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Collagenous Sprue


  • The present case suggests that CS should be considered as a differential diagnosis for intractable diarrhea, even in infants.[ncbi.nlm.nih.gov]
  • We present a patient diagnosed with concurrent CS and HH.[ncbi.nlm.nih.gov]
  • Clinically, patients present with diarrhea, abdominal pain, malabsorption, and weight loss.[ncbi.nlm.nih.gov]
  • As far as to our knowledge, the presented case is the first reported case in infancy.[ncbi.nlm.nih.gov]
  • Here, we report a case of a 78-year-old man with collagenous sprue and present the clinical and histological manifestations as well as the successful treatment course that he underwent.[ncbi.nlm.nih.gov]
Recurrent Diarrhea
  • A 67-year-old man with celiac disease developed recurrent diarrhea, profound weakness and weight loss, with evidence of marked protein depletion. His clinical course was refractory to a strict gluten-free diet and steroid therapy.[ncbi.nlm.nih.gov]
  • There are some reports that patients with primary immunodeficiency responded to a gluten-free diet, which may reflect concomitant celiac and recurrent diarrhea, with a special reference to the pathogenesis, Nippon Naika Gakkai Zasshi 66 (1977) ARTICLE IN[documents.tips]
  • CS diagnosis was made and our patient was placed under gluten-free diet (GFD), with improvement of diarrhea and initial gain of 5 kg of weight, but with subsequent relapse with persistent malabsorption, recurrent diarrhea and weight loss of 3 kg again[scielo.isciii.es]
Epigastric Pain
  • April 2016: Human Pathology # 10 Alan Hoi Lun Yau, Wei Xiong, Hin Hin Ko A 56-year-old Caucasian woman presented with epigastric pain, watery diarrhoea, bloating and flatulence following treatment with duloxetine and venlafaxine for anxiety and depression[readbyqxmd.com]
  • Flying across a neuronal network, electric impulses passes by it. Synapse. More options in my portfolio. hd 00:05 Unrecognizable hospital patient lying on MRI, tomograph, scanner, moving to and from the camera.[shutterstock.com]
  • This is exciting for folks with celiac sprue, as they previously had no good treatment options at all. Source: BMJ Open Gastro 2016; 3:e000099. doi:10.1136/bmjgast-2016-000099[celiac.com]


  • Laboratory workup revealed normal stool analysis and TSH. He also tested negative for C.Diff, celiac disease antibodies, HIV, ANA, Hepatitis A, B and C. Initial EGD and colonoscopy were essentially normal.[shmabstracts.com]
  • Provides all the necessary tools to make a comprehensive diagnostic workup including data from ancillary techniques and molecular findings whenever appropriate.[books.google.com]


  • In cases of diet-refractory 'coeliac disease' it is therefore essential to consider collagenous sprue to initiate treatment at an early stage to prevent the fibrotic progression.[ncbi.nlm.nih.gov]
  • Herein, we report the case of a 3-month-old infant with CS who responded to steroid and immunomodulator treatment and presented a thick subepithelial collagen band.[ncbi.nlm.nih.gov]
  • This case suggests that infliximab is an effective treatment in complicated cases of collagenous sprue.[ncbi.nlm.nih.gov]
  • The aim of our study was to compare the clinical features, treatments, and outcomes of CS, CD, and CC.[ncbi.nlm.nih.gov]
  • A clinical response was observed in 24 (80%) patients after treatment with a combination of a gluten-free diet and immunosuppressive drugs. Histologic improvement was confirmed in 9 patients, with complete remission in 5.[ncbi.nlm.nih.gov]


