The classic clinical presentation of hemolytic anemia is jaundice, pallor, and splenomegaly. [obgynkey.com]

Other beta chain structural defects may also present under such circumstances. [oncologynurseadvisor.com]

Splenomegaly and Heinz bodies may also be present. Reference Values Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. [mayomedicallaboratories.com]

The numbered bands specify the location of the thousands of genes that are present on each chromosome. [rarediseases.org]

Another Exotic Cause of Haemolytic Anemia Dr Wai-Chiu Tsoi Haematology Laboratory and Blood Bank, Prince of Wales Hospital Case presentation: A Chinese boy initially presented at 3 months old because of symptoms of anaemia. [fmshk.com.hk]

• Massive Splenomegaly

  Massive splenomegaly. 4. Cholecystitis and cholelithiasis 5. Aplastic, megaloblastic or hemolytic crisis (Comb’s test negative) 5. Hereditary Spherocytosis: 5 Normal spleen size of a fist…! Splenectomy: Therapy for severe HS 6. [slideshare.net]

• Anemia

  Abstract The mechanisms of hemoglobin precipitation into Heinz bodies and hemolytic anemia that characterize congenital Heinz body hemolytic anemia (CHBHA) were studied in patients with the unstable hemoglobins, Köln (beta-98 valine --> methionine) and [ncbi.nlm.nih.gov]

  NIH: National Heart, Lung, and Blood Institute Anemia (Medical Encyclopedia) Anemia - B12 deficiency (Medical Encyclopedia) Anemia caused by low iron -- infants and toddlers (Medical Encyclopedia) Anemia of chronic disease (Medical Encyclopedia) Anemia [icdlist.com]

  Entries for the ‘Depletion Anemia’ Category Hemolytic Anemias Due to Extracorpuscular Agents Anemias due to isoagglutinins (isoantibodies) These anemias are hemolytic reactions caused by antibodies within the various blood group systems. [med-life.net]

• Pain

  Case 10: Back pain Case 11: Dark stools Case 12: Chest pain Case 13: Chest pain Case 14: Chest pain Case 15: Chronic abdominal pain Case 16: Trouble sleeping Case 17: Forgetfulness Case 18: Cough Case 19: Cough Case 2: Abdominal pain Case 20: Decreased [amboss.com]

  […] anemia Excludes: sickle-cell thalassemia (282.41-282.42) sickle-cell trait (282.5) 282.60 Sickle-cell disease, unspecified Sickle-cell anemia NOS 282.61 Hb-SS disease without crisis 282.62 Hb-SS disease with crisis Hb-SS disease with vaso-occlusive pain [theodora.com]

  The disease is usually asymptomatic although patients may have joint or abdominal pain. [slideplayer.com]

  Drug-induced hemolysis can be severe, involving the sudden onset of pallor, malaise, scleral icterus, dark urine, and abdominal or back pain. [obgynkey.com]

  Anemia, fatigue, and severe pain are symptoms of this disease. [hematologylearning.weebly.com]

• Inflammation

  National Heart, Lung, and Blood Institute Anemia (Medical Encyclopedia) Anemia - B12 deficiency (Medical Encyclopedia) Anemia caused by low iron -- infants and toddlers (Medical Encyclopedia) Anemia of chronic disease (Medical Encyclopedia) Anemia of Inflammation [icdlist.com]

  Esophageal atresia Esophageal barium swallow Esophageal cancer Esophageal diverticula Esophagus Estrogen and associated diseases Eye and orbit Facial nerve palsy Febrile seizures Female reproductive organs Femoral hernia Femoral shaft fracture Fever and inflammation [amboss.com]

  Intravascular hemolysis is suggested by RBC fragments (schistocytes) on the peripheral smear and by decreased serum haptoglobin levels; however, haptoglobin levels can decrease because of hepatocellular dysfunction and can increase because of systemic inflammation [merckmanuals.com]

  It is associated with: iron-deficiency anemia thalassemias sideroblastic anemia lead poisoning chronic inflammation Polychromasia: Polychromasia is a lavender-bluish color to RBC's due to RNA retained in larger, immature cells (macrocytes). [hematologylearning.weebly.com]

  Causes of acute bleeding such as rupture of the umbilical cord may be associated with precipitous deliveries, and the cord may bleed from vascular abnormalities, inflammation or incision during cesarean section; velamentous insertion of the cord can also [oncologynurseadvisor.com]

• Pallor

  […] area of pallor. [theartofmed.wordpress.com]

  On the other hand chronic blood loss is characterized by pallor out of proportion to distress and possibly signs of congestive cardiac failure, including hepatomegaly. [oncologynurseadvisor.com]

  The classic clinical presentation of hemolytic anemia is jaundice, pallor, and splenomegaly. [obgynkey.com]

  The term used to indicate a normal color or central pallor (i.e., normal hemoglobin content) is normochromic Normocytic and Normochromic RBC Hypochromic: Erythrocytes that demonstrate a central pale area that becomes larger and paler as the hemoglobin [medical-labs.net]

