Local cytotoxic mucosal and skin lesions have been described. 19 The only adverse effect that we considered to be possibly related to the treatment was generalised oedema, which occurred 24 hours after povidone-iodine instillation in case 3. [fn.bmj.com]

The patient developed generalized seizure in the first hour which was controlled by phenobarbitone. Babygraph of the patient showing generalized edema, ascites and massive bilateral pleural effusion. [ncbi.nlm.nih.gov]