Presentation
Major presentations of Disease | Hauptbeschwerden »show table... Investigation/Procedure | Labor- und sonstige Untersuchungen »show table... [medinelingua.info]
A 16-year-old male presented with white-colored fingernails since birth [Figure 1]. Toenails were normal. None of the family members were affected. Hematological investigations were normal. [ncbi.nlm.nih.gov]
Anonychia during neonatal period may be the presenting symptom. [ijdvl.com]
Nail and skin changes are present at birth in only 50% of cases, but by 5 years, they are seen in more than 75% of children. By the age of 10 years, pain can be present as a symptom, which greatly impairs quality of life [28]. [karger.com]
Presents a new chapter on mucous membrane lesions, with increased coverage of the mouth and genital areas. Features 200 new or replaced photographs of unparalleled quality. Includes European drug names when appropriate. [books.google.com]
Entire Body System
- Congestive Heart Failure
Causes: Miscellaneous Color Changes Green Nails ( Chloronychia ) Pseudomonas pyocyanea or pseudomonas aeruginosa infection Red Nails Nail Telangiectasia Congestive Heart Failure VI. [fpnotebook.com]
Acquired leukonychia totalis has been associated with several systemic diseases, including hepatic cirrhosis, chronic renal failure, congestive heart failure, diabetes mellitus, chronic hypoalbuminemia, and Hodgkin's lymphoma. [nejm.org]
Congestive heart failure Diabetes mellitus Longstanding hypoalbuminemic states Hodgkin’s lymphoma 3. [news-medical.net]
Systemic conditions that may cause total leukonychia include cirrhosis of liver, congestive heart failure, leprosy, typhoid fever, and trichinosis. [6] Emmanuel described acquired total leukonychia involving all finger and toe-nails in a 72-year-old lady [amhsjournal.org]
- Swelling
Clubbing of the nails (hippocratic nails) is characterized by swelling of each distal digit, an increase in the angle between the nail plate and the proximal nail fold (Lovibond angle) to >180 degrees, and a spongy feeling when one pushes down and away [clinicalgate.com]
= Lipopsychie Lipoxysmus, m. poisoning with fatty acids Lippe, /. lip, labium; edge, crest, border Lippen- (in compds.), labial Lippen-abscess, m. labial abscess Lippen-ader, /. labial vein Lippen-anschwellung, /. labial swelling Lippen-arterie, /. [ebooksread.com]
Acute paronychia Erythema, swelling and throbbing pain in the nail fold caused by bacterial infection, most commonly Staphylococcus aureus. [patient.info]
[34] Melanonychia with onycholysis [35] Onychopapilloma: This benign nail bed neoplasm may be associated with leukonychia. [36] Reflex Sympathetic Dystrophy : This may be associated with changes including unilateral leukonychia, Beau lines, nailfold swelling [emedicine.medscape.com]
After the infection, an inflammatory response ensues in the digit, with resultant swelling, erythema, tenderness, and secondary pus formation [4]. [karger.com]
Cardiovascular
- Heart Failure
Causes: Miscellaneous Color Changes Green Nails ( Chloronychia ) Pseudomonas pyocyanea or pseudomonas aeruginosa infection Red Nails Nail Telangiectasia Congestive Heart Failure VI. [fpnotebook.com]
Acquired leukonychia totalis has been associated with several systemic diseases, including hepatic cirrhosis, chronic renal failure, congestive heart failure, diabetes mellitus, chronic hypoalbuminemia, and Hodgkin's lymphoma. [nejm.org]
Mee line may indicate heart failure, Hodgkin’s disease, kidney failure, generalized infection or arsenic poisoning, thallium or other heavy metals. 6. [cosmopolitanladies.com]
It can be associated with severe systemic diseases, such as hepatic cirrhosis, chronic renal failure, heart failure, diabetes mellitus, chronic hypoalbuminemia, and Hodgkin lymphoma. [consultant360.com]
