Presentation
This study was undertaken to identify risk factors, presentation, treatment, and prognosis for primary colonic lymphoma (PCL) through review of a large tertiary care hospital system experience. [ncbi.nlm.nih.gov]
EATL most commonly presents in the sixth and seventh decades of life. [dovepress.com]
Colonic Lymphoma Nodular, ulcerated, constricting neoplasm found in the proximal ascending colon of an 83 year-old woman who had presented with weight loss, abdominal pain and blood in the stool. [endoatlas.com]
Immune System
- Palpable Spleen
Physical exam was significant for a palpable spleen that extended below the level of the umbilicus. There was no palpable peripheral lymphadenopathy. [omicsonline.org]
Gastrointestinal
- Abdominal Pain
Patients' frequently present with non-specific abdominal pain, this leads to lengthy delays in diagnosis. Most of these tumors are located in the cecal area. Surgery is the most widely utilized form of therapy. [ncbi.nlm.nih.gov]
Colonic Lymphoma Nodular, ulcerated, constricting neoplasm found in the proximal ascending colon of an 83 year-old woman who had presented with weight loss, abdominal pain and blood in the stool. [endoatlas.com]
Differential therapeutic strategies, including corticosteroid, had improved the symptoms which were dominated by abdominal pain. [kjim.org]
- Abdominal Tenderness
Abdominal tenderness. Constipation or, less commonly, diarrhea. When to see a doctor Get medical attention anytime you have constant, unexplained abdominal pain, particularly if you also have fever and constipation or diarrhea. [mayoclinic.org]
Often, a person with diverticulitis has symptoms and signs that include: Abdominal pain Abdominal tenderness An obstruction in the colon (colonic obstruction) An elevated white blood cell count in the blood, and fever. [medicinenet.com]
Vital signs were normal and physical examination was unremarkable, with no peripheral lymphadenopathy, abdominal tenderness, or hepatosplenomegaly. Laboratory testing was notable for thrombocytopenia with platelets 122,000/uL and AST 51 U/L. [acgcasereports.gi.org]
The most common symptoms of diverticulitis are abdominal or pelvic pain, abdominal tenderness and fever called simple diverticulitis. There can be several secondary complications of an attack of diverticulitis. [fascrs.org]
- Left Lower Quadrant Pain
The acute presentation is typically described as a constellation of “left sided appendicitis” characterized by left lower quadrant pain, fevers and leukocytosis, which is highly suggestive of sigmoid diverticulitis.27 An astute clinician must be aware [clevelandclinicmeded.com]
- Chronic Abdominal Pain
CASE REPORT A 65-year-old Caucasian male with a history of hepatitis C virus (HCV) infection, chronic kidney disease, hypertension, on anticoagulation presented to his primary care physician with chronic abdominal pain. [edoriumjournals.com]
Workup
These previous reports described inflammatory mucosal changes typical of ulcerative colitis as being present in superficial biopsies, leading to the initial diagnosis of ulcerative colitis ; however, further workup resulted in a diagnosis of primary colonic [journals.lww.com]
Serum carcinoembryonic antigen and carbohydrate antigen 19-9 values were not measured during his initial workup. [edoriumjournals.com]
The workup for Mantle cell lymphoma is similar to the workup for many indolent lymphomas and certain aggressive lymphomas. [en.wikipedia.org]
Although a variety of laboratory and imaging studies are used in the evaluation and staging of suspected NHL (see Workup ), a well-processed hematoxylin and eosin (H&E)–stained section of an excised lymph node is the mainstay of pathologic diagnosis. [emedicine.medscape.com]
X-Ray
- Right Pleural Effusion
We report a case of primary colonic non-Hodgkin's lymphoma with peritoneal carcinomatosis and a right pleural effusion. [e-ce.org]
Treatment
Conclusion: Hereby the pathophysiology, diagnosis and the treatment of the disease is discussed on the unexpected survival of surgical treatment alone. [go.gale.com]
BACKGROUND: Surgical resection is considered a crucial treatment in patients with primary colonic lymphoma, but combining surgery with chemotherapy has provided additional therapeutic benefits in some studies. [ncbi.nlm.nih.gov]