  These are associated with: transfusion myelodysplastic syndrome vitamin B12, folate or iron deficiency Hypochromia: Hypochromia means that the central pallor zone of the red blood cell is pale. [hematologylearning.weebly.com]

• Epilepsy

  […] reflux disease Gastrointestinal bleeding Gastrointestinal tract Gene expression and transcription General bacteriology General endocrinology General histology General mycology General oncology General principles of fractures General virology Generalized epilepsy [amboss.com]

• Heart Failure

  In physiologic response to hypoxia as in congenital heart disease and congestive heart failure. Basophilic stippling: These are the inclusion in the cytoplasm of RBC e.g. Lead poisoning. Reticulocytosis. [labpedia.net]

  The clincial result is diabetes mellitus, hepatic cirrhosis, congestive heart failure, adrenal insufficiency, and failure to undergo puberty. [web2.iadfw.net]

  Severe anemia due to bleeding in a neonate or a live hydropic baby (alpha thalassemia major, Diamond Blackfan anemia, congenital parvovirus) is a pediatric emergency that requires rapid evaluation and treatment to prevent hypoxia, congestive heart failure [oncologynurseadvisor.com]

  failure Conjunctivitis Connective tissue Connective tissue diseases Conservative treatment of fractures Constipation Coronary artery bypass grafting Cough Counseling patients Coxsackie virus infections Cranial nerve palsies Craniosynostosis Craniovertebral [amboss.com]

  Congestive heart failure and metabolic disorders should be considered. [emedicine.medscape.com]

• Cyanosis

  This consisted of an acute hemolytic process having 2 characteristic features: a brown-to-green discoloration of the blood, creating a form of cyanosis when viewed in the patient; and the presence of inclusion bodies in the red cells that were evident [annals.org]

  Related Concepts SNOMET-CT Hemoglobinopathy with cyanosis (disorder) ICD-10-CM Alphabetical Index References for 'D58.2 - Other hemoglobinopathies' The ICD-10-CM Alphabetical Index links the below-listed medical terms to the ICD code D58.2. [icd.codes]

  […] range Hemoglobin C disease Hemoglobin c trait Hemoglobin D disease Hemoglobin D trait Hemoglobin E disease Hemoglobin e trait Hemoglobin low Hemoglobin O-Arab trait Hemoglobin very high Hemoglobin Zurich disease Hemoglobinopathy Hemoglobinopathy with cyanosis [icd9data.com]

  If the level of blue hemoglobin exceeds 5 g/dL in capillary blood, the clinical result is cyanosis, a bluish discoloration of skin and mucous membranes. [web2.iadfw.net]

• Hypotension

  Symptoms and Signs Systemic manifestations of hemolytic anemias resemble those of other anemias and include pallor, fatigue, dizziness, and possible hypotension. Scleral icterus and/or jaundice may occur, and the spleen may enlarge. [merckmanuals.com]

• Myopathy

  Immunosuppressants Impetigo Inborn errors of carbohydrate metabolism Inborn errors of metabolism Incomplete spinal cord syndromes Infection prevention and control Infectious mononucleosis Infective endocarditis Infertility Inflammation of the eyelids Inflammatory myopathies [amboss.com]

• Kidney Failure

  Hemolytic uremic syndrome Haemolytic-uremic syndrome or HUS is haemolytic anaemia, acute kidney failure (uraemia), and thrombocytopenia. HUS is caused by E. coli bloody diarrhea and specific strains of shiga toxin. [theartofmed.wordpress.com]

• Encephalopathy

  Virtual histology slide box Virtual histopathology slide box Vitamin B12 deficiency Vitamin K deficiency bleeding of the newborn Vitamins Vitiligo Volvulus and intestinal malrotation Vulvar and vaginal cancer Vulvovaginitis Wallenberg syndrome Wernicke encephalopathy [amboss.com]

• Tremor

  CS Toe deformities Torticollis Tourette syndrome Toxoplasmosis Trace elements Transfusion Transient global amnesia Translation and protein synthesis Transplantation Trauma- and stressor-related disorders Traumatic brain injury Traumatic eye injuries Tremor [amboss.com]

A convenient way to organize and think through the workup of an anemic infant would be: 1. [oncologynurseadvisor.com]

An array of laboratory tests are available for detecting hemolysis, and specialized tests may be indicated to diagnose the cause for hemolysis (see Workup ). [emedicine.medscape.com]

• Heinz Bodies

  Abstract The mechanisms of hemoglobin precipitation into Heinz bodies and hemolytic anemia that characterize congenital Heinz body hemolytic anemia (CHBHA) were studied in patients with the unstable hemoglobins, Köln (beta-98 valine --> methionine) and [ncbi.nlm.nih.gov]

  (Equivalent Terms) Heinz-Ehrlich Bodies Blood Test What is Heinz Bodies Blood Test? (Background Information) Heinz bodies are irregularly-shaped masses of nonfunctional hemoglobin. [dovemed.com]

  Agents such as phenylhydrazine, known to produce Heinz-bodies, could not be incriminated. [pediatrics.aappublications.org]

