Confluent and reticulated papillomatosis (CARP), also known as Gougerot-Carteaud syndrome is a rare disorder first described by Gougerot and Carteaud in 1927 [1]. It occurs in all age groups, races, and genders. Usually, patients are asymptomatic. However, they may experience mild pruritus. The lesions are most commonly observed on the trunk [2]. Physical findings are limited to the skin.

CARP lesions begin as papules of 1 to 2 millimeters in diameters that are slightly hyperkeratotic to warty. They enlarge to form 4 to 5 millimeters lesions which coalesce and form confluent plaques centrally with a reticulated periphery. Skin markings are preserved, or in the neck and axillae, they may be exaggerated. It has been described as keratotic and vertically rippled plaques, and punctate pigmented papillomatosis [3] [4]. Rarely, atrophic macules may also be seen. A fine powdery scale is produced upon scraping of the lesions. Dermoscopy reveals an ill-defined brownish pigmentation, covered with white scales and a pattern labeled "sulci and gyri" [5]. The color of lesions in CARP are characterized by an early erythematous appearance that later evolves into a grayish brown color [6].

CARP lesions initially develop in the skin of epigastric or intermammary region, and over a period of weeks to months spread over the lower abdomen, breast, pubic area, and the flanks. Exceptions to this can occur, as in one case the lesions were confined to the cheeks and in another, they were confined to the pubic area [7] [8]. The mucous membranes are spared but the involvement of the face, proximal extremities, and forehead may be seen [9] [10].

• Plethora

  Treatment A plethora of options on treatment of CRP is available in the literature. Among the myriad of therapies, minocycline and azithromycin were reported to yield good results. [dovepress.com]

• Epilepsy

  The syndrome displays distinctive clinical findings represented by developmental delay, intellectual disability, epilepsy and autistic behaviour. Skin pigmentation has been observed in several cases (1). [medicaljournals.se]

• Developmental Delay

  The syndrome displays distinctive clinical findings represented by developmental delay, intellectual disability, epilepsy and autistic behaviour. Skin pigmentation has been observed in several cases (1). [medicaljournals.se]

• Pseudotumor

  Other oral therapies include clarithromycin, tetracycline, furacycline, azfuracycline, and cefdinir.3 Because of potential adverse reactions reported for minocycline, including pseudotumor cerebri, lupus-like syndrome, and autoimmune hepatitis, and the [healio.com]

• Hematemesis

  March 1, 2018 A 49-year-old man presented to the emergency department with hematemesis and 2 episodes of melena. Examination findings included resting tachycardia and melenic stool. Blood pressure was 95/50 mm Hg. [consultant360.com]

• Hyperpigmentation

  Thus, there is the possibility that the skin hyperpigmentation associated with 15q tetrasomy syndrome is being diagnosed as CRP. [medicaljournals.se]

  We report three teenaged Caucasian patients with confluent and reticulated papillomatosis whose presentation was atypical due to the absence of hyperpigmentation and presence of a fine white scale. [ncbi.nlm.nih.gov]

  CASE STUDY: A healthy 17-year-old boy presents to clinic with a gradually progressive reticulated hyperpigmentation of the chest and back, which has been present for 1 year. It does not itch or hurt and had a gradual onset. [healio.com]

  […] papillomatosis Figure: 3 Confluent and reticulate papillomatosis Management Several antibiotics, especially minocycline and azithromycin, have been found to be effective when give for a period of 6-8 weeks Minocycline has occasionally been associated with hyperpigmentation [pcds.org.uk]

  The rash actually resolved within 2 weeks with only some residual post-inflammatory hyperpigmentation. [theketorash.com]

• Skin Disease

  Age range was 13-25 years and the skin disease had lasted for 6 months to 3 years. Initially, acanthosis nigricans was suspected in all cases as the skin histology was compatible with that diagnosis. [ncbi.nlm.nih.gov]

  […] demographics of common skin diseases, comparing Caucasian and all skin of color populations. [books.google.com]

  Key Points *Rare *Affects the trunk area *Characterized by dark, scaly papules and plaques Confluent and reticulated papillomatosis of Gougerot and Carteaud, besides being a mouthful to say, is a relatively uncommon skin disease that usually affects young [ozarkderm.com]

  disease of unknown etiology characterized by flat papules taking a reticulated appearance. 2)History: Confluent and reticulated papillomatosis (CRP) was first described by Gougerot and Carteaud in 1927. [histopathology-india.net]

  diseases, papillomatosis Abstract Introduction: Confluent and reticulated papillomatosis (CRP) of Gougerot and Carteaud is a rare dermatosis characterized by brownish papules with fine scaling, forming confluent plaques in the center and reticulated [revistas.rcaap.pt]

• Follicular Plugging

  Clinically, one case had an atypical clinical presentation, and microscopically follicular plugging was seen in the majority of cases. [ncbi.nlm.nih.gov]

• Generalized Seizure

  He had experienced frequent generalized seizures since 8 years of age, which were treated with clobazam and carbamazepine. [medicaljournals.se]

The diagnostic criteria for CARP is proposed as:

1. Scaly brown macules and patches. Some appearing papillomatous and reticulated.
2. Involvement of the neck, upper trunk, or flexural areas.
3. No response to antifungal therapy, or negative fungal staining.
4. A favorable response to antibiotics.

