He had splenomegaly and generalized lymphadenopathy on admission. Laboratory examinations showed atypical lymphocytosis, eosinophilia, and increased liver enzyme values. The platelet count slowly decreased after admission. [ncbi.nlm.nih.gov]

However, once the initial, positive effects have worn off, Adderall abuse can produce many unwanted symptoms including: 4 Fatigue. Feelings of depression and lethargy. Increased anxiety. Cravings. [drugabuse.com]

[…] depression, coma, and confusion; therapy should not be administered within 14 days of taking MAOIs Cases of adrenal insufficiency reported with opioid use, more often following greater than one month of use; symptoms may include nausea, vomiting, anorexia, fatigue [reference.medscape.com]

Case Report A 62-year-old man with a history of chronic lymphocytic leukemia presented with a three-day history of fatigue, dyspnea, fever, and a cough. He had last received chemotherapy three months earlier. [doi.org]

Rapper Lil’ Wayne was admitted to the intensive care unit in March 2013 with seizures and unconsciousness caused by extremely high levels of codeine. [addictioncenter.com]

At high doses and overdoses, opioid-induced respiratory depression can result in a shortness of breath, abnormal breathing patterns, semi-consciousness, or unconsciousness. [psychonautwiki.org]

A broader view of opioids reveals that they also can have profound effects on emotional pain—which is perhaps a frequent, if unconscious, reason for their non-medical use/abuse. [encyclopedia.com]

Drug dosing error with drops: severe clinical course of codeine intoxication in twins. Eur J Pediatr 2009;168:819-24. Ciszkowski C, Madadi P, Phillips MS, Lauwers AE, Koren G. Codeine, ultrarapid-metabolism genotype, and postoperative death. [web.archive.org]

Symptoms can include cravings, sweating, runny nose, sleeping problems, yawning, cramps, weakness, nausea, diarrhea, chills, vomiting and irritability. [web.archive.org]

Common side effects include symptoms such as: Headache Nausea Weakness Anxiety Euphoria Itching Vomiting Dry mouth Constipation Depression Lack of sex drive Additionally, known side effects include dizziness and drowsiness, which can worsen with alcohol [opiates.com]

The available evidence indicates that codeine is more effective against cancer pain than placebo, but with increased risk of nausea, vomiting, and constipation. [ncbi.nlm.nih.gov]

However this can be accompanied by a range of adverse side effects including nausea, dizziness, itching and depression. [ginad.org]

Symptoms can include cravings, sweating, runny nose, sleeping problems, yawning, cramps, weakness, nausea, diarrhea, chills, vomiting and irritability. [web.archive.org]

Common side effects include symptoms such as: Headache Nausea Weakness Anxiety Euphoria Itching Vomiting Dry mouth Constipation Depression Lack of sex drive Additionally, known side effects include dizziness and drowsiness, which can worsen with alcohol [opiates.com]

The available evidence indicates that codeine is more effective against cancer pain than placebo, but with increased risk of nausea, vomiting, and constipation. [ncbi.nlm.nih.gov]

Withdrawal symptoms usually start within a few hours after the last dose and become strongest between 48 and 72 hours. 3 These symptoms can include: Cravings for codeine Dilated pupils Abdominal cramps, diarrhoea, nausea, vomiting Lack of appetite Runny [adf.org.au]

Inability to pass urine Severe constipation and obstructed bowel Agitation Cold clammy skin with a bluish tinge Mental numbness Very slow, shallow breathing Hallucinations and sometimes seizures Coma and death 1 Long-term effects of codeine Regular use [adf.org.au]

The available evidence indicates that codeine is more effective against cancer pain than placebo, but with increased risk of nausea, vomiting, and constipation. [ncbi.nlm.nih.gov]

Other side effects with the use of Codeine include headache, nausea, weakness, anxiety, euphoria, itching, vomiting, dry mouth, constipation, depression and lack of sex drive. [web.archive.org]

Be sure to follow the directions carefully, because continuing constipation can lead to more serious problems. [mayoclinic.org]