- Vascular Disease
A 72-year-old woman with diabetes mellitus, hypertension, and peripheral vascular disease was hospitalized with chest tightness and acute shortness of breath. [nejm.org]
Red Lunula When lunula becomes red, that could indicate hair loss, carbon monoxide poisoning, heart failure, obstructive pulmonary disease, chronic urticaria, cirrhosis, collagen vascular disease, treatment with oral prednisone or psoriasis. [cosmopolitanladies.com]
Nail fold capillaries provide a readily available window to view the microvascular pathology of collagen vascular disease. [bioline.org.br]
disease, and coronary artery disease. [amhsjournal.org]
Can be a bad prognostic sign for hair regrowth Isolated pits can be a normal finding Longitudinal ridges (images 49-61) A few ridges are seen in normal nails Peripheral vascular disease Myxoid cyst - this is seen around the proximal nail fold. [pcds.org.uk]
Musculoskeletal
- Osteoporosis
Learn more about how to achieve it with Mendelian Learn more Other signs and symptoms that you may find interesting Feeding difficulties and Upslanted palpebral fissure, related diseases and genetic alterations Hyperreflexia and Osteoporosis, related [mendelian.co]
[…] syndrome Low phospholipid-associated cholelithiasis Lowry-MacLean syndrome Lowry syndrome Lowry-Wood syndrome Lowry-Yong syndrome LPA LPAC LPD LPG LPI LPL deficiency LPP LPP LP pemphigoides LP pigmentosa LP pigmentosus LQT7 LQT8 LRP5-related primary osteoporosis [orpha.net]
Skin
- Koilonychia
(文献) (1) Hellier FF: Hereditary koilonychia. Brit J Derm 62: 213-214, 1950 (2) Handa Y et al. A note in the genetics of koilonychia. [syndromefinder.ncchd.go.jp]
Pits may be seen in psoriasis, atopic dermatitis or AA. • 4 - Koilonychia - spoon-shaped nails : Koilonychia is defined as a concave dorsal surface, sufficient to hold a drop of water. [handresearch.com]
There is platyonychia and koilonychia, which may overgrow the lateral folds and involve all nails of the toes and fingers. [clinicalgate.com]
Coronary disease can present with koilonychias. [bioline.org.br]
"Nailing the Diagnosis: Koilonychia." The Permanente Journal 16.3 (2012): 65. Jalili, M. A., and S. Al Kassab. "Koilonychia and cystine content of nails." [derangedphysiology.com]
- Leukonychia Punctata
Spanish leuconiquia punteada English LEUKONYCHIA PUNCTATA Last Update: 2014-12-09 Usage Frequency: 6 Warning: This alignment may be wrong. Please delete it you feel so. [mymemory.translated.net]
Leukonychia may involve all of the nail (leukonychia totalis) or only part of the nail (leukonychia partialis), or can appear as one or more transverse bands (leukonychia striata) or white spots (leukonychia punctata). [uniprot.org]
Leukonychia punctata Leukonychia punctata is also referred to as true leukonychia. This is the most common or frequently recorded leukonychia of all types. This is the condition which causes actual whites spots to appear on nail. [symptomstreatment.org]
(white lines) Minor nail matrix or cuticle Trauma Leukonychia punctata (white spots) Minor Trauma to Nail Cuticle or matrix IV. [fpnotebook.com]
- Yellow Nails
Nail changes include thick, yellow nails, with increased transverse curvature, loss of cuticle associated with a rounded proximal nail-fold and slowed growth rate. [19] The yellow nail syndrome is associated with many pulmonary diseases like asthma, pleural [bioline.org.br]
Localized bacterial and fungal infections of the nail, the most common nail problems seen by family physicians, have been reviewed elsewhere. 3, 4 Growth Disturbances YELLOW NAIL SYNDROME A 1964 study 5 described “yellow nail syndrome,” in which nails [aafp.org]
