The present study elucidates the transcriptomes of C. sinensis and O. viverrini using a platform based on next-generation (high throughput) sequencing and advanced in silico analyses. [researchonline.jcu.edu.au]

Clinical Presentation Most infections are asymptomatic. Most pathologic manifestations result from inflammation and intermittent obstruction of the biliary ducts. [cdc.gov]

However, in the present study, we did not observe the 16 kDa band reported by Sirisinha et al. ( 1990 ). [e-sciencecentral.org]

The main goal of this book is to present the major trematodes and their corresponding diseases in the framework of modern parasitology, considering matters such as the application of novel techniques and analysis of data in the context of host-parasite [books.google.es]

The intensity of O. viverrini eggs was presented as eggs per gram (EPG) of feces with the geometric mean of 157.0 EPG, and that of C. sinensis eggs was presented with the geometric mean of 2,330.7 EPG. [parasitol.kr]

• Chronic Infection

  The greatest impact is through the malignant cancer ( = cholangiocarcinoma) that these parasites induce in chronically infected people. [semanticscholar.org]

  […] and other performance characteristics (e.g. limit of detection, cross reactivity with other helminth infections, reproducibility, feasibility for newly infected, chronically infected, and resolved infected clinical samples, test stability) of the diagnostic [sbir.gov]

  Determine the sensitivity, specificity and other performance characteristics (e.g. limit of detection, cross reactivity with other helminth infections, reproducibility, feasibility for newly infected, chronically infected, and resolved infected clinical [sbir.cancer.gov]

  Both flukes are recognized as carcinogenic, chronic infections being associated with development of a cancer of the bile duct (cholangiocarcinoma) and also of the liver (hepatocellular carcinoma) [ 5, 6 ]. [parasitol.kr]

• Laboratory Technician

  For example, microscopic examination is cumbersome and time consuming, requiring experienced laboratory technicians, and often it is difficult to distinguish eggs from those of closely related heterophyids, which have similar egg morphologies. [hindawi.com]

• Neglect

  Gasser}, booktitle={PLoS neglected tropical diseases}, year={2010} } Neil D. Young, Bronwyn Evelyn Campbell, +8 authors Robin B. [semanticscholar.org]

  PLOS Neglected Tropical Diseases. Collection. [figshare.com]

  The diseases caused by trematodes have been neglected for years, especially as compared with other parasitic diseases. [books.google.es]

  PLoS Neglected Tropical Diseases, 4 (6). e719. pp. 1-14. 117 622 Abstract The two parasitic trematodes, Clonorchis sinensis and Opisthorchis viverrini, have a major impact on the health of tens of millions of humans throughout Asia. [researchonline.jcu.edu.au]

  PLoS Neglected Tropical Diseases, 3 (1). e367. [researchrepository.murdoch.edu.au]

• Irritability

  The mechanisms by which O. viverrini causes cancer are multi-factorial, involving mechanical irritation from the activities and movements of the flukes, immunopathology, dietary nitrosamines and the secretion of parasite proteins that promote a tumourigenic [pubs.rsc.org]

• Fasciola Hepatica

  Metagonimus yokogawi Penetration of the skin by cercaria in water Fasciopolis buski Fasciola hepatica Ingest metacercaria with freshwater plant [quizlet.com]

  Resumen: Liver flukes Fasciola hepatica, Opisthorchis viverrini and Clonorchis sinensis are causing agents of liver and hepatobiliary diseases. [zaguan.unizar.es]

  hepatica • General studies to identify biomarkers associated with O. viverrini and C. sinensis infection Phase I Activities and Deliverables • Develop a working diagnostic assay and/or prototype point-of-care diagnostic device that can identify the target [sbir.gov]

  hepatica General studies to identify biomarkers associated with O. viverrini and C. sinensis infection Phase I Activities and Deliverables Develop a working diagnostic assay and/or prototype point-of-care diagnostic device that can identify the target [sbir.cancer.gov]

To compare the different alternative treatments with the reference treatment, we also calculated the posterior probability after 100 000 simulations for the cure rate of the respective treatment to exceed that of the reference treatment; uninformative [thelancet.com]

Treatment with the drug Praziquantiel has been reported as extremely effective with a single dose. Disturbingly though, use of Praziquantiel has not been associated with a decrease in cholangiocarcinoma. [web.stanford.edu]

In-depth studies are needed to clarify the current epidemiology of these helminth infections and to identify new and specific targets for both effective diagnosis and treatments. [books.google.es]

Consequently, Vietnam veterans could theoretically fall into one of two categories: (1) those with low level chronic infections, and (2) those with infections that eventually resolved without drug treatment. [sbir.gov]

Praziquantel is the only medicine recommended by WHO for treatment of clonorchiasis. It should be administered at the dose of 25 mg/kg 3 times daily for 2–3 consecutive days or of 40 mg/kg, single administration. [who.int]

Early detection of cholangiocarcinoma has been attempted to improve prognosis and reduce mortality. One possibility is to use tumor markers such as CA19-9 and CEA to identify early cancers. The drawback is that they have very low specificities. [path.upmc.edu]

Therefore, understanding how these parasites cause/promote oncogenesis and its etiology in humans will aid in the development of novel treatment strategies in effectively controlling the infection-associated malignancy. [frontiersin.org]

Clonorchiasis and cholangiocarcinoma : etiologic relationship and imaging diagnosis. Clin Microbiol Rev. 2014;17:540–552. 10. Jin Y, Kim EM, Choi MH, et al. Significance of serology by multi-antigen ELISA for tissue helminthiases in Korea. [journals.lww.com]

Here we discuss the comparative epidemiology of these three taxa comparing in detail the use of first, second and final animal hosts, and consider the potential role of humans in spreading these pathogens. [pubag.nal.usda.gov]

Addressing the biology, epidemiology, and pathogenesis of more than 60 microorganisms, Molecular Detection of Foodborne Pathogens demonstrates how to implement a surveillance system that uses state-of-the-art molecular techniques to quickly detect and [books.google.es]

Epidemiological investigation therefore currently relies on morphological examination of adult worms following expulsion chemotherapy. [researchrepository.murdoch.edu.au]

These three parasites are closely related trematodes and have similar life cycles and the same pathophysiology and disease manifestations [ 1, 2 ]. They are different only in geographic distribution. [ajronline.org]

All-Encompassing Guide to Detection Techniques One of the most effective ways to control and prevent human foodborne infections is to implement a pathogen surveillance system. [books.google.es]

Cholangiocarcinoma associated with liver fluke infection: a preventable source of morbidity in Asian immigrants. Am J Gastroenterol. 81(1):76-79, 1986. Dooley JR, Neafie RC. [path.upmc.edu]

Genomic and proteomic studies of the liver fluke secretome have accelerated the discovery of parasite proteins with known/potential roles in pathogenesis and tumourigenesis, establishing a framework towards understanding, and ultimately preventing, the [pubs.rsc.org]

This indicates that infection must be entirely avoided to prevent a future diagnosis of cancer. Are there other names for this disease? Opisthorchiasis may also be referred to as "Siberian liver fluke disease," and "cat liver fluke disease." [web.stanford.edu]