This study presents the first use of preimplantation genotyping to ensure biparental inheritance in a woman presenting with recurrent diandric complete hydatidiform mole. [ncbi.nlm.nih.gov]

• Short Arm

  To our knowledge, this is the first case report of complete hydatidiform mole with coexisting fetus diagnosed by variation of the acrocentric short arms, followed by termination with intravaginal gemeprost. [ncbi.nlm.nih.gov]

• Long Arm

  DNA probes specific for the pericentromeric regions of chromosomes 1 and X and for the long arm of chromosome Y were used. In four cases a dizygotic twin pregnancy could be proven. [ncbi.nlm.nih.gov]

• Oliguria

  Post operatively she had an eclamptic fit and developed oliguria and persistent trophoblastic disease which were all successfully treated. [ncbi.nlm.nih.gov]

  Post operatively she had an eclamptic fit and developed oliguria and persistent trophoblastic disease which were all successfully treated. Key words : hydatidiform mole, living fetus, perisitent trophoblastic disease. [ajol.info]

The metastatic workup was negative and the patient was treated with weekly intramuscular methotrexate at 30 mg/m2. The hCG levels declined appropriately and then plateaued. [ncbi.nlm.nih.gov]

Persistent cysts warrant appropriate workup and 26.  Pulmonary distress : is observed in 2% of patients. [slideshare.net]

If malignancy is suspected, workup must include an x-ray of the chest to screen for lung metastases. Hydatidiform moles are normally treated via dilation and curettage, whereas choriocarcinoma typically requires chemotherapy. [amboss.com]

Differential diagnosis of a hydatidiform mole From a diagnostic point of view, a workup for spontaneous abortion should also be carried out, since this can also cause bleeding in early pregnancy. [lecturio.com]

With rapidly increasing acquirement of molecular diagnostic capabilities at most medical centers, DNA genotyping should become an integral component of the routine diagnostic workup of both complete and partial hydatidiform moles. [omicsonline.org]

[…] until hCG plateau or increase did not affect outcomes, with no uterine perforations or treatment failures. [ncbi.nlm.nih.gov]

Seven day rest between treatment cycles. [molarpregnancy.co.uk]

Fortunately, these tumors are often curable with appropriate treatment and after treatment, a patient's fertility is often preserved. Even the most advanced cases of GTT are often curable with the right treatment. [verywell.com]

Pre- and post-treatment MRI scans of the pelvis showing a large uterine mass prior to treatment and a normal scan at completion. The treatment graph shows the fall and normalization of the hCG level with low dose methotrexate chemotherapy treatment. [lecturio.com]

OBJECTIVE: To examine whether preeclampsia is a predictive factor for fetal prognosis in complete hydatidiform mole coexistent with twin fetus (CHMCF). [ncbi.nlm.nih.gov]

Prognosis Moles may progress to persistent trophoblastic disease, placental site trophoblast tumour and choriocarcinoma. The incidence of persistent disease is far more common for complete moles (10-30%) than it is for partial moles (0.5-5%). [e-immunohistochemistry.info]

Treatment and prognosis Suction and curettage are used for evacuation are usually the routine treatment. Serial beta-hCG levels should be obtained until it reaches zero, as it is the main indicator of residual disease. [radiopaedia.org]

Management of the pregnancy in such rare conditions should be determined on one-to-one basis and the possibility of increased complications should be discussed with the family and prognosis explained. [ijpmonline.org]

Follow-up and prognosis of these women does not differfrom otherwomen with complete hydaticliform moles 3. References 1. Suzuki, M., Masunobu, A., Wakita, K. et at. Hydatidiform molewith a surviving cocxistrngfoetus. Obstet. [jpma.org.pk]

Etiology of choriocarcinoma Choriocarcinoma frequently develops from a hydatidiform mole or following a spontaneous abortion; occasionally, it also occurs after a normal pregnancy. [lecturio.com]

[…] an invasive mole Etiology Risk factors Prior molar pregnancy History of miscarriage Patients ≤ 15 and ≥ 35 years Complete mole Does not contain any fetal or embryonic parts Caused by fertilization of an empty egg that does not carry any chromosomes → [amboss.com]

Etiology and pathogenesis THE DRIFT OF THE GALLBLADDER (MOLA HYDATIDOSA) Defeat fleecy shell of the ovum with the transformation of the latter into a conglomerate of small bubbles of various sizes. Etiology and pathogenesis is not known. [lecheniebolezni.com]

A few studies have looked at the over- or underexpression of genes that may play a role in the progression or invasiveness of hydatidiform moles; however none have addressed the underlying genetic etiology. [clinicaltrials.gov]

Etiology. The reasons for the degeneration of chorionic villi and hydatidiform mole formation is still not completely understood. Development molar earlier only associated with syphilis, nephritis, chlorosis, anemia, etc. [survinat.com]

Incide… Gynecologic tumor epidemiology - Incide… Gynecologic tumor epidemiology - Worst… -Due to blockage of Bartholin gland duc… endometrial > ovarian > cervical cervical > endometrial > ovarian... [quizlet.com]

Author information 1 Department of Pathology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea. 2 Department of Pathology, Myong-JI General Hospital, Goyang-si, Gyeongi-do, Korea. 3 Department of Clinical Epidemiology and Biostatistics [ncbi.nlm.nih.gov]

PubMed Google Scholar 13.2 Grimes DA : Epidemiology of gestational trophoblastic disease. Am J Obstet Gynecol 150:309–318, 1984. [link.springer.com]

Epidemiology of choriocarcinoma Choriocarcinoma is one of the rarest carcinomas occurring in the female genital tract. It accounts for around 1 % of all female tumors. [lecturio.com]

Epidemiology of hydatidiform mole during early gestation. Am J Obstet Gynecol. 1986 Apr. 154(4):906-9. [Medline]. Grimes DA. Epidemiology of gestational trophoblastic disease. Am J Obstet Gynecol. 1984 Oct 1. 150(3):309-18. [Medline]. [emedicine.medscape.com]

CONCLUSION: MRI could provide important information about the prenatal differential diagnosis of CHMTF and PMD, based on the pathophysiology and characteristics of the diseases. © 2014 The Authors. [ncbi.nlm.nih.gov]

Pathophysiology: A complete mole contains no fetal tissue. 90% are 46XX and 10% are 46XY. All chromosomes are of paternal origin. [csh.org.tw]

Pathophysiology Hydropic degeneration of chorionic villi with concomitant proliferation of cytotrophoblasts and syncytiotrophoblasts → death of the embryo Clinical features Complete mole Vaginal bleeding during the first trimester Uterus size greater [amboss.com]

Pathophysiology of Disease, 5th ed., p. 639. ↑ Robbins and Cotran's Pathological Basis of Disease, 7th ed., p. 1112 ↑ Title of page. Website title (date). [wikidoc.org]

The comparison of findings in androgenetic CHM and PHM indicate that both maternally (under) expressed and paternally (over) expressed genes play a role in the pathophysiology of molar pregnancies. [clinicaltrials.gov]

Selection of male embryos is therefore unlikely to prevent repetitive CHM in this patient. [ncbi.nlm.nih.gov]

To prevent the morbidity and mortality associated with postmolar malignant sequelae, prophylactic hysterectomy was advocated by some (5), but it could not prevent metastasis in other body parts besides sacrificing the reproductive potential in young patients [ispub.com]