Presentation
This study was undertaken to identify risk factors, presentation, treatment, and prognosis for primary colonic lymphoma (PCL) through review of a large tertiary care hospital system experience. [ncbi.nlm.nih.gov]
Entire Body System
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Inguinal Hernia
The patient also complained of constipation, fatigue, weight loss and melena.The patient’s history included repaired right sided inguinal hernia, pulmonary fibrosis, hypertension and angina pectoris which was treated using coronary stents 5 months ago [bmcsurg.biomedcentral.com]
Immune System
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Palpable Spleen
Physical exam was significant for a palpable spleen that extended below the level of the umbilicus. There was no palpable peripheral lymphadenopathy. [omicsonline.org]
Respiratoric
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Nasal Discharge
Typically, nasal/paranasal disease presents with nasal congestion, fever, purulent/bloody nasal discharge and headache[ 22 ].Systemic symptoms such as fever, weight loss and anaemia may be present. [npplweb.com]
Gastrointestinal
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Abdominal Pain
Patients' frequently present with non-specific abdominal pain, this leads to lengthy delays in diagnosis. Most of these tumors are located in the cecal area. Surgery is the most widely utilized form of therapy. [ncbi.nlm.nih.gov]
Colonic Lymphoma Nodular, ulcerated, constricting neoplasm found in the proximal ascending colon of an 83 year-old woman who had presented with weight loss, abdominal pain and blood in the stool. [endoatlas.com]
Presenting symptoms include non-specific findings such as abdominal pain, decreased appetite, weight loss and anemia [3]. [edoriumjournals.com]
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Abdominal Tenderness
Vital signs were normal and physical examination was unremarkable, with no peripheral lymphadenopathy, abdominal tenderness, or hepatosplenomegaly. Laboratory testing was notable for thrombocytopenia with platelets 122,000/uL and AST 51 U/L. [acgcasereports.gi.org]
Abdominal tenderness. Constipation or, less commonly, diarrhea. When to see a doctor Get medical attention anytime you have constant, unexplained abdominal pain, particularly if you also have fever and constipation or diarrhea. [mayoclinic.org]
Often, a person with diverticulitis has symptoms and signs that include: Abdominal pain Abdominal tenderness An obstruction in the colon (colonic obstruction) An elevated white blood cell count in the blood, and fever. [medicinenet.com]
The most common symptoms of diverticulitis are abdominal or pelvic pain, abdominal tenderness and fever called simple diverticulitis. There can be several secondary complications of an attack of diverticulitis. [fascrs.org]
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Left Lower Quadrant Pain
The acute presentation is typically described as a constellation of “left sided appendicitis” characterized by left lower quadrant pain, fevers and leukocytosis, which is highly suggestive of sigmoid diverticulitis.27 An astute clinician must be aware [clevelandclinicmeded.com]
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Chronic Abdominal Pain
CASE REPORT A 65-year-old Caucasian male with a history of hepatitis C virus (HCV) infection, chronic kidney disease, hypertension, on anticoagulation presented to his primary care physician with chronic abdominal pain. [edoriumjournals.com]
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Left Flank Pain
One week prior to the scheduled surgery, the patient presented with acute on chronic left flank pain unresponsive to hydrocodone. He was afebrile, but had a leukocytosis (24,000) and was unable to ambulate independently. [edoriumjournals.com]
Workup
These previous reports described inflammatory mucosal changes typical of ulcerative colitis as being present in superficial biopsies, leading to the initial diagnosis of ulcerative colitis ; however, further workup resulted in a diagnosis of primary colonic [journals.lww.com]
Serum carcinoembryonic antigen and carbohydrate antigen 19-9 values were not measured during his initial workup. [edoriumjournals.com]
The workup for Mantle cell lymphoma is similar to the workup for many indolent lymphomas and certain aggressive lymphomas. [en.wikipedia.org]
Although a variety of laboratory and imaging studies are used in the evaluation and staging of suspected NHL (see Workup ), a well-processed hematoxylin and eosin (H&E)–stained section of an excised lymph node is the mainstay of pathologic diagnosis. [emedicine.medscape.com]
X-Ray
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Right Pleural Effusion
