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Clostridium Perfringens

Clostridium Plagarum


Presentation

  • One infant presented moderate T activation and two infants presented very strong T activation but only moderate decreases in sialic acid expression on the RBC membrane.[ncbi.nlm.nih.gov]
  • We also present a literature review of Clostridial brain abscesses since the 1960s. CLINICAL PRESENTATION: A 53-year-old man was brought to the emergency room after having a witnessed seizure status postassault 3 days before admission.[ncbi.nlm.nih.gov]
  • We present images demonstrating the salient features of the peripheral blood smear in cases of this uncommon but deadly cause of hemolysis.[ncbi.nlm.nih.gov]
  • The present study evaluated the antimicrobial effects of Bacillus subtilis ATCC 6633 and its metabolite on the enterotoxin and vegetative cells, spore and germinated spore of Clostridium perfringens type A in Caco-2 cells.[ncbi.nlm.nih.gov]
  • In this report, a patient was presented with an early diagnosis of Emphysematous Cholecystitis and was treated by cholecystectomy without complications. A 46-year-old male presented at the emergency department.[ncbi.nlm.nih.gov]
Weakness
  • CASE REPORT: The case of a 39-year-old woman with a history of chronic corpuscular hemolytic anemia, experiencing weakness, pallor, somnolence is presented. Hypothermia and an acute paranoid psychotic episode subsequently developed in the hospital.[ncbi.nlm.nih.gov]
  • On presentation, he was febrile, disoriented, lethargic, and demonstrated right upper extremity weakness.[ncbi.nlm.nih.gov]
  • The infant with botulism is typically afebrile with generalized weakness, a weak cry, pooling of oral secretions, and poor sucking ability. Constipation may precede the illness by several weeks.[ncbi.nlm.nih.gov]
Hyperthermia
  • Along with these findings, hyperthermia 3h postmortem, and severe anemia and thrombocytopenia without an obvious site of hemorrhage suggested hemolysis due to Cl. perfringens septicemia.[ncbi.nlm.nih.gov]
Aspiration
  • Abstract It is generally accepted that the surgical treatment of pancreatic necrosis should be delayed as long as possible and after there is laboratory confirmation of infection, determined by image guided fine-needle aspiration.[ncbi.nlm.nih.gov]
  • The case of a 76-year-old man with cystic pancreatic lesions in which sepsis developed after endoscopic ultrasound with fine-needle aspiration biopsy is described. The sepsis was managed with pancreatic resection and antibiotics.[ncbi.nlm.nih.gov]
  • An image-guided fluid aspiration revealed Clostridium perfringens as the causative organism. She was treated by placement of large bore drains along with irrigation and targeted intravenous antibiotic for 6 weeks.[ncbi.nlm.nih.gov]

Workup

  • During his ED workup, the patient became more pale and jaundiced and began to produce bright red urine. The authors suspected that his hemolyzed blood samples were not due to blood draw artifact, but to intravascular hemolysis.[mdedge.com]
Pneumoperitoneum
  • Radiologic assessment showed pneumoperitoneum. Urgent exploratory laparotomy revealed significant amount of gas and no bowel perforation. However, right retroperitoneal gas collection was noted and drained.[ncbi.nlm.nih.gov]
Pancreatic Necrosis
  • Abstract It is generally accepted that the surgical treatment of pancreatic necrosis should be delayed as long as possible and after there is laboratory confirmation of infection, determined by image guided fine-needle aspiration.[ncbi.nlm.nih.gov]
  • Cross-sectional imaging was consistent with infected pancreatic necrosis and also revealed a large collection located in the anterior pararenal space with extensive gas formation.[ncbi.nlm.nih.gov]

Treatment

  • […] and intracellular localization after C-CPE treatment.[ncbi.nlm.nih.gov]
  • At the moment, the treatment of clostridial infections is based on use of antibiotics.[ncbi.nlm.nih.gov]
  • Treatment was based on preoperative antibiotic treatment combined with cholecystectomy. This resulted in early clinical improvement of the patient and normalization of infection parameters.[ncbi.nlm.nih.gov]
  • Early recognition and aggressive treatment is necessary to avoid this outcome.[ncbi.nlm.nih.gov]
  • RESULTS: We used flow cytometry and MTT assays to evaluate the cytotoxicity effect of treatments.[ncbi.nlm.nih.gov]

