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Colchicum Autumnale


Presentation

  • We present a sporadic case of suicidal plant poisoning wherein a 24-year-old man consumed 'gowri gedde' to end his life. Initially he presented with severe vomiting, diarrhoea and epigastric pain.[ncbi.nlm.nih.gov]
  • A more severe clinical presentation should be expected in patients with pre-existing liver and renal diseases.[doi.org]
Italian
  • […] colchico autunnale Italian zafferano bastardo Italian herfsttijdloos Dutch wilde herfsttijloos Dutch açafrão-dos-prados Portuguese colquico Portuguese hösttidlösa Swedish tidlösa Swedish безвременник осенный Russian tidløyse Norwegian syysmyrkkylilja[gd.eppo.int]
  • Published on the Internet - Il cercapiante - Images and local names of vascular plants - Project Dryades/KeyToNature, coordinated by the Department of Life Sciences, University of Trieste - - Acta Plantarum - The Italian Flora -[luirig.altervista.org]
  • El-Mohar, Khamira, Qatel El-Kelb, Sourendjan Common Names in Dutch: Herfsttijlos Common Names in English: Autumn Crocus, Autumn-Crocus, Colchicum, Common Autumn-Crocus, False Autumn Crocus, Meadow Saffron, Meadow-Saffron, Naked Ladies Common Names in Italian[web.archive.org]
Pneumonia
  • The respiratory insufficiency was further deteriorated by pneumonia, confirmed by chest X-ray and later on by autopsy. Laboratory tests also revealed rhabdomyolysis, coagulopathy and deterioration of renal function and hepatic function.[ncbi.nlm.nih.gov]
  • The respiratory insufficiency was deteriorated by bilateral pneumonia, confirmed on autopsy. Acute heart failure was probably the result of a direct toxic effect of colchicine on myocardial cells [ 8, 18, 19 ].[doi.org]
Respiratory Insufficiency
  • On the second day the patient became somnolent and developed respiratory insufficiency. The echocardiogram showed heart dilatation with diffuse hypokinesia with positive troponin I.[ncbi.nlm.nih.gov]
Respiratory Distress
  • During 24–72 hours, the second stage of intoxication, life-threatening complications occur such as heart failure, arrhythmias, renal failure, hepatic injury, respiratory distress, coagulopathies, bone marrow depression and neuromuscular involvement.[doi.org]
Vomiting
  • The patient presented with nausea, vomiting, and abdominal pain 2 hours after ingestion and had diarrhea 14 hours after ingestion. Hematological values remained within normal range. Treatment was mainly supportive. The outcome was favorable.[ncbi.nlm.nih.gov]
Nausea
  • The patient presented with nausea, vomiting, and abdominal pain 2 hours after ingestion and had diarrhea 14 hours after ingestion. Hematological values remained within normal range. Treatment was mainly supportive. The outcome was favorable.[ncbi.nlm.nih.gov]
  • Stomach; nausea; from odours nausea; from odours; eggs nausea; from odours; fish nausea; from odours; soup nausea; thought of soup Vomiting retching; after vomiting vomiting; violent more ...[abchomeopathy.com]
Diarrhea
  • The patient presented with nausea, vomiting, and abdominal pain 2 hours after ingestion and had diarrhea 14 hours after ingestion. Hematological values remained within normal range. Treatment was mainly supportive. The outcome was favorable.[ncbi.nlm.nih.gov]
Abdominal Pain
  • The patient presented with nausea, vomiting, and abdominal pain 2 hours after ingestion and had diarrhea 14 hours after ingestion. Hematological values remained within normal range. Treatment was mainly supportive. The outcome was favorable.[ncbi.nlm.nih.gov]
  • Causes severe, often fatal, enteritis, characterized by diarrhea and abdominal pain. It contains two poisonous alkaloids, colchicine and colchiceine. Called also meadow saffron, saffron, autumn crocus.[medical-dictionary.thefreedictionary.com]
  • Blood 2017 130:95; doi: A previously healthy 45-year-old woman presented with severe abdominal pain, diarrhea, and vomiting persisting 12 hours after ingestion of a homemade vegetable juice.[bloodjournal.org]
Polydipsia
  • All signs to watch for include: Nausea Vomiting (may contain blood) Watery diarrhea Tarry stools Polydipsia (excessive thirst) Oral irritation Depression Tremors Shock Seizures Rapid pulse Bowel and kidney failure Respiratory failure Causes of Meadow[wagwalking.com]
Heart Failure
  • Acute heart failure was probably the result of a direct toxic effect of colchicine on myocardial cells [ 8, 18, 19 ]. Conclusion Colchicine poisoning should be considered in patients with gastroenterocolitis after a wild plant meal.[doi.org]
Alopecia
  • Alopecia began in the third week. Treatment was supportive only. Five months later she had no clinical or laboratory signs of poisoning. The patient mistakenly ingested autumn crocus instead of wild garlic because of their great similarity.[ncbi.nlm.nih.gov]
  • Alopecia began in the third week. Treatment was supportive only. Five months later she had no clinical or laboratory signs of poisoning.[link.springer.com]
  • This second phase can last for 5–7 days and is followed by the third phase, characterized by leukocytosis and alopecia [ 2, 3 ].[doi.org]
Renal Insufficiency
  • A 76-year-old man with a history of alcoholic liver disease and renal insufficiency, who mistakenly ingested Colchicum autumnale instead of wild garlic (Aliium ursinum), presented with nausea, vomiting and diarrhea 12 hours after ingestion.[ncbi.nlm.nih.gov]
Confusion
  • We report a further case in which two persons confused this highly poisonous plant with wild garlic (Allium ursinum), a popular spice in the Central European cuisine.[ncbi.nlm.nih.gov]
  • While easy enough to identify in the autumn by flowers, the spring foliage can sometimes be confused with edible plants such as ramps or ramsons . Therein lies the danger, particularly for foragers.[botanyphoto.botanicalgarden.ubc.ca]
  • No Sometimes Confused With Crocus vernus : leaf blades with a prominent white mid-stripe, and flowers with 3 stamens and an inferior ovary (vs.[gobotany.newenglandwild.org]
  • Autumn Crocus Colchicum autumnale Location Wildflower plot Description Also known as meadow saffron, but should not be confused with saffron or members of the crocus family, as Colchicum autumnale contains extremely toxic alkaloids.[sites.google.com]
  • Ten hours after ingestion, he awoke and was completely orientated; 18 hours after ingestion his condition deteriorated again and he became confused and uncooperative.[link.springer.com]
Seizure
  • He was found comatose having a seizure-like episode. On admission four hours after ingestion he was comatose, but the remaining physical and neurological examinations were unremarkable. Creatine kinase was 8.33 μkat/l.[link.springer.com]
  • All signs to watch for include: Nausea Vomiting (may contain blood) Watery diarrhea Tarry stools Polydipsia (excessive thirst) Oral irritation Depression Tremors Shock Seizures Rapid pulse Bowel and kidney failure Respiratory failure Causes of Meadow[wagwalking.com]