We present 2 cases of acute abdominal pain secondary to oral codeine that resolved after the administration of intravenous naloxone. [ncbi.nlm.nih.gov]

Common adverse reactions: drowsiness, lightheadedness, dizziness, sedation, nausea and vomiting, euphoria, dysphoria, constipation, abdominal pain, pruritus, and rash. [www2.mallinckrodt.com]

The symptoms of codeine abuse include: Dizziness Inability to focus Abdominal pain Constipation Sedated appearance Itchy skin Vision Changes Fainting Codeine Side Effects These can include: Nausea and vomiting Drowsiness A headache Difficulty breathing [addictionresource.com]

Andrew Tabner and Graham Johnson, Codeine: An Under-Recognized and Easily Treated Cause of Acute Abdominal Pain, The American Journal of Emergency Medicine, 33, 12, (1847.e1), (2015). Oscar A. Linares, Jeffrey Fudin, William E. [doi.org]

Adverse reactions ranging from tachycardia and cutaneous vasodilatation to severe hypotension and apnoea occurred in three children who were given codeine phosphate intravenously. [ncbi.nlm.nih.gov]

[…] including orthostatic hypotension and syncope in ambulatory patients; there is increased risk in patients whose ability to maintain blood pressure has already been compromised by a reduced blood volume or concurrent administration of certain CNS depressant [reference.medscape.com]

[…] adults Other Information Potential toxic dose Drug Interactions Interaction Checker codeine and No Interactions Found Interactions Found Serious - Use Alternative Significant - Monitor Closely Sort by : Adverse Effects 10% Constipation Drowsiness 1-10% Hypotension [web.archive.org]

Scarlatiniform rash and urticaria were observed twice in the same patient following codeine intake. This rare drug-induced eruption may lead to mis-diagnosis in patients taking mild analgesics containing codeine. [ncbi.nlm.nih.gov]

Significant - Monitor Closely Sort by : Adverse Effects 10% Constipation Drowsiness 1-10% Hypotension Tachycardia or bradycardia Confusion Dizziness False feeling of well being Headache Lightheadedness Malaise Paradoxical CNS stimulation Restlessness Rash, urticaria [web.archive.org]

[…] the athlete, there is a risk of positive result of doping control Side Effects: The side effects include: Allergy · Bronchospasm · Constipation · Rash · Erythema · Nausea, Drowsiness · Thrombocytopenia exceptional · Respiratory depression in type · Urticaria [macromass.com]

Common adverse reactions: drowsiness, lightheadedness, dizziness, sedation, nausea and vomiting, euphoria, dysphoria, constipation, abdominal pain, pruritus, and rash. [www2.mallinckrodt.com]

[…] particularly in ambulatory patients not experiencing severe pain): lightheadedness, dizziness, sedation, nausea, vomiting, sweating. d e f When used at antitussive doses: nausea, vomiting, constipation (with repeated doses), dizziness, sedation, palpitation, pruritus [web.archive.org]

“Many of our headache patients would take as an acute treatment for headache. [irishtimes.com]

This appears to be broadly true in postoperative pain and migraine headache across a range of different drug combinations and when tested in the same and different trials. [ncbi.nlm.nih.gov]

He said codeine-containing drugs were not a problem when used to treat genuine pain such as in terminal illnesses, but the problem emerged when they were used for "headaches" or other common ailments. [iol.co.za]

Cardiovascular side effects, ataxia, and headache occurred equally between the groups. CONCLUSIONS: Both drugs had a wide array of reported side effects, but the overall incidence of serious outcomes was low. Copyright 2016 Elsevier Inc. [ncbi.nlm.nih.gov]

Adverse Reactions and Overdosage The principal clinical manifestations of codeine toxicity are respiratory depression and obtundation. 14, 15 In children, antitussive dosages of 3 to 5 mg/kg/d have produced somnolence, ataxia, miosis, vomiting, rash, [pediatrics.aappublications.org]

His only medication was valproic acid (1500 mg daily), which he had been taking for several years after he had had a post-traumatic generalized seizure. [doi.org]