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Congenital Clubbing

Congenital Clubbed Nail


Presentation

  • The Fourth Edition of this best-selling book is packed full of information to help the reader move from a presenting problem to an accurate diagnosis.[books.google.com]
  • We therefore thought the present example worthwhile reporting. Mr. B., 34 years old, presented himself for examination with minor complaints of gastro-intestinal origin.[annals.org]
  • Presents revisions by a new authorship of experts in infectious disease, genetics and epidemiology, sports medicine, neurology, cardiac surgery, cardiac anesthesiology, and more.[books.google.ro]
  • In the present study, we investigated a large Pakistani family with 11 affected individuals having hereditary congenital nail clubbing as a single invariable clinical feature without any associated ectodermal, skeletal or systemic imperfection.[ncbi.nlm.nih.gov]
Cerebral Palsy
  • Stay current with new chapters and revised coverage of genetics, radiology, development, endocrinology, infectious diseases, cerebral palsy, skeletal syndromes, and child abuse.[books.google.ro]
  • Cerebral palsy - a general term that describes a group of conditions that cause movement problems. See separate leaflet called Cerebral Palsy for more details .[patient.info]
  • Inga, a 26-year-old living in Leeds, England, has another factor to consider when she's deciding whether to rave or behave: She has congenital cerebral palsy.[vice.com]
Congenital Digital Clubbing
  • Acronym ICNC Synonyms Clubbing of digits Hereditary acropachy Isolated congenital digital clubbing Any medical or genetic information present in this entry is provided for research, educational and informational purposes only.[uniprot.org]
  • Clinical description Isolated congenital digital clubbing is often painless and usually symmetrical and bilateral. Sometimes, some fingers or toes are spared, but the thumbs are almost always involved.[orpha.net]
  • Familial Congenital Digital Clubbing - Report of Two Siblings. Indian Journal of Child Health , 1 (1), 19-21. Retrieved from[atharvapub.net]
  • 26 thanks, 21 comments 02 Aug 2016 Thank Share Post Verified response Appears to be isolated congenital digital clubbing, usually symmetrical and bilateral.[dailyrounds.org]
Down Syndrome
  • Management in specific patient subjects, such as pregnant women, Fontan patients, and Down syndrome patients with Eisenmenger syndrome, is fully discussed, and guidance is also provided on palliative care.[books.google.ro]
  • Down's Syndrome how long they live. All four chambers share blood. Tetralogy of Fallot Most common _____ shunt. Defining features? (4) Shape of heart? Why? Right-to-Left.[quizlet.com]
  • These include: Down syndrome Turner syndrome Marfan’s syndrome Noonan syndrome In some instances, outside factors can cause this disease.[healthline.com]
  • Source: Reproduced with permission of Estudio Colaborativo Latino Americano de Malformaciones Congénitas (ECLAMC) Down syndrome Q90.9 Distinctive facial traits: upslanting palpebral fissures (Q10.3), flat nasal bridge (Q30.8).[cdc.gov]
Nail Abnormality
  • Text Reference: "Nail Abnormalities: Clues to Systemic Disease." American Family Physician.[emedicinehealth.com]
  • Nail abnormalities are a feature of many genodermatoses. One report suggests that about 75% of congenital syndromes are associated with nail abnormalities [ 3 ].[karger.com]
  • Nail abnormalities: clues to systemic disease. Am Fam Physician . 2004 Mar 15. 69(6):1417-24. [Medline] . Sridhar KS, Lobo CF, Altman RD. Digital clubbing and lung cancer. Chest . 1998 Dec. 114(6):1535-7. [Medline] .[emedicine.medscape.com]
