Similar to adults, childhood CC has a female predilection and most present with diarrhea and abdominal pain, but atypical presentations (weight loss and constipation) can also be seen. [nature.com]

[…] only where adjacent crypts cut as cross-sections Present even when adjacent crypts are cut longitudinally Indistinct edges but no entrapped elements Jagged edges with entrapped capillaries and inflammatory cells Lacks chronic inflammatory infiltrate [surgpathcriteria.stanford.edu]

Common presentation is watery diarrhea without blood. Radiology and colonoscopy is normal. [ijpmonline.org]

with female preponderance, presentation with diarrhea and abdominal pain, association with celiac disease and other autoimmune disorders Differences from adults: children have weight loss; either alternating constipation and diarrhea, constipation alone [pathologyoutlines.com]

Classically, patients present with chronic or intermittent watery diarrhea with or without abdominal pain, and usually without systemic symptoms 1. [jrheum.org]

• Abdominal Pain

  Definition / general Disorder of chronic watery diarrhea and crampy abdominal pain with normal colonoscopy and barium enema; due to inflammation and patchy thickening of subepithelial basement membrane ( eMedicine: Collagenous and Lymphocytic Colitis [pathologyoutlines.com]

  In our series, the most common symptoms were abdominal pain (4/5, 80%; Table 1 ). [nature.com]

  Symptoms are watery diarrhoea and abdominal pain. The cause of the disease is unknown. There is no cure, but the symptoms can be controlled by anti- inflammatory drugs. Stained with eosin and haematoxylin. [sciencephoto.com]

  Side effects in the prednisolone study included abdominal pain, headache, sleep disturbance, mood change and weight gain. [cochrane.org]

  A 68 years old Syrian woman complaining for eight months history of recurrent episodes of watery diarrhea, associated with colicky abdominal pain. The diarrhea was intermittent or continuous for several months with remissions and relapses. [saudijgastro.com]

• Steatorrhea

  Steatorrhea may be encountered and be secondar y to concurrent gluten-sensitive enteropathy, since up to one-third of celiac disease patients also have lymphocytic colitis. By definition, the bowel is endoscopically normal. [incytepathology.wordpress.com]

• Ankylosis

  However, evolution to chronicity may occur in some of them, with development of spinal ankylosis together with radiographic erosive lesions despite the improvement of the colitis. [onlinelibrary.wiley.com]

• Enthesopathy

  Other features relatively specific of SpA such as dactylitis and enthesopathy were found in Table 1. [onlinelibrary.wiley.com]

• Oligoarthritis

  In addition to the worsening of the low back pain, during the next weeks she developed an asymmetric oligoarthritis of the shoulders, right hip, and left knee. [onlinelibrary.wiley.com]

• Back Pain

  Successively, in July 2003 she developed an exacerbation of the low back pain. Pain woke her from sleep without relief despite rest and treatment with NSAIDs. Prior to this, she had been occasionally taking NSAIDs. [onlinelibrary.wiley.com]

• Subcutaneous Nodule

  The presence of fever or anemia is rare, and subcutaneous nodules are absent. [onlinelibrary.wiley.com]

Extensive workup failed to identify an etiology for rectal prolapse other than CC in this case. However, it remains to be determined if CC is truly the cause of rectal prolapse in this case. [nature.com]

• HLA-B27

  Rheumatoid factor, ANA, HLA–B27, and thyroid function studies were negative, as well as serologic tests for Shigella, Yersinia, and Campylobacter. [onlinelibrary.wiley.com]

treatment has been established. [gut.bmj.com]

Radiological tests, such as a barium enema are also typically normal. [2] Treatment [ edit ] First line treatment for collagenous colitis is the use of budesonide, a steroid that works locally in the colon and is highly cleared by first pass effect. [en.wikipedia.org]

Treatment of collagenous colitis and lymphocytic colitis There is no cure, but treatment can manage the symptoms. [betterhealth.vic.gov.au]

[…] with poorly understood origins, and whose best course for treatment is as equally vague. [badgut.org]

In some cases, collagenous colitis disappears on its own without treatment. However, some people need treatment. Your treatment plan will depend on the severity of your symptoms. [healthline.com]

Prognosis. Overall, the prognosis for lymphocytic colitis and collagenous colitis is good. About 20% of patients undergo a spontaneous remission without specific therapy. [incytepathology.wordpress.com]

Little is known about the long term prognosis of the selected patient group with histological diagnosis of CC but without diarrhoea at diagnosis. [tandfonline.com]

Prognosis Approximately 20% of patients with microscopic colitis may have a spontaneous remission without specific therapy. [emedicine.medscape.com]