In combination with other treatment measures, these can help combat the symptoms of immunodeficiency Undertaking treatment of underlying conditions/disorders, as warranted If lymphoma of the large intestine is not fully responsive to treatment, or if [dovemed.com]
Treatment protocols for gastric MALT lymphoma are well established but are less clear for colonic MALT lymphoma owing to its rarity. [ekjm.org]
Prognosis
Nevertheless, resection followed by chemotherapy appears to offer the best prognosis. [ncbi.nlm.nih.gov]
Large bowel lymphoma differs from gastric and small bowel lymphoma in clinical presentation, management and prognosis. Most commonly occurs in patients in their forties to sixties, with increasing incidence with age. [radiopaedia.org]
Etiology
The underlying etiology is unknown but an infective/inflammatory pathogenesis is suspected as their is higher incidence in patients with HIV/AIDS, inflammatory bowel disease and post-transplantation immunosuppression 1. [radiopaedia.org]
The etiology of colonic diverticulosis is multifactorial and not entirely known. [merckmanuals.com]
In cases of complicated diverticular disease, where a colonic fistula is present, a colonoscopy can confirm the site and etiology of the fistula. [clevelandclinicmeded.com]
The etiology of diverticulosis of the colon with special reference to the action of certain drugs on behavior of the colon. Ann R Coll Surg 1964; 34: 98. Reprinted with permission. [ncbi.nlm.nih.gov]
Epidemiology
The aim of this review is to examine the epidemiology of colonic diverticulosis and the incidence of complications, namely acute diverticulitis and diverticular hemorrhage. [karger.com]
Into Africa He first worked primarily as a general practitioner in Lira, where an unusually high incidence of hydrocele aroused his interest in geographical medicine and epidemiology. [whonamedit.com]
Epidemiology Diverticulosis is ve. 2014-04-08 · Abstract: Colonic diverticulosis is one of the most common conditions in industrialized nations. [quinix.xkqvlbva.shop]
Colonic diverticulosis and diverticular disease: Epidemiology, risk factors, and pathogenesis. https://www.uptodate.com/contents/search. Accessed July 24, 2018. Tursi A, et al. [mayoclinic.org]
Epidemiology United States statistics After a striking increase in incidence rates between 1970 and 1995 (which may in part have reflected improved diagnosis), the rates of new non-Hodgkin lymphoma (NHL) cases stabilzed. [emedicine.medscape.com]
Pathophysiology
Conclusion: Hereby the pathophysiology, diagnosis and the treatment of the disease is discussed on the unexpected survival of surgical treatment alone. [go.gale.com]
Review article: The pathophysiology and medical management of diverticulosis and diverticular disease of the colon. Alimentary Pharmacology and Therapeutics. 2015;42:664. Pemberton JH, et al. [mayoclinic.org]
Epidemiology and pathophysiology of diverticular disease. Clin Colon Rectal Surg 2018; 31(4):209–213. Aldoori WH, Giovannucci EL, Rimm EB, Wing AL, Trichopoulos DV, Willett WC. [clevelandclinicmeded.com]
The pathophysiology of diverticular bleeding is unknown, but several mechanisms are hypothesized, including Local trauma from impacted feces in a diverticulum that can erode the adjacent vessel Enlargement of the diverticulum that can stretch (and ultimately [merckmanuals.com]
Prevention
[…] and early detection of cervical cancer: American Cancer Society, American Society for Colposcopy and Cervical Pathology, and American Society for Clinical Pathology screening guidelines for the prevention and early detection of cervical cancer. [nccn.org]
I currently have no symptoms but wonder if I should do anything to prevent it from progressing. [newsnetwork.mayoclinic.org]
Although resection plays an important role in the local control of the disease and in preventing bleeding and/or perforation, it rarely eradicates the lymphoma by itself. [gastrointestinalatlas.com]
A normal fiber diet is advisable to prevent constipation and perhaps prevent the formation of more diverticula. [medicinenet.com]