Presentation
Board review style question #1 A 10 year old boy presents with chronic abdominal pain and anemia. [pathologyoutlines.com]
Collagenous Gastritis in a Young Female With IgA Deficiency Medicine Gastroenterology research 2017 A 26-year-old white female with a past medical history of gastroesophageal reflux disease and scleroderma is presented with collagenous gastritis and focal [semanticscholar.org]
Texto completo A 71-year-old female presented for diarrhea for >3 months passing up to 10 watery stools daily. Microbial stool analysis proved negative with fecal calprotectin slightly elevated (64μg/g; normal<50). [elsevier.es]
Gut 56:504–508 Article PubMed Google Scholar Bohr J, Tysk C, Eriksson S, et al (1996) Collagenous colitis: clinical presentation and treatment in 163 patients. [link.springer.com]
Gastrointestinal
- Chronic Abdominal Pain
abdominal pain and anemia. [pathologyoutlines.com]
Musculoskeletal
- Osteoporosis
Bartl Medicine, Biology The Osteoporosis Manual 2019 Sal plays a role in weight loss, lowering serum lipid levels, regulating the gut microbiota, and improving intestinal fecal metabolites in obese rats, and may exert an anti-obesity effect in rats with [semanticscholar.org]
Workup
HLA Type
- HLA-DQ2
Immunosuppression is standard therapy The absence of both HLA-DQ2 and HLA-DQ8 haplotypes essentially excludes the diagnosis The histologic features may persist for years The pediatric type of the disease is classically characterized by accompanying collagenous [pathologyoutlines.com]
Treatment
Treatment involved antidiarrhoeals and salicylates. After a mean follow-up of 12 months, the outcome was favourable in all patients. [link.springer.com]
[…] gastroesophageal reflux disease and scleroderma presenting with abdominal pain and diarrhea (Gastroenterology Res 2017;10:126) 47 year old woman with systemic lupus erythromatosis presenting with mild anemia and dyspepsia (J Med Case Rep 2014;8:278) Treatment [pathologyoutlines.com]
Successful treatment of collagenous gastritis in a child with a gluten-free diet. WMJ. 2015; 114 (6): 271-273. Hangard P, Lasfargue M, Rubio A. Collagenous gastritis and colitis in a 10-year-old girl. Arch Pediatr. 2016; 23 (7): 747-750. [medigraphic.com]
Etiology
[…] age at presentation centers around young adults (J Nat Sci Biol Med 2018;9:285) Sites Pediatric patients possibly more likely to have body / fundus predominant disease versus antrum in adults (Mod Pathol 2015;28:533) Pathophysiology Poorly understood etiology [pathologyoutlines.com]
Epidemiology
The aim of this work was to analyse the epidemiological, clinical and therapeutic characteristics of this disease and its course. [link.springer.com]
[…] subepithelial collagen in the stomach, with associated chronic inflammation in the lamina propria Often subtyped into pediatric and adult versions No standard therapy ICD coding ICD-10: K52.89 - Other specified noninfective gastroenteritis and colitis Epidemiology [pathologyoutlines.com]
Pathophysiology
Poorly understood etiology / pathophysiology Clinical features Associated with celiac disease, collagenous colitis, collagenous sprue and other autoimmune disease (Arch Pathol Lab Med 2001;125:1579) Most common clinical symptoms include abdominal pain [pathologyoutlines.com]