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Clonorchis Sinensis


Presentation

  • The patient presented with complaints of abdominal pain and was found on imaging to have clonorchiasis infestation of the bile ducts.[ncbi.nlm.nih.gov]
Pathologist
  • The Snail as the Primary Intermediate Host: The Japanese pathologist, Masatomo Muto, showed that the primary intermediate hosts of C. sinensis were snails.[web.archive.org]
High Fever
  • Metacercariae travelling through the body to the appropriate locations for excystation can cause high fevers in the host. ( Swellengrebel and Sterman, 1961 ; von Brand, 1952 ) injures humans causes disease in humans The most effective drug for treating[animaldiversity.ummz.umich.edu]
Thrombosis
  • Although this infection is associated with obstructive jaundice or choledocholithiasis, portal vein thrombosis has not been reported.[ncbi.nlm.nih.gov]
Liver Fibrosis
  • The pathogenesis of liver fibrosis caused by viruses and alcohol has been well characterized, but the molecular mechanisms underlying liver fibrosis induced by the liver fluke Clonorchis sinensis are poorly understood.[ncbi.nlm.nih.gov]
  • Zheng et al. intraperitoneally injected C. sinensis calmodulin ( Cs CaM) into rats and observed severe liver inflammation with mild to moderate liver fibrosis as the result [ 76 ].[doi.org]
Stroke
  • C. sinensis infestation which is endemic in East Asian countries should be considered as a cause of multiple microembolic stroke associated with idiopathic hypereosinophilic syndrome.[ncbi.nlm.nih.gov]

Treatment

  • Cure rates and egg reduction rates were assessed, and adverse events were monitored after treatments. Uncured patients accepted the second treatment with the same drugs after the first treatment. RESULTS: 156 patients were eligible for the study.[ncbi.nlm.nih.gov]

Prognosis

  • […] left untreated, it may lead to bile duct cancer (cholangiocarcinoma) Please find comprehensive information on Clonorchiasis regarding definition, distribution, risk factors, causes, signs & symptoms, diagnosis, complications, treatment, prevention, prognosis[dovemed.com]
  • Currently, Thai individuals in O. viverrini endemic areas are diagnosed only in the most advanced stages of CCA, where prognosis is dire and treatment essentially palliative.[ncbi.nlm.nih.gov]

Etiology

  • It is not clear whether or not clonorchiasis was etiologically related to HCC, but it was of interest that in both cases the tumor nodule was very small representing the primary lesion without metastasis.[ncbi.nlm.nih.gov]
  • Eosinophilic lung diseases have been given variable names on the basis of etiology, clinical manifestation, and their pathophysiology.[kjim.org]
  • It can be tested from three aspects: First, etiology check. Clonorchis suck eggs are found in feces, which is the only apparent evidence of Clonorchis. In general the eggs can be found after one month of infection.[technologynetworks.com]

Epidemiology

  • Detection of this parasite from the second intermediate host, the freshwater fish is the common method for epidemiological surveys of this parasite, but is time consuming, labour intensive and easily leads to misdiagnosis.[ncbi.nlm.nih.gov]
Sex distribution
Age distribution

Pathophysiology

  • These findings provide new insights into the pathophysiological role of C. sinensis excretory-secretory products in host chronic inflammatory processes, which are initial events in hepatobiliary diseases.[ncbi.nlm.nih.gov]
  • It is estimated in Asia that nearly 6000 people die from complications of C. sinensis infection each year. [4] [2] Pathophysiology C. sinensis is one of the most common parasitic infections in the world.[statpearls.com]
  • These findings reflect the pathophysiology of bile ducts in C. sinensis . Adult C. sinensis worms usually reside in the medium-sized or small intrahepatic bile ducts.[synapse.koreamed.org]
  • Eosinophilic lung diseases have been given variable names on the basis of etiology, clinical manifestation, and their pathophysiology.[kjim.org]

Prevention

  • China ; Guangxi Zhuang Autonomous Region Center for Disease Prevention and Control; Guangxi Key Laboratory for the Prevention and Control of Viral Hepatitis, Nanning 530028, P. R.[ncbi.nlm.nih.gov]

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