To conclude, the possibility of microscopic colitis should be considered while examining colonoscopic biopsy of a patient with chronic watery diarrhea and normal colonoscopy to avoid any misdiagnosis that may affect the treatment and prognosis of the [ijpmonline.org]

Long-term prognosis of clinical symptoms and health-related quality of life in microscopic colitis: a case-control study. Aliment Pharmacol Ther. 2014;39(9):963–972. 43. Capurso G, Marignani M, Attilia F, et al. [dovepress.com]

etiology Diarrhea/pathology Female Humans Intestinal Mucosa/pathology Male Middle Aged Quality of Life [ncbi.nlm.nih.gov]

This condition is of unknown etiology and, in this case, appeared to respond to Stained sections from a rectal biopsy specimen showing the normal surface epithelium, the deposition of collagen as a band beneath the basement membrane, and the sparse chronic [jamanetwork.com]

[Crossref] Park T, Cave D, Marshall C (2015) Microscopic colitis: A review of etiology, treatment and refractory disease. World J Gastroenterol 21: 8804-8810. [oatext.com]

[…] lymphocytic colitis, but is clearly distinct from inflammatory bowel disease ( Gastroenterol Clin Biol 2008;32:689 ) Pseudomembranous collagenous colitis: morphologic variant in which active inflammation with pseudomembrane formation is prominent; various etiologies [pathologyoutlines.com]

"Microscopic colitis: A review of etiology, treatment and refractory disease". World Journal of Gastroenterology. 21 (29): 8804–8810. doi : 10.3748/wjg.v21.i29.8804. ISSN 1007-9327. PMC 4528022. [en.wikipedia.org]

The epidemiology of microscopic colitis: a population based study in Olmsted County, Minnesota. Gut. 2007 ;56: 504 – 508. [tandfonline.com]

[…] inflammatory bowel disease ( Gastroenterol Clin Biol 2008;32:689 ) Pseudomembranous collagenous colitis: morphologic variant in which active inflammation with pseudomembrane formation is prominent; various etiologies ( Ann Diagn Pathol 2013;17:291 ) Epidemiology [pathologyoutlines.com]

The aim of this work was to analyse the epidemiological, clinical and therapeutic characteristics of this disease and its course. [link.springer.com]

First, we compared the observed rates of cancer in our MC cohort to data from the Surveillance, Epidemiology, and End-Results (SEER database). [bmcgastroenterol.biomedcentral.com]

[…] morphologic variant in which active inflammation with pseudomembrane formation is prominent; various etiologies ( Ann Diagn Pathol 2013;17:291 ) Epidemiology 85% in elderly women, often smokers Most cases in Western countries, rare in Asia or Africa Pathophysiology [pathologyoutlines.com]

In: Sleisenger and Fordtran's Gastrointestinal and Liver Disease: Pathophysiology, Diagnosis, Management. 10th ed. Philadelphia, Pa.: Saunders Elsevier; 2016. https://www.clinicalkey.com. Accessed Nov. 7, 2018. Pardi DS, et al. [mayoclinic.org]

Effective strategies to prevent and treat AD remain elusive despite major efforts to understand its basic biology and clinical pathophysiology. Significant investments in therapeutic ... [annualreviews.org]

The aetiology and pathophysiology remain unclear. Conditions associated with it include autoimmune diseases. There may be a genetic predisposition, as familial cases have been described. [ncbi.nlm.nih.gov]

31131860 2019 14 A case of spontaneous colonic perforation in collagenous colitis. 38 Mori H...Tani M 31152255 2019 15 Collagenous colitis diagnosed by endoscopically induced mucosal tears. 38 Shiratori Y...Fukuda K 31110073 2019 16 Microscopic colitis: pathophysiology [malacards.org]

Prevention of Collagenous and Lymphocytic Colitis With the current causes being idiopathic or microscopic, preventions are harder to identify. [medic8.com]

There are no current recommendations for preventing collagenous colitis. However, following diet and medication changes recommended by your doctor may reduce the likelihood of having a relapse. [healthline.com]

Effective strategies to prevent and treat AD remain elusive despite major efforts to understand its basic biology and clinical pathophysiology. Significant investments in therapeutic ... [annualreviews.org]

It's caused by problems in the blood vessels that, in turn, prevent the bowel from getting enough blood. [site.crohnscolitisfoundation.org]

In patients with recurrent disease, MC recurrence prevention is desirable. The recommended primary treatment of MC is with the glucocorticoid budesonide ( 9, 14 ). [atm.amegroups.com]