Atypical presentations of viral infections can be a diagnostic challenge in the newborn period. [ncbi.nlm.nih.gov]

• Respiratory Insufficiency

  We report three infants with congenital cytomegalovirus infection presenting with respiratory insufficiency associated with persistent diaphragmatic dysfunction. [ncbi.nlm.nih.gov]

• Failure to Thrive

  Caput succedaneum Craniotabes Crying - excessive (0-6 months) Failure to thrive Hemorrhagic disease of the newborn Home apnea monitor use - infants Hyperglycemia - infants Hyperviscosity - newborn Hypocalcemia - infants Intussusception (children) Irritability [icdlist.com]

  […] to Thrive (FTT) Sleeping, behavior, sensory issues Seizures Death (in rare cases) Babies born with congenital CMV can appear to be either symptomatic or asymptomatic at birth. [nationalcmv.org]

  […] to thrive, intracerebral calcifications, microcephaly, hypotonia, seizures, petechial rash, hearing loss, interstitial pneumonitis, thrombocytopenia, anemia, hepatitis, chorioretinitis, or CMV in cerebrospinal fluid Intraventricular hemorrhage [ Time [clinicaltrials.gov]

• Thrombosis

  Some investigators consider them to be secondary to a direct cytopathic effect of the virus, while others consider them to be due to intracerebral thrombosis or hemorrhage secondary to vasculitis ( 5, 7 ). [doi.org]

• Hepatomegaly

  Possible signs and symptoms include: jaundice / hepatomegaly / splenomegaly microcephaly sensorineural deafness chorioretinitis petechiae mental retardation seizures The degree of neurological impairment is variable, from mild learning and behavioral [radiopaedia.org]

  KEYWORDS: biliary atresia; cholestatic hepatitis; congenital cytomegalovirus; hepatitis; hepatomegaly; idiopathic neonatal hepatitis [ncbi.nlm.nih.gov]

  Hepatomegaly occurred from day 56 onward. [doi.org]

  Patients with generalized congenital CMV infection most commonly present with hepatomegaly, splenomegaly, microcephaly, jaundice and petechiae. 49 Thirty percent of patients with severe disease die of multiorgan dysfunction. 50 Hepatomegaly and splenomegaly [academic.oup.com]

  3 days of life ] Symptomatic CMV infection [ Time Frame: 3 weeks of life ] Symptomatic CMV infection defined as CMV isolated from an amniocentesis, or urine or saliva during the first three weeks of life and at least one of the following: jaundice, hepatomegaly [clinicaltrials.gov]

• Reduced Fetal Movement

  In the 38th week, the mother noticed reduced fetal movements, prompting a repeat ultrasound. Ultrasound showed oligohydramnios with dilated intracerebral ventricles. Labor was subsequently induced. [healio.com]

• Hearing Impairment

  They were divided into five age-matched groups: normal-hearing control, asymptomatic cCMV, normal-hearing symptomatic cCMV, hearing-impaired symptomatic cCMV, and hearing-impaired Cx26. [ncbi.nlm.nih.gov]

• Spastic Quadriplegia

  Children in this series were mostly born at term (n=8), with symptoms or signs of cCMV (n=10) and had spastic quadriplegia (n=9), epilepsy (n=8), intellectual deficit (n=12), communication (n=10) and hearing impairments (n=9). [ncbi.nlm.nih.gov]

• Quadriplegia

  Children in this series were mostly born at term (n=8), with symptoms or signs of cCMV (n=10) and had spastic quadriplegia (n=9), epilepsy (n=8), intellectual deficit (n=12), communication (n=10) and hearing impairments (n=9). [ncbi.nlm.nih.gov]

The workup for maternal infection and fetal structural anomaly was negative except for positive CMV Ige in the maternal serum Cesarean section was performed due to fetal distress. [ncbi.nlm.nih.gov]

The workup for congenital CMV infection was performed in all newborns and stillbirths but not for induced abortion. [cid.oxfordjournals.org]

A longitudinal diagnostic workup should be started with a CMV PCR of leukocyte and plasma specimens to detect the period of DNAemia. [doi.org]

After treatment, CMV DNA decreased in copy number and became undetectable. No marked side effects occurred after treatment. Surprisingly, 1 year after treatment, neurological and motor development was equivalent to that in a healthy infant. [ncbi.nlm.nih.gov]

Brain magnetic resonance imaging plays a key role in evaluating brain involvement and establishing prognosis; several characteristic features have been described. [ncbi.nlm.nih.gov]

Thus, congenital CMV infection may be etiologically associated with Hirschsprung's disease in some children. [ncbi.nlm.nih.gov]

In this book the history of this disease, its pathophysiological background, epidemiology and symptoms, as well as diagnostic and therapeutic strategies, will be discussed. [libreriauniversitaria.it]

KEYWORDS: Cytomegalovirus; epidemiology; paediatrics [ncbi.nlm.nih.gov]

Intrauterine hemodynamics may be important in pathophysiology of congenital cytomegalovirus infection. [ncbi.nlm.nih.gov]

In this book the history of this disease, its pathophysiological background, epidemiology and symptoms, as well as diagnostic and therapeutic strategies, will be discussed. [libreriauniversitaria.it]

Advances in the treatment and prevention of congenital CMV infection are a high priority nationally and globally. [ncbi.nlm.nih.gov]