PRINCIPAL FINDINGS: In the present work, we demonstrate a consistent procoagulant profile on 40 reactional and non-reactional multibacillary leprosy patients. [ncbi.nlm.nih.gov]

Collection includes both citations and many full-text, downloadable documents from mid-1900s to present. AULIMP - Air University Library Index to Military Periodicals. [dtic.mil]

• Disability

  In 2016, more than 200,000 new cases of leprosy were detected around the world, representing the most frequent cause of infectious irreversible deformities and disabilities. [ncbi.nlm.nih.gov]

  Trauma remains the leading cause of death and disability in patients under 40. Coagulopathy is common following trauma and is associated with poor outcome. [dtic.mil]

• Ecchymosis

  […] types Von Willebrand disease Definition: : a disorder of primary hemostasis characterized by either a deficiency or disorder of vWF Epidemiology: most common congenital hemostatic disorder Clinical findings Mostly asymptomatic Symptomatic patients: Ecchymosis [amboss.com]

  Ecchymosis (>10 mm diameter). Fundi for retinal haemorrhages. Joints for haemarthrosis. Rectal or vaginal examination may be appropriate. [patient.info]

  The prothrombin time (PT) is prolonged, and mucosal bleeding, gastrointestinal bleeding, or ecchymosis is the usual pattern. [what-when-how.com]

• Easy Bruising

  A history of prolonged bleeding from minor wounds, easy bruising or a family history of bleeding disorders should be asked in those patients with epistaxis. Thrombocytopenia is the common cause of the epistaxis. [tkbbv.org.tr]

  However, the main signs include: unexplained and easy bruising heavy menstrual bleeding frequent nosebleeds excessive bleeding from small cuts or an injury bleeding into joints Schedule an appointment with your doctor right away if you have one or more [healthline.com]

  Symptoms include easy bruising, bleeding in small cuts that stops and starts, abnormal bleeding after surgery, and abnormally heavy menstrual bleeding. [medical-dictionary.thefreedictionary.com]

• Abdominal Pain

  Hemoperitoneum secondary to rupture of the corpus luteum should be considered in the differential diagnosis of acute abdominal pain in women with congenital and acquired coagulation deficiencies. [ncbi.nlm.nih.gov]

  MS, a 19-year-old man, presented with a 1-month history of abdominal pain. He had a massive splenomegaly with thrombosis of the splenoportal axis. [dovepress.com]

• Chest Pain

  Symptoms of a PE include: Chest pain Shortness of breath Fast heartbeat A heart attack or stroke at a young age Recurrent pregnancy loss or stillbirth Diagnosis of Coagulation Disorders If your child displays symptoms of one of these disorders, his or [rileychildrens.org]

  Symptoms may include shortness of breath, wheezing, chest pain, increased heartbeat, leg swelling, dizziness, or coughing up blood. [health24.com]

• Bleeding Gums

  References:[9][10][11] Clinical features Onset of bleeding Type of bleeding Features of primary hemostasis disorders (i.e., platelet defects) Immediately after trauma Bleeding of mucous membranes (e.g., epistaxis, bleeding gums) Petechia, purpura, superficial [amboss.com]

• Purpura

  […] and other hemorrhagic conditions D69.0 Allergic purpura D69.1 Qualitative platelet defects D69.2 Other nonthrombocytopenic purpura D69.3 Immune thrombocytopenic purpura D69.4 Other primary thrombocytopenia D69.42 Congenital and hereditary thrombocytopenia [icd10data.com]

  Bleeding Disorders SPONTANEOUS - petechiae, purpura, mucous membranes, GI bleeding, hematuria, into joint spaces EXCESSIVE - after trauma or surgery - range is from lethal diseases (factor VIII deficiency, Bernard-Soulier's, Glanzmann's) to asymptomatic [slideshare.net]

  Disorders affecting the vessel walls Henoch-Schonlein purpura: supportive care Thrombotic thrombocytopenic purpura: prompt plasma exchange therapy (see TTP for details) Disorders of secondary hemostasis Disorders of the intrinsic pathway Hemophilia A [amboss.com]

