Presentation
We present a case of C. sordellii bacteraemia and septic shock in an immunocompromised patient who was recently diagnosed with pleomorphic gluteal sarcoma. [ncbi.nlm.nih.gov]
Microbiome profiling is the process of understanding the species present in a microbial community, also known as the microbiome. The microbiome can be present in many different environments, including the human gut. [news-medical.net]
Entire Body System
- Gangrene
Gas gangrene Gas gangrene generally occurs at the site of trauma or a recent surgical wound. The onset of gas gangrene is sudden and dramatic. About a third of cases occur on their own. [textbookofbacteriology.net]
This is known as "clostridial myonecrosis" or "gas gangrene" and also results from toxins produced by C. perfringens. Gas gangrene can occur when deep wounds are contaminated with foreign objects containing the bacteria. [bccdc.ca]
Clostridial cellulitis has a more gradual onset than gas gangrene and does not include the systemic toxemia associated with gas gangrene. [ncbi.nlm.nih.gov]
Gastrointestinal
- Food Poisoning
Most food poisoning strains studied carry cpe in their chromosomes; isolates from AAD and SD cases bear cpe in a plasmid. [textbookofbacteriology.net]
Who is at risk of C. perfringens food poisoning? Everyone is susceptible to food poisoning from C. perfringens. [cdc.gov]
It is also a common cause of food poisoning when ingested in sufficient numbers. This commonly occurs when cooked food contaminated with the bacteria is left out (i.e. temperature abused), which allows rapid multiplication of C. perfringens. [bccdc.ca]
Clostridium botulinum is the culprit responsible for the food poisoning and other problems associated with botulism. CONTINUE SCROLLING OR CLICK HERE FOR RELATED ARTICLE Reviewed on 12/27/2018 [medicinenet.com]
Cooking kills the growing C. perfringens cells that cause food poisoning, but not necessarily the spores that can grow into new cells. If cooked food is not promptly served or refrigerated, the spores can grow and produce new cells. [foodsafety.gov]
Musculoskeletal
- Arthritis
KEYWORDS: Anaerobic infection; Clostridium disporicum; Orthopedic surgical infections; Prosthetic joint infection; Septic arthritis [ncbi.nlm.nih.gov]
Sasaguri Y, Yanagihara N, Tanaka S, Katsuki I, Matsushita S, Tanaka Y: Dopamine induces IL-6-dependent IL-17 production via D1-like receptor on CD4 naive T cells and D1-like receptor antagonist SCH-23390 inhibits cartilage destruction in a human rheumatoid arthritis [doi.org]
Skin
- Ulcer
A preponderance of evidence from this systematic review confirms that collagenase ointment is a safe and effective choice for debridement of cutaneous ulcers and burn wounds. Related Topics Loading Related Articles [doi.org]
Diagnosis It is often difficult to distinguish C difficile disease from other intestinal diseases, including ulcerative colitis and Crohn's disease. [ncbi.nlm.nih.gov]
Neurologic
- Confusion
To add to the confusion, a few strains of C baratii and C butyricum have been reported to secrete botulinum toxin. In addition, certain proteolytic strains of C botulinum are indistinguishable from C sporogenes except by toxin assay. [ncbi.nlm.nih.gov]
Workup
Microbiology
- Gram-Positive Rods
Abstract Clostridium sordellii (C. sordellii) is an anaerobic gram-positive rod most commonly found in the soil and sewage but also as part of the normal flora of the gastrointestinal tract and vagina of a small percentage of healthy individuals. [ncbi.nlm.nih.gov]
positive rod usually with subterminal spores; anaerobic SECTION II - HEALTH HAZARD PATHOGENICITY: Involved with gas gangrene of wounds; C. septicum - bacteremia and infections associated with malignancy; C. butyricum - necrotizing enterocolitis in infants [msdsonline.com]
Analysis C. perfringens is a ubiquitous, anaerobic, Gram-positive, spore-forming bacillus and a frequent contaminant of meat and poultry. [textbookofbacteriology.net]
They are heterogeneous Gram-positive rods, anaerobic, fermentative, and spore forming inhabiting the human intestinal indigenous microbiota (Rocha et al. 1999). [scielo.br]
- Gram-Positive Bacteria
Clostridium, genus of rod-shaped, usually gram-positive bacteria, members of which are found in soil, water, and the intestinal tracts of humans and other animals. Most species grow only in the complete absence of oxygen. [britannica.com]