  • CS is historically associated with a poor prognosis (Marthey et al., 2014). However, histological and clinical improvements have been described in most studies with concomitant usage of corticosteroids and/or gluten-free diet (Marthey et al., 2014).[ncbi.nlm.nih.gov]
  • Collagenous sprue (CS) is a rare disease characterized by celiac type small bowel malabsorption that is resistant to gluten free diet (GFD) and is associated with a poor prognosis.[ncbi.nlm.nih.gov]
  • Nevertheless, a prompt use of steroids and/or GFD upon histologic diagnosis of CS may have contributed to an overall excellent prognosis. 2016 Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd.[ncbi.nlm.nih.gov]
  • Prognosis still remains guarded with most patients due to progressive malnutrition often requiring steroid/immunosuppressive/total parenteral nutrition for survival. Collagenous sprue is a rare malabsorption disease with very poor prognosis.[shmabstracts.com]
  • Prognosis is usually dismal. (NCI Thesaurus) ALSO IN ENCYCLOPEDIA :[tititudorancea.com]


  • Its exact etiology is still under investigation, and its relationship with classic celiac disease and other refractory, spruelike intestinal disorders remains controversial.[ncbi.nlm.nih.gov]
  • We, thus, undertook this study to gain insight into the etiology, disease manifestations and outcomes of collagenous sprue.[ncbi.nlm.nih.gov]
  • Collagenous sprue is a clinicopathological entity with an unknown etiology. Its clinical features include progressive malabsorption, diarrhea, weight loss, unresponsiveness to treatment, and high mortality rates.[ncbi.nlm.nih.gov]
  • The etiology of CS is unclear, although there are speculations that CS and celiac disease may share similar pathogenetic pathways. On the other hand, HFE hemochromatosis (HH) is a distinct disease entity.[ncbi.nlm.nih.gov]
  • The etiology remains unclear and the diagnosis is based upon patient s clinical picture and anatomopathological findings.[ncbi.nlm.nih.gov]


  • The epidemiology of microscopic colitis: a population based study in Olmsted County, Minnesota. Gut . 2007; 56(4):504-508. 11. Olesen M, Eriksson S, Bohr J, Järnerot G, Tysk C. Microscopic colitis: a common diarrhoeal disease.[consultant360.com]
  • The epidemiology of microscopic colitis: a 10-year pathology-based nationwide Danish cohort study. Scand J Gastroenterol. 2015;50(4):393–398. 16. Park YS, Baek DH, Kim WH, et al.[dovepress.com]
Sex distribution
Age distribution


  • Pathophysiology Daum and associates reported that increased collagen synthesis in the absence of adequate fibrolysis appears to be the pathophysiologic mechanism leading to the broadened subepithelial collagen band in CS. 47 This mechanism is seen in[ncbi.nlm.nih.gov]
  • It shows the specific features of the pathophysiology, diagnosis, and treatment of MAS in small bowel diseases. 2016: Terapevticheskiĭ Arkhiv # 5 COMPARATIVE STUDY Nan Lan, Bo Shen, Lisi Yuan, Xiuli Liu BACKGROUND: Collagenous sprue (CS) is a rare form[readbyqxmd.com]
  • The association between autoimmune diseases and olmesartan associated enteropathy is consistent with the emerging evidence supporting an immune-based pathophysiology.[elsevier.pt]
  • […] represent increased diagnostic activity. 15 A Korean study of chronic diarrhea detected CC in 4% of patients similar to rates recorded in the western world 16 and has been reported with lower prevalence rates in Indian and Malaysian studies. 17, 18 Pathophysiology[dovepress.com]


  • In cases of diet-refractory 'coeliac disease' it is therefore essential to consider collagenous sprue to initiate treatment at an early stage to prevent the fibrotic progression.[ncbi.nlm.nih.gov]
  • In cases of diet-refractory ‘coeliac disease’ it is therefore essential to consider collagenous sprue to initiate treatment at an early stage to prevent the fibrotic progression.[casereports.bmj.com]
  • It's caused by problems in the blood vessels that, in turn, prevent the bowel from getting enough blood.[crohnscolitisfoundation.org]
  • A randomized, double-blind study of larazotide acetate to prevent the activation of celiac disease during gluten challenge . American Journal of Gastroenterology. 2012;107:1554.[mayoclinic.org]
  • Maintain adequate hydration to prevent renal stones and increase renal clearance of d-lactate. Sipping of isotonic or hypotonic fluids between meals is recommended.[ncbi.nlm.nih.gov]

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