He had splenomegaly and generalized lymphadenopathy on admission. Laboratory examinations showed atypical lymphocytosis, eosinophilia, and increased liver enzyme values. The platelet count slowly decreased after admission. [ncbi.nlm.nih.gov]

However, once the initial, positive effects have worn off, Adderall abuse can produce many unwanted symptoms including: 4 Fatigue. Feelings of depression and lethargy. Increased anxiety. Cravings. [drugabuse.com]

[…] depression, coma, and confusion; therapy should not be administered within 14 days of taking MAOIs Cases of adrenal insufficiency reported with opioid use, more often following greater than one month of use; symptoms may include nausea, vomiting, anorexia, fatigue [reference.medscape.com]

Case Report A 62-year-old man with a history of chronic lymphocytic leukemia presented with a three-day history of fatigue, dyspnea, fever, and a cough. He had last received chemotherapy three months earlier. [doi.org]

Rapper Lil’ Wayne was admitted to the intensive care unit in March 2013 with seizures and unconsciousness caused by extremely high levels of codeine. [addictioncenter.com]

At high doses and overdoses, opioid-induced respiratory depression can result in a shortness of breath, abnormal breathing patterns, semi-consciousness, or unconsciousness. [psychonautwiki.org]

A broader view of opioids reveals that they also can have profound effects on emotional pain—which is perhaps a frequent, if unconscious, reason for their non-medical use/abuse. [encyclopedia.com]

Drug dosing error with drops: severe clinical course of codeine intoxication in twins. Eur J Pediatr 2009;168:819-24. Ciszkowski C, Madadi P, Phillips MS, Lauwers AE, Koren G. Codeine, ultrarapid-metabolism genotype, and postoperative death. [web.archive.org]

Symptoms can include cravings, sweating, runny nose, sleeping problems, yawning, cramps, weakness, nausea, diarrhea, chills, vomiting and irritability. [web.archive.org]

Common side effects include symptoms such as: Headache Nausea Weakness Anxiety Euphoria Itching Vomiting Dry mouth Constipation Depression Lack of sex drive Additionally, known side effects include dizziness and drowsiness, which can worsen with alcohol [opiates.com]

The available evidence indicates that codeine is more effective against cancer pain than placebo, but with increased risk of nausea, vomiting, and constipation. [ncbi.nlm.nih.gov]

However this can be accompanied by a range of adverse side effects including nausea, dizziness, itching and depression. [ginad.org]

Symptoms can include cravings, sweating, runny nose, sleeping problems, yawning, cramps, weakness, nausea, diarrhea, chills, vomiting and irritability. [web.archive.org]

Common side effects include symptoms such as: Headache Nausea Weakness Anxiety Euphoria Itching Vomiting Dry mouth Constipation Depression Lack of sex drive Additionally, known side effects include dizziness and drowsiness, which can worsen with alcohol [opiates.com]

The available evidence indicates that codeine is more effective against cancer pain than placebo, but with increased risk of nausea, vomiting, and constipation. [ncbi.nlm.nih.gov]

Withdrawal symptoms usually start within a few hours after the last dose and become strongest between 48 and 72 hours. 3 These symptoms can include: Cravings for codeine Dilated pupils Abdominal cramps, diarrhoea, nausea, vomiting Lack of appetite Runny [adf.org.au]

Inability to pass urine Severe constipation and obstructed bowel Agitation Cold clammy skin with a bluish tinge Mental numbness Very slow, shallow breathing Hallucinations and sometimes seizures Coma and death 1 Long-term effects of codeine Regular use [adf.org.au]

The available evidence indicates that codeine is more effective against cancer pain than placebo, but with increased risk of nausea, vomiting, and constipation. [ncbi.nlm.nih.gov]

Other side effects with the use of Codeine include headache, nausea, weakness, anxiety, euphoria, itching, vomiting, dry mouth, constipation, depression and lack of sex drive. [web.archive.org]

Be sure to follow the directions carefully, because continuing constipation can lead to more serious problems. [mayoclinic.org]

We present 2 cases of acute abdominal pain secondary to oral codeine that resolved after the administration of intravenous naloxone. [ncbi.nlm.nih.gov]

Common adverse reactions: drowsiness, lightheadedness, dizziness, sedation, nausea and vomiting, euphoria, dysphoria, constipation, abdominal pain, pruritus, and rash. [www2.mallinckrodt.com]

The symptoms of codeine abuse include: Dizziness Inability to focus Abdominal pain Constipation Sedated appearance Itchy skin Vision Changes Fainting Codeine Side Effects These can include: Nausea and vomiting Drowsiness A headache Difficulty breathing [addictionresource.com]

