The documents contained in this web site are presented for information purposes only. The material is in no way intended to replace professional medical care by a qualified specialist and should not be used as a basis for diagnosis or treatment. [orpha.net]

In the present case we used immunodot blotting (IDB) for the immediate determination of intrauterine EV71 infection. [academic.oup.com]

In infants who are live-born, effects of fetal infection may present as preterm birth, intrauterine growth restriction (IUGR), congenital anomalies, or local or systemic signs of infection. [accesspediatrics.mhmedical.com]

It presents as a large number of firmly adherent, small, white plaques that may interfere with feeding by making the mouth sore. [patient.info]

One patient presented with hepatitis without disseminated intravascular coagulopathy ( 3 ). [nature.com]

• Fever

  CDC FAQ's Typhoid Fever, Group D Typhus Vaginosis, bacterial (Yeast Infection) CDC FAQ's Varicella (Chickenpox) CDC FAQ's More Data Vibrio cholerae (Cholera) CDC FAQ's Vibriosis (Vibrio) CDC FAQ's Viral Hemorrhagic Fever (Ebola, Lassa, Marburg) CDC [health.ri.gov]

  This infant was brought to the emergency department with fever of unknown origin at 5 days post birth, and EV was first detected in a throat swab sample. [analesdepediatria.org]

  For the past few days, she has had low-grade fevers and a slight cough, and of note, her 6-year-old sister had similar symptoms. Upon further questioning, she and her sister have had all routine childhood vaccinations. [medbullets.com]

  The mother had fever for a week, 9 days before delivery, and a decrease in active fetal movements had been observed. The newborn developed fever immediately after birth and died on day one of life. [virologyj.biomedcentral.com]

  Typically, the mother presents with a fever a few days before delivery. In this cause, faecal and other specimens from the mother should be cultured for enteroviruses. [virology-online.com]

• Pleural Effusion

  Fetal anomalies of the cardiovascular, gastrointestinal and genitourinary system, along with neurodevelopmental delay, bilateral pleural effusion, abdominal ascitis, severe respiratory failure, cortical necrosis (that may lead to severe long-term neurologic [orpha.net]

  Detection of EV71 in hepatocytes of the fetal liver and in neurons of the midbrain could provide partial explanations for hepatomegaly, excessive ascites, pleural effusion, and hydrocephalus. [academic.oup.com]

  effusion 58 31 occasional (7.5%) Occasional (29-5%) HP:0002202 27 leukopenia 58 31 occasional (7.5%) Occasional (29-5%) HP:0001882 28 leukocytosis 58 31 occasional (7.5%) Occasional (29-5%) HP:0001974 29 pericardial effusion 58 31 occasional (7.5%) Occasional [malacards.org]

  Fetal enterovirus infection has been described to be responsible for sonographic findings that include cerebral ventriculomegaly, cardiomyopathy with ventricular dysfunction [19], and polyhydramnios associated with ascites, pericardial and pleural effusions [virologyj.biomedcentral.com]

• Hypoventilation

  It is characterized clinically by psychiatric features, memory disturbance, speech disorder, seizures, dyskinesias, decreased level of consciousness, autonomic instability, and hypoventilation. [neuropathology-web.org]

• Abdominal Cramps

  Case Report A 28-year-old woman (gravida 3, para 0) was referred to our hospital because of severe abdominal cramping. [academic.oup.com]

• Thrombosis

  No apparent infarction nor purulent exudate was observed in the placenta in addition to the visible thickened margin and partial intervillous thrombosis. [academic.oup.com]

  Fig. 10.6 Sinovenous thrombosis in a neonate presenting with sepsis. [mrineonatalbrain.com]

• Vascular Disease

  diabetes, thyroid dysfunction) Vascular disease Immune defects Prevention [23] CCC-Triad of congenital rubella syndrome: Cataracts, Cochlear defects, Cardiac abnormality Congenital CMV infection ∼ 0.5–1% of live births per year in the US [24] Pathogen [amboss.com]

  Additionally, necrotizing enterocolitis as a result of aortic vascular disease has been reported. There are both meningovascular and parenchymatous forms of neonatal neurosyphilis. [mrineonatalbrain.com]

