Edit concept Question Editor Create issue ticket

Clostridium Botulinum


Presentation

  • We present an unusual case of wound botulism in a pediatric patient with the intent to inform the reader and improve the time to diagnosis in such cases.[ncbi.nlm.nih.gov]
  • This is the case report of a male heroin user who presented three times to an Emergency Department in the UK before a diagnosis of wound botulism was made and treatment commenced.[ncbi.nlm.nih.gov]
  • A slight improvement may also have occurred while toxin was still present in the serum.[ncbi.nlm.nih.gov]
  • Five plasmids, constituting 13.5% of the total genetic material, were present in the completed genome. Interestingly, the set of plasmids differed compared to other isolates.[ncbi.nlm.nih.gov]
  • Abstract A low molecular weight substance that induced seizures and death in mice was present in the stool of a child with infant botulism. This interfered with mouse bioassay used for detecting Clostridium botulinum toxin.[ncbi.nlm.nih.gov]
Labored Breathing
  • Typical botulism signs in mice begin usually in the first 24 h with ruffling of fur, followed in sequence by labored breathing, weakness of limbs, and finally total paralysis with gasping for breath, followed by death due to respiratory failure.[fda.gov]
Dysphasia
  • […] controlling the head Weak cry Irritability Drooling Drooping eyelids Tiredness Difficulty sucking or feeding ParalysisBeneficial effects of botulinum toxin: Purified botulinum toxin is diluted by a physician for treatment: Congenital pelvic tilt Spasmodic dysphasia[en.wikipedia.org]

Workup

HLA-DR3
  • We found that (i) Btx and thyroid autoantigens share amino acid sequence homology; (ii) some homologous regions contain epitopes of both Btx and thyroid autoantigens; (iii) some of such regions contain HLA-DR3 and/or HLA-DR7 binding motifs, which predominate[ncbi.nlm.nih.gov]
HLA-DR7
  • We found that (i) Btx and thyroid autoantigens share amino acid sequence homology; (ii) some homologous regions contain epitopes of both Btx and thyroid autoantigens; (iii) some of such regions contain HLA-DR3 and/or HLA-DR7 binding motifs, which predominate[ncbi.nlm.nih.gov]

Treatment

  • For phase 1, none of the treatments (equilibrated pH 5.8) supported toxin production when stored at 25 C for 48 h, but toxin production was observed in all treatments at 72 h.[ncbi.nlm.nih.gov]
  • The duration and variability of times for germination, outgrowth and first doubling depended on both the historic treatment of the spores and the prevailing growth conditions, and the stage of lag most affected was treatment dependant.[ncbi.nlm.nih.gov]
  • This is the case report of a male heroin user who presented three times to an Emergency Department in the UK before a diagnosis of wound botulism was made and treatment commenced.[ncbi.nlm.nih.gov]
  • The initial contamination of raw materials, effect of thermal treatment on microbial inactivation and spore inhibition were handled mathematically using a probabilistic framework, considering only the variability dimension.[ncbi.nlm.nih.gov]
  • Treatment of cells with FK506 protected cultured cells from intoxication with C2 toxin.[ncbi.nlm.nih.gov]

Prognosis

  • A long incubation time was associated with a better prognosis. Although botulism is a potentially fatal disease, there was no mortality in this outbreak.[doi.org]
  • Metronidazole is currently recommended, and there is some evidence that it is associated with an improved prognosis.[ncbi.nlm.nih.gov]

Etiology

  • Identification of the etiologic agent from outbreak samples is laborious using conventional microbiological methods and the neurotoxin mouse bioassay.[ncbi.nlm.nih.gov]
  • Botulinum in blood and feces may be worthwhile in determining the etiology of unexplained deaths.[ncbi.nlm.nih.gov]
  • Abstract Clostridium botulinum is the etiological agent of botulism.[ncbi.nlm.nih.gov]
  • C. botulinum is the etiologic agent of botulism, a rare but severe neuroparalytic disease. Fine-resolution genetic characterization of C. botulinum isolates of any BoNT type is relevant for both epidemiological studies and forensic microbiology.[ncbi.nlm.nih.gov]
  • Of these, 20 were foodborne, 102 infant, 13 wound, and 5 of unknown or other etiology (CDC 2013). Then, in 2014 there were 161 confirmed and 16 probable cases of botulism reported.[edis.ifas.ufl.edu]

Epidemiology

  • Epidemiologically linked isolates had indistinguishable patterns, except in four instances and there were no obvious geographic trends noted.[ncbi.nlm.nih.gov]
  • We established a multiplex PCR assay for BoNT/B subtyping which will be useful for epidemiological studies of type B strains and the infectious diseases that they cause.[ncbi.nlm.nih.gov]
  • KEYWORDS: C. sporogenes; Duck liver; Epidemiological data; Microbial distribution; Risk-based approach; Thermal recovery[ncbi.nlm.nih.gov]
  • Author information 1 Institute for Medical Microbiology and Epidemiology of Infectious Diseases, University Hospital of Leipzig, Leipzig, Germany. acr@medizin.uni-leipzig.de Abstract Although botulism is usually an acute, often lethal disease that is[ncbi.nlm.nih.gov]
  • Previous epidemiologic and laboratory studies have shown that infant botulism results from the ingestion of spores of Clostridium botulinum that subsequently germinate in the infant intestine and produce botulinal toxin.[ncbi.nlm.nih.gov]
Sex distribution
Age distribution

Pathophysiology

  • However, the characteristic pattern of dysautonomia has not been clearly documented and its pathophysiologic basis is not known.[ncbi.nlm.nih.gov]
  • Pathophysiology The mechanism of action involves toxin-mediated blockade of neuromuscular transmission in cholinergic nerve fibers.[emedicine.medscape.com]
  • Tetanus: pathophysiology, management, and prophylaxis. Disease-A-Month. 1991; 37 :545. [ PubMed : 1874121 ] Coffield JA, Considine RV, Simpson LL. Clostridial neurotoxins in the age of molecular medicine.[ncbi.nlm.nih.gov]

Prevention

  • Centers for Disease Control and Prevention (CDC). 2016a. “CSTE Botulism Surveillance Summary 2014.” Accessed March 7, 2017. . Centers for Disease Control and Prevention (CDC). 2015.[edis.ifas.ufl.edu]
  • Using a risk-based approach, when the total outcome of controlling initial levels (H(0)), reducing levels (ΣR), and preventing an increase in levels (ΣI) is less than or equal to the target FSO, the product is considered safe.[ncbi.nlm.nih.gov]
  • Author information 1 Enteric Diseases Laboratory Branch, Centers for Disease Control and Prevention, 1600 Clifton Road, MS G-29, Atlanta, GA, 30329, USA, CLuquez@cdc.gov.[ncbi.nlm.nih.gov]
  • Prevention of Botulism Since botulism poisoning most commonly comes from foods improperly canned at home, the most important step in preventing botulism is to follow proper canning procedure.[foodborneillness.com]

Ask Question

5000 Characters left Format the text using: # Heading, **bold**, _italic_. HTML code is not allowed.
By publishing this question you agree to the TOS and Privacy policy.
• Use a precise title for your question.
• Ask a specific question and provide age, sex, symptoms, type and duration of treatment.
• Respect your own and other people's privacy, never post full names or contact information.
• Inappropriate questions will be deleted.
• In urgent cases contact a physician, visit a hospital or call an emergency service!