Presentation
A 16-year-old male presented with white-colored fingernails since birth [Figure 1]. Toenails were normal. None of the family members were affected. Hematological investigations were normal. [ncbi.nlm.nih.gov]
Nail and skin changes are present at birth in only 50% of cases, but by 5 years, they are seen in more than 75% of children. By the age of 10 years, pain can be present as a symptom, which greatly impairs quality of life [28]. [karger.com]
Anonychia during neonatal period may be the presenting symptom. [ijdvl.com]
Surgery Longitudinal Melanonychia Tumors of the Nail Apparatus Honors & Awards Fulbright Scholar - Hamburg, Germany, United States Department of State, Bureau of Educational and Cultural Affairs National Medical Honor Society, Alpha Omega Alpha (2009-Present [profiles.stanford.edu]
True leukonychia presents with three morphologic variants: Punctate, striate, and diffuse. Our patient had unusual and atypical presentation of true leukonychia. [ijpvmjournal.net]
Skin
- Leukonychia Punctata
Leukonychia may involve all of the nail (leukonychia totalis) or only part of the nail (leukonychia partialis), or can appear as one or more transverse bands (leukonychia striata) or white spots (leukonychia punctata). [uniprot.org]
Spanish leuconiquia punteada English LEUKONYCHIA PUNCTATA Last Update: 2014-12-09 Usage Frequency: 6 Warning: This alignment may be wrong. Please delete it you feel so. [mymemory.translated.net]
Leukonychia punctata Leukonychia punctata is also referred to as true leukonychia. This is the most common or frequently recorded leukonychia of all types. This is the condition which causes actual whites spots to appear on nail. [symptomstreatment.org]
(white lines) Minor nail matrix or cuticle Trauma Leukonychia punctata (white spots) Minor Trauma to Nail Cuticle or matrix IV. [fpnotebook.com]
- Nail Deformity
In this disorder, patients pick at and self-mutilate their nails, which can lead to parallel transverse grooves and ridges (washboard deformity or habit-tic nail deformity). [merckmanuals.com]
pitting, and pincer nail deformity. [emedicine.medscape.com]
Download Figure: 48 Alopecia areata and t rachyonychia Download Figure: 49 A myxoid cyst (black arrow) affecting nail growth Download Figure: 50 Habit-tic deformity Download Figure: 51 Habit-tic deformity Fir tree appearance Download Figure: 52 Habit-tic [pcds.org.uk]
The nail dystrophy can be permanent, with anonychia, progressive hyperkeratosis with onychogryphosis, nail thickening, and parrot beak nail deformity in adult life [19]. [karger.com]
Workup
No, this boy has congenital leukonychia totalis; a workup for underlying disease is unnecessary. [consultant360.com]
Treatment
"Psoriasis Pathogenesis and Treatment". International Journal of Molecular Sciences. 20 (6): 1475. doi:10.3390/ijms20061475. PMC 6471628. PMID 30909615. ^ "Leukonychia – Symptoms, Causes, Treatment, Pictures". byebyedoctor.com. [en.wikipedia.org]
Refer early, as timely treatment can prevent destructive permanent nail damage [ 1 ]. Treatment: Injection of steroid into the proximal nail fold is the conventional treatment. Successful treatment with etanercept has been reported [ 12, 13 ]. [patient.info]
Prognosis
Prognosis The prognosis of patients with lichen striatum is excellent. Recovery is complete. In a year lesions regress spontaneously. Relapses may occur but are rare. Hyper and hypopigmentation postinflamatorie may require up to 30 months to deliver. [medicaldb.blogspot.com]
Nonetheless, total leukonychia due to systemic disorders appears to have reasonably good prognosis as it seems to be transient and reversible. [amhsjournal.org]
Gives advice on lifestyle, management and prognosis BC CH.I.L.D. Foundation Canadian charity organization for CHildren with Intestinal and Liver Disorders (CH.I.L.D.). [catsclem.nl]
Nail biopsy is not recommended for diagnosis, due to the benignity of the disease and a good prognosis. TND can affect one nail or all nails (Fig. 14). [karger.com]
Etiology
Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology. [icd10coded.com]
Review of mycotic melanonychia and its relationship with the various etiological agents. CrossRef PubMed Google Scholar 31. Urán ME, Cano LE. [link.springer.com]
The etiology of lichen striatum is unknown. The most accepted hypothesis is one that involves a combination of predisposing factors and environmental factors genetigi. Atopy may be a predisposing factor. [medicaldb.blogspot.com]
Sudanese Longitudinal erythronychia Onychopapilloma (MC etiology) Other malignant and non-malignant neoplasms Inflammatory - Darier's, lichen planus, etc [quizlet.com]
It has multiple etiologies: hereditary, acquired, or idiopathic. [karger.com]
Epidemiology
Certification: Dermatology, American Board of Dermatology (2014) Medical Education:University of Michigan Medical School (2010) MI Internship:Oakwood Hospital and Medical CenterMI Masters in Public Health, Boston University School of Public Health, Epidemiology [profiles.stanford.edu]
White superficial onychomycosis: epidemiological, clinical, and pathological study of 79 patients. Arch Dermatol. 2004;140:696–701. CrossRef PubMed Google Scholar 18. Oyeka CA, Gugnani HC. [link.springer.com]
However, only a small amount of epidemiological data extracted from a few studies is currently available for the pediatric population [5]. [karger.com]
Pathophysiology
One common explanation is zinc deficiency. [4] Pathophysiology Associated Conditions Kidney disease Liver disease Causes Causes In Alphabetical Order Anemia Arsenic poisoning Calcium deficiency Cardiac Diseases Cirrhosis Congenital isolated nail dysplasia [wikidoc.org]
What struck me as interesting in this man was the following: i had never seen this pattern before; i could not and still can not imagine a pathophysiological process leading to such an unusual symmetrical pattern of feathered chevrons that were non-continuous [vgrd.blogspot.com]
The pathophysiology seems to be some sort of distal subungual telangiectasia. The causes of this sign are as follows: Cirrhosis CCF NIDDM Just straight-out old age. Eponymous nail lines: Muehrcke's lines This is known as "leukonychia striata". [derangedphysiology.com]
Prevention
Table 1 Classification of leukonychia The proposed white discoloration of the nail is attributable to reflection of light from large keratohyaline granules present in the parakeratotic cells of the ventral portion of nail plate thus preventing the visualisation [ncbi.nlm.nih.gov]
So it is advised to use the products in moderation.An individual can prevent it by taking better care of the nails and prevent them from being mistreated by stopping hitting, rubbing or biting them.If there has not been any improvement in these white [medigoo.com]
Treatment and Prevention of Leukonychia There is no treatment for leuconychia as such. The white marks will dissapear on their own, when the nails will grow outwards. Reducing minor injury to the nails may prevent the white marks. [thebeautytips.com]
An individual can prevent leukonychia by taking better care of the nails and prevent them from being mistreated by stopping hitting, rubbing or biting them. [byebyedoctor.com]