Presentation
Most patients initially presented with advanced FIGO stage: 9 stage IVB, 4 stage IIIC, 4 stage IIIA, 2 stage IB, and 1 stage IA. [ncbi.nlm.nih.gov]
Tumor models are also presented, which utilize expression data, pathway sensitivity, and genetic abnormalities, representing targets in cancer. [books.google.es]
Entire Body System
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Fatigue
In the AURA3 trial, the most common ( 20%) adverse reactions observed in osimertinib-treated patients were diarrhea (41%), rash (34%), dry skin (23%), nail toxicity (22%), and fatigue (22%). Dr. [astrazeneca-us.com]
It’s weakness, not fatigue or pain, that you’re looking for.” 4. Balance problems Many cancers that spread to the brain occur in the back of the brain (cerebellum), which controls balance. [cityofhope.org]
The fatigue is not generally associated with wanting to sleep, but has more to do with feeling too exhausted mentally to initiate any planned action. At times, even thinking about doing something can be exhausting. [nursingtimes.net]
Healthy Lifestyles Physical Activity Nutrition and Weight Management Supplement Use Immunizations and Infections Late Effects/Long-Term Psychosocial and Physical Problems Anthracycline-Induced Cardiac Toxicity Anxiety and Depression Cognitive Function Fatigue [nccn.org]
Sudden visual loss and fatigue may be seen with bleeding into or infarction of pituitary tumors, termed pituitary apoplexy. [cancernetwork.com]
Neurologic
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Headache
She presented with headaches, obtundation, and brain herniation, and suffered sudden death 12 months after completing high-dose chemotherapy. [ncbi.nlm.nih.gov]
Suzanne ; Fenech, Thomas ; Debono, Patricia Date: 2015 Abstract: A fifty-eight year old male patient presented to the ophthalmic department with a 3 day history of reduced visual acuity, blurred vision and floaters, associated with recent lethargy, headaches [um.edu.mt]
Headaches are the most common symptom of cerebral disease. Diplopia is the most common cranial nerve symptom. Imaging Gadolinium-enhanced MRI is the modality of choice for both cranial and spinal sites. [rtnotes.wikidot.com]
"Progressive headaches are not a typical headache or migraine that we are accustomed to. These types of headaches get worse, continue for days and won’t go away. [cityofhope.org]
The headache was slightly relieved during the treatment. On January 14, 2014, the headache worsened and was accompanied by projectile vomiting, numbness, and pain in the right limb and shoulder. [dovepress.com]
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Dizziness
Signs and symptoms of brain metastases include: Headache, sometimes with vomiting or nausea Mental changes, such as increasing memory problems Seizures Dizziness When to see a doctor Make an appointment with your doctor if you have persistent signs and [mayoclinic.org]
Patients may experience hearing loss on one side, ringing in the ears, dizziness, facial numbness, tingling or headaches. [uchospitals.edu]
Other effects from use and misuse can include: slurred speech poor concentration confusion headache light-headedness dizziness dry mouth problems with movement and memory lowered blood pressure slowed breathing If a person takes CNS depressants long term [drugabuse.gov]
Case report A 45-year-old female patient (surface area:1.72) sought treatment on November 5, 2012 due to gradually aggravated dizziness and headaches for 1 week. [dovepress.com]
Check with your displacing if any of these most common profel burgers nanocochleate or repopulate bothersome: agenesis pain; pulmonic eyes; superseded vision; cough; dizziness; ductal eyes; prejudice discomfort; immaturity that nod is in your eye; headache [almoonshowerko81.blogspot.com]
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Memory Impairment
Case 6: Prognostic considerations A 78-year-old man who resides in a nursing home due to memory impairment undergoes evaluation for recurrent falls. [intechopen.com]
Workup
A systemic workup including bone marrow biopsy and cerebrospinal fluid (CSF) analysis was done. Bone marrow was positive for tumor deposits of malignant round cells. [ijo.in]
Full blood cell count and workup for infectious diseases yielded negative results. Magnetic resonance imaging of the brain and orbit showed diffuse thickening and enhancement of the right optic nerve and meninges ( Figure 1 A and B). [jamanetwork.com]
As part of the initial workup for the trial, she received a chest x-ray which showed small nodular opacities in the bilateral lungs. [omicsonline.org]