• Fetal Disorder

  Less common means of infections include: extension of infection in adjacent tissues and/or organs, or as a result of invasive procedures for diagnosis and therapy of fetal disorders (ex. monitors, sampling fetal blood, intrauterine transfusions). [atsu.edu]

• Eczema

  Examples include the association of asthma exacerbation with enterovirus D68 and the association of acute eczema flare-up with coxsackievirus A16. [pedsinreview.aappublications.org]

• Neglect

  What should be avoided is to neglect follow-up of people found to lack antibody against rubella. [niid.go.jp]

  Viral agents in Pediatric Pneumonia in China Symposiast： Jianwei　Wang Viral and Bacterial Pathogens associated with Pediatric Acute Respiratory Infection cases in Vietnam Symposiast： Vo Minh　Hien Symposium9 Global Prospective and Local Activities for Neglected [c-linkage.co.jp]

  Despite being the most prevalent congenital infection worldwide, congenital CMV infection (cCMV) remains largely neglected in the developed and developing world[ 11 ]. [journals.plos.org]

• Monoplegia

  S387 - 90 ) 5 Monoplegia caused by enterovirus 71: an outbreak in Hong Kong, Pediatr Infect Dis J, 1987, vol. 6 (pg. 206 - 8 ) 6 Outbreak of enterovirus 71 infection in Victoria, Australia, with a high incidence of neurologic involvement, Pediatr Infect [academic.oup.com]

• Forgetful

  Do not forget that acute maternal infection may occur after screening - in resource-rich settings such as the UK and America, a significant proportion of perinatal transmission of HIV occurs due to infection acquired during pregnancy [ 10 ]. [patient.info]

The association of fetal birth defects with enteroviral infection is puzzling and suggests that more attention should be given to virologie studies in the diagnostic workup of fetal malformations otherwise considered as idiopathic. 1994 S. [karger.com]

• Pleural Effusion

  Fetal anomalies of the cardiovascular, gastrointestinal and genitourinary system, along with neurodevelopmental delay, bilateral pleural effusion, abdominal ascitis, severe respiratory failure, cortical necrosis (that may lead to severe long-term neurologic [orpha.net]

  Detection of EV71 in hepatocytes of the fetal liver and in neurons of the midbrain could provide partial explanations for hepatomegaly, excessive ascites, pleural effusion, and hydrocephalus. [academic.oup.com]

  effusion 58 31 occasional (7.5%) Occasional (29-5%) HP:0002202 27 leukopenia 58 31 occasional (7.5%) Occasional (29-5%) HP:0001882 28 leukocytosis 58 31 occasional (7.5%) Occasional (29-5%) HP:0001974 29 pericardial effusion 58 31 occasional (7.5%) Occasional [malacards.org]

  Fetal enterovirus infection has been described to be responsible for sonographic findings that include cerebral ventriculomegaly, cardiomyopathy with ventricular dysfunction [19], and polyhydramnios associated with ascites, pericardial and pleural effusions [virologyj.biomedcentral.com]

• Liver Biopsy

  Vero cells, A549 cells, and liver biopsy specimens from patients with hepatitis C infection were used as negative controls, and EV71 strain TW/2272/98—infected Vero cells were used as positive controls. [academic.oup.com]

  Usefulness of clinical features and liver biopsy in diagnosis of disseminated herpes simplex infection. Arch Dis Child 1984 ; 59 :820–4. Egawa, H, Inomata, Y, Nakayama, S. [cambridge.org]

Make informed clinical choices for each patient, from diagnosis and treatment selection through post-treatment strategies and management of complications, with new evidence-based criteria throughout. [books.google.com]

Management and treatment There is no specific curative treatment for EV maternal or congenital infection. Prognosis Prognosis of mild congenital EV infections is quite good if reanimation procedures are available. [orpha.net]

IV acyclovir (20 mg/kg/dose Q8 hrs) Side Effect: neutropenia but without adverse clinical outcomes Treatment at end of pregnancy to prevent recurrences SEM: Systemic treatment to avoid progression High dose IV acyclovir Q8hr for 14 days CNS disease: [pedclerk.bsd.uchicago.edu]

