Warfarin should be restarted, if necessary, when the INR falls below 5.0. [pharmaceutical-journal.com]

We recommend removal of the epidural catheter after the fifth postoperative day when INR falls below 1.5. [jpgmonline.com]

The patient was discharged to a skilled nursing facility (SNF) for physical therapy on low-molecular-weight heparin, with a plan to initiate warfarin once it became clear that that she was not at high risk for falls. [psnet.ahrq.gov]

Mean age 75 with almost equal sex distribution. 83.6% were ground level falls and 89.5% were GCS 15 Cohort study Immediate TICH 60 patients (6.1%; 95% CI 4.7% to 7.8%). [bestbets.org]

[…] with a PT ratio of 1.3 to 1.5, and an INR of 3.0 to 4.5 with a PT ratio of 1.5 to 1.9, depending on the sensitivity index of the prothrombin reagent. 45 The therapeutic INR range varies according to the medical indication for its use, but generally falls [nature.com]

None of the patients had hypothermia defined as temperature The incidence of pre-operative thrombocytopenia in our study was 3.5% on the 1 st day which increased to 14.7% on the 3 rd day post-injury. [jnaccjournal.org]

Patient's hypothermia is prevented by warm fluid infusion, forced-air warming and the use of warm water on the surgical field. [clinmedjournals.org]

Quantitative evaluation of hypothermia, hyperthermia, and hemodilution on coagulation. J Extra Corpor Technol 2001 ; 33 : 100 –5 57 Koh SC, Pua HL, Tay DH, et al. [academic.oup.com]

Blood clot symptoms Sudden weakness in any limb New numbness or tingling anywhere Visual changes Sudden onset of slurred speech or inability to speak Dizziness, faintness, loss of balance (lack of coordination) New pain, swelling, redness, or heat in [inrtracker.com]

Relevant Paper(s) Author, date and country Patient group Study type (level of evidence) Outcomes Key results Study Weaknesses Menditto et al 2012 Italy 97 prospectively enrolled consecutive warfarinised (for at least 1/52) patients 14 years old in Level [bestbets.org]

Aspirin, an ingredient of many prescription and over-the-counter drugs ( Table 1 ), has weak antiplatelet activity through acetylating and irreversibly inactivating the enzyme cyclo-oxygenase, which prevents the conversion of arachidonic acid to thromboxane [nature.com]

Disease - any recent illness, fever, N/V/D, significant pain or stress? Track all these things that affect your INR by signing up for a FREE account here on INR Tracker. Learn More or sign up now. [inrtracker.com]

Finally, conditions such as old age, liver disease, biliary disease, malabsorption, congestive heart failure, fever, hypo- and hyperthyroidism, malnutrition, cancer, and vitamin K excess or deficiency can all interfere with warfarin activity. [nature.com]

According to these guidelines, prophylactic platelet transfusions are indicated in leukaemia patients at platelet counts 1 in the absence of fever, heparin treatment or active minor bleeding (although lower, safe thresholds have been described by Gmür [academic.oup.com]

Antithrombotic therapy in valvular heart disease. Chest. 1995;108(4 Suppl):360S–70S. 7. Schulman S, Granqvist S, Holmstrom M, Carlsson A, Lindmarker P, Nicol P, et al. [aafp.org]

Optimal frequency of patient monitoring and intensity of oral anticoagulation therapy in valvular heart disease. J Thromb Thrombolysis. 1998;5(Suppl 1):19-24. Ansell J, Hirsh J, Dalen J, et al. Managing oral anticoagulant therapy. [myvmc.com]

disease Atrial fibrillation When You Are in Your Target INR Range It is safer when you are in your target INR range, because the risks of an INR lower than your target range could indicate potential clots and an INR higher than your target range could [inrtracker.com]

disease, and Mechanical heart valves ( Table 3 ). [nature.com]

Patients at high risk for a cardiovascular event include those patients with congestive heart failure, diabetes mellitus, renal insufficiency, ischemic heart disease, and cerebrovascular disease [ 108 ]. 3.3.2. [intechopen.com]

failure Nephrotic syndrome Stroke Myeloproliferative syndrome Behçet's disease Pregnancy, puerperium Clinical risk factors Drugs Inherited thrombophilia Acquired thrombophilia History of thromboembolism Oral contraceptives Activated protein C resistance [academic.oup.com]

Finally, conditions such as old age, liver disease, biliary disease, malabsorption, congestive heart failure, fever, hypo- and hyperthyroidism, malnutrition, cancer, and vitamin K excess or deficiency can all interfere with warfarin activity. [nature.com]

Patients at high risk for a cardiovascular event include those patients with congestive heart failure, diabetes mellitus, renal insufficiency, ischemic heart disease, and cerebrovascular disease [ 108 ]. 3.3.2. [intechopen.com]

Since platelets have an important role in coagulation and, in particular, arterial thrombosis, antiplatelet drugs are in widespread use for the prevention of morbidity and mortality from vascular disease. [nature.com]

Patients underwent craniotomy, for evacuation of either extradural haematoma (EDH), subdural haematoma (SDH) or contusion or for the elevation of depressed fracture. Patients on antiplatelet agents or anticoagulants were excluded from the study. [jnaccjournal.org]

In patients with moderate renal insufficiency, creatinine clearance 30–50 ml/min, the half‐life of fondaparinux is 29 h, and in patients with severe renal insufficiency, creatinine clearance 119 ]. [intechopen.com]

20 Comorbid disease states 26 Hypertension 20, 27 Cerebrovascular disease 20 Serious heart disease 4, 20 Renal insufficiency 20 If bleeding occurs during warfarin therapy, the physician should immediately consider the severity of bleeding, the intensity [aafp.org]