Prognosis

  • Despite these therapeutic options, the prognosis of CNS and neuromuscular involvement in an infection with C. perfringens is still poor.[doi.org]
  • Sepsis due to C. perfringens has a very poor prognosis if not detected early.[medintensiva.org]
  • Metronidazole is currently recommended, and there is some evidence that it is associated with an improved prognosis.[ncbi.nlm.nih.gov]

Etiology

  • Abstract There is usually enough time for identifying the etiology of calculous cholestasis and cholangitis by imaging and laboratory investigations, provided that antimicrobial drug therapy is started immediately after collection of blood cultures and[ncbi.nlm.nih.gov]
  • We report the case of an autistic patient who presented to our emergency department with a distended abdomen and hemolysis of unknown etiology. The patient had no history of recent surgery. Exploration of the abdomen revealed a hepatic abscess.[ncbi.nlm.nih.gov]
  • […] established clostridial diseases of the gastrointestinal tract, including the more recent observations with respect to the mechanisms of action and to critically review the data available which implicate clostridia in the gastrointestinal diseases of unknown etiology[books.google.it]
  • The evidence presented in this communication will facilitate the epidemiological, etiological, and toxicological studies of C. perfringens food poisoning, and also stimulate studies on the transfer of the toxins' gene(s) among the Genus Clostridium.[ncbi.nlm.nih.gov]
  • CONCLUSION: Anti-T antibodies are unlikely to be the etiologic factor for the hemolytic reactions observed in infants with NEC and T activation. Massive RBC desialylation and the direct action of bacterial toxins are more probable causes.[ncbi.nlm.nih.gov]

Epidemiology

  • KEYWORDS: Clostridium perfringens; epidemiology; food poisoning; outbreaks[ncbi.nlm.nih.gov]
  • Previous studies have looked at the epidemiological relationship between C. perfringens isolates from outbreak source.[ncbi.nlm.nih.gov]
  • Epidemiology of the causative organism varied over time, but anaerobes are still extremely rare. We describe a second reported case of Clostridium perfringens peritonitis in a peritoneal dialysis patient since 1998.[ncbi.nlm.nih.gov]
  • CONCLUSIONS: The study confirmed the usefulness of MALDI-TOF method in rapid identi- fication of anaerobic bacteria C. perfringens and thereby its applicability epidemiological investigations.[ncbi.nlm.nih.gov]
  • Epidemiological evidence can be used to help prosecute businesses with food safety offences in such circumstances. The Author 2015. Published by Oxford University Press on behalf of Faculty of Public Health. All rights reserved.[ncbi.nlm.nih.gov]
Sex distribution
Age distribution

Pathophysiology

  • Abstract Infectious factors are taken into consideration in pathophysiology of autism spectrum disorders (ASD). ASD patients often suffer from gastrointestinal disorders.[ncbi.nlm.nih.gov]
  • A focus is drawn towards CPE, the interaction with its receptors, cellular, and pathophysiological consequences for the intestinal epithelium.[ncbi.nlm.nih.gov]
  • ., fibroblasts, are unaffected by pathophysiologically relevant CPE concentrations in vitro However, both CPE-insensitive and CPE-sensitive host cells are present in vivo Therefore, this study tested whether CPE treatment might affect fibroblasts when[ncbi.nlm.nih.gov]
  • Importantly, C. perfringens strains are known to secrete 20 identified toxins or enzymes that could potentially be the principal virulence factors involved in pathophysiology 6 Revitt-Mills, S. A., Rood, J. I. & Adams, V.[doi.org]
  • Tetanus: pathophysiology, management, and prophylaxis. Disease-A-Month. 1991; 37 :545. [ PubMed : 1874121 ] Coffield JA, Considine RV, Simpson LL. Clostridial neurotoxins in the age of molecular medicine.[ncbi.nlm.nih.gov]

Prevention

  • Pretreatment of Ib with α-defensin-1 prior to addition of Ia prevented intoxication.[ncbi.nlm.nih.gov]
  • Outbreaks caused by C. perfringens occur regularly, are often large, and can cause substantial morbidity yet are preventable if contamination of raw meat and poultry products is prevented at the farm or slaughterhouse or, after contamination, if these[ncbi.nlm.nih.gov]
  • Therefore, more actions should be taken on the surveillance, prevention, and control of wild pig-borne diseases. KEYWORDS: Clostridium perfringens; enterotoxin; phylogenetic analysis; wild boar[ncbi.nlm.nih.gov]
  • In this study, a human single chain antibody against alpha-toxin was produced from synthetic (Tomlinson I J) naive phage display libraries, and its preventive and therapeutic efficacy in mice was examined.[ncbi.nlm.nih.gov]

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