Symptoma

Collecting Duct Carcinoma

CDC

Intracytoplasmic mucin may be present. [ncbi.nlm.nih.gov]

  • Supraclavicular Adenopathy

    The patient went to a Private Hospital for a second opinion where a supraclavicular Adenopathy FNAB ((fine-needle biopsy aspiratory) was performed for conducting a 50-gene sequencing panel study in search of a possible response to biological therapies [acanceresearch.com]

  • Abdominal Pain

    Patients have been described to usually present with hematuria, followed by abdominal pain and a palpable flank mass. General symptoms such as weight loss, fever, and anorexia have occasionally been described. [jmedsoc.org]

    CASE REPORT A 66-year old male with a history of non-insulin dependent diabetes, hypertension and chronic prostatitis presented gross hematuria, abdominal pain and renal failure. [scielo.br]

    The clinical presentation most commonly involves abdominal pain, mass at level of flanks as well as hematuria. There are currently no clinical guides setting out a definite treatment for this disease. [acanceresearch.com]

    Potential symptoms at presentation include abdominal pain, hematuria, weight loss or flank mass; or patients may be asymptomatic (3, 4, 8). [jkcvhl.com]

    Common clinical symptoms of CDC include painless gross hematuria, lumbar abdominal pain, waist and abdominal mass, fatigue, fever, and weight loss. It has a short and fast course. [diagnosticpathology.biomedcentral.com]

  • Dysgeusia

    A 54-year-old woman presented with blepharoptosis, numbness in the lower lip, dysgeusia and pain in the extremities and back. MRI showed marked meningeal thickening and multiple bone lesions accompanying a prominent enhancing effect. [ncbi.nlm.nih.gov]

  • Blepharoptosis

    A 54-year-old woman presented with blepharoptosis, numbness in the lower lip, dysgeusia and pain in the extremities and back. MRI showed marked meningeal thickening and multiple bone lesions accompanying a prominent enhancing effect. [ncbi.nlm.nih.gov]

  • Suggestibility

    The purpose of our study was to characterize the imaging features of this aggressive malignancy and determine whether the diagnosis can be reliably suggested from imaging findings. [ncbi.nlm.nih.gov]

  • Meningism

    The features of the fulminant clinical course with the lesions of the meninges, although rare, are important for the accumulation of experience of this rare disease. [ncbi.nlm.nih.gov]

    One month before his death, carcinomatous meningitis was detected. Hyponatremia, hypo-osmolality, and hypertonic urine suggested the syndrome of inappropriate antidiuresis. [ijpmonline.org]

    The features of the fulminant clinical course with the lesions of the meninges, although rare, are important for the accumulation of experience of this rare disease. 1. [journals.sagepub.com]

    Undiagnosed Collecting Duct Carcinoma Presenting as Meningeal Carcinomatosis and Multiple Bone Metastases. Japanese Society of Internal Medicine. 2010; 49(15): 1541-4. PubMed Google Scholar Mostofi FK, Davis CJ, Sobin LH. [panafrican-med-journal.com]

Further workup including cytochemical and immuno-histochemical stains confirmed it to be collecting duct carcinoma. [ncbi.nlm.nih.gov]

Given this workup, robotic partial nephrectomy (RPN) was performed for presumed endophytic RCC. The kidney was fully mobilized and the main renal artery was clamped, then extirpation was attempted. [jkcvhl.com]

The role of angiography in the workup of renal malignancy has significantly diminished, but angiography may still be used when preoperative knowledge of vascular anatomy is crucial, as with nephron-sparing surgery [5]. [ajronline.org]

  • Mediastinal Mass

    A 62-year-old man with a collecting duct carcinoma of the kidney presenting as a mediastinal mass and supra-clavicular lymph node enlargement, and with a serum alpha-fetoprotein (AFP) level of 102.8 microg/L. [ncbi.nlm.nih.gov]

She continues on sorafenib treatment with minimal toxicity, and has demonstrated a progression-free survival exceeding 13 months. This is the first reported case of a patient with CDC responding to sorafenib treatment. [ncbi.nlm.nih.gov]

Collecting duct carcinoma is associated with aggressive behavior and a poor prognosis. The imaging features (US and CT) suggest the diagnosis. [ncbi.nlm.nih.gov]

[…] of Bellini Definitions Rare, high-grade renal cell carcinoma, likely arising from cells of collecting ducts of renal medulla Diagnostic features still evolving, with characteristic but not entirely specific morphologic and immunophenotypic features ETIOLOGY [basicmedicalkey.com]

(Etiology) Currently, scientists do not know the definitive factor(s) causing Collecting Duct Carcinoma of Kidney. Studies have helped detect numerous genetic mutations in CDCK. [dovemed.com]

To improve our understanding of the biology of CDC and to explore the possibility that different genes may be involved in the etiology and prognosis of this neoplasm, we analyzed by immunohistochemistry eleven cases of CDC for the expression of five genes [bmcurol.biomedcentral.com]

We also review the epidemiological, histological and immunohistochemical criteria for diagnosis, in addition to the genetic and cytogenetic aberrations reported in the literature. [ncbi.nlm.nih.gov]

[…] cases Minimal area of deletion located at 1q32.1-32.2 also identified Amplification of HER2 present in some cases Trisomies of 7 and 17 (typical of papillary RCC) are absent Chromosome 3 losses (typical of clear cell RCC) not present CLINICAL ISSUES Epidemiology [basicmedicalkey.com]

Influence of demographic factors on outcome of collecting duct carcinoma: a surveillance, epidemiology and End Results [SEER] database analysis. Clin Genitourin Cancer. 2009; 7(2): E24-7. PubMed Google Scholar [panafrican-med-journal.com]

Epidemiology, pathology, and pathogenesis of renal cell carcinoma. UpToDate. March 2015; Accessed 7/6/2015. Dason S, Allard C, Sheridan-Jonah A, Gill J, Jamshaid H, Aziz T, Kajal B, Kapoor A. [rarediseases.info.nih.gov]

There is no way to prevent kidney cancer from forming. It is more a matter of avoiding risk factors, such as unhealthy diet and smoking. [my.clevelandclinic.org]

Surgical complications and recovery may also delay or prevent a patient from receiving systemic therapy 11. [current-oncology.com]