Prognosis Prognosis of mild congenital EV infections is quite good if reanimation procedures are available. Prognosis of severe congenital EV infections is poor and the disease has been reported to be fatal. [orpha.net]

The prognosis is depending on recovery of cardiac function and other organ functions. In extreme cases, ECMO therapy has to be considered. The duration of the cardiac therapy (beta- blockers, diuretics, ACE inhibitors, etc.) is unclear. [adc.bmj.com]

[…] children demographics more common in children than adults risk factors exposure to others with the virus daycare centers poor hygiene finger sucking Pathogenesis once infected, the virus will travel to the lymph nodes and incubate, causing a prodrome Prognosis [medbullets.com]

[…] has a different prognosis. [en.wikipedia.org]

Long-term prognosis for babies with neonatal liver disease. Arch Dis Child 1985 ; 60 :447–51. [cambridge.org]

A suggestion is proposed that the severe course of suppurative-inflammatory conditions and the general character of neonatal bacterial infection are largely determined by the immunodeficient states which are etiologically related to congenital enterovirus [ncbi.nlm.nih.gov]

Etiology Coxsackie A, B, ECHO viruses, and numbered EVs are believed to cross the placenta and cause fetal disease. [orpha.net]

Abstract The paper presents the data confirming the hypothesis on the involvement of the congenital enteroviral infection in etiology of chronic nephropathy manifesting in children in the presence of influenza-like and acute respiratory infections diseases [pubmed.ncbi.nlm.nih.gov]

A high index of suspicion for congenital infection and awareness of the prominent features of the most common etiologies will help to facilitate early diagnosis and management. [accesspediatrics.mhmedical.com]

Neonatal hepatic syndrome 187 Severe hepatocellular dysfunction 189 Hypoglycemia 192 Nonimmune fetal hydrops 193 Initial management 194 Summary comments 196 Biblipgraphy 197 Newborn screening 198 Screening for medical intervention 199 Screening to answer epidemiological [books.google.com]

Summary Epidemiology The prevalence of congenital EV infection is still unknown. EV infections are underdiagnosed in the mother (mainly because of frequent subclinical infections) and hence may be far more frequent than supposed. [orpha.net]

His PhD evaluated the impact of molecular virology on the clinical epidemiology and management of central nervous system viral infections in infants. [paediatrics.ox.ac.uk]

Objectives After completing this article, readers should be able to: Understand the epidemiology of enterovirus infections. Recognize the wide spectrum of clinical presentations with enterovirus infection. [pedsinreview.aappublications.org]

National Epidemiological Surveillance of Infectious Diseases (NESID)–Rubella : The reported number of rubella patients increased from a total of 378 in 2011 to 2,386 in 2012 and to 14,344 in 2013 ( Fig. 1, upper panel). [niid.go.jp]

Pathophysiology [ edit ] Virulence versus symbiosis [ edit ] In the spectrum of optimal virulence, vertical transmission tends to evolve benign symbiosis. It is, therefore, a critical concept for evolutionary medicine. [en.wikipedia.org]

Asian flu pandemic reported a mortality rate of approximately 50% among infected pregnant women. [21] During the 2009 H1N1 pandemic, pregnant women accounted for 5% of all deaths and were more likely to be hospitalized than the general population. [22] Pathophysiology [emedicine.medscape.com]

Special attention is given to the prevention and treatment of these diseases found in developing countries as well as the latest findings about new antimicrobial agents, gram-negative infections and their management, and recommendations for immunization [books.google.com]

Malaria transmission of moderate intensity is perennial with some seasonality and, intermittent preventive treatment during pregnancy (IPTp) for malaria prevention is recommended[ 42 ]. [journals.plos.org]

The National Institute of Infectious Diseases has produced guidelines on i) rubella prevention in the workplace, ii) rubella prevention in medical settings, iii) local government’s response to rubella outbreaks, iv) establishment of committees and other [niid.go.jp]

It can be prevented with intrapartum penicillin in high-risk cases. [patient.info]

The distinction is important because when transmission is primarily during or after birth, medical intervention can help prevent infections in the infant. [en.wikipedia.org]