The activity of erythrophagocytosis in the sinus was more distinct in patients with congenital hemolytic anemia, especially those with nonspherocytic congenital hemolytic anemia, than in patients with autoimmune hemolytic anemia. [ncbi.nlm.nih.gov]

Congenital hemolytic anemia refers to hemolytic anemia which is primarily due to congenital disorders. [en.wikipedia.org]

The typical clinical presentation is a patient with pallor, anemia, jaundice, and often splenomegaly. The laboratory features include anemia, hyperbilirubinemia, and reticulocytosis. For some congenital hemolytic anemias, splenectomy is curative. [ohsu.pure.elsevier.com]

Clinical triad for hemolytic anemia Pallor or anemia Jaundice Splenomegaly (except in newborn and G6PD deficient) Increase in this component in the serum and urine reflects ongoing hemolytic process Positive Coomb’s test favors diagnosis of this disease [brainscape.com]

Physical examination revealed intense pallor, a runny nose and bilateral cervical lymph node enlargement. He had no jaundice. [casesjournal.biomedcentral.com]

Cooley's disease is characterized by a clinic of severe progressive hemolytic anemia, which is detected by the end of the first year of life, which leads to a lag in the mental and physical development of the child, signs of "mongoloid" appear, severe pallor [en.medicine-guidebook.com]

He required phototherapy for neonatal jaundice. Laboratory studies (Table 1 ) showed severe microcytic and hypochromic anemia with reticulocytopenia, a normal white blood cell count and thrombocytosis. [casesjournal.biomedcentral.com]

The clinical picture of PK deficiency is variable, from hydrops fetalis to neonatal jaundice and anemia. 3 In our patient jaundice and anemia was present. In patients with kernicterus sometimes exchange transfusion is advised. [medcraveonline.com]

Hemolysis Splenomegaly Neonatal jaundice [cram.com]

Clinical description Clinically, PK-deficient patients suffer from a highly variable degree of chronic hemolysis, ranging from severe neonatal jaundice and fatal anemia at birth, severe transfusion-dependent chronic hemolysis, moderate hemolysis with [orpha.net]

Neonatal jaundice is common in the first 2 days of life in patients with HS and the hyperbilirubinemia can be severe enough to require exchange transfusion. [clinicaladvisor.com]

Craniofacial changes associated with Thalassemia Major Frontal bossing Maxillary overgrowth Micrognathia T/F: There is growth stunting in Thalassemia Major patients. [brainscape.com]

In addition, they present frequently complications of severe hemolysis, including anemia, splenomegaly, growth retardation, frontal bossing, and early gallbladder disease [ 1 ]. [casesjournal.biomedcentral.com]

Sulfhemoglobinemia · Reticulocytopenia Coagulation / coagulopathy Hyper- coagulability primary: Antithrombin III deficiency · Protein C deficiency / Activated protein C resistance / Protein S deficiency / Factor V Leiden · Hyperprothrombinemia acquired: Thrombocytosis [en.academic.ru]

Laboratory studies (Table 1 ) showed severe microcytic and hypochromic anemia with reticulocytopenia, a normal white blood cell count and thrombocytosis. Peripheral blood smear (PBS) showed anisocytosis and some cigar-shaped cells. [casesjournal.biomedcentral.com]

After partial splenectomy, children overall had decreased transfusion requirements, increased hematocrits, decreased bilirubin levels, decreased reticulocyte counts, and elimination of splenic sequestration. [ncbi.nlm.nih.gov]