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Coloboma of Optic Papilla

Morning Glory Syndrome


Presentation

  • The signs and symptoms of neurological disease are elusive by their very nature, presenting a confounding diagnostic challenge.[books.google.de]
  • –May be associated with postviral syndromes or meningoencephalitis –Loss of vision, pain on eye movement –Vision usually improves within a few weeks, but not full recovery * Optic neuropathy –Compressive: Associated with NF1 and optic nerve glioma, presents[checkorphan.org]
  • A scotoma is usually present, corresponding to the area of the coloboma. Coloboma of the iris.[medical-dictionary.thefreedictionary.com]
Falling
  • These children continue to "fall through the cracks" of our medical education system.[books.google.de]
  • The child may often fall in the same direction while walking, or may bump into objects placed on his/her blind side The child may have refraction symptoms, such as near vison (myopia), astigmatism, and far vision (hypermetropia) On the ophthalmoscopical[dovemed.com]
  • Often the child will fall in the same direction while walking or run into objects that are placed on his or her blind side.[en.wikipedia.org]
  • More extensive rhegmatogenous retinal detachments may occur in eyes with large associated chorioretinal colobomas. 1 Our patient’s presentation falls within the spectrum between an atypical optic nerve coloboma and a morning glory anomaly.[westcoastretina.com]
  • Most investigations of optic disc pits and associated serous macular detachment fall into two general categories: elucidation of the pathogenesis and evaluation of treatment modalities.[retinalphysician.com]
Pain
  • This first volume covers the visual sensory system, the autonomic nervous system, the ocular motor system, the eyelid, facial pain and headache, and nonorganic disease. Volume 2 covers tumors, the phacomatoses, and vascular disease.[books.google.de]
  • […] worse in morning, transient visual obscurations, diplopia –Diagnosis includes increased ICP, normal imaging, normal CSF –More common in obese females * Optic neuritis –May be associated with postviral syndromes or meningoencephalitis –Loss of vision, pain[checkorphan.org]
  • Pain on movement of eye. Possible causes include MS. Further reading Alexander L. (1995) Primary Care of the Posterior Segment. Appleton & Lang, Norwalk Barnard N.A.S. (1989) Congenital pit of the optic nerve. Ophthal.Physiol.[academy.org.uk]
  • There was no history of trauma, eye pain, glaucoma, double vision, headache, vertigo, dysarthria, tremor, paralysis, or loss of sensation. The patient did not have diabetes mellitus, hypertension, or other cardiovascular disease.[advbiores.net]
  • The patient denied pain, flashes, floaters, or any other symptoms. Her past ocular and medical history were significant for sebaceous nevus syndrome with multiple epidermal nevi and lipodermoids. Family and social history were noncontributory.[westcoastretina.com]
Feeding Difficulties
  • difficulties, if associated with cleft palate Signs: The first noticeable signs of this syndrome, usually appear in the first year of life Whitish discoloration of the pupil (leukokoria) may develop in the first few months to years of life The child[dovemed.com]
Weight Loss
  • Treatment - Coloboma of optic papilla * Condition-dependent: Treatment of underlying systemic disease is often the only treatment * Pseudotumor cerebri and other causes of intracranial hypertension: Weight loss, Diamox or Lasix, planned recumbency, LP[checkorphan.org]
Pseudotumor
  • Symptoms - Coloboma of optic papilla The list of signs and symptoms mentioned in various sources for Coloboma of optic papilla includes the 1 symptoms listed below: * Impaired vision Causes - Coloboma of optic papilla * Pseudotumor cerebri –Other symptoms[checkorphan.org]
Nausea
  • Coloboma of optic papilla The list of signs and symptoms mentioned in various sources for Coloboma of optic papilla includes the 1 symptoms listed below: * Impaired vision Causes - Coloboma of optic papilla * Pseudotumor cerebri –Other symptoms: Headache, nausea[checkorphan.org]
Vomiting
  • […] papilla The list of signs and symptoms mentioned in various sources for Coloboma of optic papilla includes the 1 symptoms listed below: * Impaired vision Causes - Coloboma of optic papilla * Pseudotumor cerebri –Other symptoms: Headache, nausea, and vomiting[checkorphan.org]
Torticollis
  • Conversely, early developmental disturbances of vision often disrupt ocular motor control systems, giving rise to complex disorders such as nystagmus, strabismus, and torticollis.[books.google.de]
Ulcer
  • Non-microbial ulcerative keratitis Infection рnline unlikely if there is corneal ulceration but no stromal inflammation.[orientir74.ru]
  • Eyelid coloboma Exposure keratopathy and corneal ulceration, if the cornea is not protected. Choroidoretinal coloboma Reduced visual acuity or visual field (variable, see 'Prognosis', below).[patient.info]
  • This is also a consideration for a patient undergoing cataract surgery. [3] [4] Complications of eyelid coloboma are mainly due to corneal exposure from large upper eyelid defects resulting in exposure keratopathy and corneal ulceration if left untreated[eyewiki.aao.org]
  • . • Subretinal neovascularizations • corneal complications ( ulcerations )in upper palpebral coloboma. 37.[slideshare.net]
Photosensitivity
  • Retinal detachment causes the separation of the photosensitive layer of the eye, called retina, from the back layers of the eyeball.[dovemed.com]
Progressive Visual Loss
  • visual loss, strabismus, nystagmus, proptosis –Infiltrative: From cancers (leukemias, lymphomas), infection, or inflammation (sarcoidosis, TB, toxocariasis, toxoplasmosis, CMV); optic disc swelling, vision loss, and hemorrhages –Toxic/nutritional optic[checkorphan.org]
Cotton Wool Spots
  • wool spots * Optic neuropathy, nonarteritic or arteritic * Demyelinating disease * Infectious conditions: Toxoplasmosis, Lyme disease, Bartonella; hard exudates may be visible funduscopically Prevention - Coloboma of optic papilla Not supplied.[checkorphan.org]
Retinal Hemorrhage
  • hemorrhage and loss of vision * Retinal vein occlusion * Malignant hypertension: Associated with retinal hemorrhage, exudates, and cotton wool spots * Optic neuropathy, nonarteritic or arteritic * Demyelinating disease * Infectious conditions: Toxoplasmosis[checkorphan.org]
Central Scotoma
  • scotoma and dyschromatopsia. 17 Initially the nerve appears hyperaemic and oedematous with non- leaking telangiectatic and tortuous blood vessels emanating. 20 However, up to 40% of patients may initially have a normal appearing nerve. 20 Pallor and[aop.org.uk]
Eye Pain
  • There was no history of trauma, eye pain, glaucoma, double vision, headache, vertigo, dysarthria, tremor, paralysis, or loss of sensation. The patient did not have diabetes mellitus, hypertension, or other cardiovascular disease.[advbiores.net]
Facial Pain
  • This first volume covers the visual sensory system, the autonomic nervous system, the ocular motor system, the eyelid, facial pain and headache, and nonorganic disease. Volume 2 covers tumors, the phacomatoses, and vascular disease.[books.google.de]
Sexual Dysfunction
  • See Career satisfaction Scramble Day, 103, 106 Secondary care, 24в25 Self-evaluation program, web-based, 47в48 Sensors compared Ronem 250mg Inj intuitives, 39 in medical specialties, 42, 43 Sexual dysfunction fellowships in, 454в455 treatment of, 445[orelnavigator.ru]
Intracranial Hemorrhage
  • hemorrhage, space-occupying lesion * Growth hormone supplementation * Retinal hemorrhage and loss of vision * Retinal vein occlusion * Malignant hypertension: Associated with retinal hemorrhage, exudates, and cotton wool spots * Optic neuropathy, nonarteritic[checkorphan.org]