  If there is suspicion for thrombotic thrombocytopenic purpura, ask the lab or your hematologist to look for fragmented red cells (schistocytes) on peripheral blood smear. [pulmccm.org]

  Potential causes include the following: Platelet dysfunction: Thrombocytopenia may be related to preexisting disease, such as idiopathic thrombocytopenic purpura (ITP) or, less commonly, functional platelet abnormalities. [medscape.com]

• Epistaxis

  The most common hereditary bleeding disorder associated with epistaxis is vonWillebrant disease(vWD). These patients are manifests clinically with epistaxis, and excessive bleeding despite local treatment. [tkbbv.org.tr]

  Although clinical features of inherited and acquired disorders may overlap, mucocutaneous bleeding (e.g., epistaxis, petechiae, gastrointestinal bleeding) is associated more with platelet disorders, while bleeding into potential spaces (e.g., hemarthrosis [amboss.com]

  Bleeding may occur also from the same lesions seen in the general population such as peptic ulcer, epistaxis, gingivorrhagia, bruising or from invasive procedures. [elsevier.es]

  As the platelet counts are usually = 50x10 9 L -1 there is an increased incidence of bruising, epistaxis and gingival bleeding. Treatment aims at increasing platelet count. [frca.co.uk]

  Patients with only spontaneous petechiae or bruising at venipuncture sites were considered to have mild bleeding; those with mucosal bleeding that did not affect the hematocrit were considered to have moderate bleeding; and those with epistaxis or gastrointestinal [academic.oup.com]

• Headache

  Bussone HEADACHES AND CEREBROVASCULAR DISEASE 125 Downloads 19 Citations Abstract. Migraine, particularly migraine with aura, is a risk factor for ischaemic stroke. The mechanisms underlying this association are obscure. [link.springer.com]

  […] occur •Avoiding accidental cuts by using an electric razor and taking care when using sharp tools or kitchen implements •Avoiding intramuscular injections •Brushing teeth with a soft toothbrush to decrease gum bleeding Recognizing bleeding symptoms: •Headache [rnceus.com]

  […] numbness or weakness of the face, arm or leg, especially on one side of the body Sudden confusion Sudden trouble speaking Sudden trouble seeing in one or both eyes Sudden trouble walking Sudden dizziness, loss of balance or coordination Sudden, severe headache [cedars-sinai.edu]

  […] coagulation disorders with difficulty clotting include: Blood in the urine or stool Bruising easily and excessively Extreme fatigue An injury that will not stop bleeding Joint pain caused by internal bleeding Nosebleeds that seem to have no cause A painful headache [rileychildrens.org]

  DF is classically a self-limiting, nonspecific illness characterized by fever, headache, myalgia, and constitutional symptoms. [academic.oup.com]

• Hematuria

  INCREASED VASCULAR FRAGILITY seldom serious skin bruises, dependent petechiae, gum bleeding, hematuria, nosebleeds, GI bleeds. Infections - damage endothelium Amyloidosis Collagen problems Immune-complex deposition in vessel walls 7. [slideshare.net]

  Aprotinin may cause anaphylactic responses and lysine analogues should not be used in patients with hematuria since obstructive clots in the urinary tract have occurred. [ncbi.nlm.nih.gov]

Diagnostic workup of patients with acquired von Willebrand syndrome: a retrospective single-centre cohort study. J Thromb Haemost. 2008;6(4):569–576. 88. Tefferi A, Barbui T. [dovepress.com]

The treatment of the two conditions is very different. [ncbi.nlm.nih.gov]

It provides assistance in recognizing the various bleeding and clotting disorders associated with cancer and includes current recommendations for the management of hemorrhage, and prevention and treatment of thrombosis in the patient with malignancy. [books.google.com]

While the chapters discuss definitions, pathophysiology, clinical course, complications, and prognosis, the primary emphasis is devoted to patient management. [books.google.com]

Additional therapeutic efforts, like administration of heparin or antifibrinolytic drugs, have failed to improve the prognosis of patients with severe coagulation abnormalities. [ncbi.nlm.nih.gov]

Many lung cancers of all histological types (adenocarcinomas being the leas in the clinical course of the disease in terms of prediction and prognosis. [md-medicaldata.com]