congenital alopecia, and nail dystrophy tinea favosa tinea unguium Trichoodontoonychial Dysplasia vitiligo + yellow nail syndrome + Yemenite Deaf-Blind Hypopigmentation Syndrome [rgd.mcw.edu]
- Pachyonychia
Congenital pterygium of nail Curry-Hall syndrome Keratoderma with pachyonychia congenita Leukonychia, congenital Onychauxis, congenital Pachydermoperiostosis of nail Pachyonychia congenita syndrome Pachyonychia congenita type II of Jackson-Lawler Pachyonychia [icd9data.com]
[…] disorder 3 nonsyndromic congenital nail disorder 4 nonsyndromic congenital nail disorder 5 nonsyndromic congenital nail disorder 6 nonsyndromic congenital nail disorder 7 nonsyndromic congenital nail disorder 8 Odontomicronychial Dysplasia Onycholysis + pachyonychia [rgd.mcw.edu]
For a discussion of pachyonychia congenita, see Chapter 650. Habit tic deformity consists of a depression down the center of the nail with numerous horizontal ridges extending across the nail from it. [clinicalgate.com]
[…] pilonidal cyst (685.0-685.1) 757.4 Specified anomalies of hair Congenital: alopecia atrichosis beaded hair hypertrichosis monilethrix Persistent lanugo 757.5 Specified anomalies of nails Anonychia Congenital: clubnail koilonychia leukonychia onychauxis pachyonychia [dhs.state.il.us]
Garrick-Wilson Pachyonychia Congenita In my personal practice I have never seen a moderate to full-blown pachyonychia congenita. [sites.google.com]
- Skin Disease
Skin disease Keyword (es) Congénito Estudio caso Estudio familiar Hombre Leuconiquia Uña patología Piel patología Classification Pascal 002 Biological and medical sciences / 002B Medical sciences / 002B08 Dermatology / 002B08H Hair and nails disorders [pascal-francis.inist.fr]
Category Skin disease Brite Human diseases [BR:br08402] Skin diseases Skin and soft tissue diseases H01307 Nonsyndromic congenital nail disorder Human diseases in ICD-11 classification [BR:br08403] 14 Diseases of the skin Genetic and developmental disorders [genome.jp]
Molecular advances in genetic skin diseases. Curr Opin Pediatr 2002; 14: 419-25 Smith F. The molecular genetics of keratin disorders. Am J Clin Dermatol 2003; 4: 347-64 Virtanen M, Smith SK, Gedde-Dahl T Jr, et al. [books.google.com]
Chapter 655 Disorders of the Nails Nail abnormalities in children may be manifestations of generalized skin disease, skin disease localized to the periungual region, systemic disease, drugs, trauma, or localized bacterial and fungal infections ( Table [clinicalgate.com]
Lens Luxatie Lens Subluxation LENTIGO LENTIGO MALIGNA LENTIGO MALIGNA MELANOMA LIVER SPOTS SOLAR LENTIGO SENILE LENTIGO LMM Zie ook: HUIDAANDOENINGEN SKIN DISEASES Zie ook: HUIDKANKER SKIN CANCER MELANOOM MELANOMA Diagnose Kanker: Wat is een melanoom [catsclem.nl]
Psychiatrical
- Compulsive Disorder
Striated leukonychia is noted in manic-depressive illness. [1] Onychotillomania, an extreme form of self mutilation of the nails is thought to be an obsessive-compulsive disorder. [1] Autoimmune disorders [24] a. [bioline.org.br]
Neurologic
- Meningism
Congenital absence of the skin, particularly on the scalp, larger defects may extend to the dura or meninges. Generally isolated lesions, but can also be associated with a variety of other genetic disorders. Heals as a flat scar or keloid lump. [embryology.med.unsw.edu.au]
[…] erosion Wide tufts of distal phalanges Ectrodactyly Split foot Small proximal tibial epiphyses Blue irides Fair hair Sparse axillary hair Slow-growing hair Aplasia/Hypoplasia of the nipples Irregular distal femoral epiphysis Hypoplasia of the thymus Meningeal [mendelian.co]
[…] en naar de leer-en gedragsproblemen bij kinderen na een bacteriele meningitis Leerstoornissen Leer- en Ontwikkelingsstoornissen Glossary of Terms for Learning Disabilities and Computer Aided Instruction Learning Disabilities Internet Resources for Special [catsclem.nl]
