The lack of TscL likely explains the positive outcome and absence of TSS-like presentation in these cases. [ncbi.nlm.nih.gov]

C. sordellii, a pathogen that is infrequently found in humans, has a broad spectrum of clinical presentations. [academic.oup.com]

Mortality correlated with both shock and leukemoid reaction at presentation. We present a case of C. sordellii sepsis in an asplenic patient with sickle beta thalassemia and inflammatory bowel disease, and we review the literature. [pubmed.ncbi.nlm.nih.gov]

The patient presented with dehydration, vomiting, and bloody diarrhea. He was transferred to the pediatric critical care unit (PICU) for initiation of peritoneal dialysis (PD). [hindawi.com]

• Sepsis

  Is capable of causing pneumonia, endocarditis, arthritis, peritonitis and myonecrosis, bacteremia and sepsis occur rarely. Most cases of sepsis from C. sordellii occur in patients with underlying conditions. [microbe-canvas.com]

  C. sordellii bacteremia and sepsis occur rarely. Most cases of sepsis from C. sordellii occur in patients with underlying conditions. [en.wikipedia.org]

  Keywords : Clostridium sordellii; sepsis; bacteremia; intraabdominal neoplasm. [scielo.org.co]

• Gangrene

  Gas gangrene: a study of 96 cases treated in an evacuation hospital, JAMA, 1945, vol. 128 (pg. 783 - 92 ) 11,. Prevention and treatment of gas gangrene, JAMA, 1971, vol. 217 (pg. 806 - 1 ) 12 ., ,. [academic.oup.com]

  Amj Obstet Gynecol. 1979; 134: 173-179 PubMed Google Scholar Altemeier WA Fuller VD Prevention and treatment of gas gangrene. [ajog.org]

  At necropsy, acute gangrenous myositis was the primary lesion. Serohemorrhagic edema was observed in the abdominal cavity, thorax, pericardium, and skeletal muscle, mostly affecting femoral, humeral, and scapular muscles. [digital.csic.es]

  J Clin Pathol. 1984; 37: 335-343 Scopus (68) PubMed Crossref Google Scholar Arseculeratne SN Panabokke RG Wijesundera S The toxins responsible for the lesions of Clostridium sordellii gas gangrene. [journalofinfection.com]

  […] of Clostridium sordellii (MLD 150 ng/kg) is one of the most potent Clostridial toxins and is responsible for most of the diseases including sudden death syndrome in cattle, sheep and toxic shock syndrome, necrotizing faciitis, neonatal omphalitis and gangrene [eurekaselect.com]

• Wound Infection

  Strains with the capacity to produce LT and HT have been associated with puerperal wound infections that are accompanied by anasarca and a clinical picture of septic shock. [taylorfrancis.com]

  Can J Microbiol. 1976; 22: 673-676 Scopus (9) PubMed Crossref Google Scholar Meleney FL Mumphreys FB Carp L An unusual fatal operative wound infection yielding a pathogenic anaerobe of the gas gangrene group not hitherto described. [journalofinfection.com]

• Acute Onset of Symptoms

  The acute onset of symptoms and death occurs before many diagnostic tests have been performed. C. sordellii can be treated with antibiotics, but many hospital laboratories do not perform antimicrobial susceptibility tests on anaerobes [1]. [microbewiki.kenyon.edu]

• Intravenous Drugs

  Resultant mortality from infection is estimated at nearly 70% and is most often correlated with gynaecological procedures, intravenous drug abuse or trauma. [ncbi.nlm.nih.gov]

• Pneumonia

  Is capable of causing pneumonia, endocarditis, arthritis, peritonitis and myonecrosis, bacteremia and sepsis occur rarely. Most cases of sepsis from C. sordellii occur in patients with underlying conditions. [microbe-canvas.com]

  Clostridium sordellii (Hall and Scott, 1927) Prévot, 1938 Bacillus sordellii Hall and Scott, 1927 (not validly published) Paeniclostridium sordellii is a rare anaerobic, gram-positive, spore-forming rod with peritrichous flagella that is capable of causing pneumonia [en.wikipedia.org]

  Transmission of C. sordellii infection What CDC is doing Additional Information General Information about C. sordellii Clostridium sordellii [klaw–strĭ–dee–um sore–dell–ee–i] (also called C. sordellii) is a rare bacterium that causes pneumonia, endocarditis [cdc.gov]

