Edit concept Question Editor Create issue ticket

Coagulation Abnormalities

Abnormality of Coagulation


Presentation

  • PRINCIPAL FINDINGS: In the present work, we demonstrate a consistent procoagulant profile on 40 reactional and non-reactional multibacillary leprosy patients.[ncbi.nlm.nih.gov]
  • Abstract A 6-year-old male patient presented with Budd-Chiari syndrome and glycoprotein abnormalities associated with carbohydrate deficient glycoprotein syndrome type I with yet unidentified molecular defect (type Ix).[ncbi.nlm.nih.gov]
  • In one of these, abnormalities frequently found in association with acute hepatic failure were present. Disseminated intravascular coagulation was noted in two, while in the fourth child laboratory data were most consistent with that process.[ncbi.nlm.nih.gov]
  • The aim of the present work was to study some coagulation parameters in the Egyptian children with type 1 Gaucher disease. Five newly diagnosed patients and another 5 patients on enzyme replacement therapy (ERT) were enrolled in the study.[ncbi.nlm.nih.gov]
  • Collection includes both citations and many full-text, downloadable documents from mid-1900s to present. AULIMP - Air University Library Index to Military Periodicals.[dtic.mil]
Massive Splenomegaly
  • Abstract In type 1 Gaucher disease a bleeding tendency occurs which is partly caused by thrombocytopenia due to massive splenomegaly. In addition, low levels of factors IX and XI have been described.[ncbi.nlm.nih.gov]
Gaucher Disease
  • Bleeding disorders in Gaucher disease are believed to be due to thrombocytopenia but there may be additional factors that influence coagulation and fibrinolysis in Gaucher disease patients.[ncbi.nlm.nih.gov]
  • Thus, severe disorders of the coagulation system occur in Gaucher disease, contributing to the bleeding tendency.[ncbi.nlm.nih.gov]
Easy Bruising
  • However, the main signs include: unexplained and easy bruising heavy menstrual bleeding frequent nosebleeds excessive bleeding from small cuts or an injury bleeding into joints Schedule an appointment with your doctor right away if you have one or more[healthline.com]
  • Symptoms include easy bruising, bleeding in small cuts that stops and starts, abnormal bleeding after surgery, and abnormally heavy menstrual bleeding.[medical-dictionary.thefreedictionary.com]
Bulimia
  • We report the case of a 26-year-old woman suffering from borderline personality disorder (BPD), major depression and bulimia nervosa according to DSM-IV who showed unexplained impairment of the vitamin K-dependent coagulation pathway.[ncbi.nlm.nih.gov]
Purpura
  • […] and other hemorrhagic conditions D69.0 Allergic purpura D69.1 Qualitative platelet defects D69.2 Other nonthrombocytopenic purpura D69.3 Immune thrombocytopenic purpura D69.4 Other primary thrombocytopenia D69.42 Congenital and hereditary thrombocytopenia[icd10data.com]
  • Cancer patients may also suffer from the impediment of hemolytic uremic syndrome or thrombotic thrombocytopenic purpura (HUS/TTP).[als-journal.com]
  • Bleeding Disorders SPONTANEOUS - petechiae, purpura, mucous membranes, GI bleeding, hematuria, into joint spaces EXCESSIVE - after trauma or surgery - range is from lethal diseases (factor VIII deficiency, Bernard-Soulier's, Glanzmann's) to asymptomatic[slideshare.net]
  • If there is suspicion for thrombotic thrombocytopenic purpura, ask the lab or your hematologist to look for fragmented red cells (schistocytes) on peripheral blood smear.[pulmccm.org]
  • If the smear shows signs of hemolysis (fragmented RBCs on smear, decreasing Hb level), thrombotic thrombocytopenic purpura (TTP) or hemolytic-uremic syndrome (HUS) is suspected.[msdmanuals.com]
Epistaxis
  • As the platelet counts are usually 50x10 9 L -1 there is an increased incidence of bruising, epistaxis and gingival bleeding. Treatment aims at increasing platelet count.[frca.co.uk]
Hematuria
  • INCREASED VASCULAR FRAGILITY seldom serious skin bruises, dependent petechiae, gum bleeding, hematuria, nosebleeds, GI bleeds. Infections - damage endothelium Amyloidosis Collagen problems Immune-complex deposition in vessel walls 7.[slideshare.net]

Workup

Platelet Aggregation Abnormal
  • In 2 patients (5.1%) with TSC and platelet aggregation abnormalities, the authors noted normal standard screening laboratory studies and an uneventful detailed personal and family history.[ncbi.nlm.nih.gov]

Treatment

  • The treatment of the two conditions is very different.[ncbi.nlm.nih.gov]
  • An understanding of the mechanisms involved in coagulation and thrombosis is valuable in choosing from the increasing treatment options available.[ncbi.nlm.nih.gov]
  • Pre-treatment aPTT and PT were prolonged in 42% and 38% of patients, respectively. In 30-60% serious deficiencies ( 50%) of coagulation factors XI, XII, VII, X, V and II were observed.[ncbi.nlm.nih.gov]
  • The incidence of bleeding at 130 days of treatment with capecitabine was 18% with warfarin versus 2% without (P 4 x 10(-13)).[ncbi.nlm.nih.gov]
  • Despite inhomogeneities in reported parameters, results, patients' collectives, and treatment strategies, these data suggest that coagulation abnormalities may play an important role in the emergence of osteonecrosis and bone marrow edema syndrome.[ncbi.nlm.nih.gov]