  • Clubbing, which is one example of a nail manifestation of systemic disease, was first described by Hippocrates in the fifth century B.C. 1 Since that time, many more nail abnormalities have been found to be clues to underlying systemic disorders.[aafp.org]
Epilepsy
  • This streamlined new edition covers the latest on genetics, neurology, infectious disease, melamine poisoning, sexual identity and adolescent homosexuality, psychosis associated with epilepsy, and more.[books.google.es]
  • Is strobe lighting being avoided for people with epilepsy? Venues should have it on the website and be specific, but I guess that could be avoided if there was some sort of registry."[vice.com]
  • […] match CONGENITAL DISORDER OF GLYCOSYLATION, TYPE IIe; CDG2E COG7-CDG is a congenital disorder of glycosylation characterised by dysmorphism, skeletal dysplasia, hypotonia, hepatosplenomegaly, jaundice, cardiac insufficiency, recurrent infections and epilepsy[mendelian.co]
Respiratory Disorders
  • Get in-depth guidance on your laptop or mobile device with online diagnostic videos of non-seizure neurological symptoms, respiratory disorders, and seizures, plus an infant development assessment tool, a downloadable image gallery (JPEGs or PPTs for[books.google.ro]
Hypotension
  • Two new chapters on Hypotension and Photophobia.[books.google.com]
  • In view of the weight loss, hypotension and pigmentation, a cosyntropin test was done and 1 hour serum cortisol was normal. Thyroid profile was noncontributory.[e-ijd.org]
Pachyonychia
  • Keywords: Late onset pachyonychia congenita, pachyonychia congenita, Pachyonychia congenita tarda How to cite this article: Sravanthi A, Srivalli P, Gopal K, Rao T N. Pachyonychia congenita with late onset (PC tarda).[idoj.in]
  • […] regeneration, warm climate half and half nails white proximal & brown distal nail (melanin); chronic renal failure, uremia AKA Lindsay’s nails hapalonychiasoftened nails due to matrix defect; malnutrition, myxedema, leprosy, Raynaud disease hard nails pachyonychia[dermadvocate.net]
  • Pathological Conditions Pachyonychia Congenita Pachyonychia congenita is an uncommon genodermatosis characterized by defective keratinization.[karger.com]
Photophobia
Seizure
  • Get in-depth guidance on your laptop or mobile device with online diagnostic videos of non-seizure neurological symptoms, respiratory disorders, and seizures, plus an infant development assessment tool, a downloadable image gallery (JPEGs or PPTs for[books.google.ro]
  • Affected individuals may have respiratory insufficiency, foot deformities, or seizures, and all reported patients have died in infancy.[mendelian.co]
  • Kalamangalam First published May 7, 2012, DOI: A 64-year-old man was evaluated for seizures due to traumatic brain injury 25 years previously.[neurology.org]
  • Underlying conditions associated with bronchiectasis include primary ciliary dyskinesia, Kartagener syndrome, cystic fibrosis, and diffuse panbronchiolitis. [6] Lung abscess Risk factors include immunosuppression, poor oral hygiene, drug abuse, alcoholism, seizure[online.epocrates.com]
Neglect
  • Benefit from authoritative guidance on genetic disorders and dysmorphic conditions, neonatology, developmental-behavioral pediatrics, allergy and immunology, conditions of each body system, child abuse and neglect, infectious disease, surgery, pediatric[books.google.ro]
  • Neglected Clubfoot - the neglected clubfoot is a clubfoot in a child older than 2 years, where little or no treatment has been performed.[physio-pedia.com]
  • Specific examination of the nails is neglected, while localization to the nails could be an initial sign of a syndrome or a systemic disorder.[karger.com]