On potassium hydroxide (KOH) test, pityrosporum ovale or pityrosporum orbiculare spores and rarely hyphae may be found. A fungal culture may also reveal these microorganisms in some cases. On wood lamp examination, yellow fluorescence can occur if pityrosporum organisms are present. Electron microscopy can help detect alterations in the structure and arrangement of cornified cells in some lesions. An increase may be observed in transitional cell layer, the number of melanosomes in the stratum corneum, and the number of lamellar bodies in the stratum granulosum [11]. On immunohistochemical analysis, suprabasal keratin 16 expression and an intense focal staining in the stratum granulosum are revealed, with an increased number of epidermal cells with Ki-67 binding in the stratum malpighii.

Histopathological features of CARP include:

1. Basket-weave hyperkeratosis.
2. Papillomatosis.
3. Focal acanthosis (limited to areas of rete pegs elongation).
4. Raised basal melanin pigmentation.

Although a variety of treatments for CARP exist, oral minocycline 50-100mg twice daily has been the preferred treatment. [ncbi.nlm.nih.gov]

Although a variety of treatments for CARP exist, oral minocycline 50–100mg twice daily has been the preferred treatment. [doi.org]

Minocycline was first used for the treatment of CRP in 1965 by Carteaud. [ijdvl.com]

(Outcomes/Resolutions) The prognosis of Confluent and Reticulated Papillomatosis is good with adequate treatment. [dovemed.com]

Prognosis CRP usually responds to minocycline and azithromycin as first-line drugs, with remission being sustained for years. Recurrences are more common in those treated with other agents, occurring in up to 15 percent of such patients. [news-medical.net]

However, given the superior safety profile of minocycline and azithromycin, systemic retinoids are typically reserved for nonresponders to antibiotics.28 Prognosis The prognosis of CRP is good with marked response (>50% improvement) when minocycline or [dovepress.com]

However, given the superior safety profile of minocycline and azithromycin, systemic retinoids are typically reserved for nonresponders to antibiotics. 28 Prognosis The prognosis of CRP is good with marked response (>50% improvement) when minocycline [ncbi.nlm.nih.gov]

In one study of 10 Lebanese cases, the mean age at diagnosis was 19 years. [8] Prognosis Confluent and reticulated papillomatosis is a chronic disease characterized by exacerbations and remissions. [emedicine.medscape.com]

Of unknown etiology, the condition is characterised by oval grayish-brown or erythematous papules that coalesce to form a reticular pattern, usually on the trunk, especially in the intermammary or interscapular region and on the neck. [ncbi.nlm.nih.gov]

Amyloidosis of the skin has also been proposed as an etiological agent. Genetic Causes While most cases of CRP are sporadic, some familial cases have been reported. [news-medical.net]

The etiology of CRP is unclear. Initially, it was thought to be caused by malessezia, the same fungal organism that causes tinea versicolor. [healio.com]

Our review of the literature on confluent and reticulated papillomatosis refutes previously accepted epidemiologic data. [ncbi.nlm.nih.gov]

Confluent and reticulated papillomatosis: response to high-dose oral isotretinoin therapy and reassessment of epidemiologic data. J Am Acad Dermatol 1994; 31: 327-331 Paul HB, Loretta SD. [medigraphic.com]

The epidemiology of CRP is not well defined. A recent case series from the Mayo Clinic of 39 patients demonstrated an average age at presentation of 15 years.1 At the first visit, the eruption had been present for a mean of 3.1 years. [healio.com]

This report defines the prevalence of genital colonization in a large population of women, characterizes the women with S. aureus, and describes epidemiologic features of genital carriage. ‎ Página 50 - Lautenschlager S, Eichmann A. [books.google.es]

This is the first electron microscopic report on CRP suggesting that the pathophysiology of this disease is related to abnormal keratinocyte differentiation. [ncbi.nlm.nih.gov]

To the best of our knowledge, her transient post-partum clearance has not been reported anywhere else in the literature and we believe it may offer a clue in the pathophysiologic process of CARP. [consultant360.com]

The macrolides, on the other hand, regulate immune activation via IL-8 suppression and preventing the neutrophil oxidative burst. [news-medical.net]

General skin care is advised by most healthcare providers typically as a preventive measure for any skin condition. [dovemed.com]

Atlanta: Centers for Disease Control and Prevention, September 1995. ‎ Página 51 - Stone KM, Reiff-Eldridge R, White AD, Cordero JF, Brown Z, Alexander ER, Andrews EB. [books.google.es]

Minocycline inhibits migration of neutrophils. prevents release of reactive oxygen species& inhibits matrix-metalloproteinase. (10)(11)(12) in both cases lesions were completely cleared in 3 weeks suggesting that the bacterial infection might be the cause [jemds.com]

Author Robert A Schwartz, MD, MPH Professor and Head of Dermatology, Professor of Pathology, Pediatrics, Medicine, and Preventive Medicine and Community Health, Rutgers New Jersey Medical School; Visiting Professor, Rutgers University School of Public [emedicine.staging.medscape.com]

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3. Min ZS, Tan C, Xu P, Zhu WY. Confluent and reticulated papillomatosis manifested as vertically rippled and keratotic plaques. Postepy Dermatol Alergol. 2014;31(5):335-7.
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10. Kim BS, Lim HJ, Kim HY, et al. Case of minocycline-effective confluent and reticulated papillomatosis with unusual location on forehead. J Dermatol. 2009;36(4):251-3.
11. Jimbow M, Talpash O, Jimbow K. Confluent and reticulated papillomatosis: clinical, light and electron microscopic studies. Int J Dermatol. 1992;31(7):480-3.