Prognosis

  • While the chapters discuss definitions, pathophysiology, clinical course, complications, and prognosis, the primary emphasis is devoted to patient management.[books.google.com]
  • Predicting the prognosis of chronic liver disease: an evolution from child to MELD. Mayo end-stage liver disease. Hepatology 2001; 33: 473-5. 8.Garrison RN, Cryer HM, Howard DA, Polk HC.[pacificejournals.com]
  • Additional therapeutic efforts, like administration of heparin or antifibrinolytic drugs, have failed to improve the prognosis of patients with severe coagulation abnormalities.[ncbi.nlm.nih.gov]
  • Prognosis The prognosis for patients with mild forms of coagulation disorders is normally good. Many people can lead a normal life and maintain a normal life expectancy.[medical-dictionary.thefreedictionary.com]
  • Prognosis The prognosis for individuals with mild forms of coagulation disorders is normally good. Many people can lead normal lives and achieve normal life expectancy.[healthofchildren.com]

Etiology

  • The etiology probably involves successive vascular occlusions, in which hypercoagulable disorders may play a role. We evaluated the etiologic role of thrombophilia in Legg-Calvé-Perthes disease in a pediatric population.[ncbi.nlm.nih.gov]
  • Thirteen etiologies were identified as possible factors for the emergence of secondary osteonecrosis, and 1 study describes cases of osteonecrosis and M Perthes (Table 2 ). 46 Table 2: Etiologic Factors for Secondary Osteonecrosis Localization of Osteonecrosis[healio.com]
  • The etiology of this coagulation abnormality remains unclear. There are 3 mechanisms currently under discussion: activation of coagulation, activation of fibrinolysis and an increased activity of specific leucocyte proteases.[ncbi.nlm.nih.gov]
  • Escherichia coli O157:H7 and the hemolytic uremic syndrome: importance of early cultures in establishing the etiology. J Infect Dis 1990 ;162: 553 - 556 3. Tsai HM, Chandler WL, Sarode R, et al.[nejm.org]

Epidemiology

  • Acute upper gastrointestinal bleeding in patients with liver cirrhosis and in noncirrhotic patients: epidemiology and predictive factors of mortality in a prospective multicenter population-based study.[pacificejournals.com]
  • Von Willebrand disease (VWD) VWD is the most common hereditary bleeding disorder with, according to epidemiological studies, an estimated prevalence worldwide as high as 1 to 2% in the general population [ 5 - 7 ].[wrbd.org]
Sex distribution
Age distribution

Pathophysiology

  • This review addresses the pathophysiology of coagulation abnormalities in HF, examines the available evidence regarding the use of anticoagulants and antiplatelet agents in HF, and discusses its therapeutic implications.[ncbi.nlm.nih.gov]
  • Kwaan Springer Science & Business Media, ٢١‏/٠٤‏/٢٠٠٩ - 339 من الصفحات Coagulation in Cancer informs professionals working in the field of cancer about the pathophysiologic mechanisms of cancer-related thrombosis and bleeding.[books.google.com]
  • In this article, we review the pathophysiological bases of coagulation abnormalities, in cirrhotic patients, the diagnostic therapeutic strategies to be followed and its impact on the clinical outcome in the cirrhotic patient.[ncbi.nlm.nih.gov]
  • While the chapters discuss definitions, pathophysiology, clinical course, complications, and prognosis, the primary emphasis is devoted to patient management.[books.google.com]
  • Discussion Our data shed light on the pathophysiology of the progression of E. coli O157:H7 infection to the hemolytic–uremic syndrome.[nejm.org]

Prevention

  • Among 1,032 patients evaluated we found that 534 coagulation tests were needed to prevent one case of bleeding associated with an abnormal coagulation test result. Copyright 2011 American Society for Reproductive Medicine. Published by Elsevier Inc.[ncbi.nlm.nih.gov]
  • Early diagnosis of hypercoagulability in the group of patients at risk may allow pharmacologic intervention that may prevent this devastating process from developing.[ncbi.nlm.nih.gov]
  • It provides assistance in recognizing the various bleeding and clotting disorders associated with cancer and includes current recommendations for the management of hemorrhage, and prevention and treatment of thrombosis in the patient with malignancy.[books.google.com]
  • Patient and family teaching includes: Preventing bleeding episodes: •Avoiding contact sports or other activities in which head injury might occur •Avoiding accidental cuts by using an electric razor and taking care when using sharp tools or kitchen implements[rnceus.com]
  • Thus, further research into the mechanisms and treatment of coagulation dysfunction after trauma will continue to prevent early and late deaths in severely injured patients.[dtic.mil]

Ask Question

5000 Characters left Format the text using: # Heading, **bold**, _italic_. HTML code is not allowed.
By publishing this question you agree to the TOS and Privacy policy.
• Use a precise title for your question.
• Ask a specific question and provide age, sex, symptoms, type and duration of treatment.
• Respect your own and other people's privacy, never post full names or contact information.
• Inappropriate questions will be deleted.
• In urgent cases contact a physician, visit a hospital or call an emergency service!