Presentation
We present a case of a 33-year old parturient after vaginal birth, who presented with severe hemorrhagic shock with low platelet count and coagulopathy resistant to treatment with plasma, platelets and coagulation factors and despite of surgical management [pubmed.ncbi.nlm.nih.gov]
In another report, a 17-year-old boy presented to the hospital with a severe bleeding disorder. "A bleeding disorder," she said, as if repeating the words would make him understand. Don't drink green tea if you have a bleeding disorder. [diki.pl]
Calò, SM Siboni, F.Peyvandi, IRCCS Fondazione Ospedale maggiore Policlinico, Mangiagalli e Regina Elena, Milano The 2end World Congress on Gender - Specific Medicine and Ageing -The endocrine impact, Roma, 8-11 marzo 2007 Session Info: Oral Presentation [luciacalo.it]
In the early hours of TIC development, hypocoagulability is typically present, resulting in bleeding, whereas later TIC is characterized by a hypercoagulable state associated with venous thromboembolism and multiple organ failure. [portailvasculaire.fr]
Trauma-induced coagulopathy: past, present and future. J Thromb Haemost 2019; 17(6):852-62. [ Links ] 24. Chang R, Kerby J, Kalkwarf K, Van Belle G, Fox E, Cotton A, et al. [scielo.edu.uy]
Hematological
- Hemophilia A
Hemophilia involves an inherited deficiency of certain clotting factors (proteins that help the blood clot, stopping bleeding). In hemophilia A, clotting factor VIII is deficient and in hemophilia B, factor IX is deficient. [msdmanuals.com]
You may have been born with a bleeding disorder such as hemophilia. For example, people with a bleeding disorder may not be able to take aspirin. Only then did I discover that she had a rare bleeding disorder. [diki.pl]
Entire Body System
- Sepsis
CRICS TRIGGERSEP Group (Clinical Research in Intensive Care and Sepsis Trial Group for Global Evaluation and Research in Sepsis). High risk of thrombosis in patients with severe SARS-CoV-2 infection:a multicenter prospective cohort study. [scielo.org.mx]
Working group on "sepsis-related problems" of the European Society of Intensive Care Medicine. Crit Care Med 1998; 26(11):1793-800. [ Links ] 12. Wafaisade A, Wutzler S, Lefering R, Tjardes T, Banerjee M, Paffrath T, et al. [scielo.edu.uy]
- Hypothermia
Br J Anaesth 95: 172–177 Article PubMed Google Scholar Gubler KD, Gentilello LM, Hassantash SA, Maier RV (1994) The impact of hypothermia on dilutional coagulopathy. [link.springer.com]
Several pathophysiological mechanisms underlie TIC; tissue injury and shock synergistically provoke endothelial, immune system, platelet and clotting activation, which are accentuated by the 'lethal triad' (coagulopathy, hypothermia and acidosis). [portailvasculaire.fr]
Treatment
The patient survived and came back to her usual activity after 22 days of treatment. Keywords: DIC; amniotic fluid embolism; consumptive coagulopathy; perinatal hemorrhage. [pubmed.ncbi.nlm.nih.gov]
Treatment depends on the specific factor that is deficient but usually includes replacing the deficient clotting factor. Deficiency of factor XI is the most common of the rare inherited clotting disorders. [msdmanuals.com]
The diagnosis and treatment of acute traumatic bleeding and coagulopathy. Dtsch Arztebl Int 2019; 116(47):799-806. [ Links ] 9. Nassar A, Malbouisson L, Moreno R. [scielo.edu.uy]
N Engl J Med 354: 353–365 Article PubMed Google Scholar Mannucci PM (2004) Treatment of von Willebrand’s disease. [link.springer.com]
Prognosis
Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia. J Thromb Haemost. 2020;18(4):844-7. [ Links ] 7. Zhang Y, Xiao M, Zhang S, Xia P, Cao W, Jiang W, et al. [scielo.org.mx]
Epidemiology
Venous thrombosis epidemiology, pathophysiology, andanticoagulant therapies and trials in severe acute respiratory syndrome coronavirus 2 infection. J Vasc Surg Venous Lymphat Disord. 2021;9(1):23-35. [ Links ] 23. [scielo.org.mx]
Pathophysiology
Several pathophysiological mechanisms underlie TIC; tissue injury and shock synergistically provoke endothelial, immune system, platelet and clotting activation, which are accentuated by the 'lethal triad' (coagulopathy, hypothermia and acidosis). [portailvasculaire.fr]
J Trauma 36: 847–851 PubMed Google Scholar Heddle NM (1999) Pathophysiology of febrile nonhemolytic transfusion reactions. [link.springer.com]
Venous thrombosis epidemiology, pathophysiology, andanticoagulant therapies and trials in severe acute respiratory syndrome coronavirus 2 infection. J Vasc Surg Venous Lymphat Disord. 2021;9(1):23-35. [ Links ] 23. [scielo.org.mx]
Prevention
Revue : Nat Rev Dis Primers. 2021 Apr 29;7(1):30 Résumé : Uncontrolled haemorrhage is a major preventable cause of death in patients with traumatic injury. [portailvasculaire.fr]
Aminocaproic acid or tranexamic acid is used to control or prevent bleeding. NOTE: This is the Consumer Version. [msdmanuals.com]
Aminocaproic acid or tranexamic acid is used to control or prevent bleeding. Generic Name Select Brand Names Aminocaproic acid AMICAR tranexamic acid CYKLOKAPRON NOTE: This is the Consumer Version. [merckmanuals.com]
Preventable and potentially preventable deaths in severely injured patients: a retrospective analysis including patterns of errors. Eur J Trauma Emerg Surg 2017; 43(4):481-9. [ Links ] 21. Maegele M. [scielo.edu.uy]