Many patients with BM diagnosed elsewhere do not opt for further workup and treatment at all after learning about the dismal prognosis of their condition. The poor economic status of most patients could be the main reason for this. [neurologyindia.com]
Moreover, high-grade meningiomas may show positivity for various cytokeratins, further complicating the diagnostic workup. [surgicalneurologyint.com]
X-Ray
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Mediastinal Mass
CT thorax showed mediastinal mass while hypodense mass was seen in right parietal convexity of brain in CT brain. [casereports.in]
Treatment
The standard treatment for multiple brain lesions remains whole-brain radiation for symptom control, with no improvement in survival. [ncbi.nlm.nih.gov]
Treatment Goals “Our treatment goals are to prolong survival, palliate neurologic symptoms, and prevent symptom progression. [ascopost.com]
Prognosis
Background Leptomeningeal metastasis (LM) is associated with grave prognosis in breast cancer (BC) and can be treated with ventriculoperitoneal shunt (VPS). [oncologypro.esmo.org]
This volume mainly contains information on the diagnosis, therapy, and prognosis of brain tumors. Insights on the understanding of molecular pathways involved in tumor biology are explained, which should lead to the development of effective drugs. [books.google.es]
Other risk factors related to CNSL prognosis were also analyzed. sVCAM-1Serum and CCL2Serum/CSF were significantly higher in the CNSL group than in the non-CNSL group and the controls (p 0.05). [ncbi.nlm.nih.gov]
Patients with brain metastases of solid tumors have a poor prognosis, despite improvements in survival achieved with modern neurosurgical and radiation techniques. [clinicaltrials.gov]
Etiology
Expert Perspective In an immunocompetent host, the differential diagnosis of isolated or multiple brain lesion(s) includes autoimmune etiologies such as neurosarcoidosis, multiple sclerosis, and acute disseminated encephalomyelitis; and neoplastic etiologies [ascopost.com]
Etiology and Risk Factors The cause of primary brain tumors is unknown, although genetic and environmental factors may contribute to their development. [cancernetwork.com]
The clinical presentation and the patient’s history of extrapulmonary tuberculosis involving the genitourinary tract suggested the possibility of disseminated tuberculosis as the etiology for the patient’s brain and spinal cord lesions; however, in light [ajnr.org]
Epidemiology
JAMA 2003;289:2849-2856 Gavrilovic IT, Posner JB: Brain metastases: epidemiology and pathophysiology. [karger.com]
Epidemiologic considerations". Neurology. 22 (1): 40–8. doi:10.1212/WNL.22.1.40. PMID 5061838. Walker AE, Robins M, Weinfeld FD (February 1985). "Epidemiology of brain tumors: the national survey of intracranial neoplasms". [en.wikipedia.org]
The descriptive epidemiology of obsessive-compulsive disorder. Prog Neuropsychopharmacol Biol Psychiatry. 2006 ; 30 ( 3 ): 327 – 337. Epub ahead of print Jan 18. 3. American Psychiatric Association. [cambridge.org]
Performance of specific immunohistochemical, molecular, or other assays will be determined using clinical and epidemiologic information provided by the submitter and the histopathologic features identified in the submitted tissue specimens. [cdc.gov]
Cutaneous malignant melanoma - Clinical epidemiology and survival. J Indian Med Assoc 1998;96:19-20, 28. 15. Srodon M, Westra WH. [ijpmonline.org]
Pathophysiology
Much needs to be learned about the pathophysiology of CNS metastasis at a molecular level. [clincancerres.aacrjournals.org]
JAMA 2003;289:2849-2856 Gavrilovic IT, Posner JB: Brain metastases: epidemiology and pathophysiology. [karger.com]
Methods A review of the literature on brain metastases was conducted, focusing on the pathophysiology and clinical aspects of the disease. [jns-journal.com]
Brain metastases: eEpidemiology and pathophysiology. J Neurooncol. 2005;75:5–14. [PubMed] [Google Scholar] 9. Salvati M, Frati A, Russo N, Brogna C, Piccirilli M, D’Andrea G, et al. Brain metastasis from prostate cancer. [ncbi.nlm.nih.gov]
Prevention
Areas for future research include the need for an understanding of site-specific metastasis, effective anticancer strategies for sanctuary sites, assays to detect drug accumulation in sanctuary sites, prevention of CNS metastasis, improving the therapeutic [ncbi.nlm.nih.gov]
This led to the use of prophylactic cranial irradiation, which was effective in preventing CNS relapse in ALL. [clincancerres.aacrjournals.org]
If the drug seems to be working for a subject's tumor, subject will have the option to continue to receive it as part of a continuation study looking at the drug effect on preventing the tumor from recurring. [clinicaltrials.gov]