Clostridium is a genus of Gram-positive bacteria, which includes several significant human pathogens, including the causative agent of botulism. [en.wikipedia.org]
In this scenario, gut commensal Clostridia consist of gram-positive, rod-shaped bacteria in the phylum Firmicutes. [doi.org]
Treatment
We discuss treatment, causes and mechanisms of this rare complication from this treatment and review the bibliography about mechanisms for the different types of immunological reactions that may occur after treatment with collagenase Clostridium histolyticum [ncbi.nlm.nih.gov]
[…] as treatment for primary C. difficile infection. [nejm.org]
Prognosis
Infectious involvement of the aorta and associated vascular structures portends a poor prognosis with a 57% mortality rate. Our case and updated review demonstrates the implications of C. septicum vascular seeding and subsequent treatment outcomes. [ncbi.nlm.nih.gov]
Etiology
Clostridium difficile, a Gram positive spore-forming anaerobe, is considered a frequent etiological agent; recently, C. perfringens has also been implicated and may act, synergically with C. difficile. [dialnet.unirioja.es]
Inhalt CHAPTER I 1 CHAPTER II 33 CHAPTER III 73 BACTERIA AND FERMENTATION 92 BACTERIA IN THE SOIL 118 CHAPTER VI 151 BACTERIA IN MILK AND MILK PKODUCTS 178 BACTERIA IN OTHER FOODS 253 CHAPTER IX 280 CHAPTER X 323 THE ETIOLOGY OF TROPICAL DISEASES 370 [books.google.com]
The etiology of NEC is not understood, although bacterial colonization of the gut is believed to play a role Footnote 11. Clostridium spp. have been particularly associated with more severe cases of NEC Footnote 4, Footnote 11. [canada.ca]
C. difficile is considered the etiologic agent of PMC and the major cause of antibiotic-associated diarrhea in adults, but the attribution of this organism to enteric diseases in children is less clear (Karlsson et al. 2000). [scielo.br]
Spores are rare in cultures of C perfringens, the most common etiologic agent of these diseases. [ncbi.nlm.nih.gov]
Epidemiology
Biology and Epidemiology 3.2.1.1.2. Chemotherapy 3.2.1.2. American Trypanosomiasis 3.2.1.2.1. Biology and Epidemiology 3.2.1.2.2. Chemotherapy 3.2.1.3. Leishmaniasis 3.2.1.3.1. Biology and Epidemiology 3.2.1.3.2. Chemotherapy 3.2.2. [doi.org]
Guidance for Management in Acute Care Settings (2013 update) Clostridium difficile : Infection Prevention and Control Guidance for Management in Long-term Care Facilities (2013) Infectious Diseases Society of America (IDSA) / Society for Healthcare Epidemiology [ecdc.europa.eu]
Clinical Practice Guidelines for Clostridium difficile Infection in Adults: 2010 Update by the Society for Healthcare Epidemiology of America (SHEA) and the Infectious Diseases Society of America (IDSA). Infection Control and Hospital Epidemiology. [labtestsonline.it]
Pathophysiology
Since the metalloproteinase profile and activity of the human gut microbiota remains uncharacterized, we explored whether bacterial-derived proteases might have the potential to contribute to physiological or pathophysiological processes within the gut [doi.org]
Cervical dystonia pathophysiology and treatment options" Drugs 2001;61:1921–1943. ^ “ Providing for a Sustainable Energy Future ”. Bioengineering Resources, inc. 2007年5月21日 閲覧。 ^ Mengesha et al. (2009). “Clostridia in Anti-tumor Therapy”. [wikiwand.com]
Tetanus: pathophysiology, management, and prophylaxis. Disease-A-Month. 1991; 37 :545. [ PubMed : 1874121 ] Coffield JA, Considine RV, Simpson LL. Clostridial neurotoxins in the age of molecular medicine. [ncbi.nlm.nih.gov]
Prevention
Infection: Infection Prevention and Control Guidance for Management in Acute Care Settings (2013 update) Clostridium difficile : Infection Prevention and Control Guidance for Management in Long-term Care Facilities (2013) Infectious Diseases Society of [ecdc.europa.eu]
How can Clostridium difficile transmission be prevented in hospitals and other health care settings? Frequent hand washing (with soap and water) is an effective way to prevent the spread of the bacteria. [ccohs.ca]
If you cannot drink enough fluids to prevent dehydration, call your doctor. How Do I Prevent It? Thoroughly cook foods, particularly meat, poultry, and gravies, to a safe internal temperature. [foodsafety.gov]
Prevention The most important measure to prevent the emergence of new strains of C. difficile in Australia is reducing the unnecessary use of antibiotics, especially those known to be closely linked to CDI. [sahealth.sa.gov.au]