The Red Blood Cell, Second Edition, Volume II provides a comprehensive treatment and review of basic biomedical knowledge about the circulating, adult red blood cell. [books.google.com]

Prognosis The prognosis for patients with hemolytic anemia depends on the underlying cause. Overall, mortality rates are low in hemolytic anemias. However, the risk is greater in older patients and patients with cardiovascular impairment. [emedicine.medscape.com]

Course and prognosis Hemolytic episodes in the A– type of deficiency are usually self-limited, even if drug administration is continued. This is not the case in the more severe Mediterranean type of deficiency. [g6pd.org]

The prognosis of homozygous Hb C disease is excellent. An individual may inherit a Hb S gene from one parent and a Hb C gene from the other. The result of this double whammy is Hb SC disease. [web2.iadfw.net]

Sickle Cell Disease Etiology Hemoglobin S (Hb S) is the predominant hemoglobin in the group of genetic disorders that encompass sickle cell disease (SCD). [obgynkey.com]

"An update on the etiology and diagnostic evaluation of a leukemoid reaction." European journal of internal medicine 17.6 (2006): 394-398. ul Haque, Anwar, and Noor ul Aan. "Leukemoid Reaction: Unusual Causes." [derangedphysiology.com]

Hemolytic anemia has multiple causes, and the clinical presentation can differ depending on the etiology. [emedicine.medscape.com]

The classification, symptomatology, and diagnostic procedures necessary for detection of such reactions and identification of the etiology are discussed in Chapter 9 and Chapter 11. [med-life.net]

It may be acquired through: immune etiologies(Rh, ABO or other blood group incompatibility, maternal autoimmune, drugs) infectious etiologies(bacterial sepsis, rubella, CMV, disseminated herpes simplex virus, adenovirus, toxoplasmosis, malaria, syphilis [oncologynurseadvisor.com]

This text is divided into eight distinct sections, and includes coverage of the molecular and genetic basis of hemoglobinopathies and thalassemias, their epidemiology and genetic selection, and the diagnosis and special treatments of ^D*b and ^D*a thalassemias [books.google.com]

[…] of Public Health Laboratories [APHL], 2015) Differential Diagnosis Sickle cell disease Congenital hemolytic anemias Glucose-6-phosphatase deficiency Pyruvate kinase deficiency Iron deficiency anemia Thalassemia Autoimmune hemolytic anemia Background Epidemiology [arupconsult.com]

[…] intracranial pressure and brain herniation Elimination disorders Embryogenesis Emotional and behavioral disorders in children and adolescents Endarterectomy Endometrial cancer Endometriosis Endophthalmitis Environmental injuries Enzymes and biocatalysis Epidemiology [amboss.com]

Epidemiology Hemolytic anemia represents approximately 5% of all anemias. Acute AIHA is relatively rare, with an incidence of one to three cases per 100,000 population per year. [27] Hemolytic anemias are not specific to any race. [emedicine.medscape.com]

Epidemiology and genetics The Hb S gene is found primarily in populations of native tropical African origin (which include most African-Americans). [web2.iadfw.net]

It stands as the definitive work on the genetics, pathophysiology, and clinical management of this wide range of disorders. Drs. [books.google.com]

Pathophysiological interactions cause unstable hemoglobins to exhibit altered solubility due to oxidation of amino acid residues in globin chains Prevents formation of intact hemoglobin tetramer through weakened binding of heme to globin Interferes with [arupconsult.com]

Useful For Suggests clinical disorders or settings where the test may be helpful Work-up of congenital hemolytic anemias Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test Unstable [mayomedicallaboratories.com]

Pathophysiology The differential count on the peripheral blood smears gives us information for Anaemias or leukemias and any other abnormality of the blood cells. DLC and CBC are less expensive, easy to perform, and can be done in a short time. [labpedia.net]

Get optimal test results with guidance on error detection, correction, and prevention as well as cost-effective test selection. [books.google.com]

[…] prevalent Inherited as autosomal dominant disorders although de novo variants do occur Pathophysiology Pathophysiological interactions cause unstable hemoglobins to exhibit altered solubility due to oxidation of amino acid residues in globin chains Prevents [arupconsult.com]

Modern obstetric practice with administration of anti-D immunoprophylaxis to RhD negative women during pregnancy and within 72 hours postnatally has prevented 96% of cases of RhD sensitization in developed countries. [oncologynurseadvisor.com]

Porphyrias Portal hypertension Postmortem skin changes Postpartum hemorrhage Postpartum period Poststreptococcal glomerulonephritis Precancerous skin lesions Pregnancy Pregnancy loss Prenatal and postnatal physiology Prenatal care Preterm labor and birth Preventive [amboss.com]

[…] macrophage mediated clearance of antibody bound RBCs) cyclophosphamide or azathioprine (third line) role of IV Ig is uncertain (used in case reports) danazol (synthetic steroid, used previously) cold AIHA keep patient and fluids warm – avoidance of cold prevents [lifeinthefastlane.com]