  Am J Obstet Gynecol. 1979; 134: 173-179 Scopus (31) PubMed Abstract Full Text PDF Google Scholar File Jr, TM Fass RJ Perkins RL Pneumonia and empyema caused by Clostridium sordellii. [journalofinfection.com]

• Nausea

  Symptoms of C. sordellii infection Symptoms of a C. sordellii infection include nausea, vomiting, diarrhea, and sometimes abdominal pain without fever. [cdc.gov]

  Gynecological patients usually seek treatment with nonspecific symptoms, such as malaise, low or absent fever, nausea, and pain at the infection site. [ncbi.nlm.nih.gov]

• Abdominal Pain

  Most of their signs and symptoms were typical of sepsis and TSS: tachycardia, hypotension, leukocytosis, hemoconcentration, weakness, vomiting, abdominal pain, and diarrhea. [nursingcenter.com]

  Five days after taking oral mifepristone, the patient presented to an emergency department with abdominal pain. [journals.lww.com]

  Symptoms of C. sordellii infection Symptoms of a C. sordellii infection include nausea, vomiting, diarrhea, and sometimes abdominal pain without fever. [cdc.gov]

  In August 2001, a 26-year-old, previously healthy woman was hospitalized because of abdominal pain, vomiting, and foul-smelling vaginal discharge. [academic.oup.com]

  Five days after receiving mifepristone, she presented to a local emergency department reporting nausea, vomiting, diarrhea, and severe abdominal pain. [nejm.org]

• Hypotension

  Treatment is mainly supportive in regard to hypotension and cardiovascular strain. [hindawi.com]

  Clinical findings included tachycardia, hypotension, edema, hemoconcentration, profound leukocytosis, and absence of fever. [nejm.org]

  In addition, a fatal case of C. sordellii toxic shock syndrome after medical abortion with mifepristone and misoprostol was reported in 2001, in Canada.2 All three cases of C. sordellii infection were notable for lack of fever, and all had refractory hypotension [jamanetwork.com]

• Arthritis

  Is capable of causing pneumonia, endocarditis, arthritis, peritonitis and myonecrosis, bacteremia and sepsis occur rarely. Most cases of sepsis from C. sordellii occur in patients with underlying conditions. [microbe-canvas.com]

  Scott, 1927) Prévot, 1938 Bacillus sordellii Hall and Scott, 1927 (not validly published) Paeniclostridium sordellii is a rare anaerobic, gram-positive, spore-forming rod with peritrichous flagella that is capable of causing pneumonia, endocarditis, arthritis [en.wikipedia.org]

  Transmission of C. sordellii infection What CDC is doing Additional Information General Information about C. sordellii Clostridium sordellii [klaw–strĭ–dee–um sore–dell–ee–i] (also called C. sordellii) is a rare bacterium that causes pneumonia, endocarditis, arthritis [cdc.gov]

  Am J Med. 1987; 83 : 605 Scopus (14) PubMed Abstract Full Text PDF Google Scholar Spindler AJ Musa H Clostridium sordellii septic arthritis. [journalofinfection.com]

• Suggestibility

  The results suggest that toxins B and LT have diverged more than toxins A and HT. Immunoblotting with antibodies to the toxins of C. difficile showed that toxins HT and LT had common antigenic determinants. [microbiologyresearch.org]

  Current literature suggests treating C. sordelli infection with a broad-spectrum penicillin, metronidazole and clindamycin. [ncbi.nlm.nih.gov]

  Numerous case studies suggest that the incubation of C. sordellii after infection is 1 to 5 days [5][6]. Around the 5th or 6th day of infection the microorganism is fatal to the host. [microbewiki.kenyon.edu]

  We suggest that localized infection with toxin-producing strains of C. sordellii can produce a rapidly lethal toxic shock-like syndrome. Further study and earlier recognition of this syndrome may be life-saving in other patients. [ajog.org]

  This could explain the mechanism of the suggested bacterial translocation in our patient. [hindawi.com]

• Vulvar Edema

  Obstet Gynecol. 1986; 68: 26-28 Google Scholar Scott WC Ewing TL Smale LE Elliott FA Maternal deaths associated with postpartum vulvar edema. [ajog.org]

  Am J Clin Pathol. 1989; 91: 104-106 PubMed Google Scholar Ewing TL Smale LE Elliott FA Maternal deaths associated with postpartum vulvar edema. [journalofinfection.com]

  Maternal deaths associated with postpartum vulvar edema. Am J Obstet Gynecol 1979;134:173-179 27. Shy KK, Eschenbach DA. Fatal perineal cellulitis from an episiotomy site. Obstet Gynecol 1979;54:292-298 28. Nakamura S, Yamakawa K, Nishida S. [nejm.org]

