Clinical presentation COD presents with loss of central vision, photophobia and colour vision disturbance. Since cone function is usually initially normal, nystagmus is often absent. [bjo.bmj.com]

Patients generally present in childhood or teenage years with symptoms of night blindness, and on examination of the retina, dark pigment changes may be seen, often described as bone spicules. Age of onset and visual prognosis are very variable. [retinauk.org.uk]

In stationary cone dystrophy, symptoms tend to remain stable and are usually present at birth or early childhood. In progressive cone dystrophy, symptoms slowly worsen over time. [rarediseases.org]

Presentation[edit] The most common symptoms of cone dystrophy are vision loss (age of onset ranging from the late teens to the sixties), sensitivity to bright lights, and poor color vision. Therefore, patients see better at dusk. [en.wikipedia.org]

• Hunting

  Michaelides M, Hunt DM, Moore AT. The cone dysfunction syndromes. Br J Ophthalmol. 2004;88:291-297. [rarediseases.org]

  CAS PubMed Google Scholar Kellsell RE, Evans K, Gregory CY, Moore AT, Bird AT, Hunt DM. Localisation of a gene for dominant cone-rod dystrophy (CORD6) to chromosome 17p. Hum Mol Genet 1997;6:597–600. [nature.com]

The inclusion of fluorescein angiography in the workup of these patients is important since it can help detect many of these characteristic ophthalmoscopic features. [en.wikipedia.org]

Other treatment is symptomatic and supportive. [rarediseases.org]

[citation needed] Treatment[edit] Though there is no treatment for cone dystrophy, certain supplements may help in delaying the progression of the disease. [en.wikipedia.org]

Gene therapy encompasses multiple techniques, including gene replacement, gene editing and gene silencing, with treatment choice dependent on whether the associated sequence variant(s) leads to a loss or gain in function.97 Human treatment trials of gene [bjo.bmj.com]

Clinical trial of docosahexaenoic acid in patients with retinitis pigmentosa receiving vitamin A treatment. Arch. Ophthalmol. 2004;122(9):1297-305 25) Hassof RW, Fishman GA. [malattierare.regione.veneto.it]

Treatment We still do not clearly understand how cone dystrophies happen, or why people’s symptoms are so different. There is limited evidence that changes to your diet may slow sight loss caused by progressive cone dystrophies. [macularsociety.org]

Age of onset and visual prognosis are very variable. The condition can be inherited in different ways, recessive being most common. [retinauk.org.uk]

An accurate diagnosis using molecular genetics is an important step to facilitate genetic counselling, advice on prognosis and participation in anticipated clinical trials.89 Patients with specific forms of COD/CORD can be advised to adopt strategies [bjo.bmj.com]

Clinical course, genetic etiology, and visual outcome in cone and cone-rod dystrophy. Ophthalmology. 2012 Apr;119(4):819-26. doi: 10.1016/j.ophtha.2011.10.011. Epub 2012 Jan 20. Citation on PubMed [medlineplus.gov]

In GUCA1A-associated retinopathy, sleeping with the lights on is advocated by some clinicians for preventing accumulation of cGMP, which otherwise occurs at night and causes photoreceptor damage. [bjo.bmj.com]