Workup

  • […] compression on the axons. [16] It can be a rare cause of AION in young patients. [8] A high index of suspicion is needed when young patients present with disc edema and loss of vision, in such patient could have avoided the unnecessary neurological workup[advbiores.net]
Central Scotoma
  • scotoma and dyschromatopsia. 17 Initially the nerve appears hyperaemic and oedematous with non- leaking telangiectatic and tortuous blood vessels emanating. 20 However, up to 40% of patients may initially have a normal appearing nerve. 20 Pallor and[aop.org.uk]

Treatment

  • Treatment - Coloboma of optic papilla * Condition-dependent: Treatment of underlying systemic disease is often the only treatment * Pseudotumor cerebri and other causes of intracranial hypertension: Weight loss, Diamox or Lasix, planned recumbency, LP[checkorphan.org]
  • CLOSE Medical Disclaimer The medical information on this site is provided as an information resource only, and is not to be used or relied on for any diagnostic or treatment purposes.[diseaseinfosearch.org]
  • Coverage includes major updates on genetics of diseases, new diagnostic techniques, and the newest treatment options.[books.google.de]
  • The treatment is symptomatic and is also directed towards preventing and treating the complications, which may arise.[dovemed.com]
  • Neurological medications and neurosurgical treatments can produce neuro-ophthalmological dysfunction that can be difficult to distinguish from disease progression.[books.google.de]

