to clonorchiasis, which suggested an etiological role for the parasite. [ncbi.nlm.nih.gov]
(Etiology) Clonorchiasis is a foodborne infection caused by Clonorchis sinensis or Chinese liver fluke, a parasitic worm which grows and resides in the bile ducts of the liver in humans and fish-eating mammals. [dovemed.com]
Epidemiology
By analysis of epidemiological data, we found that the ecologic environment was favorable for the epidemiology of clonorchiasis. Most patients with clonorchiasis were lack of knowledge about the disease. [ncbi.nlm.nih.gov]
The epidemiology of clonorchiasis is characterized by a rising trend in prevalence, variability among sex and age, as well as endemicity in different regions. [idl-bnc-idrc.dspacedirect.org]
Pathophysiology
In this article, the radiologic findings, including cholangiography, sonography, and CT of clonorchiasis are reviewed in light of the pathophysiology of the disease. [ncbi.nlm.nih.gov]
Clonorchiasis pathophysiology Clonorchiasis is infection with the liver fluke Clonorchis sinensis. Infection is acquired by eating undercooked freshwater fish. [omicsonline.org]
Pathophysiology Adult forms of C. sinensis live in the bile ducts. Eggs are passed in the stool and ingested by snails. Cercariae (free-swimming larvae) released from infected snails subsequently infect a variety of freshwater fish. [merckmanuals.com]
Prevention
Praziquantel is the treatment of choice and has been considered for preventive chemotherapy. Tribendimidine showed good safety and therapeutic profiles in phase 2 trials and warrants further investigation. [ncbi.nlm.nih.gov]
The preventative measures of Clonorchiasis include: Educating the community is the most important and effective tool in preventing Clonorchiasis Avoidance of raw or undercooked freshwater fish consumption. [dovemed.com]
Food items or nutrients that may prevent or relieve clonorchiasis Clonorchiasis can be easily prevented — making sure freshwater fish is thoroughly cooked before eating them is the most effective way to prevent the infection. [naturalpedia.com]