Andrew Tabner and Graham Johnson, Codeine: An Under-Recognized and Easily Treated Cause of Acute Abdominal Pain, The American Journal of Emergency Medicine, 33, 12, (1847.e1), (2015). Oscar A. Linares, Jeffrey Fudin, William E. [doi.org]

Adverse reactions ranging from tachycardia and cutaneous vasodilatation to severe hypotension and apnoea occurred in three children who were given codeine phosphate intravenously. [ncbi.nlm.nih.gov]

[…] including orthostatic hypotension and syncope in ambulatory patients; there is increased risk in patients whose ability to maintain blood pressure has already been compromised by a reduced blood volume or concurrent administration of certain CNS depressant [reference.medscape.com]

[…] adults Other Information Potential toxic dose Drug Interactions Interaction Checker codeine and No Interactions Found Interactions Found Serious - Use Alternative Significant - Monitor Closely Sort by : Adverse Effects 10% Constipation Drowsiness 1-10% Hypotension [web.archive.org]

Common adverse reactions: drowsiness, lightheadedness, dizziness, sedation, nausea and vomiting, euphoria, dysphoria, constipation, abdominal pain, pruritus, and rash. [www2.mallinckrodt.com]

[…] particularly in ambulatory patients not experiencing severe pain): lightheadedness, dizziness, sedation, nausea, vomiting, sweating. d e f When used at antitussive doses: nausea, vomiting, constipation (with repeated doses), dizziness, sedation, palpitation, pruritus [web.archive.org]

Scarlatiniform rash and urticaria were observed twice in the same patient following codeine intake. This rare drug-induced eruption may lead to mis-diagnosis in patients taking mild analgesics containing codeine. [ncbi.nlm.nih.gov]

Significant - Monitor Closely Sort by : Adverse Effects 10% Constipation Drowsiness 1-10% Hypotension Tachycardia or bradycardia Confusion Dizziness False feeling of well being Headache Lightheadedness Malaise Paradoxical CNS stimulation Restlessness Rash, urticaria [web.archive.org]

[…] the athlete, there is a risk of positive result of doping control Side Effects: The side effects include: Allergy · Bronchospasm · Constipation · Rash · Erythema · Nausea, Drowsiness · Thrombocytopenia exceptional · Respiratory depression in type · Urticaria [macromass.com]

[…] extracted from combination tablets (OR 16.79, 95% CI [8.67, 32.51]), obtaining codeine from friends, family, and acquaintances (OR 3.98, 95% CI [1.82, 8.7]), use of illicit controlled drugs (OR 34.99, 95% CI [8.39, 145.94]) and use of codeine to experience euphoria [ncbi.nlm.nih.gov]

Orgasm suppression Pupil constriction Cognitive euphoria - This particular substance can be considered as less intense in its cognitive euphoria when compared with that of morphine or diacetylmorphine (heroin) due to the upper limit of how much can be [psychonautwiki.org]

Other side effects with the use of Codeine include headache, nausea, weakness, anxiety, euphoria, itching, vomiting, dry mouth, constipation, depression and lack of sex drive. [web.archive.org]

Although the euphoria is not as intense as that experienced with the stronger opiates, the euphoria can still be quite intense. [erowid.org]

Effects blurred vision, confusion, constipation, difficulty urinating, dizziness, dry mouth, euphoria, heart palpitations, hives, itching, nausea, sweating, tiredness, treat cold and flu, treat cough, treat diarrhoea, treat severe pain, treats mild pain [adf.org.au]

“Many of our headache patients would take as an acute treatment for headache. [irishtimes.com]

This appears to be broadly true in postoperative pain and migraine headache across a range of different drug combinations and when tested in the same and different trials. [ncbi.nlm.nih.gov]

He said codeine-containing drugs were not a problem when used to treat genuine pain such as in terminal illnesses, but the problem emerged when they were used for "headaches" or other common ailments. [iol.co.za]

Cardiovascular side effects, ataxia, and headache occurred equally between the groups. CONCLUSIONS: Both drugs had a wide array of reported side effects, but the overall incidence of serious outcomes was low. Copyright 2016 Elsevier Inc. [ncbi.nlm.nih.gov]

Adverse Reactions and Overdosage The principal clinical manifestations of codeine toxicity are respiratory depression and obtundation. 14, 15 In children, antitussive dosages of 3 to 5 mg/kg/d have produced somnolence, ataxia, miosis, vomiting, rash, [pediatrics.aappublications.org]

His only medication was valproic acid (1500 mg daily), which he had been taking for several years after he had had a post-traumatic generalized seizure. [doi.org]