Lymphocytic interstitial pneumonia Lymphocytic variant HES Lymphoepithelial-like carcinoma Lymphogranulomatosis X Lymphoid hemopathy Lymphoid HES Lymphoid interstitial pneumonia Lymphoma Lymphomatoid granulomatosis Lymphomatoid papulosis Lymphomatous meningitis [orpha.net]
Macroencephaly Macrogyria Megalencephaly Multiple anomalies of brain NOS Porencephaly Ulegyria 742.5 Other specified anomalies of spinal cord 742.51 Diastematomyelia 742.53 Hydromyelia Hydrorhachis 742.59 Other Amyelia Atelomyelia Congenital anomaly of spinal meninges [theodora.com]
- Confusion
Muehrcke Lines and Mee 's lines would appear to be different entities often confused with this type of transverse leukonychia. Or, perhaps we are missing something inthis woman's history. References: 1. Arch Dermatol. 1983 Apr;119(4):334-5. [vgrd.blogspot.com]
They should not be confused with Mees’ and Muehrcke’s lines, which parallel the lunula across the entire nail bed and occur in more than one nail. [aafp.org]
Liver disease, chemotherapeutic drugs, and malnutrition can also be responsible. [10] Muehrcke’s lines have been reported in association with heart transplantation [6] and Peutz Jegher’s syndrome. [14] Muehrcke’s bands may be confused with Mee’s lines [bioline.org.br]
Workup
No, this boy has congenital leukonychia totalis; a workup for underlying disease is unnecessary. [consultant360.com]
Microbiology
- Pseudomonas
Causes: Miscellaneous Color Changes Green Nails ( Chloronychia ) Pseudomonas pyocyanea or pseudomonas aeruginosa infection Red Nails Nail Telangiectasia Congestive Heart Failure VI. [fpnotebook.com]
Commonly it becomes infected, especially with Candida albicans or pseudomonas. Eventually the nail fold retracts and becomes thickened and rounded. [patient.info]
Green-nail syndrome is caused by infection with Pseudomonas. It is generally a harmless infection, usually of 1 or 2 nails, and is noteworthy for its striking blue-green color. [msdmanuals.com]
Treatment
"Psoriasis Pathogenesis and Treatment". International Journal of Molecular Sciences. 20 (6): 1475. doi:10.3390/ijms20061475. PMC 6471628. PMID 30909615. ^ "Leukonychia – Symptoms, Causes, Treatment, Pictures". byebyedoctor.com. [en.wikipedia.org]
Refer early, as timely treatment can prevent destructive permanent nail damage [ 1 ]. Treatment: Injection of steroid into the proximal nail fold is the conventional treatment. Successful treatment with etanercept has been reported [ 12, 13 ]. [patient.info]
Frequent clipping of the nail increases the response to treatment. [msdmanuals.com]
Treatment: Increasing the quantity of grains, vegetables and nuts and even taking a zinc supplement (as zinc deficiency is a cause of leukonychia) is a good preventative and treatment, as is keeping affected nails out of harms way when using chemicals [medigoo.com]
Treatment of white spots on nails If you suspect that the white spot on nails is due to leukonychia, then you should adopt treatment to eradicate the issue. Unfortunately, there is no specific treatment for this condition. [symptomstreatment.org]
Prognosis
Prognosis The prognosis of patients with lichen striatum is excellent. Recovery is complete. In a year lesions regress spontaneously. Relapses may occur but are rare. Hyper and hypopigmentation postinflamatorie may require up to 30 months to deliver. [medicaldb.blogspot.com]
Nonetheless, total leukonychia due to systemic disorders appears to have reasonably good prognosis as it seems to be transient and reversible. [amhsjournal.org]
Gives advice on lifestyle, management and prognosis BC CH.I.L.D. Foundation Canadian charity organization for CHildren with Intestinal and Liver Disorders (CH.I.L.D.). [catsclem.nl]
