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Clonorchis Viverrini


Presentation

  • However, in the present study, we did not observe the 16 kDa band reported by Sirisinha et al. ( 1990 ).[e-sciencecentral.org]
  • The intensity of O. viverrini eggs was presented as eggs per gram (EPG) of feces with the geometric mean of 157.0 EPG, and that of C. sinensis eggs was presented with the geometric mean of 2,330.7 EPG.[parasitol.kr]
  • Clinical Presentation Most infections are asymptomatic. Most pathologic manifestations result from inflammation and intermittent obstruction of the biliary ducts.[cdc.gov]
  • In this presentation, we briefly consider the current scientific status for progression of CCA by heavy C. sinensis infestation from the food-borne trematode and development of CCA.[bmbreports.org]
Chronic Infection
  • The greatest impact is through the malignant cancer ( cholangiocarcinoma) that these parasites induce in chronically infected people.[semanticscholar.org]
  • Consequently, Vietnam veterans could theoretically fall into one of two categories: (1) those with low level chronic infections, and (2) those with infections that eventually resolved without drug treatment.[sbir.cancer.gov]
  • Both flukes are recognized as carcinogenic, chronic infections being associated with development of a cancer of the bile duct (cholangiocarcinoma) and also of the liver (hepatocellular carcinoma) [ 5 , 6 ].[parasitol.kr]
Weakness
  • Although stool examination is the standard diagnostic method, it has some definite weak points. Eggs of O. viverrini and C. sinensis are not easy to distinguish from each other or from eggs of minute intestinal flukes.[parasitol.kr]
Falling
  • Consequently, Vietnam veterans could theoretically fall into one of two categories: (1) those with low level chronic infections, and (2) those with infections that eventually resolved without drug treatment.[sbir.cancer.gov]
Suggestibility
  • Clonorchis sinensis, Opisthorchis viverrini, automated assay of anti-P1 allohemagglutinins in blood of infected persons showed high concentrations suggesting that parasites are responsible for immunization of patients with P1 alloantigen: Southeast Asia[agris.fao.org]
  • US veterans who served in Vietnam have shown an increasing incidence of CCA, and a pilot study conducted by the Veterans Administration (VA) suggests that 25% of Vietnam veterans were infected with C. sinensis during their military service.[sbir.cancer.gov]
  • Neutrality test analysis suggested a relatively recent population expansion for C. sinensis , whereas goodness-of-fit tests indicated deviation from the strict model of uniform expansion.[folia.paru.cas.cz]
  • Still at war — VA pilot study suggests many have liver flukes that are linked to rare bile duct cancer. Enlarge / An adult Clonorchis sinensis .[arstechnica.com]
  • The high sensitivity and specificity suggest the present test will be of diagnostic value. The difference between melting temperatures (more than 3 ) was easy to detect.[parasitol.kr]

Workup

Brugia Malayi
  • Rapid detection and identification of Brugia malayi , B. pahangi , and Dirofilaria immitis by high-resolution melting assay. Vector Borne Zoonotic Dis. 2013; 13:31–36. PMID: 23199268 . [ CrossRef ] [ Google Scholar ] 20.[e-sciencecentral.org]
  • Rapid detection and identification of Brugia malayi , B. pahangi , and Dirofilaria immitis by high-resolution melting assay. Vector Borne Zoonotic Dis 2013;13: 31-36. PMID: 23199268 . 20. Elkins DB, Haswell-Elkins M, Anderson RM.[parasitol.kr]
Dirofilaria Immitis
  • Rapid detection and identification of Brugia malayi , B. pahangi , and Dirofilaria immitis by high-resolution melting assay. Vector Borne Zoonotic Dis. 2013; 13:31–36. PMID: 23199268 . [ CrossRef ] [ Google Scholar ] 20.[e-sciencecentral.org]
  • Rapid detection and identification of Brugia malayi , B. pahangi , and Dirofilaria immitis by high-resolution melting assay. Vector Borne Zoonotic Dis 2013;13: 31-36. PMID: 23199268 . 20. Elkins DB, Haswell-Elkins M, Anderson RM.[parasitol.kr]
Paragonimus Westermani
  • Q Rev Biol 66:411–453 PubMed CrossRef Google Scholar Iwagami M, Ho LY, Su K, Lai PF, Fukushima M, Nakano M, Blair D, Kawashima K, Agasuma T (2000) Molecular phylogeographic studies on Paragonimus westermani in Asia.[link.springer.com]
  • westermani Schistosoma mansoni Schistosoma japonicum Schistosoma haemotobium Clonorchis sinensis Opisthorchis viverrini Heterophyes heterophyes Metagonimus yokogawi Penetration of the skin by cercaria in water Fasciopolis buski Fasciola hepatica Ingest[quizlet.com]
Ancylostoma Duodenale
  • Recently, the method was used for differentiation of human hookworms ( Necator americanus , Ancylostoma duodenale , A. ceylanicum , A. caninum , and A. braziliense ) [ 18 ] and of filarial nematodes ( Brugia malayi , B. pahangi , and Dirofilaria immitis[parasitol.kr]
Necator Americanus
  • Recently, the method was used for differentiation of human hookworms ( Necator americanus , Ancylostoma duodenale , A. ceylanicum , A. caninum , and A. braziliense ) [ 18 ] and of filarial nematodes ( Brugia malayi , B. pahangi , and Dirofilaria immitis[parasitol.kr]
Hepatocellular Carcinoma
  • Both flukes are recognized as carcinogenic, chronic infections being associated with development of a cancer of the bile duct (cholangiocarcinoma) and also of the liver (hepatocellular carcinoma) [ 5 , 6 ].[parasitol.kr]