• Colitis

  A report of a case of Clostridium sordellii bacteraemia arising from the gastrointestinal tract in a patient with urological malignancy and radiation colitis. [journalofinfection.com]

  Infect Immun. 1988; 56: 1215-1221 PubMed Crossref Google Scholar Rifkin GD Fekety FR Silva J Sack RB Antibiotic induced colitis: implication of a toxin neutralized by Clostridium sordellii antitoxin. [ajog.org]

  Some species have been isolated from women with bacterial vaginosis.[3] Species[edit] Notable species of this class include: Clostridium perfringens (gangrene, food poisoning) Clostridioides difficile (pseudomembranous colitis) Clostridium tetani (tetanus [en.wikipedia.org]

  We report a unique case of a new strain of Clostridium sordellii (not present in the Center for Disease Control (CDC) database) infection induced toxic shock syndrome in a previously healthy two-year-old male with colitis-related hemolytic uremic syndrome [hindawi.com]

At this time, vancomycin and clindamycin were added to her treatment regimen. [ncbi.nlm.nih.gov]

Beyond the presence of TcsL, several factors play an important role in overall prognosis, specifically, the site and nature of infection, immunocompromised state and antimicrobial resistance. [ncbi.nlm.nih.gov]

Clostridium sordellii bacteriemia is infrequent and usually comes from infections of gynecological and puerperal etiology, with mortality near 70%. There are few tools for rapid and timely diagnosis. [scielo.org.co]

From: cid.oxfordjournals.org [2] Etiology/Bacteriology Taxonomy | Domain = Bacteria | Phylum = Firmicutes | Class = Clostridia | Order = Clostridiales | Family = Clostridiaceae | Genus = Clostridium | species = Clostridium sordellii Description Clostridium [microbewiki.kenyon.edu]

Clostridium sordellii infection: epidemiology, clinical findings, and current perspectives on diagnosis and treatment. Clin Infect Dis 2006;43:1436–1446.CrossRefGoogle ScholarPubMed 2.Popoff, MR. [cambridge.org]

Stevens; Clostridium sordellii Infection: Epidemiology, Clinical Findings, and Current Perspectives on Diagnosis and Treatment; Clinical Infectious Diseases 2006; 43:1436-46 ^ Miech RP. [en.wikipedia.org]

What CDC is doing CDC experts in microbiology, epidemiology, and perinatology (pregnancy-related complications) are working together with state and local health agencies and the FDA in the investigation of recent deaths associated with C. sordellii. [cdc.gov]

Pathophysiology of mifepristone-induced septic shock due to Clostridium sordellii. Ann Pharmacother 2005; 39:1483-8 ^ Nakamura S, Yamakawa K, Nishida S. Antibacterial susceptibility of Clostridium sordellii strains. [en.wikipedia.org]

Pathophysiology of mifepristone-induced septic shock due to Clostridium sordellii. Ann Pharmacother 2005;39:1483–8. Cited Here 31. Golde S, Ledger WJ. Necrotizing fasciitis in postpartum patients. A report of four cases. [journals.lww.com]

Pathophysiology of mifepristone-induced septic shock due to Clostridium sordellii. Ann Pharmacother 2005;39:1483-1488 38. Kruse B, Poppema S, Creinin MD, Paul M. Management of side effects and complications in medical abortion. [nejm.org]

Prevention Prevention of a Clostridium sordellii infection is difficult with so little known about the transmission of the disease. [microbewiki.kenyon.edu]

Prevention and treatment of gas gangrene, JAMA, 1971, vol. 217 (pg. 806 - 1 ) 12 ., ,. [academic.oup.com]

Unsafe abortion: the preventable pandemic. Lancet. 2006; 368: 1908-1919 7. Grimes DA Unsafe abortion: the silent scourge. Br Med Bull. 2003; 67: 99-113 8. Bearak J Popinchalk A Ganatra B et al. [thelancet.com]

The Centers for Disease Control and Prevention (CDC) estimates that up to 29% of women who've undergone a medical abortion test positive for C. sordellii in vaginal fluid, compared with only 5% to 10% of women who aren't pregnant.1 (No figures are available [nursingcenter.com]

Older reports suggested that total hysterectomy32 or surgical debridement5 is necessary to remove necrotic tissue and prevent death in cases of C perfringens infection. [journals.lww.com]