Nail biopsy is not recommended for diagnosis, due to the benignity of the disease and a good prognosis. TND can affect one nail or all nails (Fig. 14). [karger.com]
Etiology
Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology. [icd10coded.com]
Review of mycotic melanonychia and its relationship with the various etiological agents. CrossRef PubMed Google Scholar 31. Urán ME, Cano LE. [link.springer.com]
The etiology of lichen striatum is unknown. The most accepted hypothesis is one that involves a combination of predisposing factors and environmental factors genetigi. Atopy may be a predisposing factor. [medicaldb.blogspot.com]
Sudanese Longitudinal erythronychia Onychopapilloma (MC etiology) Other malignant and non-malignant neoplasms Inflammatory - Darier's, lichen planus, etc [quizlet.com]
Pruritus prevalence among HD patients ranged from 19% to 90% in the prior studies. 16,19 The etiology of pruritus in CRF is unknown; however, it has been associated with the degree of renal insufficiency (urine output of < 500 mL), 20 dry skin, 21 retention [woundsresearch.com]
Epidemiology
Certification: Dermatology, American Board of Dermatology (2014) Medical Education:University of Michigan Medical School (2010) MI Internship:Oakwood Hospital and Medical CenterMI Masters in Public Health, Boston University School of Public Health, Epidemiology [profiles.stanford.edu]
White superficial onychomycosis: epidemiological, clinical, and pathological study of 79 patients. Arch Dermatol. 2004;140:696–701. CrossRef PubMed Google Scholar 18. Oyeka CA, Gugnani HC. [link.springer.com]
However, only a small amount of epidemiological data extracted from a few studies is currently available for the pediatric population [5]. [karger.com]
Pathophysiology
What struck me as interesting in this man was the following: i had never seen this pattern before; i could not and still can not imagine a pathophysiological process leading to such an unusual symmetrical pattern of feathered chevrons that were non-continuous [vgrd.blogspot.com]
One common explanation is zinc deficiency. [4] Pathophysiology Associated Conditions Kidney disease Liver disease Causes Causes In Alphabetical Order Anemia Arsenic poisoning Calcium deficiency Cardiac Diseases Cirrhosis Congenital isolated nail dysplasia [wikidoc.org]
The pathophysiology seems to be some sort of distal subungual telangiectasia. The causes of this sign are as follows: Cirrhosis CCF NIDDM Just straight-out old age. Eponymous nail lines: Muehrcke's lines This is known as "leukonychia striata". [derangedphysiology.com]
Prevention
So it is advised to use the products in moderation.An individual can prevent it by taking better care of the nails and prevent them from being mistreated by stopping hitting, rubbing or biting them.If there has not been any improvement in these white [medigoo.com]
Treatment and Prevention of Leukonychia There is no treatment for leuconychia as such. The white marks will dissapear on their own, when the nails will grow outwards. Reducing minor injury to the nails may prevent the white marks. [thebeautytips.com]
An individual can prevent leukonychia by taking better care of the nails and prevent them from being mistreated by stopping hitting, rubbing or biting them. [byebyedoctor.com]
Table 1 Classification of leukonychia The proposed white discoloration of the nail is attributable to reflection of light from large keratohyaline granules present in the parakeratotic cells of the ventral portion of nail plate thus preventing the visualisation [ncbi.nlm.nih.gov]
To prevent and reduce complications and morbidity can be given corticosteroids. They have anti-inflammatory effects and alter the body's response to different stimuli. [medicaldb.blogspot.com]