Treatment

  • Consequently, Vietnam veterans could theoretically fall into one of two categories: (1) those with low level chronic infections, and (2) those with infections that eventually resolved without drug treatment.[sbir.cancer.gov]
  • The epidemiology and control of intestinal helminths in the Pulicat Lake region of Southern India I Study design and pre-and post-treatment observations on Ascaris lumbricoides infection. Trans R Soc Trop Med Hyg. 1986; 80:774–792.[e-sciencecentral.org]
  • Treatment with the drug Praziquantiel has been reported as extremely effective with a single dose. Disturbingly though, use of Praziquantiel has not been associated with a decrease in cholangiocarcinoma.[web.stanford.edu]
  • Praziquantel is the only medicine recommended by WHO for treatment of clonorchiasis. It should be administered at the dose of 25 mg/kg 3 times daily for 2–3 consecutive days or of 40 mg/kg, single administration.[who.int]
  • Therefore, understanding how these parasites cause/promote oncogenesis and its etiology in humans will aid in the development of novel treatment strategies in effectively controlling the infection-associated malignancy.[frontiersin.org]

Etiology

  • Therefore, understanding how these parasites cause/promote oncogenesis and its etiology in humans will aid in the development of novel treatment strategies in effectively controlling the infection-associated malignancy.[frontiersin.org]
  • Clonorchiasis and cholangiocarcinoma : etiologic relationship and imaging diagnosis. Clin Microbiol Rev . 2014;17:540–552. 10. Jin Y, Kim EM, Choi MH, et al. Significance of serology by multi-antigen ELISA for tissue helminthiases in Korea.[journals.lww.com]

Epidemiology

  • Addressing the biology, epidemiology, and pathogenesis of more than 60 microorganisms, Molecular Detection of Foodborne Pathogens demonstrates how to implement a surveillance system that uses state-of-the-art molecular techniques to quickly detect and[books.google.es]
  • Here we discuss the comparative epidemiology of these three taxa comparing in detail the use of first, second and final animal hosts, and consider the potential role of humans in spreading these pathogens.[pubag.nal.usda.gov]
  • Food-borne trematodiases in Southeast Asia-epidemiology, pathology, clinical manifestation and control. Adv Parasitol. 2010; 72:305–350. PMID: 20624536 . [ CrossRef ] [ Google Scholar ] 2. Keiser J, Utzinger J. Food-borne trematodiases.[e-sciencecentral.org]
  • The epidemiology and control of intestinal helminths in the Pulicat Lake region of Southern India I Study design and pre-and post-treatment observations on Ascaris lumbricoides infection. Trans R Soc Trop Med Hyg 1986;80: 774-792.[parasitol.kr]
  • Epidemiological investigation therefore currently relies on morphological examination of adult worms following expulsion chemotherapy.[researchrepository.murdoch.edu.au]
Sex distribution
Age distribution

Pathophysiology

  • These three parasites are closely related trematodes and have similar life cycles and the same pathophysiology and disease manifestations [ 1 , 2 ]. They are different only in geographic distribution.[ajronline.org]

Prevention

  • All-Encompassing Guide to Detection Techniques One of the most effective ways to control and prevent human foodborne infections is to implement a pathogen surveillance system.[books.google.es]
  • This indicates that infection must be entirely avoided to prevent a future diagnosis of cancer. Are there other names for this disease? Opisthorchiasis may also be referred to as "Siberian liver fluke disease," and "cat liver fluke disease."[web.stanford.edu]
  • Genomic and proteomic studies of the liver fluke secretome have accelerated the discovery of parasite proteins with known/potential roles in pathogenesis and tumourigenesis, establishing a framework towards understanding, and ultimately preventing, the[pubs.rsc.org]
  • For the purposes of public health control, WHO recommends carrying out community diagnosis at the district level, and implementing preventive chemotherapy with praziquantel at a dosage of 40 mg/kg, single administration, as indicated by the attached table[who.int]

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