Workup

  • Significance of Digital Clubbing Clubbing is a clinical sign which may indicate and prompt the workup for an underlying disease. It is often seen in pulmonary conditions. However, clubbing is also seen in some people without any underlying disease.[medcaretips.com]
  • .  Medico legal PitfallsMedico legal Pitfalls  Failure to perform a thorough and exhaustiveFailure to perform a thorough and exhaustive workup of the patient who presents withworkup of the patient who presents with clubbing of the nails since clubbing[slideshare.net]
Candida
  • […] superficial; HIV, immunosuppression immunosuppression, hyperhidrosis, diabetes mellitus, aging onychomycosis proximal subungual onychomycosis (HIV); Trichophyton rubrum , T. megninii white superficial onychomycosis; T. mentagrophytes nondermatophytes; Candida[dermadvocate.net]

Treatment

  • With advances in diagnosis and treatment in children, more and more of those with CHD survive well into adulthood.[books.google.ro]
  • Stay at the forefront of your field with updated treatment methods throughout, as well as an increased focus on patients with skin of color.[books.google.com]
  • It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice .[uniprot.org]
  • The material is in no way intended to replace professional medical care by a qualified specialist and should not be used as a basis for diagnosis or treatment.[orpha.net]

Prognosis

  • Overall prognosis will often depend on other associated condition. Isolated condition may be treated successfully 8 . Promoted articles (advertising)[radiopaedia.org]
  • Prognosis Clubbing is potentially reversible if the underlying condition is treated early enough but the changes may be irreversible once collagen deposition has set in.[patient.info]
  • […] cells Associated conditions orthopaedic manifestations upper extremity deformity (see below) teratologic hip subluxation and dislocation knee contractures foot conditions clubfoot vertical talus neuromuscular C-shaped scoliosis (33%) fractures (25%) Prognosis[orthobullets.com]
  • If not, there is a positive diagnosis of clubfoot. [26] Prognosis Prognosis can be dependant on when treatment begins.[physio-pedia.com]

Etiology

  • Etiology It results from proliferation of the connective tissues between the nail matrix and the distal phalanx and abnormal function of the nail matrix.[orpha.net]
  • Etiology of clubbing in most of the time is secondary to some systemic illness. Familial clubbing is a rare occurrence and incidence or prevalence of such occurrence is not known.[atharvapub.net]
  • etiology? 26 thanks, 21 comments 02 Aug 2016 Thank Share Post Verified response Appears to be isolated congenital digital clubbing, usually symmetrical and bilateral.[dailyrounds.org]
  • […] and Pathophysiology The etiology of clubbing is poorly understood.[basicmedicalkey.com]

Epidemiology

  • Summary Epidemiology Prevalence is unknown. Clinical description Isolated congenital digital clubbing is often painless and usually symmetrical and bilateral. Sometimes, some fingers or toes are spared, but the thumbs are almost always involved.[orpha.net]
  • Presents revisions by a new authorship of experts in infectious disease, genetics and epidemiology, sports medicine, neurology, cardiac surgery, cardiac anesthesiology, and more.[books.google.ro]
  • Epidemiology Pachydermoperiostosis is rare and is characterised by skin thickening of the forehead, eyelids and hands, digital clubbing and periostosis. [ 2 ] The epidemiology of secondary clubbing depends on the cause.[patient.info]
  • Epidemiology Prevalence in the general population is unknown: Two percent of adult patients admitted to a Welsh general medicine or surgery service. 1 Thirty-eight percent and 15% of patients with Crohn disease and ulcerative colitis, respectively. 2[basicmedicalkey.com]
Sex distribution
Age distribution

Pathophysiology

  • After an introductory chapter on pathophysiology, the various types of pulmonary hypertension that may be encountered in ACHD are discussed, highlighting the specifics observed within different patient categories.[books.google.ro]
  • […] surgery service. 1 Thirty-eight percent and 15% of patients with Crohn disease and ulcerative colitis, respectively. 2 Thirty-three percent and 11% of patients with lung cancer and chronic obstructive pulmonary disease (COPD), respectively. 3 Etiology and Pathophysiology[basicmedicalkey.com]
  • Pathophysiology The exact cause for sporadic clubbing is unknown, and there are numerous theories as to its cause.[chdbabies.com]
  • The pathophysiology of clubbing is not well understood; however, it has been associated with a variety of disease states, including infectious, neoplastic, inflammatory, and vascular. Clubbing can also be a benign hereditary condition.[aafp.org]
  • Pathophysiology Advances in the study of the pathogenesis have established that vascular endothelial growth factor (VEGF) is key.[bestpractice.bmj.com]

Prevention

  • Can clubbing be prevented? The only way to prevent clubbing is by taking steps to prevent and manage the underlying conditions that cause it.[healthline.com]
  • The results also suggest that existing drugs such as aspirin, which are already used to prevent PGE2 production, may be effective in reducing the painful symptoms of finger clubbing.[sciencedaily.com]
  • Health care services aimed at preventing health problems or maintaining health are provided. Medical Knowledge 10. An investigatory and analytic thinking approach to the clinical situation is demonstrated. 11.[pediatriceducation.org]
  • This helps scientists look for better ways to prevent and treat this condition. You can opt out of the register at any time.[nhs.uk]
  • To prevent neurologic complications in this type of anomaly optimum treatment is obviously prophylactic total anatomic correction of the right-to-left shunt.[pediatrics.aappublications.org]

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