Treatment

  • Treatment was mainly supportive. The outcome was favorable. The intoxication was confirmed by high-performance liquid chromatography-mass spectrometry.[ncbi.nlm.nih.gov]
  • It is used in the treatment of nausea, diarrhoea and rheumatism[232].[pfaf.org]
  • A randomized trial comparing levothyroxine with radioactive iodine in the treatment of sporadic nontoxic goiter. Journal of Clinical Endocrinology and Metabolism 2001;86(3):998–1005.[anthromedics.org]

Prognosis

  • Hepatic and renal dysfunction as well as certain drugs could worsen the prognosis of poisoning with colchicine.[doi.org]
  • Hepatic and renal dysfunction as well as certain drugs could worsen the prognosis of poisoning with colchicine. Competing interests None declared.[ncbi.nlm.nih.gov]
  • Bismuth C, Baud F, Dally S (1986) Standardized prognosis evaluation in acute toxicology: its benefit in colchicine, paraquat, and digitalis poisonings. Journal de Toxicologie Clinique et Experimentale 6: 33–38 PubMed Google Scholar 11.[link.springer.com]
  • Recovery of Meadow Saffron Poisoning in Cats The prognosis for a cat who has been poisoned by meadow saffron depends entirely on how much of the plant has been eaten and how quickly treatment was received.[wagwalking.com]

Etiology

  • Hyperthyroidism in patients older than 55 years: an analysis of the etiology and management. Gerontology 2003;49(5):316–323. [Crossref] 15 Schouten BJ, Brownlie BEW, Frampton CM, Turner JG.[anthromedics.org]
  • Hyperthyroidism in patients older than 55 years: an analysis of the etiology and management. Gerontology . 2003; 49 (5):316–323. doi: 10.1159/000071713. [ PubMed ] [ CrossRef ] [ Google Scholar ] 15. Schouten B. J., Brownlie B. E. W., Frampton C.[ncbi.nlm.nih.gov]

Epidemiology

  • Validation of ultrasonography of the thyroid gland for epidemiological purposes. Thyroid 1999;9(11):1069–1074. [Crossref] 20 Wesche MFT, M. Tiel-v Buul MC, Lips P, Smits NJ, Wiersinga WM.[anthromedics.org]
  • Validation of ultrasonography of the thyroid gland for epidemiological purposes. Thyroid . 1999; 9 (11):1069–1074. doi: 10.1089/thy.1999.9.1069. [ PubMed ] [ CrossRef ] [ Google Scholar ] 20. Wesche M. F. T., Tiel-v Buul M. M. C., Lips P., Smits N.[ncbi.nlm.nih.gov]
Sex distribution
Age distribution

Pathophysiology

  • Institute of Pathophysiology School of Medicine, and Clinical Department of Cardiology University Medical Center Ljubljana Slovenia 3. Poison Control Center University Medical Center Ljubljana Ljubljana Slovenia[link.springer.com]
  • Medical Center Ljubljana, Ljubljana, Slovenia (5) Professor, Head, Center for Intensive Internal Medicine, University Medical Center Ljubljana, Ljubljana, Slovenia (6) Associated Professor, Medical Faculty and Department for Cardiology, Institute for Pathophysiology[doi.org]
  • The observed significant reduction of TSH may be of pathophysiologic relevance since it has been shown that the treatment effect of thyroxin in patients with goitre depends on the degree of TSH suppression [ 17 , 18 ].[ncbi.nlm.nih.gov]

Prevention

  • Colchicum autumnale, commonly known as the autumn crocus or meadow saffron, contains the antimitotic colchicine, which binds to tubulin and prevents it forming microtubules that are part of the cytoskeleton in all cells.[ncbi.nlm.nih.gov]
  • Sharp soil drainage helps prevent corm rot. Purchase dormant corms in late summer (August) and plant them immediately (3” deep and 6” apart) for bloom in fall. Dig and divide corms when plants become crowded (every 3 years).[missouribotanicalgarden.org]
  • […] place of another more serious disease, or may be expected to prevent one which is threatening, and more to he dreaded than itself. ‎[books.google.de]
  • Artificial heat is not needed and can prevent germination so be very patient as many species will only germinate in the spring after chilling or freezing in the moist seed tray in the winter.[plant-world-seeds.com]
  • This product is not intended to diagnose, treat, cure, or prevent any disease. Please log in to submit a question Log In[pureformulas.com]

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