Prognosis

  • There is also no cure for this eye disorder The treatment focusses mainly on decreasing the burden of reduced vision, using various interventions The prognosis of Morning Glory Syndrome depends upon the severity of the symptoms; which varies from one[dovemed.com]
  • Diagnosis - Coloboma of optic papilla These home medical tests may be relevant to Coloboma of optic papilla: * Vision and Eye Health: Home Testing: * Home Eye Tests * Home Vision Tests Prognosis - Coloboma of optic papilla Not supplied.[checkorphan.org]
  • Prognosis [ 9 ] The prognosis for vision depends on the severity and location of the coloboma (particularly in relation to the optic nerve, macula and maculopapular bundle) and on any complications such as retinal detachment or amblyopia.[patient.info]
  • Microphthalmos with a cyst had the worst prognosis, a cornea with microcornea and microphthalmos had a poor prognosis, a coloboma with only microcornea had an intermediate prognosis, and a simple coloboma had the best prognosis.[healio.com]
  • The visual prognosis is poor when these occur in combination with an optic nerve coloboma (less than 20/400 acuity in 67% of eyes).[disorders.eyes.arizona.edu]

Etiology

  • […] discusses the adjunctive role of visual evoked potential (VEP), multifocal VEP, electroretinogram (ERG), and mul- focal ERG in the diagnosis of more challenging visual problems, es- cially in distinguishing them from macular disorders and psychogenic etiologies[books.google.de]
  • Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology.[icd10coded.com]
  • (Etiology) The cause of Morning Glory Syndrome developmental defect is unknown A developmental defect is a birth defect that affects the baby in the mother’s womb, during pregnancy.[dovemed.com]
  • They are organised into groups, and further divided into clinical, etiological or histopathological sub-types.[orpha.net]
  • On the basis of these cases, a defect in the closure of the embryonic fissure is the most plausible etiology of the optic pit.[scielo.br]

Epidemiology

  • Epidemiology [ 1 ] The estimated incidence of coloboma is about 1 in 10,000 births. Coloboma is estimated to account for 3-11% of blindness in children worldwide. Aetiology [ 2 ] The eye develops in the embryo, from the optic cup and optic fissure.[patient.info]
  • Epidemiology of congenital eye malformations in 131,760 consecutive births. Ophthalmic Paediatr. Genet. 13, 179–186 (1992). Pagon, R. A. Ocular coloboma. Surv. Ophthalmol. 25, 223–236 (1981).[eyewiki.aao.org]
  • Lane BASICS DESCRIPTION prescripption Drooping of the upper eyelid - Maybecongenitaloracquired - Maycauseblurredvisionorlossofvisualfield EPIDEMIOLOGY Unknown COMMONLY ASSOCIATED CONDITIONS в CN Ill palsy - Congenital, compressive, vasculopathic.[orientir74.ru]
  • The inheritance pattern can be a defect in any of the 39 genes associated with colobomas or more commonly sporadic. [1] Epidemiology The prevalence has been reported to be 0.14% in the general population.[statpearls.com]
Sex distribution
Age distribution

Pathophysiology

  • A review of pathophysiology, diagnosis and treatment Ethan H. Tittler, BA • Khizer R. Khaderi, MD, MPH • Alfredo A. Sadun, MD, PhD Optic disc pit is a rare, congenital excavation of the optic nerve head, first described by Wiethe 1 in 1882.[retinalphysician.com]

Prevention

  • The cause of the condition is unknown and currently, there are no methods to prevent this eye disorder Active research is being performed to explore the possibilities for the treatment and prevention of MGS What is the Prognosis of Morning Glory Syndrome[dovemed.com]
  • Associated with retinal hemorrhage, exudates, and cotton wool spots * Optic neuropathy, nonarteritic or arteritic * Demyelinating disease * Infectious conditions: Toxoplasmosis, Lyme disease, Bartonella; hard exudates may be visible funduscopically Prevention[checkorphan.org]
  • With others, there is no treatment, or treatment may only prevent further vision loss.[medlineplus.gov]
  • Although non-prescription glasses should be worn for eye protection, this syndrome does not usually prevent the individual from living a normal life, driving cars, playing sports, reading, etc.[en.wikipedia.org]
  • The eye usually requires extra lubrication to prevent drying of the surface, and eventually may require surgery to close the defect. Does coloboma of the iris affect vision? If no other abnormalities are present, vision may be normal.[aapos.org]

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