Prognosis The prognosis for patients with mild forms of coagulation disorders is normally good. Many people can lead a normal life and maintain a normal life expectancy. [medical-dictionary.thefreedictionary.com]

Prognosis The prognosis for individuals with mild forms of coagulation disorders is normally good. Many people can lead normal lives and achieve normal life expectancy. [healthofchildren.com]

The etiology probably involves successive vascular occlusions, in which hypercoagulable disorders may play a role. We evaluated the etiologic role of thrombophilia in Legg-Calvé-Perthes disease in a pediatric population. [ncbi.nlm.nih.gov]

Thirteen etiologies were identified as possible factors for the emergence of secondary osteonecrosis, and 1 study describes cases of osteonecrosis and M Perthes (Table 2 ). 46 Table 2: Etiologic Factors for Secondary Osteonecrosis Localization of Osteonecrosis [healio.com]

Methods Analysis of key baseline characteristics, etiology, coagulation and hematological tests, use of blood products, thrombotic complications, and clinical outcomes during the first ICU week. Results We studied 62 ALF patients. [onlinelibrary.wiley.com]

Variants of von Willebrand disease Type Inheritance/etiology Pathophysiology Congenital Type 1 (80%) Autosomal dominant Quantitative deficiency of vWF and factor VIII Type 2 (15-20%) Autosomal dominant Qualitative defect in vWF Type 3 (∼ 1%) Autosomal [amboss.com]

The reader may refer to excellent reviews and guidelines on these topics.2,3 For the purpose of simplicity, we deal with each leukemia type with a case vignette, followed by epidemiology, pathophysiology, and management issues. [oncologynurseadvisor.com]

This epidemiologic information and practice variability provide baseline data for the design and powering of interventional studies. The full text of this article hosted at iucr.org is unavailable due to technical difficulties. [onlinelibrary.wiley.com]

Von Willebrand disease (VWD) VWD is the most common hereditary bleeding disorder with, according to epidemiological studies, an estimated prevalence worldwide as high as 1 to 2% in the general population [ 5 - 7 ]. [wrbd.org]

Acute upper gastrointestinal bleeding in patients with liver cirrhosis and in noncirrhotic patients: epidemiology and predictive factors of mortality in a prospective multicenter population-based study. [pacificejournals.com]

Epidemiology of trauma deaths: a reassessment. J Trauma. 1995;38:185–193. [PubMed] [Google Scholar] 2. Kauvar DS, Lefering R, Wade CE. [ncbi.nlm.nih.gov]

This review addresses the pathophysiology of coagulation abnormalities in HF, examines the available evidence regarding the use of anticoagulants and antiplatelet agents in HF, and discusses its therapeutic implications. [ncbi.nlm.nih.gov]

Kwaan Springer Science & Business Media, ٢١‏/٠٤‏/٢٠٠٩ - 339 من الصفحات Coagulation in Cancer informs professionals working in the field of cancer about the pathophysiologic mechanisms of cancer-related thrombosis and bleeding. [books.google.com]

The pathophysiology of these disorders is unique, and not only the disease but also the treatment and other factors play a role. There has been an increase in the understanding of these disorders in leukemias. [oncologynurseadvisor.com]

This article provides a summary of the pathophysiology of hemostasis (eg, bleeding and thrombosis disorders) and reviews the basic principles of history and physical findings to provide the primary care practitioner with the necessary tools for initial [pedsinreview.aappublications.org]

Among 1,032 patients evaluated we found that 534 coagulation tests were needed to prevent one case of bleeding associated with an abnormal coagulation test result. Copyright © 2011 American Society for Reproductive Medicine. [ncbi.nlm.nih.gov]

Getting prompt treatment will help prevent any potential complications. [healthline.com]

It provides assistance in recognizing the various bleeding and clotting disorders associated with cancer and includes current recommendations for the management of hemorrhage, and prevention and treatment of thrombosis in the patient with malignancy. [books.google.com]

Preventive dental care. Good oral hygiene can help prevent dental work and possible bleeding. Subcutaneous immunizations. Giving immunizations under the skin (subcutaneous) rather than into muscle reduces the chance of bleeding in the muscle. [rileychildrens.org]