We report a case of primary colonic non-Hodgkin's lymphoma with peritoneal carcinomatosis and a right pleural effusion. [e-ce.org]
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Normal Chest X-Ray
DISCUSSION To distinguish between primary and secondary gastrointestinal lymphoma, the definition of primary gastrointestinal lymphoma 5 ) is quite applicable, which consists of no palpable superficial lymphadenopathy at presentation, a normal chest X-ray [kjim.org]
Treatment
BACKGROUND: Surgical resection is considered a crucial treatment in patients with primary colonic lymphoma, but combining surgery with chemotherapy has provided additional therapeutic benefits in some studies. [ncbi.nlm.nih.gov]
Conclusion: Hereby the pathophysiology, diagnosis and the treatment of the disease is discussed on the unexpected survival of surgical treatment alone. [go.gale.com]
In combination with other treatment measures, these can help combat the symptoms of immunodeficiency Undertaking treatment of underlying conditions/disorders, as warranted If lymphoma of the large intestine is not fully responsive to treatment, or if [dovemed.com]
Prognosis
Nevertheless, resection followed by chemotherapy appears to offer the best prognosis. [ncbi.nlm.nih.gov]
Report of 37 cases with a study of factors influencing prognosis. Br J Surg 1961;49:80-9. 7. G Stanojević, M Stojanović, M Jovanović. [Primary colorectal lymphomas]. Vojnosanit Pregl 2009;66:295-301. [Article in Serbian]. 8. [pagepress.org]
Etiology
The underlying etiology is unknown but an infective/inflammatory pathogenesis is suspected as their is higher incidence in patients with HIV/AIDS, inflammatory bowel disease and post-transplantation immunosuppression 1. [radiopaedia.org]
The etiology of colonic diverticulosis is multifactorial and not entirely known. [merckmanuals.com]
However, the results did not differentiate an infectious versus neoplastic etiology of the perforation. [edoriumjournals.com]
(Etiology) Lymphocytes are a type of white blood cells that are responsible for providing immunity in the human body. B-cells and T-cells are the two different types of lymphocytes. [dovemed.com]
Epidemiology
The aim of this review is to examine the epidemiology of colonic diverticulosis and the incidence of complications, namely acute diverticulitis and diverticular hemorrhage. [karger.com]
[…] non-Hodgkin lymphoma over a 10-year period in one study. 8 Sites of tumor growth have been reported to be the cecum (71.5%), rectum (16.9%), and ascending colon (6.2%); the sigmoid colon is only rarely affected. 9 HCV has been linked to MALT lymphoma by epidemiological [acgcasereports.gi.org]
Into Africa He first worked primarily as a general practitioner in Lira, where an unusually high incidence of hydrocele aroused his interest in geographical medicine and epidemiology. [whonamedit.com]
Epidemiology Diverticulosis is ve. 2014-04-08 · Abstract: Colonic diverticulosis is one of the most common conditions in industrialized nations. [quinix.xkqvlbva.shop]
Colonic diverticulosis and diverticular disease: Epidemiology, risk factors, and pathogenesis. . Accessed July 24, 2018. Tursi A, et al. [mayoclinic.org]
Pathophysiology
Conclusion: Hereby the pathophysiology, diagnosis and the treatment of the disease is discussed on the unexpected survival of surgical treatment alone. [go.gale.com]
Review article: The pathophysiology and medical management of diverticulosis and diverticular disease of the colon. Alimentary Pharmacology and Therapeutics. 2015;42:664. Pemberton JH, et al. [mayoclinic.org]
The pathophysiology of diverticular bleeding is unknown, but several mechanisms are hypothesized, including Local trauma from impacted feces in a diverticulum that can erode the adjacent vessel Enlargement of the diverticulum that can stretch (and ultimately [merckmanuals.com]
Epidemiology and pathophysiology of diverticular disease. Clin Colon Rectal Surg 2018; 31(4):209–213. Aldoori WH, Giovannucci EL, Rimm EB, Wing AL, Trichopoulos DV, Willett WC. [clevelandclinicmeded.com]
Prevention
Although resection plays an important role in the local control of the disease and in preventing bleeding and/or perforation, it rarely eradicates the lymphoma by itself. [gastrointestinalatlas.com]
How can Lymphoma of Colon and Rectum be Prevented? Currently, it is not possible to prevent Lymphoma of Colon and Rectum. However, controlling certain factors may help lower one’s risk for the condition. [dovemed.com]
[…] and early detection of cervical cancer: American Cancer Society, American Society for Colposcopy and Cervical Pathology, and American Society for Clinical Pathology screening guidelines for the prevention and early detection of cervical cancer. [nccn.org]
I currently have no symptoms but wonder if I should do anything to prevent it from progressing. [newsnetwork.mayoclinic.org]